MX2009013169A - Moduladores alostericos positivos del mglur5 benzamida y metodos de elaboracion y uso de los mismos. - Google Patents

Moduladores alostericos positivos del mglur5 benzamida y metodos de elaboracion y uso de los mismos.

Info

Publication number: MX2009013169A
Authority: MX; Mexico
Prior art keywords: methods; compounds; making; positive allosteric; allosteric modulators
Prior art date: 2007-06-03

Application number

MX2009013169A

Other languages

English (en)

Spanish (es)

Inventor

P Jeffrey Conn

Craig W Lindsley

Charles David Weaver

Alice L Rodriguez

Colleen M Niswender

Carrie K Jones

Richard Williams

Original Assignee

Univ Vanderbilt

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-06-03

Filing date

2008-06-03

Publication date

2010-04-30

2008-06-03 Application filed by Univ Vanderbilt filed Critical Univ Vanderbilt

2010-04-30 Publication of MX2009013169A publication Critical patent/MX2009013169A/es

Links

230000003281 allosteric effect Effects 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 title 2
150000001875 compounds Chemical class 0.000 abstract 4
102000012777 Metabotropic Glutamate 5 Receptor Human genes 0.000 abstract 2
108010065028 Metabotropic Glutamate 5 Receptor Proteins 0.000 abstract 2
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
208000012902 Nervous system disease Diseases 0.000 abstract 1
208000025966 Neurological disease Diseases 0.000 abstract 1
150000003936 benzamides Chemical class 0.000 abstract 1
-1 cyclic benzamide derivatives Chemical class 0.000 abstract 1
230000004064 dysfunction Effects 0.000 abstract 1
229930195712 glutamate Natural products 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000000926 neurological effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
208000020016 psychiatric disease Diseases 0.000 abstract 1
238000010189 synthetic method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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MX2009013169A 2007-06-03 2008-06-03 Moduladores alostericos positivos del mglur5 benzamida y metodos de elaboracion y uso de los mismos. MX2009013169A (es)

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EP (1)	EP2162136A4 (pt)
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KR (1)	KR20100033981A (pt)
CN (1)	CN101795689B (pt)
AU (1)	AU2008259776A1 (pt)
BR (1)	BRPI0812363A2 (pt)
CA (1)	CA2689282A1 (pt)
EA (1)	EA200971143A1 (pt)
IL (1)	IL202508A0 (pt)
MX (1)	MX2009013169A (pt)
NZ (1)	NZ581817A (pt)
SG (1)	SG185285A1 (pt)
WO (1)	WO2008151184A1 (pt)

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JP5622568B2 (ja)	2014-11-12
KR20100033981A (ko)	2010-03-31
WO2008151184A1 (en)	2008-12-11
HK1147068A1 (en)	2011-07-29
IL202508A0 (en)	2010-06-30
CN101795689B (zh)	2014-11-19
EP2162136A1 (en)	2010-03-17
SG185285A1 (en)	2012-11-29
CA2689282A1 (en)	2008-12-11
EA200971143A1 (ru)	2010-06-30
JP2010529135A (ja)	2010-08-26
CN101795689A (zh)	2010-08-04
AU2008259776A1 (en)	2008-12-11
AU2008259776A2 (en)	2010-01-28
EP2162136A4 (en)	2012-02-15
NZ581817A (en)	2012-05-25
BRPI0812363A2 (pt)	2015-02-03

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2018-10-31	FA	Abandonment or withdrawal

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