MX2020004072A - Monitoreo de terapia bajo tratamiento con un aglutinante anti-adrenomodulina (adm). - Google Patents

Monitoreo de terapia bajo tratamiento con un aglutinante anti-adrenomodulina (adm).

Info

Publication number
MX2020004072A
MX2020004072A MX2020004072A MX2020004072A MX2020004072A MX 2020004072 A MX2020004072 A MX 2020004072A MX 2020004072 A MX2020004072 A MX 2020004072A MX 2020004072 A MX2020004072 A MX 2020004072A MX 2020004072 A MX2020004072 A MX 2020004072A
Authority
MX
Mexico
Prior art keywords
adrenomedullin
adm
binder
under treatment
monitoring under
Prior art date
Application number
MX2020004072A
Other languages
English (en)
Inventor
Andreas Bergmann
Joachim Struck
Original Assignee
Adrenomed Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adrenomed Ag filed Critical Adrenomed Ag
Publication of MX2020004072A publication Critical patent/MX2020004072A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7095—Inflammation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physiology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La materia objeto de la presente invención es un método para monitorear una terapia en un individuo, en el cual el individuo está bajo tratamiento con un aglutinante anti-adrenomedulina (ADM) que se selecciona a partir del grupo que comprende un anticuerpo, fragmento de anticuerpo y/o andamio no lg. que comprende determinar el nivel de un fragmento de pre-pro-adrenomedulina que se selecciona a partir del grupo que comprende proadreonomedulina de la región media (MR-proADM). proadrenomedulina C-terminal (CT-proADM) y/o el péptido de 20 aminoácidos N-terminal de proadrenomedulina (PAM) o fragmentos de los mismos en un fluido corporal obtenido a partir de dicho individuo: y correlacionar el nivel de dicho fragmento de pre-pro-adrenomedulina con el estado de salud clínico/médico del individuo y/o el riesgo de un resultado adverso y/o el requerimiento de adaptar las medidas terapéuticas.
MX2020004072A 2017-10-18 2018-10-18 Monitoreo de terapia bajo tratamiento con un aglutinante anti-adrenomodulina (adm). MX2020004072A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17197177 2017-10-18
PCT/EP2018/078647 WO2019077082A1 (en) 2017-10-18 2018-10-18 SURVEILLANCE OF THERAPY UNDER TREATMENT WITH ANTI-ADRENOMEDULIN BINDER (ADM)

Publications (1)

Publication Number Publication Date
MX2020004072A true MX2020004072A (es) 2020-07-28

Family

ID=60301753

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020004072A MX2020004072A (es) 2017-10-18 2018-10-18 Monitoreo de terapia bajo tratamiento con un aglutinante anti-adrenomodulina (adm).

Country Status (10)

Country Link
US (1) US20220268761A1 (es)
EP (1) EP3698134A1 (es)
JP (1) JP2021500548A (es)
CN (1) CN111480076A (es)
AU (1) AU2018350861A1 (es)
BR (1) BR112020005682A2 (es)
CA (1) CA3079112A1 (es)
MX (1) MX2020004072A (es)
SG (1) SG11202002268XA (es)
WO (1) WO2019077082A1 (es)

Families Citing this family (8)

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EP3682236A1 (en) * 2017-09-13 2020-07-22 B.R.A.H.M.S GmbH Proadrenomedullin as indicator for renal replacement therapy in critically ill patients
JP2022546061A (ja) * 2019-08-30 2022-11-02 ４ティーン４ ファーマシューティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング ショック症治療のための治療法の誘導および／または治療法の監視
EP3871689A1 (en) * 2020-02-26 2021-09-01 sphingotec GmbH Anti-adm-antibodies binding to the free n-terminus for accelerated transition of adm-gly to bio-adm in patients with adm-gly/ bio-adm ratio above a threshold and combination with vitamin c
US20230104578A1 (en) * 2020-02-27 2023-04-06 Adrenomed Ag Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in therapy or prevention of shock
BR112022015215A2 (pt) * 2020-02-27 2022-10-11 4TEEN4 Pharmaceuticals GmbH Dpp3 para orientação, monitoramento e estratificação de terapia de anticorpos nt-adm em pacientes com choque
WO2022234111A1 (en) 2021-05-07 2022-11-10 Sphingotec Gmbh Mature adrenomedullin for therapy stratification of corticosteroids in critically ill patients
CA3254142A1 (en) * 2022-03-15 2023-09-21 Adrenomed Ag STABLE AQUEOUS FORMULATION OF AN ANTI-ADRENOMEDULLIN (ADM) ANTIBODY OR AN ANTI-ADM ANTIBODY FRAGMENT
WO2025133235A1 (en) 2023-12-22 2025-06-26 Pam Theragnostics Gmbh Adm-gly as marker for early predicting sepsis

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Also Published As

Publication number Publication date
JP2021500548A (ja) 2021-01-07
BR112020005682A2 (pt) 2020-10-20
RU2020115794A3 (es) 2022-01-27
CN111480076A (zh) 2020-07-31
US20220268761A1 (en) 2022-08-25
SG11202002268XA (en) 2020-04-29
RU2020115794A (ru) 2021-11-19
CA3079112A1 (en) 2019-04-25
EP3698134A1 (en) 2020-08-26
AU2018350861A1 (en) 2020-04-09
WO2019077082A1 (en) 2019-04-25

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