MX2012012007A - Proceso para preparar amidas de acidos carboxilicos pirazolicos. - Google Patents
Proceso para preparar amidas de acidos carboxilicos pirazolicos.Info
- Publication number
- MX2012012007A MX2012012007A MX2012012007A MX2012012007A MX2012012007A MX 2012012007 A MX2012012007 A MX 2012012007A MX 2012012007 A MX2012012007 A MX 2012012007A MX 2012012007 A MX2012012007 A MX 2012012007A MX 2012012007 A MX2012012007 A MX 2012012007A
- Authority
- MX
- Mexico
- Prior art keywords
- compound
- formula
- reacting
- preparation
- carboxylic acid
- Prior art date
Links
- BNYCHCAYYYRJSH-UHFFFAOYSA-N 1h-pyrazole-5-carboxamide Chemical class NC(=O)C1=CC=NN1 BNYCHCAYYYRJSH-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 13
- ZSWFCLXCOIISFI-UHFFFAOYSA-N cyclopentadiene Chemical compound C1C=CC=C1 ZSWFCLXCOIISFI-UHFFFAOYSA-N 0.000 abstract 2
- 239000007800 oxidant agent Substances 0.000 abstract 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 abstract 2
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- XNNQFQFUQLJSQT-UHFFFAOYSA-N bromo(trichloro)methane Chemical compound ClC(Cl)(Cl)Br XNNQFQFUQLJSQT-UHFFFAOYSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
La invención se refiere a un proceso para preparar la fórmula (I) (Ver Formula) comprendiendo el proceso a) hacer reaccionar el compuesto (II) (Ver Formula) con ciclopentadieno para obtener (III) (Ver Formula) b) hacer reaccionar este compuesto en presencia de un oxidante para obtener el compuesto de fórmula (IV) (Ver Formula) c) hidrogenar este compuesto en presencia de un catalizador metálico y un disolvente inerte en atmósfera de hidrógeno para obtener el compuesto de fórmula (V) (Ver Formula) d) hacer reaccionar este compuesto en presencia de un ácido de Bránsted seguido de un agente reductor para obtener el compuesto de fórmula (VI) (Ver Formula) e) hacer reaccionar (VI) con un compuesto (VII) en presencia de una base para obtener un compuesto de fórmula (VIII) (Ver Formula) f) convertir el compuesto de fórmula (VIII) en presencia de un agente oxidante en el compuesto de fórmula (IX) (Ver Formula) y g) hacer reaccionar el compuesto de fórmula (IX) en presencia de trifenilfosfano/tetra cloruro de carbono o trifenilfosfano/bromotriclorometano para obtener el compuesto de fórmula (1).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10160440 | 2010-04-20 | ||
| PCT/EP2011/055869 WO2011131543A1 (en) | 2010-04-20 | 2011-04-14 | Process for the preparation of pyrazole carboxylic acid amides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2012012007A true MX2012012007A (es) | 2012-12-17 |
Family
ID=44080322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012012007A MX2012012007A (es) | 2010-04-20 | 2011-04-14 | Proceso para preparar amidas de acidos carboxilicos pirazolicos. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8450499B2 (es) |
| EP (1) | EP2560957B1 (es) |
| JP (1) | JP5684895B2 (es) |
| CN (1) | CN102858750A (es) |
| AR (1) | AR080924A1 (es) |
| BR (1) | BR112012026720B1 (es) |
| ES (1) | ES2478875T3 (es) |
| IL (1) | IL222399A (es) |
| MX (1) | MX2012012007A (es) |
| TW (1) | TWI419881B (es) |
| UY (1) | UY33342A (es) |
| WO (1) | WO2011131543A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112012026456B1 (pt) * | 2010-04-20 | 2017-06-27 | Syngenta Participations Ag | Process for the preparation of carboxylic pyrazole acid amides |
| CN106588745B (zh) * | 2016-12-02 | 2019-06-14 | 杭州百昂锐地科技有限公司 | 一种苯并烯氟菌唑的中间体及其制备方法和应用 |
| CN106588668A (zh) * | 2016-12-02 | 2017-04-26 | 杭州百昂锐地科技有限公司 | 2‑溴‑5‑硝基‑1,2,3,4‑四氢‑1,4‑桥亚甲基‑萘‑9‑酚及其制备方法 |
| CN108003030B (zh) * | 2017-11-09 | 2020-03-31 | 浙江工业大学 | 一种管道化连续制备5-硝基-1,4-二氢-1,4-桥亚甲基-萘的方法及装置 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5093347A (en) | 1991-01-28 | 1992-03-03 | Monsanto Company | 3-difluoromethylpyrazolecarboxamide fungicides, compositions and use |
| WO1993023420A1 (en) * | 1992-05-20 | 1993-11-25 | Merck & Co., Inc. | NEW 7β-SUBSTITUTED-4-AZA-5α-ANDROSTAN-3-ONES AS 5α-REDUCTASE INHIBITORS |
| TW200401635A (en) * | 2002-07-23 | 2004-02-01 | Yamanouchi Pharma Co Ltd | 2-Cyano-4-fluoropyrrolidine derivative or salt thereof |
| CN101962364B (zh) | 2005-09-16 | 2013-01-09 | 先正达参股股份有限公司 | 酰胺的制备方法 |
| ATE489372T1 (de) * | 2005-10-25 | 2010-12-15 | Syngenta Participations Ag | Als mikrobiozide geeignete heterocyclische amidderivate |
| BRPI0923527A2 (pt) * | 2008-12-24 | 2016-08-09 | Syngenta Ltd | métodos de preparo de fungicidas |
-
2011
- 2011-04-14 ES ES11714295.0T patent/ES2478875T3/es active Active
- 2011-04-14 MX MX2012012007A patent/MX2012012007A/es active IP Right Grant
- 2011-04-14 WO PCT/EP2011/055869 patent/WO2011131543A1/en not_active Ceased
- 2011-04-14 EP EP11714295.0A patent/EP2560957B1/en active Active
- 2011-04-14 US US13/642,512 patent/US8450499B2/en active Active
- 2011-04-14 JP JP2013505407A patent/JP5684895B2/ja active Active
- 2011-04-14 CN CN2011800197688A patent/CN102858750A/zh active Pending
- 2011-04-14 BR BR112012026720-5A patent/BR112012026720B1/pt active IP Right Grant
- 2011-04-15 UY UY0001033342A patent/UY33342A/es active IP Right Grant
- 2011-04-18 AR ARP110101328A patent/AR080924A1/es active IP Right Grant
- 2011-04-19 TW TW100113509A patent/TWI419881B/zh active
-
2012
- 2012-10-11 IL IL222399A patent/IL222399A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| JP5684895B2 (ja) | 2015-03-18 |
| BR112012026720B1 (pt) | 2018-01-30 |
| EP2560957A1 (en) | 2013-02-27 |
| EP2560957B1 (en) | 2014-05-07 |
| ES2478875T3 (es) | 2014-07-23 |
| UY33342A (es) | 2011-12-01 |
| BR112012026720A2 (pt) | 2015-10-06 |
| US20130041161A1 (en) | 2013-02-14 |
| TWI419881B (zh) | 2013-12-21 |
| AR080924A1 (es) | 2012-05-16 |
| CN102858750A (zh) | 2013-01-02 |
| JP2013525316A (ja) | 2013-06-20 |
| WO2011131543A1 (en) | 2011-10-27 |
| TW201204705A (en) | 2012-02-01 |
| US8450499B2 (en) | 2013-05-28 |
| IL222399A (en) | 2015-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |