MX2020007079A - Particulas conjugadas con peptidos. - Google Patents

Particulas conjugadas con peptidos.

Info

Publication number
MX2020007079A
MX2020007079A MX2020007079A MX2020007079A MX2020007079A MX 2020007079 A MX2020007079 A MX 2020007079A MX 2020007079 A MX2020007079 A MX 2020007079A MX 2020007079 A MX2020007079 A MX 2020007079A MX 2020007079 A MX2020007079 A MX 2020007079A
Authority
MX
Mexico
Prior art keywords
particles
peptides
particles conjugated
plg
peptide
Prior art date
Application number
MX2020007079A
Other languages
English (en)
Inventor
Stephen D Miller
Jonathan Woon Teck Yap
Daniel R Getts
Shea Lonnie D
Derrick Mccarthy
Original Assignee
Univ Northwestern
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52468804&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2020007079(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Northwestern filed Critical Univ Northwestern
Publication of MX2020007079A publication Critical patent/MX2020007079A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
    • A61K47/6935—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
    • A61K47/6935—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol
    • A61K47/6937—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol the polymer being PLGA, PLA or polyglycolic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/577—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/622—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier non-covalent binding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Optics & Photonics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención proporciona composiciones que comprenden partículas de poli(lactida-coglicólido) (PLG) biodegradable acopladas a péptidos. Particularmente, las partículas de PLG tienen la superficie funcionalizada para permitir el acoplamiento de moléculas peptídicas a la superficie de las partículas (por ejemplo, para usar en la generación de inducción de tolerancia inmunológica).
MX2020007079A 2013-08-13 2016-02-12 Particulas conjugadas con peptidos. MX2020007079A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361865389P 2013-08-13 2013-08-13
US201361869279P 2013-08-23 2013-08-23
US201361887112P 2013-10-04 2013-10-04

Publications (1)

Publication Number Publication Date
MX2020007079A true MX2020007079A (es) 2020-09-09

Family

ID=52468804

Family Applications (5)

Application Number Title Priority Date Filing Date
MX2016001931A MX372849B (es) 2013-08-13 2014-08-13 Partículas conjugadas con péptidos.
MX2020004799A MX2020004799A (es) 2013-08-13 2016-02-12 Particulas conjugadas con peptidos.
MX2023000194A MX2023000194A (es) 2013-08-13 2016-02-12 Particulas conjugadas con peptidos.
MX2020007079A MX2020007079A (es) 2013-08-13 2016-02-12 Particulas conjugadas con peptidos.
MX2023000192A MX2023000192A (es) 2013-08-13 2016-02-12 Particulas conjugadas con peptidos.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
MX2016001931A MX372849B (es) 2013-08-13 2014-08-13 Partículas conjugadas con péptidos.
MX2020004799A MX2020004799A (es) 2013-08-13 2016-02-12 Particulas conjugadas con peptidos.
MX2023000194A MX2023000194A (es) 2013-08-13 2016-02-12 Particulas conjugadas con peptidos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2023000192A MX2023000192A (es) 2013-08-13 2016-02-12 Particulas conjugadas con peptidos.

