WO2012173448A3 - 인다논 유도체, 이의 약학적으로 허용되는 염 또는 이의 광학 이성질체, 이의 제조방법 및 이를 유효성분으로 함유하는 바이러스성 질환의 예방 또는 치료용 약학적 조성물 - Google Patents

인다논 유도체, 이의 약학적으로 허용되는 염 또는 이의 광학 이성질체, 이의 제조방법 및 이를 유효성분으로 함유하는 바이러스성 질환의 예방 또는 치료용 약학적 조성물 Download PDF

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WO2012173448A3
WO2012173448A3 PCT/KR2012/004806 KR2012004806W WO2012173448A3 WO 2012173448 A3 WO2012173448 A3 WO 2012173448A3 KR 2012004806 W KR2012004806 W KR 2012004806W WO 2012173448 A3 WO2012173448 A3 WO 2012173448A3
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same
preventing
viral
pharmaceutically acceptable
active ingredient
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French (fr)
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WO2012173448A2 (ko
Inventor
정영식
이종교
김해수
정희춘
김필호
한수봉
렛츠요한
티바웃핸드릭
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Katholieke Universiteit Leuven
Korea Research Institute of Chemical Technology KRICT
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Katholieke Universiteit Leuven
Korea Research Institute of Chemical Technology KRICT
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Priority to US14/126,485 priority Critical patent/US9464067B2/en
Priority to RU2014101180/04A priority patent/RU2574591C2/ru
Priority to AU2012270311A priority patent/AU2012270311B2/en
Priority to EA201490026A priority patent/EA026149B1/ru
Priority to BR112013032306-0A priority patent/BR112013032306B1/pt
Priority to JP2014515764A priority patent/JP5906309B2/ja
Priority to EP12800577.4A priority patent/EP2722042B1/en
Priority to ES12800577T priority patent/ES2743199T3/es
Priority to EP19169080.9A priority patent/EP3597184B1/en
Application filed by Katholieke Universiteit Leuven, Korea Research Institute of Chemical Technology KRICT filed Critical Katholieke Universiteit Leuven
Priority to CA2838703A priority patent/CA2838703C/en
Priority to MX2013014241A priority patent/MX363405B/es
Priority to CN201280029664.XA priority patent/CN103764140B/zh
Publication of WO2012173448A2 publication Critical patent/WO2012173448A2/ko
Publication of WO2012173448A3 publication Critical patent/WO2012173448A3/ko
Anticipated expiration legal-status Critical
Priority to US15/189,771 priority patent/US9890133B2/en
Ceased legal-status Critical Current

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Abstract

본 발명은 신규한 인다논 유도체, 이의 약학적으로 허용되는 염 또는 이의 광학 이성질체, 이의 제조방법 및 이를 유효성분으로 함유하는 바이러스성 질환의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 따른 인다논 유도체는 세포독성이 낮을 뿐만 아니라, 콕싸키바이러스, 엔테로바이러스, 에코바이러스, 폴리오바이러스, 라이노바이러스 등과 같은 피코르나바이러스에 대해 매우 우수한 항바이러스 활성을 가지므로, 소아마비, 마비, 급성출혈성 결막염, 바이러스성 수막염, 수족구병, 수포병, A형 간염, 근육염, 심근염, 췌장염, 당뇨, 유행성 근육통, 뇌염, 감기, 포진성 구협염, 구제역, 천식, 만성 폐쇄성 폐질환, 폐렴, 축농증 또는 중이염 등의 바이러스성 질환의 예방 또는 치료용 약학적 조성물로 유용하게 사용될 수 있다.
PCT/KR2012/004806 2011-06-16 2012-06-18 인다논 유도체, 이의 약학적으로 허용되는 염 또는 이의 광학 이성질체, 이의 제조방법 및 이를 유효성분으로 함유하는 바이러스성 질환의 예방 또는 치료용 약학적 조성물 Ceased WO2012173448A2 (ko)

Priority Applications (13)

