ME03672B - 1h-pirazolo[4,3-b]piridini kao pde1 inhibitori - Google Patents

1h-pirazolo[4,3-b]piridini kao pde1 inhibitori

Info

Publication number: ME03672B
Authority: ME; Montenegro
Prior art keywords: pyrazolo; pyridines; pde1 inhibitors; pde1; inhibitors
Prior art date: 2016-07-04

Application number

MEP-2020-50A

Other languages

German (de)

English (en)

French (fr)

Inventor

Jan Kehler

Karsten Juhl

Mauro Marigo

Paulo Jorge Vieira Vital

Mikkel Jessing

Morten Langgård

Lars Kyhn Rasmussen

Carl Martin Sebastian Clementson

Original Assignee

H Lundbeck As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-07-04

Filing date

2017-06-30

Publication date

2020-10-20

2017-06-30 Application filed by H Lundbeck As filed Critical H Lundbeck As

2020-10-20 Publication of ME03672B publication Critical patent/ME03672B/me

Links

RQMWVVBHJMUJNZ-UHFFFAOYSA-N 4-chloropyridin-2-amine Chemical compound NC1=CC(Cl)=CC=N1 RQMWVVBHJMUJNZ-UHFFFAOYSA-N 0.000 title 1
229940121836 Phosphodiesterase 1 inhibitor Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/04—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D305/06—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychiatry (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

MEP-2020-50A 2016-07-04 2017-06-30 1h-pirazolo[4,3-b]piridini kao pde1 inhibitori ME03672B (me)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
DKPA201600397		2016-07-04
DKPA201600612		2016-10-11
DKPA201700236		2017-04-04
PCT/EP2017/066255 WO2018007249A1 (en)	2016-07-04	2017-06-30	1h-pyrazolo[4,3-b]pyridines as pde1 inhibitors
EP17734307.6A EP3478681B1 (en)	2016-07-04	2017-06-30	1h-pyrazolo[4,3-b]pyridines as pde1 inhibitors

Publications (1)

Publication Number	Publication Date
ME03672B true ME03672B (me)	2020-10-20

Family

ID=60806291

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MEP-2020-50A ME03672B (me)	2016-07-04	2017-06-30	1h-pirazolo[4,3-b]piridini kao pde1 inhibitori

Country Status (39)

Country	Link
US (7)	US10034861B2 (me)
EP (2)	EP3478681B1 (me)
JP (1)	JP7096171B2 (me)
KR (2)	KR102488909B1 (me)
CN (1)	CN109311872B (me)
AU (1)	AU2017291794C1 (me)
CA (1)	CA3026857A1 (me)
CL (1)	CL2019000010A1 (me)
CO (1)	CO2018013803A2 (me)
CR (1)	CR20190003A (me)
CY (1)	CY1122957T1 (me)
DK (1)	DK3478681T3 (me)
DO (1)	DOP2018000266A (me)
EC (1)	ECSP18093944A (me)
ES (1)	ES2784655T3 (me)
GE (2)	GEP20207172B (me)
HR (1)	HRP20200440T1 (me)
HU (1)	HUE048576T2 (me)
IL (1)	IL263511B (me)
JO (1)	JOP20180116B1 (me)
LT (1)	LT3478681T (me)
MA (1)	MA52593A (me)
ME (1)	ME03672B (me)
MX (1)	MX375782B (me)
MY (1)	MY197140A (me)
PE (1)	PE20190339A1 (me)
PH (1)	PH12018502604A1 (me)
PL (1)	PL3478681T3 (me)
PT (1)	PT3478681T (me)
RS (1)	RS60072B1 (me)
RU (1)	RU2759380C2 (me)
SG (1)	SG11201810965YA (me)
SI (1)	SI3478681T1 (me)
SM (1)	SMT202000148T1 (me)
SV (1)	SV2018005801A (me)
TW (1)	TWI763683B (me)
UA (1)	UA122824C2 (me)
WO (1)	WO2018007249A1 (me)
ZA (1)	ZA201808257B (me)

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US20180344680A1 (en)	2015-12-08	2018-12-06	The Arizona Board Of Regents On Behalf Of The University Of Arizona	Compositions and methods for treatment, amelioration, and prevention of diabetes-related skin ulcers
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JOP20190126A1 (ar)	2016-12-22	2019-05-28	H Lundbeck As	بيرازولو [3، 4-b] بيريدينات وإيميدازو [1، 5-b] بيريدازينات على هيئة مثبطات PDE1
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AR113926A1 (es)	2017-12-14	2020-07-01	H Lundbeck As	Derivados de 1h-pirazolo[4,3-b]piridinas
TW201927784A (zh)	2017-12-20	2019-07-16	丹麥商Ｈ朗德貝克公司	作為pde1抑制劑之大環
US11535611B2 (en)	2017-12-20	2022-12-27	H. Lundbeck A/S	Pyrazolo[3,4-B]pyridines and imidazo[1,5-B]pyridazines as PDE1 inhibitors
US10766893B2 (en)	2017-12-20	2020-09-08	H. Lundbeck A/S	1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors

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IL263511A (en)	2019-01-31
PE20190339A1 (es)	2019-03-07
SV2018005801A (es)	2019-02-13
RU2759380C2 (ru)	2021-11-12
UA122824C2 (uk)	2021-01-06
US11026924B2 (en)	2021-06-08
JP7096171B2 (ja)	2022-07-05
KR20190025606A (ko)	2019-03-11
CY1122957T1 (el)	2021-10-29
ZA201808257B (en)	2020-05-27
MX375782B (es)	2025-03-07
PL3478681T3 (pl)	2020-06-15
CO2018013803A2 (es)	2019-01-18
CN109311872A (zh)	2019-02-05
PT3478681T (pt)	2020-04-03
US20200375950A1 (en)	2020-12-03
SG11201810965YA (en)	2019-01-30
KR20220154262A (ko)	2022-11-21
US20210015794A1 (en)	2021-01-21
US11026923B2 (en)	2021-06-08
KR102488909B1 (ko)	2023-01-13
GEP20207172B (en)	2020-10-26
US20210023056A1 (en)	2021-01-28
US10806718B2 (en)	2020-10-20
PH12018502604A1 (en)	2019-10-21
SI3478681T1 (sl)	2020-04-30
EP3478681B1 (en)	2020-02-26
AU2017291794B2 (en)	2021-07-22
RS60072B1 (sr)	2020-05-29
JOP20180116A1 (ar)	2019-01-30
RU2018143324A3 (me)	2020-08-12
RU2018143324A (ru)	2020-08-04
AU2017291794A1 (en)	2018-12-20
MX2018015734A (es)	2019-03-21
DOP2018000266A (es)	2019-03-15
US20190105302A1 (en)	2019-04-11
US20200360343A1 (en)	2020-11-19
HRP20200440T1 (hr)	2020-06-12
EP3478681A1 (en)	2019-05-08
JP2019524689A (ja)	2019-09-05
WO2018007249A1 (en)	2018-01-11
CL2019000010A1 (es)	2019-02-22
CN109311872B (zh)	2021-08-20
MY197140A (en)	2023-05-26
TWI763683B (zh)	2022-05-11
US10512632B2 (en)	2019-12-24
US11491140B2 (en)	2022-11-08
EP3689874A1 (en)	2020-08-05
US10034861B2 (en)	2018-07-31
ECSP18093944A (es)	2019-01-31
US20180000786A1 (en)	2018-01-04
JOP20180116B1 (ar)	2021-01-31
LT3478681T (lt)	2020-04-10
SMT202000148T1 (it)	2020-05-08
MA52593A (fr)	2021-03-17
CR20190003A (es)	2019-05-06
ES2784655T3 (es)	2020-09-29
HUE048576T2 (hu)	2020-08-28
AU2017291794C1 (en)	2022-01-13
IL263511B (en)	2020-11-30
DK3478681T3 (da)	2020-03-23
CA3026857A1 (en)	2018-01-11
KR102576888B1 (ko)	2023-09-08
US20200129480A1 (en)	2020-04-30
GEAP202014955A (en)	2020-07-10
TW201806950A (zh)	2018-03-01

