MX2017016030A - Derivado de dihidropirrolopirazol sustituido. - Google Patents

Derivado de dihidropirrolopirazol sustituido.

Info

Publication number
MX2017016030A
MX2017016030A MX2017016030A MX2017016030A MX2017016030A MX 2017016030 A MX2017016030 A MX 2017016030A MX 2017016030 A MX2017016030 A MX 2017016030A MX 2017016030 A MX2017016030 A MX 2017016030A MX 2017016030 A MX2017016030 A MX 2017016030A
Authority
MX
Mexico
Prior art keywords
dihydropirrolopirazol
substituted
derived
alkyl group
independently represent
Prior art date
Application number
MX2017016030A
Other languages
English (en)
Other versions
MX394157B (es
Inventor
Kojima Masahiro
Iwase Noriaki
Aga Yasuhiro
Ushiyama Shigeru
Kono Shigeyuki
Sunamoto Hidetoshi
Matsushita Takashi
Ogi Sayaka
UMEZAKI Satoshi
Onuma Kazuhiro
SHIRAISHI Yusuke
Okudo Makoto
Kimura Tomio
Original Assignee
Ube Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ube Industries filed Critical Ube Industries
Publication of MX2017016030A publication Critical patent/MX2017016030A/es
Publication of MX394157B publication Critical patent/MX394157B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/12—Organo silicon halides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención proporciona un compuesto representado por la fórmula general (la), o una sal farmacológicamente aceptable del mismo. En la fórmula general (la), dos fracciones R representan cada una independientemente un grupo alquilo C1-3 o similar; y R1, R2 y R3 representan cada uno independientemente un grupo alquilo C1-4 lineal o ramificado opcionalmente sustituido. Fórmula química 1 (ver Fórmula).
MX2017016030A 2015-06-15 2016-06-14 Derivado de dihidropirrolopirazol sustituido. MX394157B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2015120372 2015-06-15
JP2016091128 2016-04-28
PCT/JP2016/067703 WO2016204153A1 (ja) 2015-06-15 2016-06-14 置換ジヒドロピロロピラゾール誘導体

Publications (2)

Publication Number Publication Date
MX2017016030A true MX2017016030A (es) 2018-08-01
MX394157B MX394157B (es) 2025-03-24

Family

ID=57545307

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017016030A MX394157B (es) 2015-06-15 2016-06-14 Derivado de dihidropirrolopirazol sustituido.

Country Status (10)

Country Link
US (2) US10273252B2 (es)
EP (1) EP3309163A4 (es)
JP (1) JP6787314B2 (es)
KR (1) KR102588426B1 (es)
CN (1) CN107735401B (es)
AU (1) AU2016281225B2 (es)
CA (1) CA2989519C (es)
MX (1) MX394157B (es)
RU (1) RU2765718C1 (es)
WO (1) WO2016204153A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6690543B2 (ja) * 2014-10-31 2020-04-28 宇部興産株式会社 置換ジヒドロピロロピラゾール化合物
CN107028949A (zh) * 2017-05-25 2017-08-11 瑞阳制药有限公司 尼达尼布用于治疗银屑病的外用制剂药物中的用途
EP3705124A4 (en) * 2017-10-30 2021-07-14 Ube Industries, Ltd. PHARMACEUTICAL COMPOSITION ADMINISTERED IN COMBINATION WITH A SUBSTITUTED DIHYDROPYRROLOPYRAZOLE COMPOUND AND AN IMMUNOTHERAPEUTIC
US12304913B2 (en) 2018-11-14 2025-05-20 Ube Industries, Ltd. Dihydropyrrolopyrazole derivative
ES3031581T3 (en) * 2019-08-05 2025-07-09 Dana Farber Cancer Inst Inc Degraders of cyclin-dependent kinase 7 (cdk7) and uses thereof
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections
CN113384702A (zh) * 2021-05-20 2021-09-14 温州医科大学附属第一医院 H1组胺受体拮抗剂在制备治疗神经胶质瘤的药物中的应用
KR102348901B1 (ko) 2021-08-26 2022-01-07 충북대학교 산학협력단 레고라페닙을 유효성분으로 포함하는 만성폐쇄성 폐질환의 예방 또는 치료용 조성물
WO2025250118A1 (en) * 2024-05-25 2025-12-04 Tampa Bay Research Institute, Inc. Method of use for benzofuran compounds

