MX384752B - ANTAGONISTAS SOLUBLES DE RECEPTOR DE C5a (C5aR). - Google Patents

ANTAGONISTAS SOLUBLES DE RECEPTOR DE C5a (C5aR).

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Publication number
MX384752B
MX384752B MX2018011831A MX2018011831A MX384752B MX 384752 B MX384752 B MX 384752B MX 2018011831 A MX2018011831 A MX 2018011831A MX 2018011831 A MX2018011831 A MX 2018011831A MX 384752 B MX384752 B MX 384752B
Authority
MX
Mexico
Prior art keywords
sup
receptor
compounds
c5ar
antagonists
Prior art date
Application number
MX2018011831A
Other languages
English (en)
Other versions
MX2018011831A (es
Inventor
Antoni Krasinski
Penglie Zhang
Pingchen Fan
Shichang Miao
Sreenivas Punna
Valentino J Stella
Venkat Reddy Mali
Yang Song
Yibin Zeng
Original Assignee
Chemocentryx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemocentryx Inc filed Critical Chemocentryx Inc
Publication of MX2018011831A publication Critical patent/MX2018011831A/es
Publication of MX384752B publication Critical patent/MX384752B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
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  • Dermatology (AREA)
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Abstract

Se proporcionan compuestos para modular el receptor de C5a. Los compuestos tienen la siguiente fórmula (I): (ver fórmula) incluyendo estereoisómeros y sales farmacéuticamente aceptables de los mismos; en donde R1, R2 y R3 son como se definen en la presente. También se describen métodos asociados con la preparación y uso de estos compuestos, así como composiciones farmacéuticas que comprenden estos compuestos.
MX2018011831A 2016-04-04 2017-04-03 ANTAGONISTAS SOLUBLES DE RECEPTOR DE C5a (C5aR). MX384752B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662317721P 2016-04-04 2016-04-04
PCT/US2017/025704 WO2017176620A2 (en) 2016-04-04 2017-04-03 SOLUBLE C5aR ANTAGONISTS

Publications (2)

Publication Number Publication Date
MX2018011831A MX2018011831A (es) 2019-02-13
MX384752B true MX384752B (es) 2025-03-14

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MX2018011831A MX384752B (es) 2016-04-04 2017-04-03 ANTAGONISTAS SOLUBLES DE RECEPTOR DE C5a (C5aR).

Country Status (18)

Country Link
US (4) US20170283446A1 (es)
EP (1) EP3439658B1 (es)
JP (1) JP7121722B2 (es)
KR (1) KR102395093B1 (es)
CN (1) CN109310686B (es)
AR (1) AR108097A1 (es)
AU (1) AU2017246228B2 (es)
CA (1) CA3019137C (es)
CL (1) CL2018002803A1 (es)
IL (1) IL261997B (es)
MA (1) MA44629A (es)
MX (1) MX384752B (es)
NZ (1) NZ747259A (es)
RU (1) RU2748260C2 (es)
SG (1) SG11201808625QA (es)
TW (1) TWI760331B (es)
WO (1) WO2017176620A2 (es)
ZA (1) ZA201806632B (es)

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