ME02722B - Prevencija neželjenih efekata uzrokovanih cd3-specifičnim vezujućim domenima - Google Patents
Prevencija neželjenih efekata uzrokovanih cd3-specifičnim vezujućim domenimaInfo
- Publication number
- ME02722B ME02722B MEP-2017-104A MEP10417A ME02722B ME 02722 B ME02722 B ME 02722B ME P10417 A MEP10417 A ME P10417A ME 02722 B ME02722 B ME 02722B
- Authority
- ME
- Montenegro
- Prior art keywords
- glucocorticoid
- use according
- binding domain
- dose
- administered
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Developing Agents For Electrophotography (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Materials For Medical Uses (AREA)
Claims (13)
1. Glukokortikoid (GC) za upotrebu u postupku poboljšanja, lečenja ili profilakse neuroloških neželjenih događaja putem primene CD3-vezujućeg domena, naznačen time što se GC primenjuje pre primene prve doze CD3-vezujućeg domena i pre primene druge doze i/ili treće doze CD3-vezujućeg domena.
2. Glukokortikoid za upotrebu prema patentnom zahtevu 1, naznačen time što navedeni GC je deksametazon.
3. Glukokortikoid za upotrebu prema prema bilo kom od prethodnih patentnih zahteva, naznačen time što se prva doza CD3-vezujućeg domena primenjuje tokom prvog vremenskog perioda i uzastopno druga doza CD3-vezujućeg domena se primenjuje tokom drugog vremenskog perioda, pri čemu druga doza prekoračuje prvu dozu.
4. Glukokortikoid za upotrebu prema patentnom zahtevu 3, naznačen time što se posle prve i druge doze CD3-vezujućeg domena tokom prvog i drugog vremenskog perioda, primenjuje treća doza CD3-vezujućeg domena, pri čemu treća doza prekoračuje prvu i drugu dozu.
5. Glukokortikoid za upotrebu prema patentnom zahtevu 1 ili 2, naznačen time što se CD3-vezujući domen primenjuje kontinuirano.
6. Glukokortikoid za upotrebu prema bilo kom od prethodnih patentnih zahteva, naznačen time što navedeni neurološki neželjeni događaj je jedan ili više od poremećaja u čulima, konvulzija, encefalopatije, cerebralnog edema, konfuzije, ataksije, apraksije, poremećaja govora, halucinacija, pareze, tremora, glavobolje ili dezorijentacije.
7. Glukokortikoid za upotrebu prema bilo kom od prethodnih patentnih zahteva, naznačen time što se GC primenjuje posle pojave neurološkog neželjenog događaja.
8. Glukokortikoid za upotrebu prema bilo kom od prethodnih patentnih zahteva, naznačen time što je navedeni CD3-vezujući domen bispecifično jednolančano antitelo.
9. Glukokortikoid za upotrebu prema patentnom zahtevu 8, naznačen time što navedeno bispecifično jednolančano antitelo je CD19 x CD3 bispecifično jednolančano antitelo.
10. Glukokortikoid za upotrebu prema patentnom zahtevu 9, naznačen time što navedeno CD19 x CD3 bispecifično jednolančano antitelo je MT103.
11. Glukokortikoid za upotrebu prema bilo kom od prethodnih patentnih zahteva, naznačen time što navedeni pacijent je čovek.
12. Glukokortikoid za upotrebu prema bilo kom od prethodnih patentnih zahteva, pri čemu je navedeni pacijent naznačen odnosom B/T-ćelija od manje od 1:5.
13. Glukokortikoid za upotrebu prema bilo kom od patentnih zahteva 1 do 12, naznačen time što se navedeni CD3-vezujući domen vezuje za humani CD3 epsilon.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41222910P | 2010-11-10 | 2010-11-10 | |
| EP11788077.3A EP2637670B2 (en) | 2010-11-10 | 2011-10-27 | Prevention of adverse effects caused by cd3 specific binding domains |
| PCT/EP2011/068862 WO2012062596A1 (en) | 2010-11-10 | 2011-10-27 | Prevention of adverse effects caused by cd3 specific binding domains |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME02722B true ME02722B (me) | 2017-10-20 |
Family
ID=45044532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2017-104A ME02722B (me) | 2010-11-10 | 2011-10-27 | Prevencija neželjenih efekata uzrokovanih cd3-specifičnim vezujućim domenima |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US10130638B2 (me) |
| EP (3) | EP2637670B2 (me) |
| JP (2) | JP6023717B2 (me) |
| KR (1) | KR101891845B1 (me) |
| CN (2) | CN103533943B (me) |
| AU (3) | AU2011328393B2 (me) |
| CA (1) | CA2816668C (me) |
| CL (1) | CL2013001287A1 (me) |
| CR (1) | CR20130278A (me) |
| CY (1) | CY1118894T1 (me) |
| DK (1) | DK2637670T4 (me) |
| EA (1) | EA026075B1 (me) |
| ES (2) | ES2842937T3 (me) |
| FI (1) | FI2637670T4 (me) |
| HR (1) | HRP20170814T4 (me) |
| HU (1) | HUE032782T2 (me) |
| IL (2) | IL226268B (me) |
| LT (1) | LT2637670T (me) |
| MA (1) | MA34726B1 (me) |
| ME (1) | ME02722B (me) |
| MY (1) | MY173177A (me) |
| NZ (1) | NZ610034A (me) |
| PH (1) | PH12013500940A1 (me) |
| PL (1) | PL2637670T5 (me) |
| PT (1) | PT2637670T (me) |
| RS (1) | RS55995B2 (me) |
| SG (2) | SG10201508789TA (me) |
| SI (1) | SI2637670T2 (me) |
| SM (1) | SMT201700250T1 (me) |
| TN (1) | TN2013000250A1 (me) |
| UA (1) | UA113397C2 (me) |
| WO (1) | WO2012062596A1 (me) |
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| PL1874821T3 (pl) | 2005-04-26 | 2013-09-30 | Trion Pharma Gmbh | Kombinacja przeciwciał i glikokortykoidów do leczenia raka |
| EA026075B1 (ru) | 2010-11-10 | 2017-02-28 | Эмджен Рисерч (Мьюник) Гмбх | Предотвращение неблагоприятных эффектов, вызванных cd3-специфическими связывающими доменами |
| KR102345943B1 (ko) * | 2011-04-28 | 2021-12-31 | 암젠 리서치 (뮌헨) 게엠베하 | 잠재적 유해 효과의 위험에 처한 환자에게 cd19xcd3 이중특이적 항체를 투여하기 위한 투여 요법 |
| US10851178B2 (en) | 2011-10-10 | 2020-12-01 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
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