ME02705B - Inženjerisana anti-il-23 antitela - Google Patents

Inženjerisana anti-il-23 antitela

Info

Publication number
ME02705B
ME02705B MEP-2017-73A MEP7317A ME02705B ME 02705 B ME02705 B ME 02705B ME P7317 A MEP7317 A ME P7317A ME 02705 B ME02705 B ME 02705B
Authority
ME
Montenegro
Prior art keywords
antibody
binding fragment
antigen
residues
seq
Prior art date
Application number
MEP-2017-73A
Other languages
German (de)
English (en)
French (fr)
Inventor
Leonard G Presta
Peter Orth
Brian M Beyer
Yan-Hui Liu
Richard N Ingram
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37685722&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME02705(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of ME02705B publication Critical patent/ME02705B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Claims (17)

1. Antitelo, ili njegov antigen-vezujući fragment, naznačen time, što se vezuje za humani IL-23p19 na epitopu koji sadrži rezidue 82-95 i rezidue 133-140 SEQ ID NO: 29.
2. Antitelo, ili njegov antigen-vezujući fragment, iz zahteva 1, naznačen time, što se vezuje za epitop koji sadrži rezidue E82, G86, S87, D88, T91, G92, E93, P94, S95, H106, P133, S134, Q135, P136, W137, R139 i L140 SEQ ID NO: 29.
3. Antitelo, ili njegov antigen-vezujući fragment, iz zahteva 1, naznačen time, što antitelo sadrži: CDRL1 koji se sastoji od rezidua 43-53 SEQ ID NO: 4; CDRL2 koji se sastoji od rezidua 69-75 SEQ ID NO: 4; CDRL3 koji se sastoji od rezidua 108-116 SEQ ID NO: 4; CDRH1 koji se sastoji od rezidua 45-54 SEQ ID NO: 3; CDRH2 koji se sastoji od rezidua 69-85 SEQ ID NO: 3; i CDRH3 koji se sastoji od rezidua 118-123 SEQ ID NO: 3.
4. Antitelo, ili njegov antigen-vezujući fragment, iz zahteva 3, naznačen time, što: varijabilni region lakog lanca antitela, ili njegovog vezujućeg fragmenta, sadrži sekvencu rezidua 20-129 SEQ ID NO: 4, ili njenu varijantu; i varijabilni region teškog lanca antitela, ili njegovog vezujućeg fragmenta, sadrži sekvencu rezidua 20-134 SEQ ID NO: 3, ili njenu varijantu; pri čemu varijanta sadrži do 20 konzervativno modifikovanih aminokiselinskih supstitucija.
5. Antitelo, ili njegov antigen-vezujući fragment, iz zahteva 4, naznačen time, što je vezujuće jedinjenje antitelo, ili njegov vezujući fragment, koji uključuje: varijabilni region lakog lanca koji sadrži rezidue 20-129 SEQ ID NO: 4; i varijabilni region teškog lanca koji sadrži rezidue 20-134 SEQ ID NO: 3.
6. Antitelo ili njegov antigen-vezujući fragment iz zahteva 3, naznačen time, što blokira aktivnost posredovanu IL-23.
7. Izolovana nukleinska kiselina, naznačena time, što kodira varijabilni region lakog lanca i varijabilni region teškog lanca antitela, ili njegovog antigen- vezujućeg fragmenta, iz zahteva 4.
8. Ekspresioni vektor, naznačen time, što sadrži nukleinsku kiselinu iz zahteva 7 operabilno povezanu sa kontrolnim sekvencama koje prepoznaje ćelija-domaćin, kada se ćelija-domaćin transfektuje vektorom.
9. Ćelija-domaćin, naznačena time, što sadrži ekspresioni vektor iz zahteva 8.
10. Metod proizvodnje polipeptida, naznačen time, što uključuje: kultivisanje ćelije-domaćina iz zahteva 9 u kultivacionom medijumu pod uslovima pod kojima se eksprimira sekvenca nukleinske kiseline, čime se proizvode polipeptidi koji sadrže varijabilne regione lakog i teškog lanca; i sakupljanje polipeptida iz ćelije-domaćina ili kultivacionog medijuma.
11. Antitelo, ili njegov antigen-vezujući fragment, iz zahteva 2, naznačen time, što sadrži konstantni region humanog γ1 teškog lanca.
12. Antitelo ili njegov antigen-vezujući fragment iz zahteva 2, naznačen time, što sadrži konstantni region humanog γ4 teškog lanca.
13. Antitelo, ili njegov antigen-vezujući fragment, iz zahteva 1, naznačen time, što se fragment antitela bira iz grupe koja se sastoji od Fab, Fab’, Fab’-SH, Fv, scFv, F(ab’)2 i dijatela.
14. Smeša, naznačena time, što sadrži antitelo, ili njegov antigen-vezujući fragment, iz zahteva 4 u kombinaciji sa farmaceutski prihvatljivim nosačem ili razblaživačem.
15. Smeša iz zahteva 14, naznačena time, što sadrži još i imunosupresivno ili antizapaljensko sredstvo.
16. Ćelija-domaćin, naznačena time, što sadrži: (a) ekspresioni vektor koji uključuje sekvencu nukleinske kiseline koja kodira laki lanac antitela, ili njegovog antigen-vezujućeg fragmenta, iz zahteva 4; i (b) ekspresioni vektor koji uključuje sekvencu nukleinske kiseline koja kodira teški lanac antitela, ili njegovog antigen-vezujućeg fragmenta, iz zahteva 4.
17. Metod proizvodnje vezujućeg jedinjenja naznačen time, što uključuje: kultivisanje ćelije-domaćina iz zahteva 16 u kultivacionom medijumu pod uslovima u kojima se eksprimiraju sekvence nukleinske kiseline, čime se proizvode polipeptidi koji sadrže lake i teške lance antitela, ili njegovog antigen- vezujućeg fragmenta; i sakupljanje antitela, ili njegovog antigen-vezujućeg fragmenta iz ćelije-domaćina ili kultivacionog medijuma.
MEP-2017-73A 2005-08-31 2006-08-29 Inženjerisana anti-il-23 antitela ME02705B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71358505P 2005-08-31 2005-08-31
PCT/US2006/033764 WO2007027714A2 (en) 2005-08-31 2006-08-29 Engineered anti-il-23 antibodies
EP06802592.3A EP1931710B1 (en) 2005-08-31 2006-08-29 Engineered anti-il-23 antibodies

Publications (1)

Publication Number Publication Date
ME02705B true ME02705B (me) 2017-10-20

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ID=37685722

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2017-73A ME02705B (me) 2005-08-31 2006-08-29 Inženjerisana anti-il-23 antitela

Country Status (17)

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US (3) US7807160B2 (me)
EP (3) EP1931710B1 (me)
JP (2) JP5350793B2 (me)
CN (1) CN101296944A (me)
CA (1) CA2620802A1 (me)
CY (2) CY1118760T1 (me)
DK (1) DK1931710T3 (me)
ES (1) ES2619845T3 (me)
HR (1) HRP20170444T1 (me)
HU (2) HUE032131T2 (me)
LT (2) LT1931710T (me)
ME (1) ME02705B (me)
PL (1) PL1931710T3 (me)
PT (1) PT1931710T (me)
RS (1) RS55788B1 (me)
SG (2) SG165322A1 (me)
WO (1) WO2007027714A2 (me)

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