ME01444B - Supstituisani indolil alkil amino derivati kao novi inhibitori histon deacetilaze - Google Patents
Supstituisani indolil alkil amino derivati kao novi inhibitori histon deacetilazeInfo
- Publication number
- ME01444B ME01444B MEP-2012-53A MEP5312A ME01444B ME 01444 B ME01444 B ME 01444B ME P5312 A MEP5312 A ME P5312A ME 01444 B ME01444 B ME 01444B
- Authority
- ME
- Montenegro
- Prior art keywords
- formula
- 6alkyl
- hydrogen
- compound
- reaction
- Prior art date
Links
- 102000003964 Histone deacetylase Human genes 0.000 title 1
- 108090000353 Histone deacetylase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 27
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- -1 hydroxy, amino Chemical group 0.000 claims 14
- 150000002431 hydrogen Chemical group 0.000 claims 13
- 239000000543 intermediate Substances 0.000 claims 12
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000005843 halogen group Chemical group 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 4
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 claims 4
- 150000003254 radicals Chemical class 0.000 claims 4
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 claims 2
- MBVFRSJFKMJRHA-UHFFFAOYSA-N 4-fluoro-1-benzofuran-7-carbaldehyde Chemical compound FC1=CC=C(C=O)C2=C1C=CO2 MBVFRSJFKMJRHA-UHFFFAOYSA-N 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000000815 N-oxide group Chemical group 0.000 claims 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000001041 indolyl group Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims 1
- 239000003929 acidic solution Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000002585 base Substances 0.000 claims 1
- 239000003637 basic solution Substances 0.000 claims 1
- 239000012964 benzotriazole Substances 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000004494 ethyl ester group Chemical group 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 1
- 125000002346 iodo group Chemical group I* 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04077172 | 2004-07-28 | ||
| US59218204P | 2004-07-29 | 2004-07-29 | |
| PCT/EP2005/053612 WO2006010750A1 (en) | 2004-07-28 | 2005-07-25 | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME01444B true ME01444B (me) | 2013-12-20 |
Family
ID=34928411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2012-53A ME01444B (me) | 2004-07-28 | 2005-07-25 | Supstituisani indolil alkil amino derivati kao novi inhibitori histon deacetilaze |
Country Status (10)
| Country | Link |
|---|---|
| CN (1) | CN1993353B (de) |
| AT (1) | ATE542812T1 (de) |
| DK (1) | DK1781639T3 (de) |
| ES (1) | ES2381117T3 (de) |
| ME (1) | ME01444B (de) |
| PT (1) | PT1781639E (de) |
| RS (1) | RS52304B (de) |
| SI (1) | SI1781639T1 (de) |
| UA (1) | UA93352C2 (de) |
| ZA (1) | ZA200700764B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115487191B (zh) * | 2016-02-22 | 2024-05-14 | 中国科学院上海巴斯德研究所 | Quisinostat，一种新型的高效抗疟药物 |
| CN107721980B (zh) * | 2017-08-25 | 2019-07-12 | 南京医科大学 | 一类氟尿嘧啶和Quisinosta的乏氧靶向前药及其应用 |
| CN112485233B (zh) * | 2020-11-03 | 2022-08-26 | 山东师范大学 | 一种检测去乙酰化酶用纳米传感器及其检测方法和应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4648628B2 (ja) * | 2002-03-13 | 2011-03-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼの新規な阻害剤としてのカルボニルアミノ誘導体 |
-
2005
- 2005-07-25 PT PT05767934T patent/PT1781639E/pt unknown
- 2005-07-25 CN CN2005800256290A patent/CN1993353B/zh not_active Expired - Lifetime
- 2005-07-25 SI SI200531516T patent/SI1781639T1/sl unknown
- 2005-07-25 ES ES05767934T patent/ES2381117T3/es not_active Expired - Lifetime
- 2005-07-25 ME MEP-2012-53A patent/ME01444B/me unknown
- 2005-07-25 RS RS20120165A patent/RS52304B/sr unknown
- 2005-07-25 UA UAA200614022A patent/UA93352C2/ru unknown
- 2005-07-25 AT AT05767934T patent/ATE542812T1/de active
- 2005-07-25 DK DK05767934.2T patent/DK1781639T3/da active
-
2007
- 2007-01-26 ZA ZA200700764A patent/ZA200700764B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| UA93352C2 (ru) | 2011-02-10 |
| CN1993353B (zh) | 2010-12-01 |
| ATE542812T1 (de) | 2012-02-15 |
| ES2381117T3 (es) | 2012-05-23 |
| RS52304B (sr) | 2012-12-31 |
| CN1993353A (zh) | 2007-07-04 |
| SI1781639T1 (sl) | 2012-06-29 |
| PT1781639E (pt) | 2012-05-02 |
| DK1781639T3 (da) | 2012-05-14 |
| ZA200700764B (en) | 2008-09-25 |
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