MX2016007726A - Inmunoterapia de cancer mediante el suministro de antigenos mhc clase ii usando un replicon de vlp. - Google Patents

Inmunoterapia de cancer mediante el suministro de antigenos mhc clase ii usando un replicon de vlp.

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Publication number
MX2016007726A
MX2016007726A MX2016007726A MX2016007726A MX2016007726A MX 2016007726 A MX2016007726 A MX 2016007726A MX 2016007726 A MX2016007726 A MX 2016007726A MX 2016007726 A MX2016007726 A MX 2016007726A MX 2016007726 A MX2016007726 A MX 2016007726A
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Mexico
Prior art keywords
vlp
antigens
replication
supply
mhc class
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MX2016007726A
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English (en)
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MX387755B (es
Inventor
K Chatterjee Deb
J Kaczmarczyk Stanislaw
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Us Health
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Publication date
Application filed by Us Health filed Critical Us Health
Publication of MX2016007726A publication Critical patent/MX2016007726A/es
Publication of MX387755B publication Critical patent/MX387755B/es

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Abstract

Se describe en la presente un método para prevenir o tratar una enfermedad en un sujeto mamífero, que comprende administrar al sujeto quién está en necesidad del mismo una dosificación efectiva de una composición farmacéutica que comprende una partícula similar a virus (VLP) que comprende: un replicón de alfavirus que comprende un polinucleótido recombinante, en donde el polinucleótido comprende una secuencia que codifica ambas subunidades de un antígeno de histocompatibilidad mayor clase II humano, una proteína gag retroviral y una proteína de envoltura fusogénica, en donde la VLP no contiene un gen de proteína estructural de alfavirus.
MX2016007726A 2013-12-16 2014-12-16 Uso de antígenos mhc de clase ii liberados por un replicón vlp en lnmunoterapia de cáncer. MX387755B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361916394P 2013-12-16 2013-12-16
PCT/US2014/070552 WO2015095167A2 (en) 2013-12-16 2014-12-16 Cancer immunotherapy by delivering class ii mhc antigens using a vlp-replicon

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Publication Number Publication Date
MX2016007726A true MX2016007726A (es) 2016-10-28
MX387755B MX387755B (es) 2025-03-18

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MX2016007726A MX387755B (es) 2013-12-16 2014-12-16 Uso de antígenos mhc de clase ii liberados por un replicón vlp en lnmunoterapia de cáncer.

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US (3) US20160312242A1 (es)
EP (3) EP3082851A2 (es)
JP (2) JP6861516B2 (es)
KR (1) KR102467982B1 (es)
CN (2) CN106232807A (es)
AU (1) AU2014365777B2 (es)
BR (1) BR112016013804A2 (es)
CA (1) CA2934075C (es)
ES (1) ES2899078T3 (es)
MX (1) MX387755B (es)
SG (2) SG11201604868YA (es)
WO (1) WO2015095167A2 (es)

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CN106232807A (zh) 2013-12-16 2016-12-14 美利坚合众国, 由健康及人类服务部部长代表 通过使用vlp复制子投递ii类mhc抗原的癌症免疫疗法
SG11202005792RA (en) 2017-12-20 2020-07-29 Vlp Therapeutics Llc Alphavirus replicon particle
US20230398200A1 (en) * 2020-07-31 2023-12-14 Replicate Bioscience, Inc. Modified chikungunya viruses and sindbis viruses and uses thereof
WO2022261343A1 (en) 2021-06-09 2022-12-15 Chimeron Bio Corporation Peptide vlp-based vaccines
WO2022261355A1 (en) 2021-06-09 2022-12-15 Chimeron Bio Corporation Self-amplifying rna-based vlp vaccines
EP4612305A4 (en) * 2022-11-04 2026-03-18 Univ British Columbia BINARY SELF-AMPLIFICATION NUCLEIC ACID PLATFORM AND ITS USES
WO2024240006A1 (zh) * 2023-05-19 2024-11-28 粤港澳大湾区精准医学研究院(广州) 一种递送基因或治疗药物的细胞及其用途
CN117778432B (zh) * 2024-02-26 2024-05-28 苏州左旋星生物科技有限公司 自复制rna载体、其制备方法及应用

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