MX2018012902A - Composiciones y métodos para el tratamiento de trastornos de almacenamiento lisosomal y trastornos caracterizados por disfunción lisosomal. - Google Patents
Composiciones y métodos para el tratamiento de trastornos de almacenamiento lisosomal y trastornos caracterizados por disfunción lisosomal.Info
- Publication number
- MX2018012902A MX2018012902A MX2018012902A MX2018012902A MX2018012902A MX 2018012902 A MX2018012902 A MX 2018012902A MX 2018012902 A MX2018012902 A MX 2018012902A MX 2018012902 A MX2018012902 A MX 2018012902A MX 2018012902 A MX2018012902 A MX 2018012902A
- Authority
- MX
- Mexico
- Prior art keywords
- lysosomal
- disorders
- methods
- compositions
- treatment
- Prior art date
Links
- 208000015439 Lysosomal storage disease Diseases 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000004064 dysfunction Effects 0.000 title 1
- 230000002132 lysosomal effect Effects 0.000 title 1
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 abstract 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 abstract 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a composiciones y métodos para tratar enfermedades de almacenamiento lisosomal y métodos para usar trehalosa.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662325535P | 2016-04-21 | 2016-04-21 | |
| US201762475295P | 2017-03-23 | 2017-03-23 | |
| PCT/US2017/028904 WO2017185010A1 (en) | 2016-04-21 | 2017-04-21 | Compositions and methods for the treatment of lysosomal storage disorders and disorders characterized by lysosomal dysfunction |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2018012902A true MX2018012902A (es) | 2019-06-06 |
| MX388562B MX388562B (es) | 2025-03-20 |
Family
ID=60089338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018012902A MX388562B (es) | 2016-04-21 | 2017-04-21 | Composiciones y métodos para el tratamiento de trastornos de almacenamiento lisosomal y trastornos caracterizados por disfunción lisosomal. |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US10512656B2 (es) |
| EP (1) | EP3445451B1 (es) |
| JP (1) | JP7302871B2 (es) |
| CN (1) | CN109789316B (es) |
| AU (1) | AU2017252563B2 (es) |
| DK (1) | DK3445451T3 (es) |
| MX (1) | MX388562B (es) |
| NZ (1) | NZ748599A (es) |
| WO (1) | WO2017185010A1 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014181333A2 (en) | 2013-05-07 | 2014-11-13 | Bio Blast Pharma Ltd. | Treatment of protein aggregation myopathic and neurodegenerative diseases by parenteral administration of trehalose |
| MX389001B (es) | 2015-10-23 | 2025-03-20 | Navitor Pharm Inc | Moduladores de interacción de sestrina-gator2 y sus usos. |
| US10512656B2 (en) | 2016-04-21 | 2019-12-24 | Baylor College Of Medicine | Compositions and methods for the treatment of lysosomal storage disorders and disorders characterized by lysosomal dysfunction |
| ES3040534T3 (en) | 2017-04-26 | 2025-11-03 | Navitor Pharm Inc | Modulator of sestrin-gator2 interaction for use in the treatment of treatment-resistant depression |
| WO2020086816A1 (en) * | 2018-10-24 | 2020-04-30 | Navitor Pharmaceuticals, Inc. | Polymorphic compounds and uses thereof |
| KR20210113606A (ko) | 2018-12-05 | 2021-09-16 | 워싱턴 유니버시티 | 신경 질환을 검출, 예방, 회복 및 치료하는 방법 |
| US20220211813A1 (en) * | 2019-04-12 | 2022-07-07 | Loma Linda University | Methods for treatment of niemann-pick disease type c |
| US12612380B2 (en) | 2019-05-10 | 2026-04-28 | Alectos Therapeutics 1Nc | Non-lysosomal glucosylceramidase inhibitors and uses thereof |
| US20220313722A1 (en) * | 2019-09-09 | 2022-10-06 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods of restoring lysosomal function of retinal pigment epithelial cells by activation of tfeb |
| CA3150309A1 (en) | 2019-10-01 | 2021-04-08 | Seelos Therapeutics, Inc. | Trehalose formulations and uses thereof |
| AU2020376950B2 (en) | 2019-11-01 | 2026-06-11 | Supernus Pharmaceuticals, Inc. | Methods of treatment using an mTORC1 modulator |
| PE20231423A1 (es) | 2020-05-07 | 2023-09-13 | Alectos Therapeutics Inc | Inhibidores de glucosilceramidasa no lisosomal y los usos de los mismos |
| EP3944858A1 (en) | 2020-07-30 | 2022-02-02 | Beyond Batten Disease Foundation | Combination product containing trehalose and miglustat for treating lysosomal diseases |
| US12019081B2 (en) | 2020-11-06 | 2024-06-25 | University Of Kentucky Research Foundation | Method for detection and quantification of CLN3 protein |
