ME02765B - (z)-2-cijan0-3-hidroksi-but-2-enske kiseline (4'-trifluormetilfenil) -amid formulacije tableta sa poboljšanom stabilnošću - Google Patents
(z)-2-cijan0-3-hidroksi-but-2-enske kiseline (4'-trifluormetilfenil) -amid formulacije tableta sa poboljšanom stabilnošćuInfo
- Publication number
- ME02765B ME02765B MEP-2017-134A MEP13417A ME02765B ME 02765 B ME02765 B ME 02765B ME P13417 A MEP13417 A ME P13417A ME 02765 B ME02765 B ME 02765B
- Authority
- ME
- Montenegro
- Prior art keywords
- pharmaceutical composition
- solid pharmaceutical
- weight
- composition according
- sodium
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
- C07C255/44—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms at least one of the singly-bound nitrogen atoms being acylated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Otolaryngology (AREA)
- Ophthalmology & Optometry (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (13)
1. Čvrsta farmaceutska kompozicija koja se u osnovi sastoji od a) 1 % do 30 % težina: težine Teriflunomida, ili farmaceutski prihvatljive bazne adicione soli, b) 5 % do 20 % težina: težine rastvarača, c) 0 % do 40 % težina: težine veziva, d) 0.1 % do 2 % težina: težine lubrikanta i e) ostalog procenta razblaživača, omogućava takvu farmaceutsku kompoziciju koja ne sadrži silicijum dioksid.
2.Čvrsta farmaceutska kompozicija prema patentnom zahtevu 1 gde se navedeni rastvarač bira iz grupe koja se sastoji od karboksimetilceluloze, nisko suspstituisane hidroksipropil celuloze, microkristalinske celuloze, celuloze u prahu, natrijum kroskarmelze, metil celuloze, polakrilin kalijuma, natrijum alginata, natrijum skrob glikolata ili mešavine jednog ili više pomenutih rastvarača.
3.Čvrsta farmaceutska kompozicija prema patentnom zahtevu 2 gde se navedeni rastvarač bira iz grupe koja se sastoji od nisko suspstituisane hidroksipropil celuloze, mikrokristalinske celuloze, celuloze u prahu, natrijum kroskarmelze, natrijum skrob glikolata ili mešavine jednog ili više pomeutih rastvarača.
4.Čvrsta farmaceutska kompozicija prema patentnom zahtevu 1 gde se navedeno vezivo bira iz grupe koja se sastoji od akacije, carboksimetilceluloze, hidroksiethilceluloze, hidroksipropilceluloze, dekstrina, želatina, guar gume, hidroksipropil metilceluloze, maltodekstrina, metilceluloze, natrijum alginata, preželatiniziranog skroba, skroba krompira, skroba kukuruza ili skroba žitarica i zejna ili mešavine jednog ili više pomenutih veziva.
5.Čvrsta farmaceutska kompozicija prema patentnom zahtevu 4 gde se vezivo bira iz grupe koja se sastoji od hidroksipropilceluloze, hidroksipropil metilceluloze, preželatiniziranog skroba, skroba krompira, skroba kukuruza ili skroba žitarica ili mešavine jednog ili više pomenutih veziva.
6.Čvrsta farmaceutska kompozicija prema patentnom zahtevu 1 gde se navedeni lubrikant bira iz grupe koja se sastoji od kalcijum stearata, gliceril palmitostearata, natrijum benzoata, natrijum lauril sulfata, natrijum stearil fumarata, stearinske kiseline, talka, zink stearata i magnezijum stearata ili mešavine jednog ili više pomenutih lubrikanata.
7.Čvrsta farmaceutska kompozicija prema patentnom zahtevu 6 gde se navedeni lubrikant bira iz grupe koja se sastoji od natrijum stearil fumarata i magnezijum stearata ili mešavine jednog ili više pomenutih lubrikanata.
