MEP23308A - Cyclohexyl(alkyl)-propanolamines, preparation method and pharmaceutical compositions containing same - Google Patents

Cyclohexyl(alkyl)-propanolamines, preparation method and pharmaceutical compositions containing same

Info

Publication number: MEP23308A
Authority: ME; Montenegro
Prior art keywords: alkyl group; group; phenyl; alkyl; halogen atom
Prior art date: 2000-11-30

Application number

MEP-233/08A

Other languages

Bosnian (bs)

English (en)

Inventor

Ambrogio Oliva

Philippe R Bovy

Roberto Cecchi

Gilles Courtemanche

Nunzia Viviani

Tiziano Croci

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-30

Filing date

2001-11-30

Publication date

2010-06-10

2001-11-30 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2010-06-10 Publication of MEP23308A publication Critical patent/MEP23308A/xx

Links

125000000217 alkyl group Chemical group 0.000 title abstract 3
238000002360 preparation method Methods 0.000 title abstract 2
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 14
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
125000005843 halogen group Chemical group 0.000 abstract 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
-1 -CONR4R5 Chemical group 0.000 abstract 3
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
125000004429 atom Chemical group 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Ophthalmology & Optometry (AREA)
Gynecology & Obstetrics (AREA)
Child & Adolescent Psychology (AREA)
Pregnancy & Childbirth (AREA)
Neurology (AREA)
Emergency Medicine (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)

MEP-233/08A 2000-11-30 2001-11-30 Cyclohexyl(alkyl)-propanolamines, preparation method and pharmaceutical compositions containing same MEP23308A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR0015477A FR2817257B1 (fr)	2000-11-30	2000-11-30	Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant
YU41703A RS51571B (sr)	2000-11-30	2001-11-30	Cikloheksil(aril)propanolamini, njihovo dobijanje i farmaceutski preparati
PCT/FR2001/003784 WO2002044139A1 (fr)	2000-11-30	2001-11-30	Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant

Publications (1)

Publication Number	Publication Date
MEP23308A true MEP23308A (en)	2010-06-10

Family

ID=8857054

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MEP-233/08A MEP23308A (en)	2000-11-30	2001-11-30	Cyclohexyl(alkyl)-propanolamines, preparation method and pharmaceutical compositions containing same

Country Status (24)

Country	Link
US (3)	US7388031B2 (pt)
EP (1)	EP1341753B1 (pt)
JP (1)	JP4024149B2 (pt)
CN (2)	CN1283622C (pt)
AR (1)	AR031438A1 (pt)
AT (1)	ATE374177T1 (pt)
AU (2)	AU2207902A (pt)
BR (1)	BR0115768A (pt)
CA (1)	CA2429267C (pt)
CY (1)	CY1106997T1 (pt)
CZ (1)	CZ305140B6 (pt)
DE (1)	DE60130676T2 (pt)
DK (1)	DK1341753T3 (pt)
ES (1)	ES2290201T3 (pt)
FR (1)	FR2817257B1 (pt)
HU (1)	HU229583B1 (pt)
ME (1)	MEP23308A (pt)
MX (1)	MXPA03004884A (pt)
PL (1)	PL206695B1 (pt)
PT (1)	PT1341753E (pt)
RS (1)	RS51571B (pt)
SI (1)	SI1341753T1 (pt)
SK (1)	SK287551B6 (pt)
WO (1)	WO2002044139A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2817257B1 (fr)	2000-11-30	2009-03-20	Sanofi Synthelabo	Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant
FR2840301B1 (fr) *	2002-05-29	2007-03-23	Sanofi Synthelabo	Derives de phenyl-cyclohexyl-propanolamine, leur preparation et leur applicaton en therapeutique
FR2840304B1 (fr) *	2002-05-29	2007-05-18	Sanofi Synthelabo	Derives d'oxophenyl-cyclohexyl-propanolamine, leur preparation et leur application en therapeutique
EP2011490A1 (en) *	2007-07-05	2009-01-07	Sanofi-Aventis	Beta adrenergic receptor ligand derivatives for modulating apoptosis
FR2935141B1 (fr) *	2008-08-21	2010-10-08	Sanofi Aventis	Procede de preparation de l'ester ethylique de l'acide 4-[trans-4-[(phenylmethyl)-amino]cyclohexyl]benzoique et de son sel hemifumarate
AU2009308708B2 (en) *	2008-10-31	2015-11-19	Medivation Technologies, Inc.	Azepino [4, 5-b] indoles and methods of use
CN116143575B (zh) *	2023-04-21	2023-06-30	研峰(天津)科学技术应用研究有限公司	昆虫信息素原料3-环己基-1-丙炔合成方法

