MX2016016682A - Metodo para preparar acetato de abiraterona de alta pureza aplicable a escala industrial. - Google Patents
Metodo para preparar acetato de abiraterona de alta pureza aplicable a escala industrial.Info
- Publication number
- MX2016016682A MX2016016682A MX2016016682A MX2016016682A MX2016016682A MX 2016016682 A MX2016016682 A MX 2016016682A MX 2016016682 A MX2016016682 A MX 2016016682A MX 2016016682 A MX2016016682 A MX 2016016682A MX 2016016682 A MX2016016682 A MX 2016016682A
- Authority
- MX
- Mexico
- Prior art keywords
- abiraterone acetate
- formula
- abiraterone
- high purity
- industrial scale
- Prior art date
Links
- 229960004103 abiraterone acetate Drugs 0.000 title abstract 4
- UVIQSJCZCSLXRZ-UBUQANBQSA-N abiraterone acetate Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CC[C@@H](CC4=CC[C@H]31)OC(=O)C)C=C2C1=CC=CN=C1 UVIQSJCZCSLXRZ-UBUQANBQSA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 4
- 229960000853 abiraterone Drugs 0.000 abstract 2
- GZOSMCIZMLWJML-VJLLXTKPSA-N abiraterone Chemical compound C([C@H]1[C@H]2[C@@H]([C@]3(CC[C@H](O)CC3=CC2)C)CC[C@@]11C)C=C1C1=CC=CN=C1 GZOSMCIZMLWJML-VJLLXTKPSA-N 0.000 abstract 2
- 230000003197 catalytic effect Effects 0.000 abstract 2
- 229910052763 palladium Inorganic materials 0.000 abstract 2
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 abstract 2
- 238000006069 Suzuki reaction reaction Methods 0.000 abstract 1
- 230000021736 acetylation Effects 0.000 abstract 1
- 238000006640 acetylation reaction Methods 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- OJKBCQOJVMAHDX-UHFFFAOYSA-N diethyl(pyridin-3-yl)borane Chemical compound CCB(CC)C1=CC=CN=C1 OJKBCQOJVMAHDX-UHFFFAOYSA-N 0.000 abstract 1
- -1 halo steroid Chemical class 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- YJVFFLUZDVXJQI-UHFFFAOYSA-L palladium(ii) acetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O YJVFFLUZDVXJQI-UHFFFAOYSA-L 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ2014-475A CZ2014475A3 (cs) | 2014-07-09 | 2014-07-09 | Způsob přípravy Abirateron acetátu o vysoké čistotě aplikovatelný v průmyslovém měřítku |
| PCT/CZ2015/000075 WO2016004910A1 (en) | 2014-07-09 | 2015-07-09 | Method of preparing abiraterone acetate of high purity applicable on industrial scale |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016016682A true MX2016016682A (es) | 2017-04-25 |
Family
ID=53776254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016016682A MX2016016682A (es) | 2014-07-09 | 2015-07-09 | Metodo para preparar acetato de abiraterona de alta pureza aplicable a escala industrial. |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP3166958A1 (cs) |
| CZ (1) | CZ2014475A3 (cs) |
| MX (1) | MX2016016682A (cs) |
| WO (1) | WO2016004910A1 (cs) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105503992A (zh) * | 2016-01-22 | 2016-04-20 | 江苏联环药业股份有限公司 | 一种醋酸阿比特龙的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2138618T3 (es) | 1992-03-31 | 2000-01-16 | Btg Int Ltd | Esteroides 17-sustituidos utiles en el tratamiento del cancer. |
| ES2127413T3 (es) | 1993-09-30 | 1999-04-16 | Btg Int Ltd | Sintesis de esteroides 17-(3-piridilo). |
| EP1781683B1 (en) | 2004-08-24 | 2011-11-16 | BTG International Limited | Process for the preparation of 17-vinyl- triflates as intermediates |
| EP2607371A1 (en) | 2011-12-23 | 2013-06-26 | Crystal Pharma, S.A.U. | Processes for the preparation of abiraterone and related compouds |
| ITMI20121788A1 (it) * | 2012-10-22 | 2014-04-23 | Olon Spa | Procedimento per la purificazione di abiraterone acetato |
| CN103864878A (zh) * | 2012-12-12 | 2014-06-18 | 天津大学 | 阿比特龙醋酸酯的制备方法 |
| WO2014188445A1 (en) * | 2013-04-26 | 2014-11-27 | Srinivasan Thirumalai Rajan | PROCESS FOR THE PREPARATION OF (3β)-17-(3-PYRIDINYL)ANDROSTA-5,16-DIEN-3-YL ACETATE AND POLYMORPH THEREOF |
-
2014
- 2014-07-09 CZ CZ2014-475A patent/CZ2014475A3/cs unknown
-
2015
- 2015-07-09 EP EP15745371.3A patent/EP3166958A1/en not_active Withdrawn
- 2015-07-09 WO PCT/CZ2015/000075 patent/WO2016004910A1/en not_active Ceased
- 2015-07-09 MX MX2016016682A patent/MX2016016682A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3166958A1 (en) | 2017-05-17 |
| CZ2014475A3 (cs) | 2016-01-20 |
| WO2016004910A1 (en) | 2016-01-14 |
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