| KR102580852B1 (ko) * | 2021-04-13 | 2023-09-20 | 강원대학교 산학협력단 | 발리다마이신 a를 포함하는 뇌전증 완화 및 치료용 조성물 |
| US20250144101A1 (en) * | 2022-01-20 | 2025-05-08 | The Johns Hopkins University | Lysosomal dysfunction in neurological and psychiatric disorders |
| TW202400160A (zh) * | 2022-04-22 | 2024-01-01 | 美商米突倍基公司 | 轉錄因子eb活化子及其用途 |
| CN116819066A (zh) * | 2023-06-30 | 2023-09-29 | 复旦大学附属中山医院 | 肝癌微环境检测试剂盒 |
| US12639967B2 (en) | 2023-07-05 | 2026-05-26 | Nice North America Llc | Systems and methods for detecting and recognizing a railcar identifier |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0693558B1 (en) * | 1994-07-19 | 2002-12-04 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Trehalose and its production and use |
| EP3782655A1 (en) | 2005-05-17 | 2021-02-24 | Amicus Therapeutics, Inc. | A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives |
| GB0712494D0 (en) | 2007-06-27 | 2007-08-08 | Isis Innovation | Substrate reduction therapy |
| US8785168B2 (en) * | 2009-06-17 | 2014-07-22 | Biomarin Pharmaceutical Inc. | Formulations for lysosomal enzymes |
| US20130312784A1 (en) | 2012-05-24 | 2013-11-28 | For Your Ease Only, Inc. | Cosmetic organizer |
| WO2014089449A1 (en) * | 2012-12-07 | 2014-06-12 | Rush University Nedical Center | Composition and method for treating neuronal ceroid lipofuscinosis |
| AU2014205378B2 (en) | 2013-01-09 | 2018-08-30 | Amicus Therapeutics, Inc. | Stable parenteral DNJ compositions |
| US9084720B2 (en) | 2013-05-07 | 2015-07-21 | BioBlast Pharma Ltd. | Compositions and methods for treating oculopharyngeal muscular dystrophy |
| WO2014181333A2 (en) | 2013-05-07 | 2014-11-13 | Bio Blast Pharma Ltd. | Treatment of protein aggregation myopathic and neurodegenerative diseases by parenteral administration of trehalose |
| JP6130224B2 (ja) * | 2013-05-27 | 2017-05-17 | 公益財団法人微生物化学研究会 | 新規化合物レンツトレハロース、その製造方法、及びその用途、並びに、新規微生物 |
| US20160136123A1 (en) * | 2013-06-14 | 2016-05-19 | Vojo P. Deretic | Treatment of autophagy-related disorders |
| WO2015089443A2 (en) | 2013-12-12 | 2015-06-18 | The Brigham And Women's Hospital, Inc. | Treating neurodegenerative disease |
| PT3086784T (pt) | 2013-12-23 | 2019-06-27 | Bcn Peptides Sa | Análogos de bicalutamida ou (s)-bicalutamida como compostos ativadores de exocitose para utilização no tratamento de um distúrbio de armazenamento lisossómico ou glicogenose |
| CA3012502A1 (en) * | 2016-02-08 | 2017-08-17 | Junaxo, Inc. | Use of trehalose for treatment of neurological diseases |
| US10512656B2 (en) | 2016-04-21 | 2019-12-24 | Baylor College Of Medicine | Compositions and methods for the treatment of lysosomal storage disorders and disorders characterized by lysosomal dysfunction |
| EP3318277A1 (en) | 2016-11-04 | 2018-05-09 | Institut du Cerveau et de la Moelle Epiniere-ICM | Inhibitors of glucosylceramide synthase for the treatment of motor neuron diseases |
-
2017
- 2017-04-21 US US15/494,136 patent/US10512656B2/en active Active
- 2017-04-21 EP EP17786739.7A patent/EP3445451B1/en active Active
- 2017-04-21 DK DK17786739.7T patent/DK3445451T3/da active
- 2017-04-21 NZ NZ748599A patent/NZ748599A/en unknown
- 2017-04-21 AU AU2017252563A patent/AU2017252563B2/en active Active
- 2017-04-21 MX MX2018012902A patent/MX388562B/es unknown
- 2017-04-21 JP JP2019531851A patent/JP7302871B2/ja active Active
- 2017-04-21 CN CN201780038419.8A patent/CN109789316B/zh active Active
- 2017-04-21 WO PCT/US2017/028904 patent/WO2017185010A1/en not_active Ceased
-
2019
- 2019-04-04 US US16/375,521 patent/US20200000832A1/en not_active Abandoned
- 2019-04-04 US US16/375,445 patent/US11083741B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2017252563B2 (en) | 2022-07-21 |
| EP3445451B1 (en) | 2021-08-18 |
| US20170304339A1 (en) | 2017-10-26 |
| DK3445451T3 (da) | 2021-11-08 |
| US20200000832A1 (en) | 2020-01-02 |
| CA3021846A1 (en) | 2017-10-26 |
| EP3445451A4 (en) | 2019-12-18 |
| CN109789316B (zh) | 2022-09-27 |
| US11083741B2 (en) | 2021-08-10 |
| NZ748599A (en) | 2022-08-26 |
| US10512656B2 (en) | 2019-12-24 |
| BR112018071684A2 (pt) | 2019-02-19 |
| AU2017252563A1 (en) | 2018-12-06 |
| JP2021517552A (ja) | 2021-07-26 |
| MX388562B (es) | 2025-03-20 |
| EP3445451A1 (en) | 2019-02-27 |
| WO2017185010A1 (en) | 2017-10-26 |
| JP7302871B2 (ja) | 2023-07-04 |
| US20190321383A1 (en) | 2019-10-24 |
| CN109789316A (zh) | 2019-05-21 |
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