Application Number Priority Date Filing Date Title
EP19169080.9A EP3597184B1 (en) 2011-06-16 2012-06-18 Indanone derivatives, pharmaceutically acceptable salts or optical isomers thereof, preparation method for same, and pharmaceutical compositions containing same as active ingredient for preventing or treating viral diseases
AU2012270311A AU2012270311B2 (en) 2011-06-16 2012-06-18 Indanone derivatives, pharmaceutically acceptable salts or optical isomers thereof, preparation method for same, and pharmaceutical compositions containing same as active ingredient for preventing or treating viral diseases
EA201490026A EA026149B1 (ru) 2011-06-16 2012-06-18 Производное инданона, его фармацевтически приемлемая соль или оптический изомер, способ его получения и содержащая его фармацевтическая композиция для профилактики или лечения вирусного заболевания
BR112013032306-0A BR112013032306B1 (pt) 2011-06-16 2012-06-18 derivados de indanona, método de preparação dos mesmos, composições farmacêuticas e uso dos mesmos para prevenção ou tratamento de doenças virais
JP2014515764A JP5906309B2 (ja) 2011-06-16 2012-06-18 インダノン誘導体、その薬学的に許容される塩又は光学異性体、その調製方法及びそれを活性成分として含有するウイルス疾患の予防又は治療用の医薬組成物
EP12800577.4A EP2722042B1 (en) 2011-06-16 2012-06-18 Indanone derivatives, pharmaceutically acceptable salts or optical isomers thereof, preparation method for same, and pharmaceutical compositions containing same as active ingredient for preventing or treating viral diseases
ES12800577T ES2743199T3 (es) 2011-06-16 2012-06-18 Derivados de indanona, sales farmacéuticamente aceptables o isómeros ópticos de los mismos, método de preparación para los mismos y composiciones farmacéuticas que los contienen como ingrediente activo para prevenir o tratar enfermedades virales
US14/126,485 US9464067B2 (en) 2011-06-16 2012-06-18 Indanone derivatives, pharmaceutically acceptable salts or optical isomers thereof, preparation method for same, and pharmaceutical compositions containing same as active ingredient for preventing or treating viral diseases
CA2838703A CA2838703C (en) 2011-06-16 2012-06-18 Indanone derivatives, pharmaceutically acceptable salts or optical isomers thereof, preparation method for same, and pharmaceutical compositions containing same as active ingredient for preventing or treating viral diseases
RU2014101180/04A RU2574591C2 (ru) 2011-06-16 2012-06-18 Производное инданона, его фармацевтически приемлемая соль или энантиомер, способ его получения и содержащая его фармацевтическая композиция для профилактики или лечения вирусного заболевания
MX2013014241A MX363405B (es) 2011-06-16 2012-06-18 Derivados de indanona, sales farmaceuticamente aceptables o isomeros opticos de los mismos, metodo de preparacion de los mismos, y composiciones farmaceuticas que contienen los mismos como ingrediente activo para prevención o tratamiento de enfermedades virales.
CN201280029664.XA CN103764140B (zh) 2011-06-16 2012-06-18 茚酮衍生物、其药学可接受的盐或光学异构体,其制备方法以及包含其作为活性成分用于预防或治疗病毒性疾病的药物组合物
US15/189,771 US9890133B2 (en) 2011-06-16 2016-06-22 Indanone derivatives, pharmaceutically acceptable salts or optical isomers thereof, preparation method for same, and pharmaceutical compositions containing same as active ingredient for preventing or treating viral diseases

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US15/189,771 Continuation US9890133B2 (en) 2011-06-16 2016-06-22 Indanone derivatives, pharmaceutically acceptable salts or optical isomers thereof, preparation method for same, and pharmaceutical compositions containing same as active ingredient for preventing or treating viral diseases

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ES2863985T3 (es) * 2012-12-14 2021-10-13 Korea Res Inst Chemical Tech Nuevo compuesto, sal farmacéuticamente aceptable o isómero óptico del mismo, método para prepararlo y composición farmacéutica para la prevención o el tratamiento de enfermedades virales que lo contienen como ingrediente activo
CN104211666B (zh) * 2013-05-31 2017-11-14 中国人民解放军军事医学科学院毒物药物研究所 2,3‑环氧丁二酰胺类化合物、其制备方法和用途
CN104744283A (zh) * 2015-02-09 2015-07-01 西北师范大学 茚酮羧酸酯的三氟甲基化方法
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JP7592748B2 (ja) * 2020-04-20 2024-12-02 ノバルティス アーゲー 抗ウイルス１，３－ジ－オキソ－インデン化合物
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EA026149B1 (ru) 2017-03-31
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MX363405B (es) 2019-03-22
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EP2722042A2 (en) 2014-04-23
CN103764140A (zh) 2014-04-30
BR112013032306A2 (pt) 2016-12-20
AU2012270311A1 (en) 2014-01-16
JP2016128465A (ja) 2016-07-14
US9890133B2 (en) 2018-02-13
US20160297789A1 (en) 2016-10-13
CA2838703A1 (en) 2012-12-20
WO2012173448A2 (ko) 2012-12-20
CA2984974C (en) 2021-08-24
ES2743199T3 (es) 2020-02-18
EP2722042B1 (en) 2019-05-29
US9464067B2 (en) 2016-10-11
BR112013032306B1 (pt) 2021-05-25
KR20120139605A (ko) 2012-12-27
EP3597184A3 (en) 2020-04-22
JP5906309B2 (ja) 2016-04-20
CN103764140B (zh) 2017-05-17
EP3597184A2 (en) 2020-01-22
EP3597184B1 (en) 2026-03-04
RU2014101180A (ru) 2015-07-27
CA3293510A1 (en) 2026-03-02
CA2838703C (en) 2017-12-19
CA2984974A1 (en) 2012-12-20
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