ME02724B - Novi anti-malarijski agensi - Google Patents
Novi anti-malarijski agensiInfo
- Publication number
- ME02724B ME02724B MEP-2017-110A MEP2017110A ME02724B ME 02724 B ME02724 B ME 02724B ME P2017110 A MEP2017110 A ME P2017110A ME 02724 B ME02724 B ME 02724B
- Authority
- ME
- Montenegro
- Prior art keywords
- derivative
- fluorophenyl
- pyrazole
- pyrazole derivative
- methyl
- Prior art date
Links
- 230000000078 anti-malarial effect Effects 0.000 title claims 2
- 239000000126 substance Substances 0.000 title 1
- 150000003217 pyrazoles Chemical class 0.000 claims 8
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- BLUAFEHZUWYNDE-NNWCWBAJSA-N artemisinin Chemical group C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-NNWCWBAJSA-N 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 2
- LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 claims 2
- DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 claims 2
- 229960003722 doxycycline Drugs 0.000 claims 2
- XQTWDDCIUJNLTR-CVHRZJFOSA-N doxycycline monohydrate Chemical compound O.O=C1C2=C(O)C=CC=C2[C@H](C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]1[C@H]2O XQTWDDCIUJNLTR-CVHRZJFOSA-N 0.000 claims 2
- 201000004792 malaria Diseases 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- WHTVZRBIWZFKQO-AWEZNQCLSA-N (S)-chloroquine Chemical compound ClC1=CC=C2C(N[C@@H](C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-AWEZNQCLSA-N 0.000 claims 1
- IOTAOYHKWICOBK-UHFFFAOYSA-N 1-[amino-(4-chloroanilino)methylidene]-2-propan-2-ylguanidine;3-[4-(4-chlorophenyl)cyclohexyl]-4-hydroxynaphthalene-1,2-dione;hydrochloride Chemical compound Cl.CC(C)N=C(N)\N=C(/N)NC1=CC=C(Cl)C=C1.O=C1C(=O)C2=CC=CC=C2C(O)=C1C(CC1)CCC1C1=CC=C(Cl)C=C1 IOTAOYHKWICOBK-UHFFFAOYSA-N 0.000 claims 1
- LUBUTTBEBGYNJN-UHFFFAOYSA-N 4-amino-n-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide;5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine Chemical compound CCC1=NC(N)=NC(N)=C1C1=CC=C(Cl)C=C1.COC1=NC=NC(NS(=O)(=O)C=2C=CC(N)=CC=2)=C1OC LUBUTTBEBGYNJN-UHFFFAOYSA-N 0.000 claims 1
- OVCDSSHSILBFBN-UHFFFAOYSA-N Amodiaquine Chemical compound C1=C(O)C(CN(CC)CC)=CC(NC=2C3=CC=C(Cl)C=C3N=CC=2)=C1 OVCDSSHSILBFBN-UHFFFAOYSA-N 0.000 claims 1
- 235000001258 Cinchona calisaya Nutrition 0.000 claims 1
- FOHHNHSLJDZUGQ-VWLOTQADSA-N Halofantrine Chemical compound FC(F)(F)C1=CC=C2C([C@@H](O)CCN(CCCC)CCCC)=CC3=C(Cl)C=C(Cl)C=C3C2=C1 FOHHNHSLJDZUGQ-VWLOTQADSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 241000694408 Isomeris Species 0.000 claims 1
- 208000030852 Parasitic disease Diseases 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 229960001444 amodiaquine Drugs 0.000 claims 1
- 239000003430 antimalarial agent Substances 0.000 claims 1
- 229960000981 artemether Drugs 0.000 claims 1
- 229960004191 artemisinin Drugs 0.000 claims 1
- 229930101531 artemisinin Natural products 0.000 claims 1
- 229960002521 artenimol Drugs 0.000 claims 1