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CN1023402C (zh) *	1988-06-03	1994-01-05	伊莱利利公司	制备5-羟色胺拮抗药的方法
US5158956A (en)	1990-05-04	1992-10-27	Eli Lilly And Company	Method of inhibiting gastric acid secretion with benzodioxanes
US5258379A (en)	1990-05-04	1993-11-02	Eli Lilly And Company	Method of inhibiting gastric acid secretion with n-arylpiperazines
US5340838A (en)	1990-05-04	1994-08-23	Eli Lilly And Company	Method of inhibiting gastric acid secretion with 2-phenylcyclopropylamines
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DE4035961A1 (de) *	1990-11-02	1992-05-07	Thomae Gmbh Dr K	Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
IL107611A0 (en)	1992-11-18	1994-02-27	Smithkline Beecham Corp	Steroid compounds and pharmaceutical compositions containing them
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DK0764632T3 (da) *	1995-09-21	2001-09-24	Lilly Co Eli	Selektive beta3-adrenerge agonister
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EP1303509B1 (en)	2000-07-13	2012-11-28	Eli Lilly And Company	Beta3 adrenergic agonists
FR2817257B1 (fr)	2000-11-30	2009-03-20	Sanofi Synthelabo	Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant
US6693125B2 (en)	2001-01-24	2004-02-17	Combinatorx Incorporated	Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders
FR2840301B1 (fr)	2002-05-29	2007-03-23	Sanofi Synthelabo	Derives de phenyl-cyclohexyl-propanolamine, leur preparation et leur applicaton en therapeutique
FR2840304B1 (fr) *	2002-05-29	2007-05-18	Sanofi Synthelabo	Derives d'oxophenyl-cyclohexyl-propanolamine, leur preparation et leur application en therapeutique
AU2003251904A1 (en)	2002-07-15	2004-02-02	Combinatorx, Incorporated	Combinations of drugs for the treatment of neoplasms
AU2003262947A1 (en)	2002-08-30	2004-03-19	Pharmacia And Upjohn Company	Method of preventing or treating atherosclerosis or restenosis
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JP2007528400A (ja)	2004-03-09	2007-10-11	エランファーマシューティカルズ，インコーポレイテッド	置換ヒドロキシエチルアミン系のアスパラギン酸プロテアーゼ阻害薬

