MW2674A1 - Pharmacologically active compounds - Google Patents

Pharmacologically active compounds

Info

Publication number
MW2674A1
MW2674A1 MW26/74*UA MW2674A MW2674A1 MW 2674 A1 MW2674 A1 MW 2674A1 MW 2674 A MW2674 A MW 2674A MW 2674 A1 MW2674 A1 MW 2674A1
Authority
MW
MALAWI
Prior art keywords
active compounds
pharmacologically active
pharmacologically
compounds
active
Prior art date
Application number
MW26/74*UA
Other languages
English (en)
Original Assignee
Smith Kline French Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab
Publication of MW2674A1 publication Critical patent/MW2674A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/46—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
MW26/74*UA 1973-07-13 1974-06-19 Pharmacologically active compounds MW2674A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3342873A GB1431589A (en) 1973-07-13 1973-07-13 Ureas, thioureas and guanidines n,n-disubstituted by heterocyclo- alkylene and/or heterocycloalkylenethioalkylene groups

Publications (1)

Publication Number Publication Date
MW2674A1 true MW2674A1 (en) 1975-05-13

Family

ID=10352834

Family Applications (1)

Application Number Title Priority Date Filing Date
MW26/74*UA MW2674A1 (en) 1973-07-13 1974-06-19 Pharmacologically active compounds

Country Status (31)

Country Link
US (1) US4499101A (de)
JP (1) JPS5830314B2 (de)
AR (3) AR204928A1 (de)
AT (1) AT346855B (de)
BE (1) BE816850A (de)
BG (1) BG25792A3 (de)
CA (1) CA1049524A (de)
CH (1) CH601252A5 (de)
CS (1) CS199255B2 (de)
DD (1) DD112449A5 (de)
DE (1) DE2433625A1 (de)
DK (1) DK334674A (de)
EG (1) EG11259A (de)
ES (3) ES428246A1 (de)
FI (1) FI213274A7 (de)
FR (1) FR2274298A1 (de)
GB (1) GB1431589A (de)
HU (1) HU169394B (de)
IE (1) IE39607B1 (de)
IL (1) IL45006A (de)
IN (1) IN140943B (de)
LU (1) LU70507A1 (de)
MW (1) MW2674A1 (de)
NL (1) NL7408942A (de)
NO (1) NO143063C (de)
OA (1) OA04814A (de)
PH (1) PH11618A (de)
PL (3) PL98609B1 (de)
SE (1) SE416202B (de)
SU (3) SU559647A3 (de)
ZM (1) ZM10374A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4215125A (en) * 1973-07-13 1980-07-29 Smith Kline & French Laboratories Limited Pyridyl ureas, thioureas and guanidines
US4062967A (en) * 1974-02-07 1977-12-13 Smith Kline & French Laboratories Limited Bis-guanidino-alkane compounds
US4151289A (en) 1975-01-22 1979-04-24 Smith Kline & French Laboratories Limited Nitromethylene amidino derivatives containing imidazole groups
GB1542840A (en) * 1975-02-03 1979-03-28 Smith Kline French Lab Heterocyclic dithiocarbamates and isothioureas
US4120972A (en) 1975-02-03 1978-10-17 Smith Kline & French Laboratories Limited Imidazolylmethylthio-ethyl isothiourea compounds
IL49528A (en) * 1975-05-21 1980-11-30 Smith Kline French Lab Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them
US4165378A (en) 1977-04-20 1979-08-21 Ici Americas Inc. Guanidine derivatives of imidazoles and thiazoles
NZ186965A (en) 1977-04-20 1980-02-21 Ici Ltd Guanidino derivatives and pharmaceutical compositions
US4233302A (en) 1977-12-23 1980-11-11 Glaxo Group Limited Amine derivatives and pharmaceutical compositions containing them
US4309435A (en) 1978-10-16 1982-01-05 Imperial Chemical Industries Ltd. Antisecretory guanidine derivatives and pharmaceutical compositions containing them
EP0014057B1 (de) 1979-01-18 1985-01-02 Imperial Chemical Industries Plc Guanidin-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
JPS5610175A (en) * 1979-07-06 1981-02-02 Fujisawa Pharmaceut Co Ltd Preparation of imidazole derivative
EP0050407A1 (de) * 1980-08-27 1982-04-28 Glaxo Group Limited 3,5-Disubstituierte-1,2,4-Triazol-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
EP0089765A3 (de) * 1982-03-17 1984-05-23 Smith Kline & French Laboratories Limited Pyridin-Derivate
DE3512084A1 (de) * 1985-04-02 1986-10-09 Ludwig Heumann & Co GmbH, 8500 Nürnberg Guanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3579000D1 (de) 1985-04-02 1990-09-06 Heumann Pharma Gmbh & Co Imidazolylalkylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
DE3631334A1 (de) * 1986-09-15 1988-03-17 Heumann Pharma Gmbh & Co Neue imidazolylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
NL9100365A (nl) * 1991-02-27 1992-09-16 Seed Capital Investments Imidazoolderivaten met agonistische of antagonistische activiteit op de histamine h3-receptor.
EP0573542B1 (de) * 1991-02-27 1997-10-15 Seed Capital Investments( Sci) B.V. Imidazol-derivate mit antagonistischer aktivität auf den histamin-h3-receptor
US7041702B1 (en) 1997-10-21 2006-05-09 Scion Pharmaceuticals, Inc. Pharmaceutically active compounds and methods of use
JP2001520215A (ja) * 1997-10-21 2001-10-30 ケンブリッジ・ニューロサイエンス・インコーポレイティッド 薬学的に活性な化合物ならびに利用法
EP4196793A1 (de) 2020-08-11 2023-06-21 Université de Strasbourg Auf lebermakrophagen abzielende h2-blocker zur prävention und behandlung von lebererkrankungen und krebs