Country Status (24)

Country Link
US (10) US9616113B2 (es)
EP (2) EP3033102B2 (es)
JP (4) JP6553033B2 (es)
KR (7) KR20230008909A (es)
CN (2) CN105555301B (es)
AU (4) AU2014306603B2 (es)
BR (1) BR112016003084A2 (es)
CY (1) CY1122558T1 (es)
DK (1) DK3033102T4 (es)
ES (1) ES2762187T5 (es)
FI (1) FI3033102T4 (es)
HR (1) HRP20192270T4 (es)
HU (1) HUE047329T2 (es)
IL (4) IL318076A (es)
LT (1) LT3033102T (es)
ME (1) ME03590B (es)
MX (5) MX372849B (es)
PL (1) PL3033102T5 (es)
PT (1) PT3033102T (es)
RS (1) RS59801B2 (es)
RU (1) RU2685186C2 (es)
SI (1) SI3033102T2 (es)
SM (1) SMT201900717T1 (es)
WO (1) WO2015023796A2 (es)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5909745B2 (ja) 2010-11-12 2016-04-27 クール ファーマシューティカルズ ディベロップメント カンパニー 炎症性疾患の治療薬、ならびにウイルスまたは細菌感染疾患の治療薬
WO2013163176A1 (en) 2012-04-23 2013-10-31 Allertein Therapeutics, Llc Nanoparticles for treatment of allergy
CA2876495C (en) 2012-06-21 2023-10-17 Northwestern University Peptide conjugated particles
HK1220368A1 (zh) 2013-03-13 2017-05-05 Cour Pharmaceuticals Development Company 用於治疗炎症的免疫修饰性颗粒
KR102233251B1 (ko) 2013-04-03 2021-03-26 엔-폴드 엘엘씨 신규 나노입자 조성물
CN105555301B (zh) 2013-08-13 2021-04-16 西北大学 肽缀合颗粒
EP4299058A3 (en) 2014-06-24 2024-03-27 The Trustees of Princeton University Process for encapsulating soluble biologics, therapeutics, and imaging agents
GB201508025D0 (en) 2015-05-11 2015-06-24 Ucl Business Plc Fabry disease gene therapy
EP3095440B1 (en) * 2015-05-19 2020-01-15 PLS-Design GmbH Antigen-specific immunotherapy using tolerizing liposomes
EP3355903A1 (en) 2015-10-02 2018-08-08 University of Copenhagen Small molecules blocking histone reader domains
AU2016378743A1 (en) * 2015-12-22 2018-08-02 The Trustees Of Princeton University Process for encapsulating soluble biologics, therapeutics, and imaging agents
EP3393514A4 (en) 2015-12-23 2019-08-14 Cour Pharmaceuticals Development Company Inc. KOVALENTE POLYMER ANTIGEN CONJUGATED PARTICLES
JP6904959B2 (ja) * 2016-01-04 2021-07-21 クール ファーマシューティカルズ ディベロップメント カンパニー インコーポレイテッド 結合エピトープを含有する融合タンパク質を封入する粒子
KR20180105243A (ko) * 2016-02-09 2018-09-27 코어 파마슈티칼스 디벨롭먼트 컴퍼니 인크. 일본 삼나무 꽃가루 에피토프를 캡슐화하는 ｔｉｍｐｓ
CA3015074C (en) 2016-02-18 2024-05-28 Cour Pharmaceuticals Development Company, Inc. Process for the preparation of tolerizing immune-modulating particles
WO2019055539A1 (en) 2017-09-12 2019-03-21 Prudhomme Robert K CELLULOSIC POLYMER NANOPARTICLES AND METHODS OF FORMING THE SAME
US12480162B2 (en) 2017-10-06 2025-11-25 The Regents Of The University Of Michigan Detection of metastatic disease and related methods
US12357582B2 (en) 2017-11-03 2025-07-15 The Trustees Of Princeton University Hydrophobic ion pairing and flash nanoprecipitation for formation of controlled-release nanocarrier formulations
CN111867565A (zh) 2018-02-08 2020-10-30 库尔制药发展公司股份有限公司 使用耐受颗粒治疗乳糜泻
WO2020018890A1 (en) 2018-07-19 2020-01-23 Prudhomme Robert K Triblock copolymer stabilizers for the formation of nanoparticles encapsulating soluble biologics, therapeutics, and imaging agents
US11731099B2 (en) 2018-07-20 2023-08-22 The Trustees Of Princeton University Method for controlling encapsulation efficiency and burst release of water soluble molecules from nanoparticles and microparticles produced by inverse flash nanoprecipitation
