ME02107B - Heteroaril jedinjenja kao ligandi 5-ht4 receptora - Google Patents
Heteroaril jedinjenja kao ligandi 5-ht4 receptoraInfo
- Publication number
- ME02107B ME02107B MEP-2015-47A MEP201547A ME02107B ME 02107 B ME02107 B ME 02107B ME P201547 A MEP201547 A ME P201547A ME 02107 B ME02107 B ME 02107B
- Authority
- ME
- Montenegro
- Prior art keywords
- receptor ligands
- heteroaryl compounds
- integer
- alkyl
- range
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Semiconductor Integrated Circuits (AREA)
- Structures Or Materials For Encapsulating Or Coating Semiconductor Devices Or Solid State Devices (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Claims (1)
1.Jedinjenje opste formule (I):pri čemu,jeJeje tacka vezivanja ;R1 je alkil, R3-O-R3 iliR2 je cikloalkil iii heterociklil, i opciono je supstituisan sa vodonikom, alkilom ili -CO-OR3;R3 je alkil;"Y"je C ili 0 ;"m" je ceo broj u opsegu od 0 do 1; uz uslov da kada m je 0, onda je R1 cikloalkil iliheterociklil;"n" je ceo broj u opsegu od 0 do 2;"p" je ceo broj u opsegu od 0 do 1; iii njegova farmaceutski prihvatljiva so.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3203CH2011 | 2011-09-19 | ||
| EP12716662.7A EP2758394B1 (en) | 2011-09-19 | 2012-01-05 | Heteroaryl compounds as 5-ht4 receptor ligands |
| PCT/IN2012/000011 WO2013042135A1 (en) | 2011-09-19 | 2012-01-05 | Heteroaryl compounds as 5-ht4 receptor ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME02107B true ME02107B (me) | 2015-10-20 |
Family
ID=46001349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2015-47A ME02107B (me) | 2011-09-19 | 2012-01-05 | Heteroaril jedinjenja kao ligandi 5-ht4 receptora |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US9079894B2 (me) |
| EP (1) | EP2758394B1 (me) |
| JP (1) | JP5714729B2 (me) |
| KR (1) | KR101551481B1 (me) |
| CN (1) | CN103380131B (me) |
| AP (1) | AP3307A (me) |
| AU (1) | AU2012311057B2 (me) |
| BR (1) | BR112014001083B8 (me) |
| CA (1) | CA2823548C (me) |
| CY (1) | CY1116173T1 (me) |
| DK (1) | DK2758394T3 (me) |
| EA (1) | EA022374B1 (me) |
| ES (1) | ES2531885T3 (me) |
| HR (1) | HRP20150229T1 (me) |
| IL (1) | IL231305A0 (me) |
| ME (1) | ME02107B (me) |
| MX (1) | MX337721B (me) |
| PL (1) | PL2758394T3 (me) |
| PT (1) | PT2758394E (me) |
| RS (1) | RS53940B1 (me) |
| SG (1) | SG2014003560A (me) |
| SI (1) | SI2758394T1 (me) |
| SM (1) | SMT201500087B (me) |
| WO (1) | WO2013042135A1 (me) |
| ZA (1) | ZA201309100B (me) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2833507A1 (en) * | 2011-06-07 | 2012-12-13 | Dainippon Sumitomo Pharma Co., Ltd. | Indazole- and pyrrolopyridine-derivative and pharmaceutical use thereof |
| CN105120851A (zh) * | 2013-04-05 | 2015-12-02 | Abc生物科学公司 | 用于医疗用途，具体为用于治疗与氧化应激相关的疾病或者炎症和用于保存或者洗涤器官的barettin及其衍生物 |
| EA029951B1 (ru) * | 2013-12-16 | 2018-06-29 | Сувен Лайф Сайенсиз Лимитед | Соединения индазола в качестве агонистов 5-ht-рецептора |
| HRP20201478T1 (hr) * | 2014-08-16 | 2021-02-19 | Suven Life Sciences Limited | Proces proizvodnje 1-izopropil-3-{5-[1-(3-metoksipropil)piperidin-4-il]-[1,3,4]oksadiazol-2-il}-1h-indazol oksalata u velikom razmjeru |
| CN107406434B (zh) * | 2015-02-13 | 2020-09-11 | 苏文生命科学有限公司 | 作为5-ht4受体激动剂的酰胺化合物 |
| CN107540568A (zh) * | 2017-08-25 | 2018-01-05 | 许昌恒生制药有限公司 | 一种乙氧酰胺苯甲酯的制备方法 |
| CA3116650C (en) | 2018-10-18 | 2023-08-22 | Suven Life Sciences Limited | New uses of a 5-ht4 receptor agonist |
| US11458149B1 (en) | 2019-05-31 | 2022-10-04 | Ikena Oncology, Inc. | TEAD inhibitors and uses thereof |