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE632032A (de) * 1962-05-09
CH484918A (de) * 1965-10-28 1970-01-31 Ciba Geigy Verfahren zur Herstellung heterocyclischer, Aethylendoppelbindungen enthaltender Verbindungen
US3770755A (en) * 1967-09-26 1973-11-06 Ici Ltd 4-(4-bromophenyl)-2-(2-hydroxysopropyl) thiazole
US3868457A (en) * 1969-10-29 1975-02-25 Smith Kline French Lab Method of inhibiting histamine activity with guanidine compounds
BE758146A (fr) * 1969-10-29 1971-04-28 Smith Kline French Lab Derives de l'amidine
US3749728A (en) * 1972-02-15 1973-07-31 Smith Kline French Lab N-cycloalkyl and n-cycloalkane-alkylthioamides
US3821229A (en) * 1972-12-07 1974-06-28 American Cyanamid Co Diquaternary salts of di-4-pyridyl ketone
US4013659A (en) * 1973-07-13 1977-03-22 Smith Kline & French Laboratories Limited Certain n,n'-disubstituted guanidine compounds and their use
US4156727A (en) * 1975-07-31 1979-05-29 Smith Kline & French Laboratories Limited Alkoxy pyridine compounds

Also Published As

Publication number Publication date
PL96460B1 (pl) 1977-12-31
SE416202B (sv) 1980-12-08
SU559647A3 (ru) 1977-05-25
FI213274A7 (de) 1975-01-14
DK334674A (de) 1975-03-03
IE39607B1 (en) 1978-11-22
NO143063B (no) 1980-09-01
NO143063C (no) 1980-12-10
AT346855B (de) 1978-11-27
IE39607L (en) 1975-01-13
AU6984574A (en) 1975-12-11
DD112449A5 (de) 1975-04-12
ES428246A1 (es) 1976-07-16
ATA552674A (de) 1978-04-15
SU571193A3 (ru) 1977-08-30
BE816850A (fr) 1974-12-27
CH601252A5 (de) 1978-06-30
SU567405A3 (ru) 1977-07-30
AR202618A1 (es) 1975-06-24
JPS5830314B2 (ja) 1983-06-28
HU169394B (de) 1976-11-28
ZM10374A1 (en) 1975-04-21
IN140943B (de) 1977-01-01
AR204928A1 (es) 1976-03-19
EG11259A (en) 1977-01-31
FR2274298B1 (de) 1978-07-21
GB1431589A (en) 1976-04-07
PL98609B1 (pl) 1978-05-31
FR2274298A1 (fr) 1976-01-09
US4499101A (en) 1985-02-12
BG25792A3 (bg) 1978-12-12
ES437770A1 (es) 1977-01-16
OA04814A (fr) 1980-10-31
DE2433625A1 (de) 1975-01-30
LU70507A1 (de) 1974-11-28
IL45006A (en) 1978-07-31
NO742563L (de) 1975-02-10
AR202617A1 (es) 1975-06-24
JPS5032174A (de) 1975-03-28
CS199255B2 (en) 1980-07-31
PH11618A (en) 1978-04-12
CA1049524A (en) 1979-02-27
PL98705B1 (pl) 1978-05-31
ES437769A1 (es) 1977-02-01
NL7408942A (nl) 1975-01-15
SE7409188L (sv) 1975-01-14
IL45006A0 (en) 1974-09-10

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