- BJDCWCLMFKKGEE-ISOSDAIHSA-N artenimol Chemical compound C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2O[C@H](O)[C@@H]4C BJDCWCLMFKKGEE-ISOSDAIHSA-N 0.000 claims 1
- KUCQYCKVKVOKAY-CTYIDZIISA-N atovaquone Chemical compound C1([C@H]2CC[C@@H](CC2)C2=C(C(C3=CC=CC=C3C2=O)=O)O)=CC=C(Cl)C=C1 KUCQYCKVKVOKAY-CTYIDZIISA-N 0.000 claims 1
- 229960003159 atovaquone Drugs 0.000 claims 1
- 229940114027 atovaquone / proguanil Drugs 0.000 claims 1
- DNSISZSEWVHGLH-UHFFFAOYSA-N butanamide Chemical compound CCCC(N)=O DNSISZSEWVHGLH-UHFFFAOYSA-N 0.000 claims 1
- 229960003677 chloroquine Drugs 0.000 claims 1
- WHTVZRBIWZFKQO-UHFFFAOYSA-N chloroquine Natural products ClC1=CC=C2C(NC(C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-UHFFFAOYSA-N 0.000 claims 1
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229930016266 dihydroartemisinin Natural products 0.000 claims 1
- SXYIRMFQILZOAM-HVNFFKDJSA-N dihydroartemisinin methyl ether group Chemical group CO[C@@H]1[C@@H]([C@@H]2CC[C@H]([C@@H]3CC[C@]4(OO[C@]32[C@H](O1)O4)C)C)C SXYIRMFQILZOAM-HVNFFKDJSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 229960003242 halofantrine Drugs 0.000 claims 1
- RERZNCLIYCABFS-UHFFFAOYSA-N harmaline Chemical compound C1CN=C(C)C2=C1C1=CC=C(OC)C=C1N2 RERZNCLIYCABFS-UHFFFAOYSA-N 0.000 claims 1
- 230000000415 inactivating effect Effects 0.000 claims 1
- DYLGFOYVTXJFJP-MYYYXRDXSA-N lumefantrine Chemical compound C12=CC(Cl)=CC=C2C=2C(C(O)CN(CCCC)CCCC)=CC(Cl)=CC=2\C1=C/C1=CC=C(Cl)C=C1 DYLGFOYVTXJFJP-MYYYXRDXSA-N 0.000 claims 1
- 229960004985 lumefantrine Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- OLMXEDHUPRLENN-UHFFFAOYSA-N n-[4-(4-chloro-2-fluorophenyl)-2-methyl-5-(trifluoromethyl)pyrazol-3-yl]-2-(2-propan-2-ylbenzimidazol-1-yl)acetamide Chemical group CC(C)C1=NC2=CC=CC=C2N1CC(=O)NC(N(N=C1C(F)(F)F)C)=C1C1=CC=C(Cl)C=C1F OLMXEDHUPRLENN-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 229960000948 quinine Drugs 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (14)
1. Derivat plrazola u skladu sa Formulom (I),naznačen time što je X1 odabran od F i H; X2 je odabran od Cl i F; R1 je odabran od metila i trifluorometila; R2 je odabran od sledećih grupa:ikao i njegova farmaceutski prihvatljiva so, hidrat, solvat, pollmorf, tautomeri, geometrijski izomeri, ili optički aktivni izomeri.
2. Derivat pirazola prema zahtjevu 1 naznačen time što je R2:
3. Derivat pfrazola prema zahtjevu 1 naznačen time što je R 2:
4. Derivat pirazola prema zahtjevu 1 ili 2 odabran iz sledeće grupe:N-(4-(4-hloro-2-fluorofenil)-3-(trifluorometil)-1-metil-1H-pirazol-5-il)-2-(2-izopropil-1H-benzo[d]imidazol-1-fl)acetamid;N-(4-(4-hloro-2-fluorofenil)-1,3-dimetil-1H-pirazol-5-fl)-2-(2-fzopropil-1H-benzo[d]imidazol-1-il)ac etamid; (R)-3-amfno-N-(3-(trffluorometll)-4-(4-fluorofenil)-1-metil-1H-pfrazol-5-fl)-4-(4-fluorofenil) butanamfd; i (R)-3-amino-4-(4-fluorofenil)-N-(4-(4-fluorofenil)-1,3-dimetil-1H-pirazol-5-fl)butanamid; kao i bilo koja farmaceutski prihvatljiva so, hidrat, solvat, polimorf, tautomerf, geometrijski izomeri ili njihovi optički aktivni oblici.
