MX2020002571A - Derivados de 1-(4-(isoxazol-5-il)-1h-pirazol-1-il)-2-metilpropan-2 -ol y compuestos relacionados como inhibidores de il-17 e ifn-gamma para tratar enfermedades autoinmunes e inflamacion cronica. - Google Patents

Derivados de 1-(4-(isoxazol-5-il)-1h-pirazol-1-il)-2-metilpropan-2 -ol y compuestos relacionados como inhibidores de il-17 e ifn-gamma para tratar enfermedades autoinmunes e inflamacion cronica.

Info

Publication number
MX2020002571A
MX2020002571A MX2020002571A MX2020002571A MX2020002571A MX 2020002571 A MX2020002571 A MX 2020002571A MX 2020002571 A MX2020002571 A MX 2020002571A MX 2020002571 A MX2020002571 A MX 2020002571A MX 2020002571 A MX2020002571 A MX 2020002571A
Authority
MX
Mexico
Prior art keywords
autoimmune diseases
chronic inflammation
methylpropan
isoxazol
pyrazol
Prior art date
Application number
MX2020002571A
Other languages
English (en)
Inventor
Stefan Tasler
Mirko Zaja
Hella Kohlhof
Jakob Felding
Manfred Gröppel
Rolf Andreas Mühler
Daniel Vitt
Carine Chevrier
Original Assignee
Immunic Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunic Ag filed Critical Immunic Ag
Publication of MX2020002571A publication Critical patent/MX2020002571A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a compuestos de la fórmula general (I), y las sales y solvatos farmacéuticamente aceptables de los mismos, en los cuales Ar, Z y Y son como se describen en la presente solicitud y R1 es un grupo de la estructura (ver Fórmula) en la cual n es 0 o 1; R2 es H, deuterio o metilo; R3 es metilo, trifluorometilo, etilo, o tomado con R2 juntos forman un grupo ciclopropilo, o R3 forma un puente de metileno al átomo de carbono marcado con *, los cuales son apropiados para el tratamiento de enfermedades autoinmunes e inflamación crónica.
MX2020002571A 2017-09-06 2018-09-06 Derivados de 1-(4-(isoxazol-5-il)-1h-pirazol-1-il)-2-metilpropan-2 -ol y compuestos relacionados como inhibidores de il-17 e ifn-gamma para tratar enfermedades autoinmunes e inflamacion cronica. MX2020002571A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17189652 2017-09-06
PCT/EP2018/073993 WO2019048541A1 (en) 2017-09-06 2018-09-06 1- (4- (ISOXAZOL-5-YL) -1H-PYRAZOL-1-YL) -2-METHYLPROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF IL-17 AND IFN- GAMMA FOR THE TREATMENT OF AUTOIMMUNE DISEASES AND CHRONIC INFLAMMATION

Publications (1)

Publication Number Publication Date
MX2020002571A true MX2020002571A (es) 2020-10-01

Family

ID=59799324

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020002571A MX2020002571A (es) 2017-09-06 2018-09-06 Derivados de 1-(4-(isoxazol-5-il)-1h-pirazol-1-il)-2-metilpropan-2 -ol y compuestos relacionados como inhibidores de il-17 e ifn-gamma para tratar enfermedades autoinmunes e inflamacion cronica.

Country Status (27)

Country Link
US (1) US11292788B2 (es)
EP (2) EP4074708A1 (es)
JP (2) JP2020532575A (es)
KR (1) KR20200069299A (es)
CN (1) CN111433202A (es)
AU (1) AU2018330633C1 (es)
CA (1) CA3074891A1 (es)
CY (1) CY1125514T1 (es)
DK (1) DK3679034T3 (es)
ES (1) ES2925538T3 (es)
HR (1) HRP20221042T1 (es)
HU (1) HUE059822T2 (es)
IL (1) IL273064B2 (es)
LT (1) LT3679034T (es)
MA (1) MA50069B1 (es)
MD (1) MD3679034T2 (es)
MX (1) MX2020002571A (es)
PH (1) PH12020500461A1 (es)
PL (1) PL3679034T3 (es)
PT (1) PT3679034T (es)
RS (1) RS63532B1 (es)
SG (1) SG11202001409UA (es)
SI (1) SI3679034T1 (es)
SM (1) SMT202200343T1 (es)
UA (1) UA126689C2 (es)
WO (1) WO2019048541A1 (es)
ZA (1) ZA202001179B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3679034T (lt) * 2017-09-06 2022-09-12 Immunic Ag 1-(4-(izoksazol-5-il)-1h-pirazol-1-il)-2-metilpropan-2-olio dariniai ir susiję junginiai, kaip il-7 ir ifn- gama inhibitoriai, skirti autoimuninių ligų ir lėtinių uždegimų gydymui
US20240368145A1 (en) 2021-07-09 2024-11-07 Immunic Ag Methods for treating cancer
CN113683505A (zh) * 2021-09-29 2021-11-23 厦门大华本安化工安全研究院有限公司 一种含氧代环丁基的羧酸酯类化合物的制备方法
WO2023198873A1 (en) 2022-04-14 2023-10-19 Immunic Ag Deuterated rorgamma/rorgammat inverse agonists
WO2023232870A1 (en) 2022-05-31 2023-12-07 Immunic Ag Rorg/rorgt modulators for the treatment of virus infections like covid-19
CN119192167B (zh) * 2024-11-28 2025-03-21 英矽智能科技(上海)有限公司 一类抑制il-17的化合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2668183T3 (da) 2011-01-28 2018-01-29 4Sc Discovery Gmbh Hæmning af IL17 og IFN-gamma til behandling af autoimmun inflammation
CN103476771B (zh) 2011-01-28 2015-12-23 4Sc探索有限责任公司 用于治疗自身免疫炎症的IL17和IFN-γ抑制
LT3679034T (lt) * 2017-09-06 2022-09-12 Immunic Ag 1-(4-(izoksazol-5-il)-1h-pirazol-1-il)-2-metilpropan-2-olio dariniai ir susiję junginiai, kaip il-7 ir ifn- gama inhibitoriai, skirti autoimuninių ligų ir lėtinių uždegimų gydymui

