MEP23808A - Pyridine[3,4-b]pyrazinones - Google Patents

Pyridine[3,4-b]pyrazinones

Info

Publication number: MEP23808A
Authority: ME; Montenegro
Prior art keywords: compounds; pyrazinones; pyridine; disclosed; intermediates
Prior art date: 2006-04-21

Application number

MEP-238/08A

Other languages

Bosnian (bs)

English (en)

Unknown language (me)

Inventor

Robert O Hughes

Andrew Simon Bell

David Graham Brown

Dafydd Rhys Owen

Michael John Palmer

Christopher Phillips

David Louis Brown

Yvette Marlene Fobian

John Nicholas Freskos

Steven Edward Heasley

Eric Jon Jacobsen

Todd Michael Maddux

Brent Virgil Mischke

John Major Molyneaux

Joseph Blair Moon

Donald Joseph Rogier Jr

Michael Brent Tollefson

John Keith Walker

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-04-21

Filing date

2007-04-10

Publication date

2010-06-10

2007-04-10 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2010-06-10 Publication of MEP23808A publication Critical patent/MEP23808A/xx

Links

JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 2
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
239000000543 intermediate Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000001308 synthesis method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Epidemiology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Separation Of Suspended Particles By Flocculating Agents (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Epoxy Compounds (AREA)

MEP-238/08A 2006-04-21 2007-04-10 Pyridine[3,4-b]pyrazinones MEP23808A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US79397106P	2006-04-21	2006-04-21
PCT/IB2007/001001 WO2007122466A1 (en)	2006-04-21	2007-04-10	Pyridine[3,4-b]pyrazinones

Publications (1)

Publication Number	Publication Date
MEP23808A true MEP23808A (en)	2010-06-10

Family

ID=38431249

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MEP-238/08A MEP23808A (en)	2006-04-21	2007-04-10	Pyridine[3,4-b]pyrazinones

Country Status (41)

Country	Link
US (1)	US7902195B2 (da)
EP (1)	EP2013208B1 (da)
JP (1)	JP4436892B2 (da)
KR (1)	KR101061328B1 (da)
CN (1)	CN101454320B (da)
AP (1)	AP2408A (da)
AR (1)	AR060525A1 (da)
AT (1)	ATE513831T1 (da)
AU (1)	AU2007242555B2 (da)
BR (1)	BRPI0710658A2 (da)
CA (1)	CA2649775C (da)
CR (1)	CR10327A (da)
CU (1)	CU23777B7 (da)
CY (1)	CY1111739T1 (da)
DK (1)	DK2013208T3 (da)
DO (1)	DOP2007000080A (da)
EA (1)	EA014919B1 (da)
EC (1)	ECSP088803A (da)
ES (1)	ES2366239T3 (da)
GT (1)	GT200700035A (da)
HR (1)	HRP20110539T1 (da)
IL (1)	IL194591A (da)
MA (1)	MA30352B1 (da)
ME (1)	MEP23808A (da)
MX (1)	MX2008012456A (da)
MY (1)	MY148583A (da)
NL (1)	NL2000583C2 (da)
NO (1)	NO20084129L (da)
NZ (1)	NZ571540A (da)
PA (1)	PA8724201A1 (da)
PE (1)	PE20080192A1 (da)
PL (1)	PL2013208T3 (da)
RS (2)	RS20080484A (da)
SI (1)	SI2013208T1 (da)
SV (1)	SV2008003074A (da)
TN (1)	TNSN08408A1 (da)
TW (1)	TWI337609B (da)
UA (1)	UA92637C2 (da)
UY (1)	UY30291A1 (da)
WO (1)	WO2007122466A1 (da)
ZA (1)	ZA200808283B (da)

