ME02846B - Phosphoramidates nucléosidiques - Google Patents
Phosphoramidates nucléosidiquesInfo
- Publication number
- ME02846B ME02846B MEP-2017-196A MEP19617A ME02846B ME 02846 B ME02846 B ME 02846B ME P19617 A MEP19617 A ME P19617A ME 02846 B ME02846 B ME 02846B
- Authority
- ME
- Montenegro
- Prior art keywords
- perfluorophenoxy
- propanoate
- phosphoryl
- phenoxy
- pyridine
- Prior art date
Links
- -1 Nucleoside phosphoramidates Chemical class 0.000 title 1
- 239000002777 nucleoside Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims 6
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 4
- 239000007788 liquid Substances 0.000 claims 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- 238000002425 crystallisation Methods 0.000 claims 3
- 230000008025 crystallization Effects 0.000 claims 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 3
- 230000000269 nucleophilic effect Effects 0.000 claims 3
- MIILDBHEJQLACD-ZJPIPACBSA-N propan-2-yl (2s)-2-[[(2,3,4,5,6-pentafluorophenoxy)-phenoxyphosphoryl]amino]propanoate Chemical compound O([P@@](=O)(N[C@@H](C)C(=O)OC(C)C)OC=1C(=C(F)C(F)=C(F)C=1F)F)C1=CC=CC=C1 MIILDBHEJQLACD-ZJPIPACBSA-N 0.000 claims 3
- RKMGAJGJIURJSJ-UHFFFAOYSA-N 2,2,6,6-tetramethylpiperidine Chemical compound CC1(C)CCCC(C)(C)N1 RKMGAJGJIURJSJ-UHFFFAOYSA-N 0.000 claims 2
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 claims 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical group [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims 2
- SGUVLZREKBPKCE-UHFFFAOYSA-N 1,5-diazabicyclo[4.3.0]-non-5-ene Chemical compound C1CCN=C2CCCN21 SGUVLZREKBPKCE-UHFFFAOYSA-N 0.000 claims 1
- YFOOEYJGMMJJLS-UHFFFAOYSA-N 1,8-diaminonaphthalene Chemical compound C1=CC(N)=C2C(N)=CC=CC2=C1 YFOOEYJGMMJJLS-UHFFFAOYSA-N 0.000 claims 1
- VSTXCZGEEVFJES-UHFFFAOYSA-N 1-cycloundecyl-1,5-diazacycloundec-5-ene Chemical compound C1CCCCCC(CCCC1)N1CCCCCC=NCCC1 VSTXCZGEEVFJES-UHFFFAOYSA-N 0.000 claims 1
- XBNGYFFABRKICK-UHFFFAOYSA-N 2,3,4,5,6-pentafluorophenol Chemical compound OC1=C(F)C(F)=C(F)C(F)=C1F XBNGYFFABRKICK-UHFFFAOYSA-N 0.000 claims 1
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 claims 1
- 239000012296 anti-solvent Substances 0.000 claims 1
- FJDQFPXHSGXQBY-UHFFFAOYSA-L caesium carbonate Chemical compound [Cs+].[Cs+].[O-]C([O-])=O FJDQFPXHSGXQBY-UHFFFAOYSA-L 0.000 claims 1
- 229910000024 caesium carbonate Inorganic materials 0.000 claims 1
- UAOMVDZJSHZZME-UHFFFAOYSA-N diisopropylamine Chemical compound CC(C)NC(C)C UAOMVDZJSHZZME-UHFFFAOYSA-N 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- IZUPBVBPLAPZRR-UHFFFAOYSA-N pentachloro-phenol Natural products OC1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1Cl IZUPBVBPLAPZRR-UHFFFAOYSA-N 0.000 claims 1
- 229910000027 potassium carbonate Inorganic materials 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- MIILDBHEJQLACD-KPORQTCDSA-N propan-2-yl (2s)-2-[[(2,3,4,5,6-pentafluorophenoxy)-phenoxyphosphoryl]amino]propanoate Chemical compound FC=1C(F)=C(F)C(F)=C(F)C=1OP(=O)(N[C@@H](C)C(=O)OC(C)C)OC1=CC=CC=C1 MIILDBHEJQLACD-KPORQTCDSA-N 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- SBYHFKPVCBCYGV-UHFFFAOYSA-N quinuclidine Chemical compound C1CC2CCN1CC2 SBYHFKPVCBCYGV-UHFFFAOYSA-N 0.000 claims 1
- 229930195734 saturated hydrocarbon Natural products 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- IMNIMPAHZVJRPE-UHFFFAOYSA-N triethylenediamine Chemical compound C1CN2CCN1CC2 IMNIMPAHZVJRPE-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31951310P | 2010-03-31 | 2010-03-31 | |
| US31954810P | 2010-03-31 | 2010-03-31 | |
| US12/783,680 US8642756B2 (en) | 2009-05-20 | 2010-05-20 | Nucleoside phosphoramidates |
| EP13159791.6A EP2609923B1 (fr) | 2010-03-31 | 2011-03-31 | Procede de crystallisation de (s)-isopropyl 2-(((s)-(perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME02846B true ME02846B (fr) | 2018-01-20 |