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2349762T3 (es) * 2000-08-10 2011-01-11 Pfizer Italia S.R.L. Biciclo-pirazoles activos como inhibidores de quinasas, procedimientos para su preparación y composiciones farmacéuticas que los comprenden.
FR2848554A1 (fr) * 2002-12-12 2004-06-18 Aventis Pharma Sa Nouveaux derives d'aminoindazoles a titre de medicaments et compositions pharmaceutiques les renfermant
PL376789A1 (pl) 2002-12-12 2006-01-09 Aventis Pharma S.A. Pochodne aminoindazoli i ich zastosowanie jako inhibitorów kinazy
UA81790C2 (uk) * 2002-12-19 2008-02-11 Фармация Италия С.П.А. Заміщені піролопіразольні похідні як інгібітори кінази
MXPA05009719A (es) 2003-03-11 2005-10-18 Pharmacia Italia Spa Derivados de biciclo-pirazol activos como inhibidores de cinasa, procedimiento para su preparacion y composiciones farmaceuticas que los comprenden.
US7141568B2 (en) * 2003-07-09 2006-11-28 Pfizer Italia S.R.L. Pyrrolo[3,4-c]pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
AU2005323797B2 (en) * 2005-01-10 2009-07-09 Pfizer Inc. Pyrrolopyrazoles, potent kinase inhibitors
WO2007068637A1 (en) 2005-12-12 2007-06-21 Nerviano Medical Sciences S.R.L. Substituted pyrrolo-pyrazole derivatives active as kinase inhibitors
EA015513B1 (ru) 2005-12-21 2011-08-30 Пфайзер Продактс Инк. Карбониламинопирролопиразолы в качестве эффективных ингибиторов киназ
WO2007099171A2 (en) 2006-03-03 2007-09-07 Nerviano Medical Sciences S.R.L. Bicyclo-pyrazoles active as kinase inhibitors
WO2008043745A1 (en) * 2006-10-11 2008-04-17 Nerviano Medical Sciences S.R.L. Substituted pyrrolo-pyrazole derivatives as kinase inhibitors
EP2195321B1 (en) * 2007-04-12 2016-10-19 Pfizer Inc. 3-amido-pyrrolo[3,4-c]pyrazole-5(1h, 4h,6h) carbaldehyde derivatives as inhibitors of protein kinase c
CA2688616A1 (en) 2007-06-05 2008-12-11 Emory University Selective inhibitors for cyclin-dependent kinases
WO2011044264A2 (en) 2009-10-06 2011-04-14 Afraxis, Inc. Pyrrolopyrazoles for treating cns disorders
UA110703C2 (uk) * 2010-06-03 2016-02-10 Байєр Кропсайнс Аг Фунгіцидні похідні n-[(тризаміщений силіл)метил]-карбоксаміду
EP2634190A1 (en) 2012-03-01 2013-09-04 Lead Discovery Center GmbH Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhinitors
EP2634189A1 (en) 2012-03-01 2013-09-04 Lead Discovery Center GmbH Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhibitors
EP2909194A1 (en) 2012-10-18 2015-08-26 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
AU2014337067B2 (en) 2013-10-18 2019-01-24 Syros Pharmaceuticals, Inc. Heteroaromatic compounds useful for the treatment of proliferative diseases
EP3057955B1 (en) 2013-10-18 2018-04-11 Syros Pharmaceuticals, Inc. Heteroaromatic compounds useful for the treatment of prolferative diseases
US10047070B2 (en) 2013-10-18 2018-08-14 Dana-Farber Cancer Institute, Inc. Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7)
GB201403093D0 (en) 2014-02-21 2014-04-09 Cancer Rec Tech Ltd Therapeutic compounds and their use
CN106458990B (zh) 2014-04-04 2019-06-07 希洛斯医药品股份有限公司 细胞周期蛋白依赖性激酶7(cdk7)的抑制剂
EP3129371B1 (en) 2014-04-05 2020-07-29 Syros Pharmaceuticals, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
JP6690543B2 (ja) * 2014-10-31 2020-04-28 宇部興産株式会社 置換ジヒドロピロロピラゾール化合物
JP2019112307A (ja) * 2016-04-28 2019-07-11 宇部興産株式会社 置換ジヒドロピロロピラゾール化合物および他の乾癬治療薬が組み合わせて投与される医薬組成物
JP2019112305A (ja) * 2016-04-28 2019-07-11 宇部興産株式会社 アトピー性皮膚炎の治療または予防のための医薬組成物
JP2019112306A (ja) * 2016-04-28 2019-07-11 宇部興産株式会社 慢性閉塞性肺疾患の治療または予防のための医薬組成物

