MX2013014241A - Derivados de indanona, sales farmaceuticamente aceptables o isomeros opticos de los mismos, metodo de preparacion de los mismos, y composiciones farmaceuticas que contienen los mismos como ingrediente activo para prevención o tratamiento de enfermedades virales. - Google Patents

Derivados de indanona, sales farmaceuticamente aceptables o isomeros opticos de los mismos, metodo de preparacion de los mismos, y composiciones farmaceuticas que contienen los mismos como ingrediente activo para prevención o tratamiento de enfermedades virales.

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Publication number
MX2013014241A
MX2013014241A MX2013014241A MX2013014241A MX2013014241A MX 2013014241 A MX2013014241 A MX 2013014241A MX 2013014241 A MX2013014241 A MX 2013014241A MX 2013014241 A MX2013014241 A MX 2013014241A MX 2013014241 A MX2013014241 A MX 2013014241A
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MX
Mexico
Prior art keywords
same
prevention
active ingredient
treatment
viral diseases
Prior art date
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MX2013014241A
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English (en)
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MX363405B (es
Inventor
Johan Neyts
Young Sik Jung
Chong Kgo Lee
Hae Soon Kim
Hee Chun Jeong
Pil Ho Kim
Soo Bong Han
Jin Soo Shin
Hendrik Jan Thibaut
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Univ Leuven Kath
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Application filed by Univ Leuven Kath filed Critical Univ Leuven Kath
Publication of MX2013014241A publication Critical patent/MX2013014241A/es
Publication of MX363405B publication Critical patent/MX363405B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
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    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C07C233/32—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
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    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/04—Ortho-condensed systems
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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    • C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
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  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
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  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Otolaryngology (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
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  • Hematology (AREA)
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Abstract

Se describen derivados de indanona, sales farmacéuticamente aceptables de los mismos o enantiómeros, un método de preparación de los mismos, y una composición farmacéutica para la prevención o tratamiento de enfermedades virales, que comprenden los mismos como un ingrediente activo. Los derivados de indanona tienen excelente actividad inhibitoria contra picornavirus incluyendo virus coxsackie, enterovirus, ecovirus, poliovirus y rinovirus, así como exhiben baja citotoxicidad, de modo que pueden ser útiles como un ingrediente activo de una composición farmacéutica para la prevención y tratamiento de enfermedades virales incluyendo poliomielitis, parálisis, conjuntivitis hemorrágica aguda, meningitis viral, enfermedad de manos-pies y boca, enfermedad vesicular, hepatitis A, miositis, miocarditis, pancreatitis, diabetes, mialgia epidémica, encefalitis, gripe, herpangina, enfermedad de pies y boca, asma, enfermedad pulmonar obstructiva crónica, neumonía, sinusitis u otitis media.
MX2013014241A 2011-06-16 2012-06-18 Derivados de indanona, sales farmaceuticamente aceptables o isomeros opticos de los mismos, metodo de preparacion de los mismos, y composiciones farmaceuticas que contienen los mismos como ingrediente activo para prevención o tratamiento de enfermedades virales. MX363405B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20110058705 2011-06-16
KR1020120065022A KR101391746B1 (ko) 2011-06-16 2012-06-18 인다논 유도체, 이의 약학적으로 허용되는 염 또는 이의 광학 이성질체, 이의 제조방법 및 이를 유효성분으로 함유하는 바이러스성 질환의 예방 또는 치료용 약학적 조성물
PCT/KR2012/004806 WO2012173448A2 (ko) 2011-06-16 2012-06-18 인다논 유도체, 이의 약학적으로 허용되는 염 또는 이의 광학 이성질체, 이의 제조방법 및 이를 유효성분으로 함유하는 바이러스성 질환의 예방 또는 치료용 약학적 조성물

Publications (2)

Publication Number Publication Date
MX2013014241A true MX2013014241A (es) 2014-05-14
MX363405B MX363405B (es) 2019-03-22

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MX2013014241A MX363405B (es) 2011-06-16 2012-06-18 Derivados de indanona, sales farmaceuticamente aceptables o isomeros opticos de los mismos, metodo de preparacion de los mismos, y composiciones farmaceuticas que contienen los mismos como ingrediente activo para prevención o tratamiento de enfermedades virales.

Country Status (12)

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US (2) US9464067B2 (es)
EP (2) EP3597184B1 (es)
JP (2) JP5906309B2 (es)
KR (1) KR101391746B1 (es)
CN (1) CN103764140B (es)
AU (1) AU2012270311B2 (es)
BR (1) BR112013032306B1 (es)
CA (4) CA2838703C (es)
EA (1) EA026149B1 (es)
ES (1) ES2743199T3 (es)
MX (1) MX363405B (es)
WO (1) WO2012173448A2 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013032306B1 (pt) * 2011-06-16 2021-05-25 Korea Research Institute Of Chemical Technology derivados de indanona, método de preparação dos mesmos, composições farmacêuticas e uso dos mesmos para prevenção ou tratamento de doenças virais
ES2863985T3 (es) * 2012-12-14 2021-10-13 Korea Res Inst Chemical Tech Nuevo compuesto, sal farmacéuticamente aceptable o isómero óptico del mismo, método para prepararlo y composición farmacéutica para la prevención o el tratamiento de enfermedades virales que lo contienen como ingrediente activo
CN104211666B (zh) * 2013-05-31 2017-11-14 中国人民解放军军事医学科学院毒物药物研究所 2,3‑环氧丁二酰胺类化合物、其制备方法和用途
CN104744283A (zh) * 2015-02-09 2015-07-01 西北师范大学 茚酮羧酸酯的三氟甲基化方法
WO2020055858A1 (en) * 2018-09-10 2020-03-19 Cocrystal Pharma, Inc. Pyridopyrazine and pyridotriazine inhibitors of influenza virus replication
JP7592748B2 (ja) * 2020-04-20 2024-12-02 ノバルティス アーゲー 抗ウイルス１，３－ジ－オキソ－インデン化合物
US12083092B2 (en) * 2020-04-20 2024-09-10 Novartis Ag Antiviral 1,3-di-oxo-indene compounds
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