5. Derivat pirazola prema bilo kojem od zahtjeva od 1 do 4, za upotrebu kao lijek.
6. Farmaceutska kompozicija koja sadrži najmanje jedan derivat pfrazola prema bilo kom od zahtjeva od 1 do 4 lli njegovu farmaceutski prihvatljivu so i farmaceutski prihvatljiv nosač, dfluent ill ekscipijens.
7. Farmaceutska kompozicija prema zahtjevu 6 koja sadrži f antfmalarijski ko-agens.
8. Farmaceutska kompozicija prema zahtjevu 7 u kojoj je ko-agens odabran od artemisinina ili derivata artemisinina, hlorokvfna, kinina, meflohfna, amodijahina, atovakvon/proguanila, doksiciklina, lumefantrina, piperakvfna, pfronaridina, halofantrina, pirimetamin-sulfadoksina, prfmakvfna, kvfnakrina, doksiciklina, atovakona, proguanil hidrohlorida, piperakvfna, ferokvfna, tafenokvfna, arterolana, Spfro[3H-indol-3,1'-[1H]pfrido[3,4-b]indol]-2(1H)-ona (CAS Reg Br: 1193314-23-6), 5,T-dihloro-6'-fluoro-2',3',4',9'-tetrahfdro-3'-metil-, (1'R,3'S)-], Sumpora, [4-[[2-(1,1- difluoretil)-5-metil[1,2,4]trfazolo[1,5-a]pfrimidfn-7-fl]amfno]fenfl]pentafluoro-] (CAS Reg. Br: 1282041-94-4), Morfolina, i 4-[2-(4-cis-dfspfro[cikloheksan-1,3'-[1,2,4]trfoksolan-5'2"-triciklo [3.3.1.13,7]dekan]-4-ilfenoksi)etil]-] (CAS Reg. B r.: 1029939-86-3).
9. Farmaceutska kompozicija prema zahtjevu 7, u kojoj je derivat artemisinina artemeter ili dihidroartemisinin.
10. Derivat pirazola prema bilo kojem od zahtjeva od 1 do 4 za upotrebu u prevencijiililečenju malarije.
11. Derivat pirazola za upotrebu prema zahtjevu 1O pri čemu derivat plrazola treba da bude administriran u kombinacijisa ko-agensom korisnim u lečenju malarije.
12. Derivat pirazola za upotrebu prema zahtjevu 10 ili11, naznačen time što je derivat pirazola prema zahtjevu 4.
13. Derivat pirazola za upotrebu prema zahtjevu 10 ili 11, naznačen time što je derivat pirazola N-(4-(4 hloro-2- fluorofenil)-3-(trifluorometil)-1-metil-1H-pirazol 5-il)-2-(2-izopropil-1H-benzo[d]imidazol -1-il)acetamid.