CN118542841A (zh) * 2018-07-31 2024-08-27 onCOUR制药股份有限公司 用于治疗癌症的免疫修饰粒子
US20210382050A1 (en) 2018-10-19 2021-12-09 The Regents Of The University Of Michigan Method for monitoring autoimmune disease
JP7520877B2 (ja) 2019-04-05 2024-07-23 エーエスピー ヘルス インク． 流体サンプル分配システムおよび方法における消耗部品
WO2020214849A1 (en) * 2019-04-16 2020-10-22 Regents Of The University Of Minnesota Biomarker for transplantation tolerance induced by apoptotic donor leukocytes
CN110317255B (zh) * 2019-07-19 2020-07-31 北京工商大学 αs1-酪蛋白的抗原表位制备得到的单抗及牛乳过敏原检测方法
CN114502557A (zh) * 2019-07-31 2022-05-13 onCOUR制药股份有限公司 免疫逃避性肿瘤的治疗
EP4021490A4 (en) * 2019-08-30 2023-10-25 Universidad De Chile Autoantigenic peptides (calvicifiv), presented by tolerogenic dentritic cells, useful for the personalized treatment of rheumatoid arthritis
GB201913408D0 (en) * 2019-09-17 2019-10-30 King S College London Proinsulin peptides for type 1 diabetes
US20230026969A1 (en) * 2019-12-03 2023-01-26 China Medical University Oligopeptide, Testing Kit Thereof And Medical Composition Thereof
WO2021155281A1 (en) * 2020-01-31 2021-08-05 Applied Molecular Transport Inc. Compositions and methods for treatment of celiac disease
US20230270859A1 (en) * 2020-03-20 2023-08-31 Monash University Compositions and methods for treating lupus
ES2963150T3 (es) * 2020-10-27 2024-03-25 Elucida Oncology Inc Procedimientos para funcionalizar nanopartículas
AU2022224567A1 (en) * 2021-02-16 2023-08-24 Barinthus Biotherapeutics North America, Inc. Self-assembling nanoparticles based on amphiphilic peptides
CN117813111A (zh) * 2021-04-16 2024-04-02 库尔制药开发公司 用耐受纳米粒子治疗花生过敏
MX2023012257A (es) * 2021-04-16 2024-01-08 Cour Pharmaceuticals Dev Company Inc Método de rastreo del mantenimiento de la inmunotolerancia.
AU2022371668A1 (en) 2021-10-21 2024-05-09 Cour Pharmaceuticals Development Company Inc. Treatment of primary biliary cholangitis (pbc) with tolerizing nanoparticles
US20250319155A1 (en) * 2021-11-24 2025-10-16 Cour Pharmaceuticals Development Company Inc. Preparation of tolerizing nanoparticles for the treatment of peanut allergy
CN113908256B (zh) * 2021-11-26 2023-05-26 中国农业科学院兰州兽医研究所 Lancl1蛋白在制备抗病毒药物中的应用
US20250177503A1 (en) * 2022-02-22 2025-06-05 The Regents Of The University Of Michigan Compositions and methods for treating autoimmune disorders
CN116693607A (zh) * 2022-02-24 2023-09-05 中国科学院大连化学物理研究所 抗菌多肽及应用和细菌生长抑制剂、抗感染药物或保健品
CN114773434B (zh) * 2022-03-17 2024-04-05 南京市妇幼保健院 一种用于激活原始卵泡从而治疗或辅助治疗卵巢早衰的多肽pfap1及其应用
KR102924689B1 (ko) * 2022-04-19 2026-02-06 충북대학교 산학협력단 종양 특이적 펩타이드가 부착된 복합체의 제조방법 및 이로부터 제조된 복합체를 포함하는 종양 성장 억제용 약학 조성물
JP2025515424A (ja) 2022-04-29 2025-05-15 クール ファーマシューティカルズ ディベロップメント カンパニー インコーポレイテッド 治療用ベクター及びタンパク質の免疫原性を克服するための寛容化免疫改変ナノ粒子
GB202211696D0 (en) * 2022-08-10 2022-09-21 Univ London Queen Mary Peptides and method
EP4593882A1 (en) * 2022-09-26 2025-08-06 The Methodist Hospital Microparticle formulations for intravenous therapy and methods for their manufacture and use
IL320303A (en) 2022-10-19 2025-06-01 Cour Pharmaceuticals Dev Company Inc Treatment of peanut allergy with tolerizing nanoparticles
EP4611796A1 (en) * 2022-11-01 2025-09-10 Universität Zürich Novel mbp peptides and their use in the treatment of multiple sclerosis
