MX2020002041A - Formulacion liposomal para la lubricacion articular. - Google Patents

Formulacion liposomal para la lubricacion articular.

Info

Publication number
MX2020002041A
MX2020002041A MX2020002041A MX2020002041A MX2020002041A MX 2020002041 A MX2020002041 A MX 2020002041A MX 2020002041 A MX2020002041 A MX 2020002041A MX 2020002041 A MX2020002041 A MX 2020002041A MX 2020002041 A MX2020002041 A MX 2020002041A
Authority
MX
Mexico
Prior art keywords
pharmaceutical composition
joint lubrication
liposomal formulation
gpl
membrane
Prior art date
Application number
MX2020002041A
Other languages
English (en)
Inventor
Gadi Sarfati
Yechezkel Barenholz
Yaniv Dolev
Keren Turjeman
- Hershkovitz Maty Ayal
Original Assignee
Moebius Medical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Moebius Medical Ltd filed Critical Moebius Medical Ltd
Publication of MX2020002041A publication Critical patent/MX2020002041A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/22—Lipids, fatty acids, e.g. prostaglandins, oils, fats, waxes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/10—Materials for lubricating medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención proporciona una composición farmacéutica para la lubricación de las articulaciones, la composición farmacéutica comprende un agente de tonicidad no iónico que comprende un poliol, y liposomas que comprenden al menos una membrana que comprende al menos un fosfolípido (PL) seleccionado de un glicerofosfolípido (GPL), dicho GPL que tiene dos cadenas de hidrocarburo C12-C18, que son iguales o diferentes, y esfingomielina (SM) que tiene una cadena de hidrocarburo C12-C18, la composición farmacéutica que está esencialmente libre de un agente farmacéuticamente activo adicional, en donde la al menos una membrana tiene una temperatura de transición de fase en el intervalo de aproximadamente 20°C a aproximadamente 39°C y la articulación tiene una temperatura de articulación que está por encima de la temperatura de transición de fase.
MX2020002041A 2017-08-22 2018-08-21 Formulacion liposomal para la lubricacion articular. MX2020002041A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762548429P 2017-08-22 2017-08-22
PCT/IL2018/050923 WO2019038763A1 (en) 2017-08-22 2018-08-21 LIPOSOMAL FORMULATION FOR JOINT LUBRICATION

Publications (1)

Publication Number Publication Date
MX2020002041A true MX2020002041A (es) 2020-08-13

Family

ID=65439381

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020002041A MX2020002041A (es) 2017-08-22 2018-08-21 Formulacion liposomal para la lubricacion articular.
MX2023009082A MX2023009082A (es) 2017-08-22 2020-02-21 Formulacion liposomal para la lubricacion articular.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2023009082A MX2023009082A (es) 2017-08-22 2020-02-21 Formulacion liposomal para la lubricacion articular.

Country Status (25)

Country Link
US (3) US11123293B2 (es)
EP (2) EP3672653B1 (es)
JP (2) JP7082336B2 (es)
KR (2) KR102607729B1 (es)
CN (2) CN111065423B (es)
AU (3) AU2018319594B2 (es)
BR (1) BR112020003767B1 (es)
CA (2) CA3073368C (es)
DK (1) DK3672653T3 (es)
EA (1) EA202090476A1 (es)
ES (1) ES2948715T3 (es)
FI (1) FI3672653T3 (es)
HR (1) HRP20230566T1 (es)
HU (1) HUE062030T2 (es)
IL (3) IL301801B2 (es)
LT (1) LT3672653T (es)
MA (1) MA49959B1 (es)
MX (2) MX2020002041A (es)
MY (1) MY197149A (es)
PH (1) PH12020500331A1 (es)
PL (1) PL3672653T3 (es)
PT (1) PT3672653T (es)
SG (1) SG11202000773QA (es)
SI (1) SI3672653T1 (es)
WO (1) WO2019038763A1 (es)

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TWI782181B (zh) * 2019-02-11 2022-11-01 以色列商莫比斯醫療有限公司 用於關節潤滑的脂質體調配物
JP2021013788A (ja) * 2020-11-10 2021-02-12 株式会社三洋物産 遊技機
AU2022425700A1 (en) * 2022-01-02 2024-07-18 Moebius Medical Ltd. Determination of the trapped volume of a liposome
EP4522178A1 (en) 2023-01-19 2025-03-19 Moebius Medical Ltd. A long-acting liposomal composition for treatment of pain in articular disorders
KR20250018222A (ko) * 2023-07-26 2025-02-05 차의과학대학교 산학협력단 미토콘드리아가 캡슐화된 세포막 융합유도 리포좀을 포함하는 골관절염 치료를 위한 약학 조성물
IL314549A (en) * 2024-07-25 2026-02-01 Moebius Medical Ltd Liposomal conjugates and their uses

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Also Published As

Publication number Publication date
AU2023203309B2 (en) 2024-10-10
US20250114304A1 (en) 2025-04-10
HUE062030T2 (hu) 2023-09-28
MA49959A (fr) 2020-07-01
IL312816B1 (en) 2026-02-01
CA3073368A1 (en) 2019-02-28
PL3672653T3 (pl) 2023-08-14
IL272630A (en) 2020-03-31
EP3672653A1 (en) 2020-07-01
EP3672653B1 (en) 2023-03-29
HRP20230566T1 (hr) 2023-08-18
FI3672653T3 (fi) 2023-06-07
CN111065423B (zh) 2022-04-12
SI3672653T1 (sl) 2023-08-31
PT3672653T (pt) 2023-06-29
MX2023009082A (es) 2023-08-08
CA3073368C (en) 2024-01-02
NZ761298A (en) 2024-03-22
US12214077B2 (en) 2025-02-04
JP7082336B2 (ja) 2022-06-08
IL301801B2 (en) 2024-10-01
MY197149A (en) 2023-05-26
KR20200044006A (ko) 2020-04-28
CA3219776A1 (en) 2019-02-28
BR112020003767B1 (pt) 2023-10-10
EP4223284A1 (en) 2023-08-09
SG11202000773QA (en) 2020-03-30
CN114601799B (zh) 2023-09-26
EA202090476A1 (ru) 2020-06-29
ES2948715T3 (es) 2023-09-18
US11123293B2 (en) 2021-09-21
AU2023203309A1 (en) 2023-06-22
WO2019038763A1 (en) 2019-02-28
US20210369613A1 (en) 2021-12-02
JP7383759B2 (ja) 2023-11-20
JP2020531538A (ja) 2020-11-05
EP3672653A4 (en) 2021-01-13
PH12020500331A1 (en) 2020-10-05
IL301801B1 (en) 2024-06-01
LT3672653T (lt) 2023-07-10
AU2025200077A1 (en) 2025-01-23
MA49959B1 (fr) 2023-07-31
US20200170948A1 (en) 2020-06-04
IL272630B2 (en) 2023-09-01
CN114601799A (zh) 2022-06-10
IL312816A (en) 2024-07-01
DK3672653T3 (da) 2023-06-12
JP2022110090A (ja) 2022-07-28
AU2018319594B2 (en) 2023-06-15
BR112020003767A2 (pt) 2020-09-01
AU2025200077B2 (en) 2026-01-08
KR20230166148A (ko) 2023-12-06
AU2018319594A1 (en) 2020-02-20
KR102607729B1 (ko) 2023-11-29
KR102808544B1 (ko) 2025-05-19
IL301801A (en) 2023-05-01
CN111065423A (zh) 2020-04-24
IL272630B1 (en) 2023-05-01

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