14. Postupak ex vivo za inaktlvaciju parazitske Infekcije u ćeliji koji obuhvata korak dovođenja u kontakt ex vivo ćelije sa efikasnom količinom najmanje jednog jedinjenja prema bilo kojem od zahtjeva 1 do 4.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361847185P | 2013-07-17 | 2013-07-17 | |
| EP14759317.2A EP3022200B1 (en) | 2013-07-17 | 2014-07-17 | New anti-malarial agents |
| PCT/IB2014/063180 WO2015008246A1 (en) | 2013-07-17 | 2014-07-17 | New anti-malarial agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME02724B true ME02724B (me) | 2017-10-20 |
Family
ID=51492402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2017-110A ME02724B (me) | 2013-07-17 | 2014-07-17 | Novi anti-malarijski agensi |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9464057B2 (me) |
| EP (1) | EP3022200B1 (me) |
| JP (1) | JP2016527228A (me) |
| CN (1) | CN105377838A (me) |
| CA (1) | CA2918290A1 (me) |
| CY (1) | CY1118913T1 (me) |
| ES (1) | ES2625160T3 (me) |
| HK (1) | HK1219728A1 (me) |
| HR (1) | HRP20170773T1 (me) |
| HU (1) | HUE033124T2 (me) |
| LT (1) | LT3022200T (me) |
| ME (1) | ME02724B (me) |
| PL (1) | PL3022200T3 (me) |
| PT (1) | PT3022200T (me) |
| RS (1) | RS55998B1 (me) |
| SI (1) | SI3022200T1 (me) |
| SM (1) | SMT201700316T1 (me) |
| WO (1) | WO2015008246A1 (me) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107149604A (zh) * | 2017-03-17 | 2017-09-12 | 高雪亚 | 一种治疗非酒精性脂肪肝的药物组合物 |
| PL233259B1 (pl) * | 2017-07-10 | 2019-09-30 | Politechnika Poznanska | Indolilooctany 1-alkilochininy, sposób ich otrzymywania oraz zastosowanie jako środki bakteriostatyczne i bakteriobójcze |
| EP3710492B1 (en) | 2017-11-13 | 2021-08-11 | INEOS Styrolution Group GmbH | Thermoplastic molding composition and articles made thereof having improved surface quality |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009065096A1 (en) | 2007-11-16 | 2009-05-22 | University Of Medicine And Dentistry Of New Jersey | Mechanism-based small-molecule parasite inhibitors |
-
2014
- 2014-07-17 RS RS20170488A patent/RS55998B1/sr unknown
- 2014-07-17 HK HK16107699.1A patent/HK1219728A1/zh unknown
- 2014-07-17 ME MEP-2017-110A patent/ME02724B/me unknown
- 2014-07-17 JP JP2016526745A patent/JP2016527228A/ja not_active Withdrawn
- 2014-07-17 CA CA2918290A patent/CA2918290A1/en not_active Abandoned
- 2014-07-17 LT LTEP14759317.2T patent/LT3022200T/lt unknown
- 2014-07-17 WO PCT/IB2014/063180 patent/WO2015008246A1/en not_active Ceased
- 2014-07-17 PL PL14759317T patent/PL3022200T3/pl unknown
- 2014-07-17 EP EP14759317.2A patent/EP3022200B1/en active Active
- 2014-07-17 PT PT147593172T patent/PT3022200T/pt unknown
- 2014-07-17 SI SI201430230A patent/SI3022200T1/sl unknown
- 2014-07-17 ES ES14759317.2T patent/ES2625160T3/es active Active
- 2014-07-17 HR HRP20170773TT patent/HRP20170773T1/hr unknown
- 2014-07-17 SM SM20170316T patent/SMT201700316T1/it unknown
- 2014-07-17 US US14/905,369 patent/US9464057B2/en not_active Expired - Fee Related
- 2014-07-17 HU HUE14759317A patent/HUE033124T2/en unknown
- 2014-07-17 CN CN201480040428.7A patent/CN105377838A/zh active Pending
-
2017
- 2017-05-12 CY CY20171100508T patent/CY1118913T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2625160T3 (es) | 2017-07-18 |
| HK1219728A1 (zh) | 2017-04-13 |
| PT3022200T (pt) | 2017-06-12 |
| SMT201700316T1 (it) | 2017-07-18 |
| RS55998B1 (sr) | 2017-09-29 |
| WO2015008246A1 (en) | 2015-01-22 |
| HUE033124T2 (en) | 2017-11-28 |
| LT3022200T (lt) | 2017-06-12 |
| US20160194286A1 (en) | 2016-07-07 |
| JP2016527228A (ja) | 2016-09-08 |
| PL3022200T3 (pl) | 2017-08-31 |
| CY1118913T1 (el) | 2018-01-10 |
| CN105377838A (zh) | 2016-03-02 |
| SI3022200T1 (sl) | 2017-06-30 |
| HRP20170773T1 (hr) | 2017-08-11 |
| EP3022200A1 (en) | 2016-05-25 |
| CA2918290A1 (en) | 2015-01-22 |
| US9464057B2 (en) | 2016-10-11 |
| EP3022200B1 (en) | 2017-03-01 |
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