CN121175067A (zh) 2023-03-24 2025-12-19 库尔制药开发公司 用于重症肌无力治疗的耐受性免疫修饰纳米颗粒
EP4716528A1 (en) 2023-05-23 2026-04-01 Cour Pharmaceuticals Development Company Inc. Preparation of tolerizing nanoparticles for the treatment of primary biliary cholangitis
AU2024277573A1 (en) 2023-05-25 2025-12-11 Cour Pharmaceuticals Development Company Inc. Treatment of type 1 diabetes (t1d) with tolerizing nanoparticles
CN118005728B (zh) * 2024-02-26 2025-04-15 杭州禾泰健宇生物科技有限公司 一种抗光老化多肽及其应用
WO2025199149A1 (en) 2024-03-18 2025-09-25 Cour Pharmaceuticals Development Company Inc. Sting agonism for antigen specific tolerance
KR20260001113A (ko) * 2024-06-25 2026-01-05 가톨릭대학교 산학협력단 면역조절과 항섬유화 동시 조절을 위한 전신경화증 치료용 자가항원 특이 나노융합 백신 조성물
WO2026015713A1 (en) * 2024-07-10 2026-01-15 The Regents Of The University Of Michigan Tolerizing immune modifying nanoparticles for treatment of alpha gal syndrome
WO2026019942A2 (en) 2024-07-16 2026-01-22 Cour Pharmaceuticals Development Company Inc. Tolerizing immune modifying nanoparticles for treatment of narcolepsy

Family Cites Families (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3512940A (en) 1968-12-30 1970-05-19 Justin J Shapiro Test tube filter device
CH624011A5 (es) * 1977-08-05 1981-07-15 Battelle Memorial Institute
US4348384A (en) * 1980-10-17 1982-09-07 Dainippon Pharmaceutical Co., Ltd. Pharmaceutical composition for oral administration containing coagulation factor VIII or IX
GB8311730D0 (en) 1983-04-29 1983-06-02 Bagshawe K D Handling of reaction mixtures
US4751180A (en) 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
US4935233A (en) 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US4990253A (en) 1988-01-25 1991-02-05 Abbott Laboratories Fluid sample filtration device
US5358690A (en) 1989-01-10 1994-10-25 Lamina, Ltd. Environmental sample collection and membrane testing device
DE9013914U1 (de) 1990-10-05 1991-02-14 Walter Sarstedt Geräte und Verbrauchsmaterial für Medizin und Wissenschaft, 5223 Nümbrecht Trennvorrichtung für Flüssigkeits-, insbesondere Blutfraktionen
ES2190784T3 (es) 1992-02-28 2003-08-16 Autoimmune Inc Supresion de enfermedades autoinmunes por antigenos espectadores.
FR2695563B1 (fr) 1992-09-11 1994-12-02 Pasteur Institut Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires.
US6004763A (en) 1992-09-11 1999-12-21 Institut Pasteur Antigen-carrying microparticles and their use in the induction of humoral or cellular responses
JPH06157592A (ja) 1992-11-24 1994-06-03 Hitachi Chem Co Ltd ペプチドもしくはその誘導体、それらとタンパク質との結合体、及びこれらを免疫源とする抗エンドセリン−１抗体の製造方法
WO1994027634A1 (en) 1993-06-02 1994-12-08 Institute For Child Health Research Cryptic peptides for use in inducing immunologic tolerance
US5833860A (en) 1995-08-28 1998-11-10 Millipore Investment Holdings Limited Centrifugal adsorptive sample preparation device and method
US5804201A (en) 1996-03-11 1998-09-08 The Rockefeller University Immunomodulatory peptides of vespid antigen 5
EP0991705B1 (en) 1997-03-31 2003-09-10 The Regents Of The University Of Michigan Open pore biodegradable matrices
US7427602B1 (en) 1998-05-13 2008-09-23 The Regents Of The University Of Michigan Sustained DNA delivery from structural matrices
AU5307899A (en) * 1999-08-18 2001-03-13 Catholic Educational Foundation Immunological tolerance-induction agent
