MX2020003555A - Sistemas de espectroscopia raman in situ y metodos para controlar variables de proceso en cultivos celulares. - Google Patents

Sistemas de espectroscopia raman in situ y metodos para controlar variables de proceso en cultivos celulares.

Info

Publication number
MX2020003555A
MX2020003555A MX2020003555A MX2020003555A MX2020003555A MX 2020003555 A MX2020003555 A MX 2020003555A MX 2020003555 A MX2020003555 A MX 2020003555A MX 2020003555 A MX2020003555 A MX 2020003555A MX 2020003555 A MX2020003555 A MX 2020003555A
Authority
MX
Mexico
Prior art keywords
process variables
raman spectroscopy
methods
cell culture
situ raman
Prior art date
Application number
MX2020003555A
Other languages
English (en)
Inventor
Anthony Debiase
Mark Czeterko
William Pierce
Matthew Conway
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2020003555A publication Critical patent/MX2020003555A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Sustainable Development (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Computer Hardware Design (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención proporciona métodos y sistemas de espectroscopía Raman in situ para monitorear y controlar una o más variables de proceso en un cultivo celular de biorreactor para mejorar la calidad y la consistencia del producto. Los métodos y sistemas utilizan espectroscopía Raman in situ y técnicas de modelado quimiométrico para las evaluaciones en tiempo real de los cultivos celulares, combinadas con técnicas de procesamiento de señales, para la retroalimentación continua precisa y control predictivo del modelo de variables de proceso de cultivo celular. Mediante el uso de datos en tiempo real de la espectroscopía Raman, las variables del proceso dentro del cultivo celular pueden monitorearse de forma continua o intermitente y los controladores de retroalimentación automáticos mantienen las variables del proceso en los puntos de ajuste predeterminados o mantienen un protocolo de alimentación específico que administra cantidades variables de agentes al biorreactor para maximizar la calidad del bioproducto.
MX2020003555A 2017-10-16 2018-10-15 Sistemas de espectroscopia raman in situ y metodos para controlar variables de proceso en cultivos celulares. MX2020003555A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762572828P 2017-10-16 2017-10-16
US201862662322P 2018-04-25 2018-04-25
PCT/US2018/055837 WO2019079165A1 (en) 2017-10-16 2018-10-15 RAMAN IN SITU SPECTROSCOPY SYSTEMS AND METHODS FOR CONTROLLING PROCESSING VARIABLES IN CELL CULTURES

Publications (1)

Publication Number Publication Date
MX2020003555A true MX2020003555A (es) 2020-08-03

Family

ID=64316979

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2020003555A MX2020003555A (es) 2017-10-16 2018-10-15 Sistemas de espectroscopia raman in situ y metodos para controlar variables de proceso en cultivos celulares.
MX2025001414A MX2025001414A (es) 2017-10-16 2020-07-13 Sistemas de espectroscopia raman in situ y metodos para controlar variables de proceso en cultivos celulares
MX2024013644A MX2024013644A (es) 2017-10-16 2020-07-13 Sistemas de espectroscopia raman in situ y metodos para controlar variables de proceso en cultivos celulares

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2025001414A MX2025001414A (es) 2017-10-16 2020-07-13 Sistemas de espectroscopia raman in situ y metodos para controlar variables de proceso en cultivos celulares
MX2024013644A MX2024013644A (es) 2017-10-16 2020-07-13 Sistemas de espectroscopia raman in situ y metodos para controlar variables de proceso en cultivos celulares

Country Status (13)

Country Link
US (1) US20190112569A1 (es)
EP (1) EP3698125A1 (es)
JP (5) JP2020536497A (es)
KR (2) KR20200070218A (es)
CN (1) CN111201434A (es)
AU (2) AU2018350890B2 (es)
BR (2) BR122023022045A2 (es)
CA (1) CA3078956A1 (es)
IL (1) IL272472B1 (es)
MX (3) MX2020003555A (es)
SG (1) SG11202001127TA (es)
TW (1) TW201928042A (es)
WO (1) WO2019079165A1 (es)

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CN121249491A (zh) * 2019-10-25 2026-01-02 里珍纳龙药品有限公司 用于种子培养和生产过程中的自动接种的系统和方法
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CN114651218B (zh) * 2019-11-15 2023-09-15 赛多利斯司特蒂姆数据分析公司 基于拉曼光谱学预测生物过程中的参数的方法和装置组件以及控制生物过程的方法和装置组件
CN116830204B (zh) * 2021-02-08 2026-04-14 株式会社岛津制作所 估计装置、学习装置、优化装置、估计方法、学习方法以及优化方法
AU2022246000A1 (en) * 2021-03-23 2023-11-09 Janssen Biotech, Inc Multiparameter materials, methods and systems for bioreactor glycated species manufacture
KR102792081B1 (ko) * 2021-10-27 2025-04-08 프레스티지바이오로직스 주식회사 인공지능을 이용하여 세포 배양조건을 결정하기 위한 장치 및 장치의 동작 방법
JP7784870B2 (ja) * 2021-11-24 2025-12-12 日機装株式会社 グルコースを含む細胞培地のラマンスペクトルから補正されたスペクトル強度を算出する方法
CN116893164A (zh) * 2022-04-06 2023-10-17 上海君实生物医药科技股份有限公司 一种基于doe实验设计的在线拉曼校准模型的建立方法
JP7168118B1 (ja) 2022-06-23 2022-11-09 横河電機株式会社 検量装置、検量方法および検量プログラム
JP2024061408A (ja) * 2022-10-21 2024-05-07 横河電機株式会社 検量線出力装置、検量線出力方法および検量線出力プログラム
CN115985404A (zh) * 2022-12-12 2023-04-18 无锡药明生物技术股份有限公司 监测和自动化控制生物反应器的方法和装置
JP2024146482A (ja) * 2023-03-31 2024-10-15 株式会社日立プラントサービス 培養スケールアップ用培養データ収集装置および培養スケールアップ用培養データ収集方法
CN116855370A (zh) * 2023-07-19 2023-10-10 安及义实业（上海）有限公司 生物反应器或发酵罐的自动补料装置及方法
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Also Published As

Publication number Publication date
KR20240149973A (ko) 2024-10-15
IL272472B1 (en) 2026-01-01
MX2025001414A (es) 2025-03-07
TW201928042A (zh) 2019-07-16
US20190112569A1 (en) 2019-04-18
MX2024013644A (es) 2024-12-06
IL272472A (en) 2020-03-31
WO2019079165A1 (en) 2019-04-25
AU2018350890B2 (en) 2024-07-04
JP2022153617A (ja) 2022-10-12
KR20200070218A (ko) 2020-06-17
BR122023022045A2 (pt) 2024-01-16
JP2020195370A (ja) 2020-12-10
EP3698125A1 (en) 2020-08-26
AU2018350890A1 (en) 2020-03-19
CN111201434A (zh) 2020-05-26
JP2026063384A (ja) 2026-04-10
BR112020003122A2 (pt) 2020-08-04
JP2020536497A (ja) 2020-12-17
CA3078956A1 (en) 2019-04-25
JP2024015034A (ja) 2024-02-01
SG11202001127TA (en) 2020-03-30
AU2024223985A1 (en) 2024-10-24

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