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RS20080484A (sr)	2006-04-21	2009-07-15	Pfizer Products Inc.,	PIRIDIN[3,4-b] PIRAZINONI
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TW201020233A (en) *	2008-10-09	2010-06-01	Kyorin Seiyaku Kk	Isoquinoline derivative, and pde inhibitor comprising same as active ingredient
MY177695A (en) *	2009-10-26	2020-09-23	Signal Pharm Llc	Methods of synthesis and purification of heteroaryl compounds
NZ610012A (en)	2010-10-15	2015-05-29	Gilead Sciences Inc	Compositions and methods of treating pulmonary hypertension
EP2691393B1 (en)	2011-03-31	2016-09-14	Pfizer Inc	Novel bicyclic pyridinones
WO2012172449A1 (en)	2011-06-13	2012-12-20	Pfizer Inc.	Lactams as beta secretase inhibitors
ES2605565T3 (es)	2011-08-31	2017-03-15	Pfizer Inc	Compuestos de hexahidropirano [3,4-D][1,3]tiazin-2-amina
ES2585262T3 (es)	2012-05-04	2016-10-04	Pfizer Inc	Compuestos heterocíclicos de hexahidropiran[3,4-d][1,3]tiazin-2-amina sustituidos como inhibidores de PPA, BACE1 y BACE2
CA2882389A1 (en)	2012-09-20	2014-03-27	Pfizer Inc.	Alkyl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
UA110688C2 (uk)	2012-09-21	2016-01-25	Пфайзер Інк.	Біциклічні піридинони
WO2014091352A1 (en)	2012-12-11	2014-06-19	Pfizer Inc.	Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds as inhibitors of bace1
CA2893333C (en)	2012-12-19	2017-10-24	Pfizer Inc.	Carbocyclic-and heterocyclic-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
WO2014125394A1 (en)	2013-02-13	2014-08-21	Pfizer Inc.	HETEROARYL-SUBSTITUTED HEXAHYDROPYRANO [3,4-d][1,3] THIAZIN-2-AMINE COMPOUNDS
US9233981B1 (en)	2013-02-15	2016-01-12	Pfizer Inc.	Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
CN105121439A (zh)	2013-02-19	2015-12-02	辉瑞公司	作为pde4亚型抑制剂用于治疗cns和其他病症的氮杂苯并咪唑化合物
ES2742078T3 (es)	2013-10-04	2020-02-13	Pfizer	Piridonas bicíclicas novedosas como moduladores de gamma-secretasa
JO3466B1 (ar) *	2013-12-20	2020-07-05	Takeda Pharmaceuticals Co	مواد ضابطة لتترا هيدرو بيريدوبيرازينات من gpr6
DK3126361T3 (da)	2014-04-01	2020-01-02	Pfizer	Chromen og 1,1a,2,7b-tetrahydrocyclopropa[c]chromen- pyridopyrazindioner som gamma-sekretase-modulatorer
PE20170327A1 (es)	2014-04-10	2017-04-21	Pfizer	2-AMINO-6-METIL-4,4a,5,6-TETRAHIDROPIRANO[3,4d] [1,3] TIAZIN-8a(8H)-IL-1,3-TIAZOL-4-ILAMIDAS
WO2016012896A1 (en)	2014-07-24	2016-01-28	Pfizer Inc.	Pyrazolopyrimidine compounds
PL3177624T3 (pl)	2014-08-06	2019-09-30	Pfizer Inc.	Związki imidazopirydazynowe
MX368391B (es)	2015-02-03	2019-09-30	Pfizer	Ciclopropabenzofuranil-piridopirazindionas novedosas.
EP3766885B1 (en)	2015-06-17	2022-05-25	Pfizer Inc.	Tricyclic compounds and their use as phosphodiesterase inhibitors
WO2017051276A1 (en)	2015-09-24	2017-03-30	Pfizer Inc.	N-[2-(2-amino-6,6-disubstituted-4, 4a, 5, 6-tetrahydropyrano [3,4-d][1,3] thiazin-8a (8h)-yl) -1, 3-thiazol-4-yl] amides
WO2017051294A1 (en)	2015-09-24	2017-03-30	Pfizer Inc.	N-[2-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl] amides useful as bace inhibitors
EP3353182A1 (en)	2015-09-24	2018-08-01	Pfizer Inc	Tetrahydropyrano[3,4-d][1,3]oxazin derivatives and their use as bace inhibitors
SG11201806383TA (en)	2016-02-23	2018-09-27	Pfizer	6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds
WO2018002760A1 (en)	2016-07-01	2018-01-04	Pfizer Inc.	5,7-dihydro-pyrrolo-pyridine derivatives for treating neurological and neurodegenerative diseases
BR112019026955A2 (pt)	2017-06-22	2020-06-30	Pfizer Inc.	derivados de di-hidro-pirrolo-piridina
CN111182898B (zh) *	2017-06-28	2024-04-16	Ptc医疗公司	用于治疗亨廷顿氏病的方法
EP4219464A1 (en)	2018-03-23	2023-08-02	Pfizer Inc.	Piperazine azaspiro derivaves
EP4297868A4 (en)	2021-02-23	2025-01-08	Hoth Therapeutics, Inc.	USE OF APREPITANT TO TREAT ALZHEIMER'S
WO2024118524A1 (en)	2022-11-28	2024-06-06	Cerevel Therapeutics, Llc	Azaindole compounds and their use as phosphodiesterase inhibitors
WO2025145091A1 (en)	2023-12-29	2025-07-03	Pfizer Inc.	Crystalline forms of a muscarinic m4 receptor modulator and methods of treating diseases
WO2025160132A1 (en) *	2024-01-23	2025-07-31	Maplight Therapeutics, Inc.	Gpr6 inverse agonists