US20010031262A1 (en) * 1999-12-06 2001-10-18 Michael Caplan Controlled delivery of antigens
CA2410510A1 (en) 2000-06-02 2001-12-13 Memorial Sloan-Kettering Cancer Center Artificial antigen presenting cells and methods of use thereof
WO2002016414A2 (en) 2000-08-22 2002-02-28 Micromet Ag Composition for the elimination of autoreactive b-cells
US7029697B2 (en) 2001-02-14 2006-04-18 Northwestern University Controlled surface-associated delivery of genes and oligonucleotides
US6890556B1 (en) 2001-02-14 2005-05-10 Northwestern University Controlled surface-associated delivery of genes and oligonucleotides
US20020187147A1 (en) * 2001-02-15 2002-12-12 City Of Hope Antigen specific recombinant MHC class II molecules and methods of use
US20030166509A1 (en) 2001-11-20 2003-09-04 Advanced Inhalation Research, Inc. Compositions for sustained action product delivery and methods of use thereof
ATE491471T1 (de) 2002-03-19 2011-01-15 Powderject Res Ltd Adjuvantien für dns impstoffe basierend auf imidazochinoline
AU2003243191B2 (en) 2002-05-02 2007-09-20 President And Fellows Of Harvard College Formulations limiting spread of pulmonary infections
CA2493081C (en) 2002-07-12 2013-04-23 The Johns Hopkins University Reagents and methods for engaging unique clonotypic lymphocyte receptors
US7465463B2 (en) 2002-09-04 2008-12-16 Polyheal, Ltd. Compositions comprising microspheres with anti-inflammatory properties for healing of ocular tissues
WO2004053056A2 (en) * 2002-09-24 2004-06-24 University Of Kentucky Research Foundation Nanoparticle-based vaccine delivery system containing adjuvant
US20050002999A1 (en) * 2003-06-04 2005-01-06 Rahul Mehta Long-circulating liposomal compositions
US20060051407A1 (en) 2003-06-27 2006-03-09 Yoram Richter Method of treating ischemia-reperfusion injury
US8592197B2 (en) 2003-07-11 2013-11-26 Novavax, Inc. Functional influenza virus-like particles (VLPs)
WO2005015160A2 (en) 2003-08-07 2005-02-17 The Children's Hospital Of Philadelphia Functionalized polymeric colloids
WO2005019429A2 (en) 2003-08-22 2005-03-03 Potentia Pharmaceuticals, Inc. Compositions and methods for enhancing phagocytosis or phagocyte activity
US9149440B2 (en) 2003-09-02 2015-10-06 University Of South Florida Nanoparticles for drug-delivery
EP1687024B1 (en) 2003-11-05 2011-10-19 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Carbohydrate antigen-nanoparticle conjugates and uses thereof as antimetastatic agents in treating cancer
ATE438973T1 (de) 2004-04-02 2009-08-15 Research In Motion Ltd Einsatz und provisionierung drahtloser in der hand gehaltener einrichtungen
US7846466B2 (en) 2004-06-10 2010-12-07 Northwestern University Biodegradable scaffolds and uses thereof
AU2005326322B2 (en) 2004-07-01 2009-02-05 Yale University Targeted and high density drug loaded polymeric materials
AU2006209335A1 (en) * 2005-01-18 2006-07-27 National University Corporation Hokkaido University Method for coating particle with lipid film
ES2438145T3 (es) 2005-02-02 2014-01-16 Novo Nordisk A/S Nuevos derivados de insulina
JP2006248978A (ja) 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
MX2007016039A (es) 2005-06-17 2008-10-27 Univ North Carolina Metodos, sistemas y materiales de fabricacion de nanoparticulas.