8.Čvrsta farmaceutska kompozicija prema patentnom zahtevu 1 gde se navedeni razblaživači biraju iz grupe koja se sastoji od celuloze, celuloza acetata, dekstrata, dekstrina, dekstroze, fruktoze, 1-O-α-D-Glucopiranozil-D-manitola, gliceril palmitostearata, hidrogenizovanog ulja povrća, kaolina, laktitola, laktoze, lactoza mono-hidrata, maltitola, manitola, maltodekstrina, maltoze, preželatiniziranog skroba, natrijum hlorida, sorbitola, skroba, saharoze, talka and ksilitola ili mešavine jednog ili više navedenig razblaživača.
9.Čvrsta farmaceutska kompozicija prema patentnom zahtevu 8 gde se navedeni razblaživači biraju iz grupe koja se sastoji od laktoze, lactoza mono-hidrata, manitola i skrobova ili mešavine jednog ili više navedenog razblaživača.
10.Čvrsta farmaceutska kompozicija prema bilo kom od prethodnih patentnih zahteva u kom je kompozicija obložena.
11.Čvrsta farmaceutska kompozicija prema patentnom zahtevu 10, koja je tableta ili pilula sa omotačem na bazi hidromeloze. .
12.Čvrsta farmaceutska kompozicija prema bilo kom od prethodnih patentnih zahteva koja se u osnovi sastoji od: (a) 2 % do 15 % težina: težine Teriflunomida (b) 7 % do 15 % težina: težine rastvarača selektovanog od jednog ili vise od mikrokristalinske celuloze ili natrijum skrob glikolata, (c) 15 % do 35 % težina: težine veziva selektovanog od jednog ili vise od hidroksipropilceluloze ili skroba kukuruza, (d) 0.1 % do 1.0 % težina: težine lubrikanta selektovanog od magnezijum stearata i, (e) ostalog procenta razblaživača selektovanih od mono-hidrata.
13.Čvrsta farmaceutska kompozicija prema patentnim zahtevima 1 do 12 za korišćenje u tretmanu sepse, alergija, reakcija graft protiv domaćina, rekacija domaćin protiv grafta, reumatoidnog artritisa, sistemskog lupusa eritematodusa, multiple skleroze, psorijaze, astme, urtikarija, ritinisa, uveitisa, karcinoma pluća, leukemija, kacinoma jajnika, sarkoma, Karpošijevog sarkoma, meningeoma, karcinoma creva, karcinoma limfnih čvorova, tumora mozga, karcinoma dojke, karcinoma pankreasa, karcinoma prostate i karcinoma kože. 3
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09290716 | 2009-09-18 | ||
| US36338210P | 2010-07-12 | 2010-07-12 | |
| EP10752585.9A EP2477611B1 (en) | 2009-09-18 | 2010-09-14 | (z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluormethylphenyl)-amide tablet formulations with improved stability |
| PCT/EP2010/063439 WO2011032929A1 (en) | 2009-09-18 | 2010-09-14 | (z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluormethylphenyl)-amide tablet formulations with improved stability |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME02765B true ME02765B (me) | 2018-01-20 |
Family
ID=41510564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2017-134A ME02765B (me) | 2009-09-18 | 2010-09-14 | (z)-2-cijan0-3-hidroksi-but-2-enske kiseline (4'-trifluormetilfenil) -amid formulacije tableta sa poboljšanom stabilnošću |
Country Status (42)
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013505213A (ja) * | 2009-09-18 | 2013-02-14 | サノフイ | 改善された安定性を有する（ｚ）−２−シアノ−３−ヒドロキシ−ブタ−２−エン酸−（４’−トリフルオロメチルフェニル）−アミド錠製剤 |
| RU2493845C1 (ru) * | 2012-06-07 | 2013-09-27 | Общество с ограниченной ответственностью "ВАЛЕНТА ИНТЕЛЛЕКТ" | Композиция для лечения рассеянного склероза (варианты) |
| KR20160079123A (ko) * | 2013-11-22 | 2016-07-05 | 젠자임 코포레이션 | 신경변성 질병을 치료하기 위한 신규한 방법 |