Also Published As

Publication number Publication date
PH12020500461A1 (en) 2021-01-11
AU2018330633A1 (en) 2020-03-05
BR112020004332A2 (pt) 2020-09-08
IL273064A (en) 2020-04-30
UA126689C2 (uk) 2023-01-11
AU2018330633C1 (en) 2022-02-24
SMT202200343T1 (it) 2022-11-18
RU2020112319A (ru) 2021-10-06
DK3679034T3 (da) 2022-08-29
JP2020532575A (ja) 2020-11-12
RS63532B1 (sr) 2022-09-30
ES2925538T3 (es) 2022-10-18
KR20200069299A (ko) 2020-06-16
IL273064B2 (en) 2023-06-01
LT3679034T (lt) 2022-09-12
PT3679034T (pt) 2022-08-29
MA50069B1 (fr) 2023-08-31
SG11202001409UA (en) 2020-03-30
MD3679034T2 (ro) 2022-10-31
HRP20221042T1 (hr) 2022-11-11
EP3679034A1 (en) 2020-07-15
ZA202001179B (en) 2023-03-29
SI3679034T1 (sl) 2022-11-30
EP3679034B1 (en) 2022-06-01
US20210061796A1 (en) 2021-03-04
HUE059822T2 (hu) 2022-12-28
JP2023052060A (ja) 2023-04-11
PL3679034T3 (pl) 2022-11-14
CN111433202A (zh) 2020-07-17
CY1125514T1 (el) 2026-02-25
US11292788B2 (en) 2022-04-05
MA50069A (fr) 2021-05-05
WO2019048541A1 (en) 2019-03-14
RU2020112319A3 (es) 2022-02-07
AU2018330633B2 (en) 2021-02-25
EP4074708A1 (en) 2022-10-19
CA3074891A1 (en) 2019-03-14
NZ761897A (en) 2023-10-27

Similar Documents

Publication Publication Date Title
CL2019003747A1 (es) Amidas heterocíclicas de 5 miembros y bicíclicas como inhibidores de rock.
CY1125784T1 (el) Υποκατεστημενες δικυκλικες ετεροκυκλικες ενωσεις ως αναστολεις της prmt5
CY1125245T1 (el) Ετεροκυκλικες ενωσεις ως αναστολεις ρι3κ-γαμμα
EA201691302A1 (ru) Новые гетероциклические соединения
CO2018008173A2 (es) Salicilamidas de espiroheptanos y compuestos relacionados como inhibidores de cinasa rho (rock)
CY1122046T1 (el) Δικυκλικα ετεροκυκλικα παραγωγα ως αναστολεις βρομοτομεων
PH12020500461A1 (en) 1-(4-(isoxazol-5-yl)-1h-pyrazol-1-yl)-2-methylpropan-2-ol derivatives and related compounds as il-17 and ifn-gamma inhibitors for treating autoimmune diseases and chronic inflammation
EA201592199A1 (ru) Производные бипиразола в качестве ингибиторов jak
EA201690223A1 (ru) Ингибиторы фактора в комплемента на основе производных пиперидинилиндола и их применение
CL2017000992A1 (es) Compuestos de indol carboxamida utiles como inhibidores de cinasa
DOP2015000158A (es) Inhibidores de prmt5 y sus usos
EA201891501A1 (ru) Фталазиноны и изохинолиноны в качестве ингибиторов rock
EA201890307A1 (ru) Индазольные и азаиндазольные соединения как ингибиторы irak-4
EA201692418A1 (ru) Замещенные индазольные соединения в качестве irak4 ингибиторов
EA201491671A1 (ru) Гетероциклильные соединения
JOP20190174B1 (ar) مثبطات jak1 انتقائية
MX390747B (es) Compuesto heterociclico sustituido con alquinilo, su metodo de preparacion y su uso medico.
AR101210A1 (es) Métodos de tratamiento de cáncer usando antagonistas de unión al eje pd-1 e inhibidores de mek
EA201691058A1 (ru) Производные пирролопирролона и их применение для лечения заболеваний
CY1124251T1 (el) Παραγωγα καρβοξαμιδιου
EA201690888A1 (ru) Новые гетероциклические соединения
EA202192900A1 (ru) Модуляторы пути интегрированной реакции на стресс
EA201791289A1 (ru) Ингибиторы клеточного некроза и связанные с ними способы
UA124939C2 (uk) СПОСІБ ЗБІЛЬШЕННЯ КОНЦЕНТРАЦІЇ ДЕЗОКСІУРИДИНУ (dUrd) В ПЛАЗМІ У СУБ’ЄКТА-ЛЮДИНИ
EA201890684A1 (ru) Производные фториндола в качестве положительных аллостерических модуляторов мускаринового рецептора m1