WO2007003327A1 (en) * 2005-07-01 2007-01-11 Roche Diagnostics Gmbh Carboxylated latex particles
WO2007008755A2 (en) 2005-07-08 2007-01-18 The Board Of Regents, The University Of Texas System Surface functionalization of polymeric materials
GB0514262D0 (en) * 2005-07-12 2005-08-17 Renovo Ltd Promotion of epithelial regeneration
US20070041934A1 (en) 2005-08-12 2007-02-22 Regents Of The University Of Michigan Dendrimer based compositions and methods of using the same
WO2007076295A2 (en) * 2005-12-16 2007-07-05 University Of Kansas Nanoclusters for delivery of therapeutics
WO2007087341A2 (en) 2006-01-25 2007-08-02 The Board Of Trustees Of The University Of Illinois Tolerogenic biodegradable artificial antigen presenting system
US20090304726A1 (en) * 2006-02-15 2009-12-10 Ramot At Tel Aviv University Ltd. Viral display vehicles for treating multiple sclerosis
CA2644058C (en) 2006-03-02 2016-08-09 Cbio Limited Regulation of immune responses by modulation of the function of antigen presenting cells
AU2007309727A1 (en) * 2006-04-11 2008-05-02 Albany College Of Pharmacy And Health Sciences Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations thereof
WO2008012563A2 (en) * 2006-07-28 2008-01-31 University Court Of The University Of Edinburgh Use of cdk inhibitors for the treatment of granulocyte mediated disorders
CA2702340C (en) * 2006-10-12 2014-12-16 The University Of Queensland Compositions and methods for modulating immune responses
US20090214474A1 (en) 2006-11-01 2009-08-27 Barbara Brooke Jennings Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
RU2481125C2 (ru) 2006-12-18 2013-05-10 Колороббия Италия С.П.А. Магнитные наночастицы для применения при гипертермии, их приготовление и применение в магнитных системах для фармакологического использования
AU2008222678B2 (en) 2007-03-07 2013-01-17 The General Hospital Corporation Compositions and methods for the prevention and treatment of autoimmune conditions
AU2008240155B2 (en) 2007-04-13 2012-09-20 University Of North Texas Health Science Center At Fort Worth Formulation of active agent loaded activated PLGA nanoparticles for targeted cancer nano-therapeutics
US20080311140A1 (en) 2007-05-29 2008-12-18 Baylor College Of Medicine Antigen specific immunosuppression by dendritic cell therapy
CA2917512C (en) 2007-10-12 2025-08-05 President And Fellows Of Harvard College VACCINE NANOTECHNOLOGY
WO2009049365A1 (en) 2007-10-15 2009-04-23 Cooperative Research Centre For Asthma A method of prophylaxis and agents for use therein
WO2009052561A1 (en) 2007-10-22 2009-04-30 The Walter And Eliza Hall Institute Of Medical Research Compositions and methods for manipulating an immune response
EP2057998A1 (en) 2007-10-31 2009-05-13 Universitätsklinikum Hamburg-Eppendorf Use of modified cells for the treatment of multiple sclerosis
US20090123509A1 (en) * 2007-11-08 2009-05-14 Cory Berkland Biodegradable Colloidal Gels as Moldable Tissue Engineering Scaffolds
US20090238879A1 (en) 2008-01-24 2009-09-24 Northwestern University Delivery scaffolds and related methods of use
JP2009203174A (ja) 2008-02-26 2009-09-10 Hokkaido Univ タンパク質−リポソーム複合体を含有するイオントフォレーシス用組成物
WO2009131712A2 (en) 2008-04-25 2009-10-29 Duke University Medical Center Regulatory b cells and their uses
US20110206773A1 (en) 2008-05-20 2011-08-25 Yale University Sustained delivery of drugs from biodegradable polymeric microparticles
EP2123261A1 (en) 2008-05-20 2009-11-25 Stallergenes S.A. Mucoadhesive particulate formulation for inducing antigen-specific immune tolerance
WO2010003009A2 (en) 2008-07-01 2010-01-07 Emory University Synergistic induction of humoral and cellular immunity by combinatorial activation of toll-like receptors
US8323696B2 (en) 2008-08-29 2012-12-04 Ecole Polytechnique Federale De Lausanne Nanoparticles for immunotherapy
CA2738855A1 (en) * 2008-09-29 2010-04-01 The Corporation Of Mercer University Nanospheres encapsulating bioactive material and method for formulation of nanospheres
ES2651948T3 (es) 2008-10-02 2018-01-30 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Administración de un polímero adsorbente para el tratamiento de la inflamación sistémica
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
MX346450B (es) 2008-11-30 2017-03-17 Immusant Inc * Composiciones y métodos para el tratamiento de la enfermedad celíaca.