2000
- 2000-11-30 FR FR0015477A patent/FR2817257B1/fr not_active Expired - Fee Related
2001
- 2001-11-29 AR ARP010105555A patent/AR031438A1/es not_active Application Discontinuation
- 2001-11-30 ME MEP-233/08A patent/MEP23308A/xx unknown
- 2001-11-30 AU AU2207902A patent/AU2207902A/xx active Pending
- 2001-11-30 HU HU0400565A patent/HU229583B1/hu not_active IP Right Cessation
- 2001-11-30 CN CNB018198880A patent/CN1283622C/zh not_active Expired - Fee Related
- 2001-11-30 DE DE60130676T patent/DE60130676T2/de not_active Expired - Lifetime
- 2001-11-30 CZ CZ2003-1499A patent/CZ305140B6/cs not_active IP Right Cessation
- 2001-11-30 US US10/432,493 patent/US7388031B2/en not_active Expired - Lifetime
- 2001-11-30 PL PL364746A patent/PL206695B1/pl unknown
- 2001-11-30 CN CNA2006101518761A patent/CN1935787A/zh active Pending
- 2001-11-30 BR BR0115768-0A patent/BR0115768A/pt active Search and Examination
- 2001-11-30 DK DK01998533T patent/DK1341753T3/da active
- 2001-11-30 SI SI200130783T patent/SI1341753T1/sl unknown
- 2001-11-30 AU AU2002222079A patent/AU2002222079B2/en not_active Ceased
- 2001-11-30 AT AT01998533T patent/ATE374177T1/de active
- 2001-11-30 CA CA2429267A patent/CA2429267C/fr not_active Expired - Fee Related
- 2001-11-30 JP JP2002546509A patent/JP4024149B2/ja not_active Expired - Fee Related
- 2001-11-30 WO PCT/FR2001/003784 patent/WO2002044139A1/fr not_active Ceased
- 2001-11-30 EP EP01998533A patent/EP1341753B1/fr not_active Expired - Lifetime
- 2001-11-30 PT PT01998533T patent/PT1341753E/pt unknown
- 2001-11-30 SK SK652-2003A patent/SK287551B6/sk not_active IP Right Cessation
- 2001-11-30 ES ES01998533T patent/ES2290201T3/es not_active Expired - Lifetime
- 2001-11-30 RS YU41703A patent/RS51571B/sr unknown
- 2001-11-30 MX MXPA03004884A patent/MXPA03004884A/es active IP Right Grant
2006
- 2006-08-15 US US11/464,537 patent/US7419974B2/en not_active Expired - Lifetime
2007
- 2007-11-08 CY CY20071101450T patent/CY1106997T1/el unknown
2008
- 2008-06-24 US US12/144,843 patent/US7718646B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE60130676D1 (de)	2007-11-08
HUP0400565A3 (en)	2004-08-30
PL364746A1 (en)	2004-12-13
US20040053916A1 (en)	2004-03-18
US20070015745A1 (en)	2007-01-18
AR031438A1 (es)	2003-09-24
PL206695B1 (pl)	2010-09-30
SK287551B6 (sk)	2011-01-04
EP1341753A1 (fr)	2003-09-10
US7718646B2 (en)	2010-05-18
SK6522003A3 (en)	2003-11-04
DE60130676T2 (de)	2008-07-17
FR2817257A1 (fr)	2002-05-31
EP1341753B1 (fr)	2007-09-26
BR0115768A (pt)	2003-12-30
AU2002222079B2 (en)	2006-12-14
CZ20031499A3 (cs)	2003-08-13
AU2207902A (en)	2002-06-11
CZ305140B6 (cs)	2015-05-20
WO2002044139A1 (fr)	2002-06-06
US20080261949A1 (en)	2008-10-23
HUP0400565A2 (hu)	2004-06-28
FR2817257B1 (fr)	2009-03-20
JP2004514708A (ja)	2004-05-20
YU41703A (sh)	2006-05-25
ES2290201T3 (es)	2008-02-16
HU229583B1 (en)	2014-02-28
CN1935787A (zh)	2007-03-28
RS51571B (sr)	2011-08-31
MXPA03004884A (es)	2004-05-04
PT1341753E (pt)	2007-11-13
SI1341753T1 (sl)	2007-12-31
US7388031B2 (en)	2008-06-17
CA2429267C (fr)	2010-09-28
CN1283622C (zh)	2006-11-08
US7419974B2 (en)	2008-09-02
CN1478074A (zh)	2004-02-25
JP4024149B2 (ja)	2007-12-19
DK1341753T3 (da)	2008-01-14
ATE374177T1 (de)	2007-10-15
CY1106997T1 (el)	2012-01-25
CA2429267A1 (fr)	2002-06-06
HK1055945A1 (zh)	2004-01-30

Publication	Publication Date	Title
ATE356624T1 (de)	2007-04-15	Phenoxypropanolamin-derivate, ihre herstellung und therapeutische verwendung
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