MEP51308A - Postupak za dobijanje novih soli tiotropijuma, nove soli tiotropijuma kao takve, kao i farmaceutske formulacije koje ih sadrže - Google Patents

Postupak za dobijanje novih soli tiotropijuma, nove soli tiotropijuma kao takve, kao i farmaceutske formulacije koje ih sadrže

Info

Publication number
MEP51308A
MEP51308A MEP-513/08A MEP51308A MEP51308A ME P51308 A MEP51308 A ME P51308A ME P51308 A MEP51308 A ME P51308A ME P51308 A MEP51308 A ME P51308A
Authority
ME
Montenegro
Prior art keywords
tiotropium salts
pharmaceutical formulations
same
producing
salts
Prior art date
Application number
MEP-513/08A
Other languages
English (en)
Inventor
Rolf Banholzer
Waldemar Pfrengle
Peter Sieger
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34530660&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MEP51308(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of MEP51308A publication Critical patent/MEP51308A/bs
Publication of ME00361B publication Critical patent/ME00361B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Pronalazak se odnosi na postupak za dobijanje novih soli titropijuma, na ove nove soli titropijuma kao takve, zatim na farmaceutske formulacije koje ih sadrže, kao i na njihovu primjenu za pripremanje lijeka za liječenje bolesti disajnih puteva, a naročito COPD (chronici obstructive pulmonary disease = hronična obstruktivna bolest pluća) i astme.
MEP-2008-513A 2003-11-03 2004-10-29 Postupak za dobijanje soli tiotropijuma ME00361B (me)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03025075 2003-11-03
PCT/EP2004/012268 WO2005042526A1 (de) 2003-11-03 2004-10-29 Verfahren zur herstellung von tiotropiumsalze, tiotropiumsalze sowie arzneimitte lformulierungen diese enthaltend

Publications (2)

Publication Number Publication Date
MEP51308A true MEP51308A (bs) 2011-05-10
ME00361B ME00361B (me) 2011-10-10

Family

ID=34530660

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2008-513A ME00361B (me) 2003-11-03 2004-10-29 Postupak za dobijanje soli tiotropijuma

Country Status (34)

Country Link
US (1) US8686148B2 (bs)
EP (3) EP2067779B9 (bs)
JP (1) JP5165244B2 (bs)
KR (1) KR20060117334A (bs)
CN (3) CN100549010C (bs)
AR (1) AR046317A1 (bs)
AT (1) ATE460414T1 (bs)
AU (1) AU2004285683C1 (bs)
BR (1) BRPI0416136A (bs)
CA (1) CA2544348A1 (bs)
CO (1) CO5690553A2 (bs)
CY (2) CY1110048T1 (bs)
DE (1) DE502004010885D1 (bs)
DK (2) DK2067779T3 (bs)
EA (1) EA012326B1 (bs)
ES (2) ES2342468T3 (bs)
HR (1) HRP20100149T1 (bs)
IL (1) IL175023A (bs)
ME (1) ME00361B (bs)
MX (1) MXPA06004697A (bs)
MY (1) MY143364A (bs)
NO (1) NO335814B1 (bs)
NZ (1) NZ547276A (bs)
PE (1) PE20050446A1 (bs)
PL (2) PL2067779T3 (bs)
PT (2) PT2067779E (bs)
RS (2) RS20060292A (bs)
SG (1) SG137859A1 (bs)
SI (2) SI2067779T1 (bs)
TW (2) TWI435876B (bs)
UA (1) UA82413C2 (bs)
UY (1) UY28590A1 (bs)
WO (1) WO2005042526A1 (bs)
ZA (1) ZA200602342B (bs)

Families Citing this family (12)