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WO2005040337A2 (en)	2003-05-20	2005-05-06	The Regents Of The University Of California	METHODS FOR BINDING AGENTS TO β-AMYLOID PLAQUES
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2007
- 2007-04-10 RS RSP-2008/0484A patent/RS20080484A/sr unknown
- 2007-04-10 EP EP07734320A patent/EP2013208B1/en active Active
- 2007-04-10 AU AU2007242555A patent/AU2007242555B2/en not_active Ceased
- 2007-04-10 MY MYPI20084131A patent/MY148583A/en unknown
- 2007-04-10 ES ES07734320T patent/ES2366239T3/es active Active
- 2007-04-10 PL PL07734320T patent/PL2013208T3/pl unknown
- 2007-04-10 AT AT07734320T patent/ATE513831T1/de active
- 2007-04-10 EA EA200801998A patent/EA014919B1/ru not_active IP Right Cessation
- 2007-04-10 WO PCT/IB2007/001001 patent/WO2007122466A1/en not_active Ceased
- 2007-04-10 JP JP2009505983A patent/JP4436892B2/ja not_active Expired - Fee Related
- 2007-04-10 DK DK07734320.0T patent/DK2013208T3/da active
- 2007-04-10 ME MEP-238/08A patent/MEP23808A/xx unknown
- 2007-04-10 AP AP2008004640A patent/AP2408A/xx active
- 2007-04-10 SI SI200730675T patent/SI2013208T1/sl unknown
- 2007-04-10 MX MX2008012456A patent/MX2008012456A/es active IP Right Grant
- 2007-04-10 HR HR20110539T patent/HRP20110539T1/hr unknown
- 2007-04-10 RS RS20110363A patent/RS51885B/sr unknown
- 2007-04-10 BR BRPI0710658-0A patent/BRPI0710658A2/pt not_active IP Right Cessation
- 2007-04-10 CN CN2007800198932A patent/CN101454320B/zh not_active Expired - Fee Related
- 2007-04-10 CA CA2649775A patent/CA2649775C/en not_active Expired - Fee Related
- 2007-04-10 KR KR1020087028465A patent/KR101061328B1/ko not_active Expired - Fee Related
- 2007-04-10 NZ NZ571540A patent/NZ571540A/en not_active IP Right Cessation
- 2007-04-11 NL NL2000583A patent/NL2000583C2/nl not_active IP Right Cessation
- 2007-04-18 UY UY30291A patent/UY30291A1/es not_active Application Discontinuation
- 2007-04-18 AR ARP070101657A patent/AR060525A1/es not_active Application Discontinuation
- 2007-04-19 GT GT200700035A patent/GT200700035A/es unknown
- 2007-04-19 PE PE2007000483A patent/PE20080192A1/es not_active Application Discontinuation
- 2007-04-20 DO DO2007000080A patent/DOP2007000080A/es unknown
- 2007-04-20 PA PA20078724201A patent/PA8724201A1/es unknown
- 2007-04-20 US US11/737,966 patent/US7902195B2/en not_active Expired - Fee Related
- 2007-04-20 TW TW096114037A patent/TWI337609B/zh not_active IP Right Cessation
- 2007-10-04 UA UAA200812397A patent/UA92637C2/ru unknown
2008
- 2008-09-29 NO NO20084129A patent/NO20084129L/no not_active Application Discontinuation
- 2008-09-29 ZA ZA200808283A patent/ZA200808283B/xx unknown
- 2008-09-30 CR CR10327A patent/CR10327A/es unknown
- 2008-10-07 IL IL194591A patent/IL194591A/en not_active IP Right Cessation
- 2008-10-08 EC EC2008008803A patent/ECSP088803A/es unknown
- 2008-10-17 CU CU20080194A patent/CU23777B7/es active IP Right Grant
- 2008-10-17 TN TNP2008000408A patent/TNSN08408A1/fr unknown
- 2008-10-21 MA MA31321A patent/MA30352B1/fr unknown
- 2008-10-21 SV SV2008003074A patent/SV2008003074A/es unknown
2011
- 2011-07-25 CY CY20111100731T patent/CY1111739T1/el unknown