Publication	Publication Date	Title
MA52593A (fr)	2021-03-17	1h-pyrazolo[4,3-b]pyridines en tant qu'inhibiteurs pde1
FR22C1058I1 (fr)	2023-01-06	Formulation de comprimé de 2-fluoro-n-méthyl-4-[7-(quinoline -6-ylméthyl) imidazo[1,2-b][1,2,4]triazine -2-yl]benzamide
MA53675A (fr)	2021-11-17	Composés substitués de pyrazolo[1,5-a]pyridine en tant qu'inhibiteurs de la kinase ret
SMT202200415T1 (it)	2022-11-18	Derivati di tetraidro imidazo[4,5-c]piridina come induttori di internalizzazione di pd-l1
MA41551A (fr)	2017-12-26	Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
ZA201705802B (en)	2019-07-31	4h-pyrrolo[3,2-c]pyridin-4-one derivatives
IL252065A0 (en)	2017-07-31	Thiano[2,3-c]pyrrol-4-ion derivatives as erk inhibitors
HUE048395T2 (hu)	2020-08-28	Pirrolo[2,3-C]piridinek mint képalkotó szerek neurofibrilláris fonatok számára
EP3452481A4 (en)	2020-02-26	IMIDAZO [1,2-B] SUBSTITUTED PYRIDAZINES, IMIDAZO [1,5-B] SUBSTITUTED PYRIDAZINES, RELATED COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL CONDITIONS
DK3371185T3 (da)	2020-11-30	4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridin og 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepinderivater som janus-kinase-inhibitorer
DK3712152T3 (da)	2021-03-22	4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridin og 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepinderivater som janus kinase-inhibitorer
EP3328840A4 (en)	2019-02-20	SUBSTITUTED BICYCLIC TRIAZOL COMPOUNDS AS PDE2 INHIBITORS
LT3442975T (lt)	2020-09-25	1,5-dihidro-4h-pirazol[3,4-d]pirimidin-4-onai ir 1,5-dihidro-4h-pirazol[4,3-c]piridin-4-onai kaip pde1 inhibitoriai
EP3487851A4 (en)	2019-12-25	AMINOPYRIDE DERIVATIVES AND THEIR USE AS SELECTIVE ALK-2 INHIBITORS
EP2922543A4 (en)	2016-06-01	SUBSTITUTED PYRIDONE DERIVATIVES AS PDE10 INHIBITORS
MA46690A (fr)	2019-09-11	Composés de [1,2,4]triazolo [1,5-a]pyrimidine en tant qu'inhibiteurs de pde2
LT3230289T (lt)	2019-10-10	7-(morfolinil)-2-(n-piperazinil)metiltieno[2, 3-c]piridino dariniai kaip priešvėžiniai vaistai
HUE057202T2 (hu)	2022-04-28	Kombinációs kezelések 1H-pirazolo[4,3-b]piridinek alkalmazásával
EP3190111A4 (en)	2018-02-07	Pyrazolo[3,4-c]pyridine derivatives
EP3331887A4 (en)	2019-01-09	BENZODIAZEPINE AS BROMDOMÄNENHEMMER
DK3356329T3 (da)	2020-07-13	Fremgangsmåde til fremstilling af 1-(4-methansulfonyl-2-trifluormethylbenzyl)-2-methyl-1H-pyrrolo[2,3-B]pyridin-3-yleddikesyre
MA42604A (fr)	2018-06-20	2-amino-7a-phényl-3,4,4a,5,7,7a-hexahydrofuro[3,4-b]pyridines comme inhibiteurs de bace1
MA46557A (fr)	2019-08-28	Imidazopyrazinones, pyrazolopyrimidinones et pyrazolopyridinones en tant qu'inhibiteurs de pde1
MA47070A (fr)	2019-10-30	Pyrazolo[3,4-b]pyridines et imidazo[1,5-b]pyridazines utilisés en tant qu'inhibiteurs de pde1
MA46463A (fr)	2019-08-14	Composés de pyrazolo[1,5-a]pyridine substitués en tant qu'inhibiteurs de la kinase ret