Family
ID=55359000
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2015-199A ME02294B (fr) | 2010-03-31 | 2011-03-31 | Phosphoramidates de nucléosides |
| MEP-2017-196A ME02846B (fr) | 2010-03-31 | 2011-03-31 | Phosphoramidates nucléosidiques |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2015-199A ME02294B (fr) | 2010-03-31 | 2011-03-31 | Phosphoramidates de nucléosides |
Country Status (4)
| Country | Link |
|---|---|
| BR (1) | BR122013004621A2 (fr) |
| ME (2) | ME02294B (fr) |
| RS (1) | RS56229B1 (fr) |
| SI (1) | SI2552930T1 (fr) |
-
2011
- 2011-03-31 BR BR122013004621A patent/BR122013004621A2/pt not_active Application Discontinuation
- 2011-03-31 ME MEP-2015-199A patent/ME02294B/fr unknown
- 2011-03-31 RS RS20170840A patent/RS56229B1/sr unknown
- 2011-03-31 SI SI201130617T patent/SI2552930T1/sl unknown
- 2011-03-31 ME MEP-2017-196A patent/ME02846B/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SI2552930T1 (sl) | 2016-02-29 |
| ME02294B (fr) | 2016-02-20 |
| BR122013004621A2 (pt) | 2016-11-22 |
| RS56229B1 (sr) | 2017-11-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20171267T1 (hr) | Postupak za kristalizaciju (s)-izopropil 2-(((s)(perfluorofenoksi)(fenoksi)fosforil)amino)proanoata | |
| WO2012170952A3 (fr) | Composés pour l'administration de médicament ciblée et l'augmentation de l'activité arnsi | |
| KR101720885B1 (ko) | (e)-n-메틸-n-((3-메틸벤조푸란-2-일)메틸)-3-(7-옥소-5,6,7,8-테트라히드로-1,8-나프티리딘-3-일)아크릴아미드의전구약물 유도체 | |
| WO2008142482A3 (fr) | Composition | |
| PH12013501197B1 (en) | Indeno-fused ring compounds | |
| IN2014MN01839A (fr) | ||
| MX2013002149A (es) | Nuevo proceso para la preparacion de intermediarios utiles para la elaboracion de inhibidores de nep. | |
| MX347429B (es) | Cristales de múltiples componentes que comprenden dasatinib y formadores de cocristales seleccionados. | |
| WO2008100921A3 (fr) | Huile d'enrobage comprenant des sous-produits de la fabrication d'esters alkyliques d'acides gras et/ou de biodiesel | |
| JP2016519165A5 (fr) | ||
| MX2013002150A (es) | Proceso para la preparacion de intermediarios para la elaboracion de inhibidores de nep. | |
| IN2014CN03482A (fr) | ||
| RU2013151867A (ru) | Ингибиторы гидролазы амидов жирных кислот для лечения боли | |
| AR071274A1 (es) | Derivados de pregabalina , composiciones farmaceuticas que los contienen y proceso de preparacion de los mismos | |
| PE20121743A1 (es) | Derivados de piridina triciclicos, medicamentos que contienen tales compuestos, su uso y proceso para su preparacion | |
| ME02846B (fr) | Phosphoramidates nucléosidiques | |
| IL220706A (en) | Compounds whose molecule includes groups 2– (phenyl / troaryl) - [3,1] oxazolo [4,5– d] pyrimidine and carboxy, their hydrocarbyl esters, their preparation process and pharmaceutical preparations containing them | |
| Fabris et al. | The use of a lactonized statin side-chain precursor in a concise and efficient assembly of pitavastatin | |
| WO2012112841A3 (fr) | Préparation de sels d'acide [1,2,4]oxadiazol-3-yl]-ylique et formes cristallines et leur préparation | |
| MY186194A (en) | Pest control composition | |
| IL220708A (en) | Compounds whose molecule contains groups 2 - (phenyl / heteroaryl) - [3,1] oxazolo [4,5– d] pyrimidine and carboxy - (heterocyclic nitrogen) carbonyl, also a process for their preparation and pharmaceutical preparations containing them | |
| PH12014502064A1 (en) | Crystalline form of a succinate salt | |
| EP2624693A4 (fr) | Procédé de préparation d'intermédiaires de tolvaptan | |
| IL278644B2 (en) | A process for the stereoselective preparation of chiral 2-[(hetero)arylalkylsulfanyl]pyrimidines and products obtainable therefrom | |
| HRP20160407T1 (hr) | Postupak za pripravu skopin estera di-(2-tienil) glikolne kiseline, međuprodukta u sintezi tiotropij bromida |