Also Published As

Publication number Publication date
CA2989519A1 (en) 2016-12-22
AU2016281225A1 (en) 2018-02-01
JP6787314B2 (ja) 2020-11-18
US10273252B2 (en) 2019-04-30
CN107735401A (zh) 2018-02-23
KR20180018661A (ko) 2018-02-21
CN107735401B (zh) 2021-08-31
US20180186818A1 (en) 2018-07-05
EP3309163A4 (en) 2019-01-09
RU2765718C1 (ru) 2022-02-02
US10894798B2 (en) 2021-01-19
WO2016204153A1 (ja) 2016-12-22
MX394157B (es) 2025-03-24
EP3309163A1 (en) 2018-04-18
AU2016281225B2 (en) 2020-10-15
KR102588426B1 (ko) 2023-10-13
US20190256531A1 (en) 2019-08-22
JPWO2016204153A1 (ja) 2018-03-29
CA2989519C (en) 2023-09-26

Similar Documents

Publication Publication Date Title
MX2017016030A (es) Derivado de dihidropirrolopirazol sustituido.
CY1124215T1 (el) Μκ2 αναστολεις και χρησεις αυτων
CY1123920T1 (el) Αντιγριπικο πολυκυκλικο παραγωγο πυριδονης και προφαρμακο αυτου
PL3577110T3 (pl) Związki podstawione 8-oksetan-3-ylo-3,8-diazabicyklo[3.2.1]oktan-3-ylem jako inhibitory hiv
MX381417B (es) Inhibidores de glucosidasa.
CY1119361T1 (el) 3,4-διυδροισοκινολιν-2(1h)-υλικες ενωσεις
PL3868741T3 (pl) Kompozycja zawierająca związek pirymidynowy i antygen pochodzący od patogenu
CR20160419A (es) Nuevos compuestos biciclicos
TR201900038T4 (tr) GPR6'nın tetrahidropiridopirazin modülatörleri.
TR201906354T4 (tr) Bi̇r hareketli̇ mobi̇lya parçasi i̇çi̇n tahri̇k ci̇hazi
UA112428C2 (uk) Пестицидні композиції і пов'язані з ними способи
CY1119489T1 (el) Υποκατεστημενη πιπεριδυλο-αιθυλο-πυριμιδινη ως αναστολεας της ο-ακυλο τρανσφερασης της γκρελινης
MA39803A (fr) Anticorps hémagglutinine dirigés contre le virus de la grippe b et méthodes d'utilisation
CR20170315A (es) Inhibridores bace 1 selectivos
MX2018008815A (es) Inhibidores de tirosina quinasa de bruton.
EP3416647A4 (en) N3-SUBSTITUTED IMINOPYRIMIDINONE AS ANTIMALARIAMIDAL
EA201891586A1 (ru) Антипролиферативные соединения и их фармацевтические композиции и применения
EA201792000A1 (ru) Ингибиторы грелин-o-ацилтрансферазы
EA201791992A1 (ru) Ингибиторы грелин-o-ацилтрансферазы
MX383577B (es) Derivados sustituidos de guanidina.
MX386975B (es) Fármacos precursores de oxabicicloheptanos.
MA46615A (fr) Inhibiteurs de nav1.7 de type acyl-sulfonamide
CL2018001067A1 (es) Compuesto piranodipiridínico.
NZ739518A (en) Compounds useful for inhibiting ror-gamma-t
EA201692028A1 (ru) Применение замещенных оксотетрагидрохинолинилсульфонамидов или их солей для повышения стрессоустойчивости растений