MX2020002958A - Compuestos de porfirina sustituidos con fluoro, composiciones farmaceuticas que comprenden los mismos y metodos de preparacion y uso de los mismos. - Google Patents

Compuestos de porfirina sustituidos con fluoro, composiciones farmaceuticas que comprenden los mismos y metodos de preparacion y uso de los mismos.

Info

Publication number
MX2020002958A
MX2020002958A MX2020002958A MX2020002958A MX2020002958A MX 2020002958 A MX2020002958 A MX 2020002958A MX 2020002958 A MX2020002958 A MX 2020002958A MX 2020002958 A MX2020002958 A MX 2020002958A MX 2020002958 A MX2020002958 A MX 2020002958A
Authority
MX
Mexico
Prior art keywords
same
methods
porphyrin compounds
preparing
pharmaceutical compositions
Prior art date
Application number
MX2020002958A
Other languages
English (en)
Inventor
Ines Batinic-Haberle
Ivan Spasojevic
Artak Tovmasyan
Original Assignee
Univ Duke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Duke filed Critical Univ Duke
Publication of MX2020002958A publication Critical patent/MX2020002958A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/32—Manganese; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092—Details
    • A61N2005/1094—Shielding, protecting against radiation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

En el presente documento se proporcionan compuestos de porfirina sustituidos con fluoro, tales como los que tienen una estructura representada por la Fórmula (I), en donde R1 es un alquilo C1-C8 que está sustituido con por lo menos 1 flúor (por ejemplo, un alquilo C1-C8 sustituido con 1-17 átomos de flúor); y X es un anión (por ejemplo, un ión halógeno (por ejemplo, cloruro, etc.), PF6, tosilato, besilato y/o mesilato). También se proporcionan en el presente documento métodos para preparar los compuestos de porfirina sustituidos con fluoro, formulaciones farmacéuticas que los contienen y métodos de uso de los mismos.
MX2020002958A 2017-09-29 2018-09-26 Compuestos de porfirina sustituidos con fluoro, composiciones farmaceuticas que comprenden los mismos y metodos de preparacion y uso de los mismos. MX2020002958A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762565436P 2017-09-29 2017-09-29
PCT/US2018/052826 WO2019067523A1 (en) 2017-09-29 2018-09-26 FLUOROSUBSTITUTED PORPHYRIN COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS OF PREPARATION AND USE THEREOF

Publications (1)

Publication Number Publication Date
MX2020002958A true MX2020002958A (es) 2020-08-20

Family

ID=65903171

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020002958A MX2020002958A (es) 2017-09-29 2018-09-26 Compuestos de porfirina sustituidos con fluoro, composiciones farmaceuticas que comprenden los mismos y metodos de preparacion y uso de los mismos.

Country Status (8)

Country Link
US (1) US11344574B2 (es)
EP (1) EP3687551A4 (es)
JP (1) JP7336805B2 (es)
KR (1) KR102699638B1 (es)
CN (1) CN111417400B (es)
CA (1) CA3076008A1 (es)
MX (1) MX2020002958A (es)
WO (1) WO2019067523A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11285162B2 (en) 2017-04-04 2022-03-29 Biomimetix Jv, Llc Methods, compositions, and kits for treating and/or preventing a side effect associated with radiation and/or chemotherapy exposure
CA3076008A1 (en) 2017-09-29 2019-04-04 Duke University Fluoro substituted porphyrin compounds, pharmaceutical compositions comprising the same, and methods of preparing and using the same
CN115192705B (zh) * 2021-04-13 2023-10-13 中国科学院化学研究所 一种两性离子共价有机聚合物/二氧化钛纳米复合材料及其制备方法和应用
CN116333037A (zh) * 2021-12-17 2023-06-27 化学与精细化工广东省实验室 含巯基肽与氟代卟啉类偶联用作生物探针

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2520735B2 (ja) * 1988-07-14 1996-07-31 東洋薄荷工業株式会社 ポルフィリン誘導体
AU737650B2 (en) 1997-11-03 2001-08-23 Duke University Substituted porphyrins
JPH11217385A (ja) * 1998-01-30 1999-08-10 Nihon Schering Kk 含フッ素ポルフィリン錯体およびそれを含有する造影剤
US6448239B1 (en) * 1999-06-03 2002-09-10 Trustees Of Princeton University Peroxynitrite decomposition catalysts and methods of use thereof
WO2002060383A2 (en) 2001-01-19 2002-08-08 National Jewish Medical And Research Center Cancer therapy
WO2005077269A1 (en) * 2004-02-09 2005-08-25 Duke University Substituted porphyrins
EP1740094A4 (en) * 2004-03-29 2008-09-03 Inotek Pharmaceuticals Corp PYRIDYL-SUBSTITUTED PORPHYRIN COMPOUNDS AND METHODS OF USE THEREOF
CN101235036A (zh) 2007-02-02 2008-08-06 济南赛文医药技术有限公司 一类卟啉衍生物及其作为小分子抗氧化剂的应用
GB0819594D0 (en) 2008-10-24 2008-12-03 Univ Coimbrra Process
WO2010080881A1 (en) 2009-01-07 2010-07-15 Duke University Substituted porphyrins
US20160113940A1 (en) 2013-09-03 2016-04-28 Biomimetix J.V., Llc Methods of treating biofilms
US10080759B2 (en) 2014-01-22 2018-09-25 Duke University Methods of treating pruritus
WO2015112588A1 (en) 2014-01-22 2015-07-30 Biomimetix Jv, Llc Methods of treating skin disorders
KR20190098211A (ko) 2016-12-20 2019-08-21 듀크 유니버시티 치환 포르피린 약학적 화합물 및 조성물의 제조 방법
WO2018237249A1 (en) 2017-06-22 2018-12-27 Biomimetix Jv, Llc Methods, compositions, and kits for treating inflammatory skin conditions
CA3076008A1 (en) 2017-09-29 2019-04-04 Duke University Fluoro substituted porphyrin compounds, pharmaceutical compositions comprising the same, and methods of preparing and using the same

Also Published As

Publication number Publication date
US11344574B2 (en) 2022-05-31
EP3687551A1 (en) 2020-08-05
EP3687551A4 (en) 2021-06-23
CN111417400B (zh) 2022-12-02
JP7336805B2 (ja) 2023-09-01
CA3076008A1 (en) 2019-04-04
JP2020536055A (ja) 2020-12-10
WO2019067523A1 (en) 2019-04-04
KR102699638B1 (ko) 2024-08-28
US20210361702A1 (en) 2021-11-25
CN111417400A (zh) 2020-07-14
KR20200079237A (ko) 2020-07-02

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