| CN103656657A (zh) * | 2013-12-18 | 2014-03-26 | 北京科源创欣科技有限公司 | 特立氟胺药物组合物及制备方法 |
| MA39784B1 (fr) | 2014-03-26 | 2021-03-31 | Astex Therapeutics Ltd | Combinaisons des inhibiteurs du fgfr et du cmet destinées au traitement du cancer |
| US20160058730A1 (en) * | 2014-08-29 | 2016-03-03 | Cadila Healthcare Limited | Pharmaceutical compositions of teriflunomide |
| WO2016079687A1 (en) * | 2014-11-18 | 2016-05-26 | Lupin Limited | Oral pharmaceutical composition of teriflunomide |
| JO3695B1 (ar) | 2015-02-10 | 2020-08-27 | Astex Therapeutics Ltd | تركيبات صيدلانية تشتمل على n- (3.5- ثنائي ميثوكسي فينيل)-n-(1-ميثيل إيثيل)-n- 3-( ميثيل-h1-بيرازول-4-يل) كينوكسالين-6-يل) إيثان- 1.2-ثنائي الأمين) |
| US20180147148A1 (en) | 2015-05-23 | 2018-05-31 | Ftf Pharma Private Limited | Pharmaceutical composition of teriflunomide |
| EP3344243B1 (en) * | 2015-09-01 | 2020-12-09 | The Broad Institute, Inc. | Compounds and methods useful for treating or preventing hematological cancers |
| WO2017037645A1 (en) * | 2015-09-02 | 2017-03-09 | Leiutis Pharmaceuticals Pvt Ltd | Stable pharmaceutical formulations of teriflunomide |
| WO2017056104A1 (en) * | 2015-09-28 | 2017-04-06 | Natco Pharma Limited | Stable pharmaceutical compositions of teriflunomide |
| WO2017125841A1 (en) * | 2016-01-20 | 2017-07-27 | Emcure Pharmaceuticals Limited | Pharmaceutical compositions of teriflunomide |
| JOP20190207A1 (ar) * | 2017-03-14 | 2019-09-10 | Actelion Pharmaceuticals Ltd | تركيبة صيدلانية تشتمل على بونيسيمود |
| LT3999038T (lt) * | 2019-07-17 | 2024-03-25 | Cytokinetics, Inc. | Širdies sarkomerų inhibitoriaus geriamosios vaistinės formos |
| SI4178548T1 (sl) * | 2020-07-07 | 2024-10-30 | Celgene Corporation | Farmacevtski sestavki, ki obsegajo (S)-4-(4-(4-(((2-(2,6-dioksopiperidin-3-il)-1-oksoizoindolin-4-il)oksi) metil)benzil)piperazin-1-il)-3-fluorobenzonitril, in postopki uporabe le-teh |
| WO2022085015A1 (en) * | 2020-10-24 | 2022-04-28 | V-Ensure Pharma Technologies Private Limited | A solid oral composition of teriflunomide |
| GR1010137B (el) | 2020-12-15 | 2021-12-07 | Φαρματεν Α.Β.Ε.Ε., | Στερεη φαρμακοτεχνικη μορφη αμεσης αποδεσμευσης περιεχουσα τεριφλουνομιδη και μεθοδος παρασκευης αυτης |
| TR202022336A2 (tr) * | 2020-12-30 | 2022-07-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | A film coated tablet comprising teriflunomide |
| EP4382097A1 (en) | 2022-11-25 | 2024-06-12 | Sanovel Ilac Sanayi Ve Ticaret A.S. | A tablet comprising teriflunomide |
| TR2022017840A1 (tr) * | 2022-11-25 | 2024-06-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Teri̇flunomi̇d i̇çeren bi̇r tablet |
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| US6133301A (en) | 1991-08-22 | 2000-10-17 | Aventis Pharma Deutschland Gmbh | Pharmaceuticals for the treatment of rejection reactions in organ transplantations |
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| GB9408117D0 (en) * | 1994-04-23 | 1994-06-15 | Smithkline Beecham Corp | Pharmaceutical formulations |
| KR100365064B1 (ko) | 1994-10-17 | 2003-04-11 | 훽스트파마슈티칼스앤드케미칼스가부시키가이샤 | I형알레르기성질환의예방및치료제 |
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| JP2013505213A (ja) * | 2009-09-18 | 2013-02-14 | サノフイ | 改善された安定性を有する（ｚ）−２−シアノ−３−ヒドロキシ−ブタ−２−エン酸−（４’−トリフルオロメチルフェニル）−アミド錠製剤 |
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