| BR112021024108A2 (pt) | 2019-05-31 | 2022-03-22 | Ikena Oncology Inc | Inibidores de tead e usos dos mesmos |
| CN110746450A (zh) * | 2019-09-17 | 2020-02-04 | 济南康和医药科技有限公司 | 一种贝前列素钠关键中间体的合成方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5492919A (en) * | 1991-08-03 | 1996-02-20 | Smithkline Beecham P.L.C. | 5-HT4 receptor antagonists |
| TW360653B (en) * | 1995-03-01 | 1999-06-11 | Janssen Pharmaceutica Nv | A oxadiazole compound having colon motility stimulating properties, its preparation process and its pharmaceutical composition |
| JP4263240B2 (ja) * | 1995-11-09 | 2009-05-13 | サノフィ−アベンティス | ５−フェニル−３−（ピペリジン−４−イル）−１，３，４−オキサジアゾール−２（３ｈ）−オン誘導体、及びその５−ｈｔ４又はｈ３レセプターリガンドとしての用途 |
| GB0115862D0 (en) * | 2001-06-28 | 2001-08-22 | Smithkline Beecham Plc | Compounds |
| ES2338882T3 (es) | 2003-11-24 | 2010-05-13 | Pfizer, Inc. | Compuestos de acido quinolona-carboxilico que tienen actividad agonista del receptor 5-ht4. |
| AU2006217534B8 (en) | 2005-02-22 | 2011-12-08 | Pfizer Inc. | Oxyindole derivatives as 5HT4 receptor agonists |
| US8816090B2 (en) | 2005-02-25 | 2014-08-26 | Pfizer Inc. | Benzisoxazole derivatives |
| WO2007010390A1 (en) | 2005-07-22 | 2007-01-25 | Pfizer Japan Inc. | Indazolecarboxamide derivatives as 5ht4 receptor agonists |
| RU2426731C2 (ru) * | 2005-12-23 | 2011-08-20 | Ф. Хоффманн-Ля Рош Аг | Производные арил-изоксазоло-4-ил-оксадиазола |
| US20080167286A1 (en) * | 2006-12-12 | 2008-07-10 | Abbott Laboratories | Pharmaceutical compositions and their methods of use |
| US20080255203A1 (en) * | 2007-04-12 | 2008-10-16 | Abbott Laboratories | Heterocyclic compounds and their methods of use |
| US8524751B2 (en) * | 2009-03-09 | 2013-09-03 | GlaxoSmithKline Intellecutual Property Development | 4-oxadiazol-2-YL-indazoles as inhibitors of P13 kinases |
-
2012
- 2012-01-05 DK DK12716662.7T patent/DK2758394T3/en active
- 2012-01-05 PL PL12716662T patent/PL2758394T3/pl unknown
- 2012-01-05 HR HRP20150229AT patent/HRP20150229T1/hr unknown
- 2012-01-05 EP EP12716662.7A patent/EP2758394B1/en active Active
- 2012-01-05 AU AU2012311057A patent/AU2012311057B2/en active Active
- 2012-01-05 WO PCT/IN2012/000011 patent/WO2013042135A1/en not_active Ceased
- 2012-01-05 KR KR1020137020582A patent/KR101551481B1/ko active Active
- 2012-01-05 SI SI201230163T patent/SI2758394T1/sl unknown
- 2012-01-05 BR BR112014001083A patent/BR112014001083B8/pt not_active IP Right Cessation
- 2012-01-05 US US13/982,486 patent/US9079894B2/en active Active
- 2012-01-05 EA EA201391056A patent/EA022374B1/ru unknown
- 2012-01-05 CA CA2823548A patent/CA2823548C/en active Active
- 2012-01-05 RS RS20150234A patent/RS53940B1/sr unknown
- 2012-01-05 ME MEP-2015-47A patent/ME02107B/me unknown
- 2012-01-05 SG SG2014003560A patent/SG2014003560A/en unknown
- 2012-01-05 CN CN201280009072.1A patent/CN103380131B/zh active Active
- 2012-01-05 PT PT127166627T patent/PT2758394E/pt unknown
- 2012-01-05 AP AP2013007301A patent/AP3307A/xx active
- 2012-01-05 JP JP2013554062A patent/JP5714729B2/ja active Active
- 2012-01-05 ES ES12716662.7T patent/ES2531885T3/es active Active
- 2012-01-05 MX MX2013014577A patent/MX337721B/es active IP Right Grant
-
2013
- 2013-12-04 ZA ZA2013/09100A patent/ZA201309100B/en unknown
-
2014
- 2014-03-04 IL IL231305A patent/IL231305A0/en active IP Right Grant
-
2015
- 2015-03-30 CY CY20151100308T patent/CY1116173T1/el unknown
- 2015-04-09 SM SM201500087T patent/SMT201500087B/xx unknown
- 2015-06-10 US US14/735,237 patent/US9636335B2/en active Active
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