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US20060079544A1 (en) * 2004-08-13 2006-04-13 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
NZ564697A (en) * 2005-06-15 2010-04-30 Boehringer Ingelheim Int Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
TW200738634A (en) * 2005-08-02 2007-10-16 Astrazeneca Ab New salt
US8163913B2 (en) 2005-12-19 2012-04-24 Sicor Inc. Forms of tiotropium bromide and processes for preparation thereof
DK1971332T3 (da) * 2006-01-04 2011-04-18 Boehringer Ingelheim Int Anvendelse af tiotropium-salte til behandling af moderat vedvarende astma
EP1953156A1 (de) * 2007-01-29 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopiniumsalzen
CZ201241A3 (cs) 2012-01-20 2013-07-31 Zentiva, K.S. Nové polymorfní formy tiotropium jodidu a zpusob jejich prípravy
WO2014042605A1 (en) * 2012-09-11 2014-03-20 Mahmut Bilgic New tiotropium bromide crystalline form
JP6042197B2 (ja) * 2012-12-11 2016-12-14 エア・ウォーター株式会社 肺障害治療剤

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JP5165244B2 (ja) 2003-11-03 2013-03-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング チオトロピウム塩の製法、チオトロピウム塩及びそれを含有する医薬組成物
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DK2083007T3 (da) * 2003-11-03 2013-07-29 Boehringer Ingelheim Int Tiotropiumsalte, fremgangsmåder til deres fremstilling og lægemiddelformuleringer indeholdende disse
SE0303270L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Metod för administration av tiotropium
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NZ564697A (en) * 2005-06-15 2010-04-30 Boehringer Ingelheim Int Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
ES2422729T3 (es) 2013-09-13
CY1114157T1 (el) 2016-08-31
HK1153409A1 (en) 2012-03-30
TWI363758B (en) 2012-05-11
SI2067779T1 (sl) 2013-08-30
JP5165244B2 (ja) 2013-03-21
CN101407514B (zh) 2013-05-29
TW201231465A (en) 2012-08-01
CN102070630A (zh) 2011-05-25
MY143364A (en) 2011-04-29
DE502004010885D1 (de) 2010-04-22
EA200600886A1 (ru) 2006-10-27
PE20050446A1 (es) 2005-08-02
CA2544348A1 (en) 2005-05-12
PL1682541T3 (pl) 2010-08-31
EP2336126A1 (de) 2011-06-22
UY28590A1 (es) 2005-06-30
AU2004285683B2 (en) 2011-04-21
PL2067779T3 (pl) 2013-09-30
NO20061440L (no) 2006-07-12
HK1129111A1 (en) 2009-11-20
CO5690553A2 (es) 2006-10-31
MXPA06004697A (es) 2006-07-05
BRPI0416136A (pt) 2007-01-02
WO2005042526A1 (de) 2005-05-12
RS20060292A (sr) 2008-08-07
AR046317A1 (es) 2005-11-30
EP2067779B9 (de) 2013-10-16
RS51758B (sr) 2011-12-31
DK2067779T3 (da) 2013-07-29
CN101407514A (zh) 2009-04-15
KR20060117334A (ko) 2006-11-16
AU2004285683A1 (en) 2005-05-12
CN1882582A (zh) 2006-12-20
CY1110048T1 (el) 2015-01-14
ATE460414T1 (de) 2010-03-15
AU2004285683C1 (en) 2011-09-08
CN102070630B (zh) 2013-04-17
JP2007509893A (ja) 2007-04-19
EP2067779B1 (de) 2013-04-24
IL175023A0 (en) 2006-08-20
EP1682541A1 (de) 2006-07-26
NZ547276A (en) 2009-08-28
DK1682541T3 (da) 2010-06-28
EP1682541B1 (de) 2010-03-10
IL175023A (en) 2011-02-28
PT2067779E (pt) 2013-07-25
HRP20100149T1 (hr) 2010-04-30
ZA200602342B (en) 2007-06-27
EA012326B1 (ru) 2009-08-28
PT1682541E (pt) 2010-04-14
ES2342468T3 (es) 2010-07-07
ME00361B (me) 2011-10-10
SI1682541T1 (sl) 2010-06-30
US8686148B2 (en) 2014-04-01
EP2067779A1 (de) 2009-06-10
CN100549010C (zh) 2009-10-14
UA82413C2 (uk) 2008-04-10
TW200526653A (en) 2005-08-16
HK1099748A1 (zh) 2007-08-24
SG137859A1 (en) 2007-12-28
NO335814B1 (no) 2015-02-23
US20050131007A1 (en) 2005-06-16
TWI435876B (zh) 2014-05-01

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