MX2020006355A - Pirrolidinamidas ii sustituidas. - Google Patents

Pirrolidinamidas ii sustituidas.

Info

Publication number
MX2020006355A
MX2020006355A MX2020006355A MX2020006355A MX2020006355A MX 2020006355 A MX2020006355 A MX 2020006355A MX 2020006355 A MX2020006355 A MX 2020006355A MX 2020006355 A MX2020006355 A MX 2020006355A MX 2020006355 A MX2020006355 A MX 2020006355A
Authority
MX
Mexico
Prior art keywords
pyrrolidinamides
substituted
glucocorticoid receptor
prophylaxis
disorders
Prior art date
Application number
MX2020006355A
Other languages
English (en)
Inventor
Jo Alen
Florian Jakob
Sebastian Krüger
Markus Schade
Daniela Friebe
Stephanie Hennen
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of MX2020006355A publication Critical patent/MX2020006355A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención se refiere a compuestos de acuerdo con la fórmula general (I), (ver formula) que actúan como moduladores del receptor de glucocorticoides y se pueden utilizar en el tratamiento y/o la profilaxis de trastornos que están al menos parcialmente mediados por el receptor de glucocorticoides.
MX2020006355A 2017-12-18 2018-12-18 Pirrolidinamidas ii sustituidas. MX2020006355A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17208180 2017-12-18
PCT/EP2018/085390 WO2019121611A1 (en) 2017-12-18 2018-12-18 Substituted pyrrolidine amides ii

Publications (1)

Publication Number Publication Date
MX2020006355A true MX2020006355A (es) 2020-08-17

Family

ID=60673848

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020006355A MX2020006355A (es) 2017-12-18 2018-12-18 Pirrolidinamidas ii sustituidas.

Country Status (14)

Country Link
US (2) US20190185470A1 (es)
EP (1) EP3728233B1 (es)
JP (1) JP2021506965A (es)
CN (1) CN111491931A (es)
AR (1) AR113968A1 (es)
AU (1) AU2018387747A1 (es)
BR (1) BR112020012221A2 (es)
CA (1) CA3085879A1 (es)
EA (1) EA202091428A1 (es)
ES (1) ES2920359T3 (es)
IL (1) IL275375A (es)
MX (1) MX2020006355A (es)
TW (1) TW201927769A (es)
WO (1) WO2019121611A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3085874A1 (en) 2017-12-18 2019-06-27 Grunenthal Gmbh Substituted pyrrolidine amides i
WO2020144375A1 (en) 2019-01-11 2020-07-16 Grünenthal GmbH Substituted pyrrolidine amides iii
EP3986885B1 (en) * 2019-06-19 2023-05-03 Grünenthal GmbH Substituted pyrrolidine amides iv
IL298957A (en) * 2020-06-22 2023-02-01 Corcept Therapeutics Inc Quaternary indazole glucocorticoid receptor antagonists
ES3057363T3 (en) * 2020-07-09 2026-03-02 Gruenenthal Gmbh Substituted pyrrolidine amines and amides as mediator of the glucocortoid receptor
MX2024007590A (es) * 2021-12-21 2024-08-20 Corcept Therapeutics Inc Antagonistas piperazino indazólicos del receptor de glucocorticoides.
KR20240125035A (ko) * 2021-12-21 2024-08-19 코어셉트 쎄라퓨틱스 인코포레이티드 이환 인다졸 글루코코르티코이드 수용체 길항제

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008535884A (ja) * 2005-04-14 2008-09-04 グラクソ グループ リミテッド グルココルチコイド受容体リガンドとしてのインダゾール
EA200801997A1 (ru) 2006-04-20 2009-04-28 Глаксо Груп Лимитед Новые соединения
GB0620385D0 (en) 2006-10-13 2006-11-22 Glaxo Group Ltd Novel compounds
TW200829578A (en) * 2006-11-23 2008-07-16 Astrazeneca Ab Chemical compounds 537
JO2754B1 (en) 2006-12-21 2014-03-15 استرازينكا ايه بي Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders
JP2009084273A (ja) 2007-09-13 2009-04-23 Santen Pharmaceut Co Ltd １，３，３−トリメチル−７−フェニル−３，４−ジヒドロ−１ｈ−キノキサリン−２−オン誘導体からなるグルココルチコイド受容体アゴニスト
UY31832A (es) 2008-05-20 2010-01-05 Astrazeneca Ab Derivados de indazol sustituidos con fenilo y benzodioxinilo
US9624170B2 (en) * 2013-12-26 2017-04-18 Takeda Pharmaceutical Company Limited 4-(piperrazin-1-yl)-pyrrolidin-2-one compounds as monoacylglycerol lipase (MAGL) inhibitors
TW201609693A (zh) * 2014-01-03 2016-03-16 必治妥美雅史谷比公司 雜芳基取代之菸鹼醯胺化合物
PE20171110A1 (es) 2014-09-26 2017-08-07 Astrazeneca Ab Compuestos de 1-alquil-6-oxo-1,6-dihidropiridin-3-ilo y usos de los mismos
HK1252159A1 (zh) 2015-08-25 2019-05-17 参天制药株式会社 [4-(1，3，3-三甲基-2-氧代-3，4-二氢-1h-喹喔啉-7-基)苯氧基]乙基氧基化合物或其盐
ES2745284T3 (es) * 2015-09-11 2020-02-28 Boehringer Ingelheim Int Heteroarilos sustituidos con pirazolilo y su uso como medicamentos
CA3085874A1 (en) * 2017-12-18 2019-06-27 Grunenthal Gmbh Substituted pyrrolidine amides i

Also Published As

Publication number Publication date
US12344605B2 (en) 2025-07-01
JP2021506965A (ja) 2021-02-22
AU2018387747A1 (en) 2020-08-06
EA202091428A1 (ru) 2020-10-27
IL275375A (en) 2020-07-30
TW201927769A (zh) 2019-07-16
CN111491931A (zh) 2020-08-04
EP3728233A1 (en) 2020-10-28
AR113968A1 (es) 2020-07-01
WO2019121611A1 (en) 2019-06-27
US20190185470A1 (en) 2019-06-20
EP3728233B1 (en) 2022-04-20
BR112020012221A2 (pt) 2020-11-24
ES2920359T3 (es) 2022-08-03
CA3085879A1 (en) 2019-06-27
US20220127264A1 (en) 2022-04-28

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