Also Published As

Publication number	Publication date
EP2013208B1 (en)	2011-06-22
TWI337609B (en)	2011-02-21
IL194591A (en)	2012-07-31
PA8724201A1 (es)	2009-08-26
CA2649775A1 (en)	2007-11-01
PE20080192A1 (es)	2008-03-01
NL2000583C2 (nl)	2007-12-14
UA92637C2 (en)	2010-11-25
GT200700035A (es)	2008-02-05
KR101061328B1 (ko)	2011-08-31
CR10327A (es)	2008-10-21
DK2013208T3 (da)	2011-08-15
MX2008012456A (es)	2008-10-10
AP2408A (en)	2012-05-30
CN101454320B (zh)	2012-12-19
NZ571540A (en)	2010-10-29
CN101454320A (zh)	2009-06-10
CA2649775C (en)	2011-05-31
CU20080194A7 (es)	2011-03-21
TW200808794A (en)	2008-02-16
HRP20110539T1 (hr)	2011-08-31
DOP2007000080A (es)	2007-11-15
CU23777B7 (es)	2012-02-15
SV2008003074A (es)	2010-01-12
UY30291A1 (es)	2007-11-30
AP2008004640A0 (en)	2008-10-31
NO20084129L (no)	2008-10-29
ES2366239T3 (es)	2011-10-18
KR20080110930A (ko)	2008-12-19
AR060525A1 (es)	2008-06-25
ZA200808283B (en)	2009-11-25
US20070249615A1 (en)	2007-10-25
RS20080484A (sr)	2009-07-15
NL2000583A1 (nl)	2007-10-23
MY148583A (en)	2013-04-30
US7902195B2 (en)	2011-03-08
WO2007122466A1 (en)	2007-11-01
CY1111739T1 (el)	2015-10-07
MA30352B1 (fr)	2009-04-01
EA200801998A1 (ru)	2009-04-28
PL2013208T3 (pl)	2011-10-31
EP2013208A1 (en)	2009-01-14
RS51885B (sr)	2012-02-29
SI2013208T1 (sl)	2011-09-30
ATE513831T1 (de)	2011-07-15
JP2009534368A (ja)	2009-09-24
JP4436892B2 (ja)	2010-03-24
AU2007242555B2 (en)	2010-12-16
EA014919B1 (ru)	2011-04-29
BRPI0710658A2 (pt)	2011-08-16
TNSN08408A1 (fr)	2010-04-14
AU2007242555A1 (en)	2007-11-01
ECSP088803A (es)	2008-11-27
HK1133875A1 (en)	2010-04-09

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