CA2746124A1 (en) 2008-12-11 2010-06-17 The Governors Of The University Of Alberta Methods and systems for inducing immunologic tolerance to non-self antigens
MX2011007559A (es) * 2009-01-20 2011-12-06 Myelin Repair Foundation Inc Composiciones y metodos para induccion de tolerancia antigeno-especifica.
EP2255831A1 (en) * 2009-05-25 2010-12-01 Institut Pasteur Liposome based diepitope constructs
WO2010138192A2 (en) 2009-05-27 2010-12-02 Selecta Biosciences, Inc. Nanocarriers possessing components with different rates of release
WO2011031441A1 (en) 2009-08-28 2011-03-17 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Therapy with a chimeric molecule and a pro-apoptotic agent
JP5486750B2 (ja) 2009-09-18 2014-05-07 国立大学法人九州大学 金微粒子被覆体とその製造方法、およびその用途
RU2448685C2 (ru) * 2009-11-30 2012-04-27 Российская Федерация в лице Министерства промышленности и торговли Российской Федерации Липосомы, содержащие олигопептиды - фрагменты основного белка миелина, фармацевтическая композиция и способ лечения рассеянного склероза
US20110135744A1 (en) 2009-12-03 2011-06-09 The Regents Of The University Of California Nanoparticle Based Therapy for Dispersing Mucin
EP2538969A4 (en) * 2010-02-22 2013-11-27 Liquidia Technologies Inc VACCINES FROM POLYSACCHARIDE PARTICLES
WO2011119262A1 (en) 2010-03-26 2011-09-29 Cerulean Pharma Inc. Methods and systems for generating nanoparticles
US9168225B2 (en) * 2010-04-23 2015-10-27 The Board Of Trustees Of The University Of Illinois Nano-hybrid delivery system for sequential utilization of passive and active targeting
JP5703372B2 (ja) 2010-06-04 2015-04-15 トンジ ユニバーシティＴｏｎｇｊｉ Ｕｎｉｖｅｒｓｉｔｙ ピレンおよびピロールのコポリマーならびに該コポリマーの生成方法
AU2011261203B2 (en) 2010-06-04 2014-11-20 Flow Pharma Inc. Peptide particle formulation
CA2805024A1 (en) 2010-06-30 2012-01-05 Compugen Ltd. Polypeptides and uses thereof as a drug for treatment of multiples sclerosis, rheumatoid arthritis and other autoimmune disorders
CA2799934C (en) * 2010-07-07 2020-01-28 Artificial Cell Technologies, Inc. Respiratory syncytial virus antigenic compositions and methods
CA2807141C (en) 2010-07-31 2019-02-26 The Scripps Research Institute Compositions and methods for inducing immune tolerance
US10131875B2 (en) 2010-08-04 2018-11-20 Duke University Regulatory B cells and their uses
JP5909745B2 (ja) 2010-11-12 2016-04-27 クール ファーマシューティカルズ ディベロップメント カンパニー 炎症性疾患の治療薬、ならびにウイルスまたは細菌感染疾患の治療薬
US20130295186A1 (en) 2010-11-24 2013-11-07 Say Chye Joachim Loo Method for coating particles with calcium phosphate and particles, microparticles and nanoparticles formed thereof
US10064406B2 (en) 2011-01-06 2018-09-04 Cytosorbents Corporation Polymeric sorbent for removal of impurities from whole blood and blood products
US20140079642A1 (en) * 2011-01-24 2014-03-20 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Nanoparticles based for dermal and systemic delivery of drugs
EP2678007A4 (en) * 2011-02-25 2015-08-12 Univ South Dakota PROTEIN NANOTRIER FOR TOPICAL ADMINISTRATION
KR20140041505A (ko) 2011-04-29 2014-04-04 셀렉타 바이오사이언시즈, 인크. 조절 b 세포 유도를 위한 관용원성 합성 나노운반체
US20130028857A1 (en) 2011-07-29 2013-01-31 Selecta Biosciences, Inc. Synthetic nanocarriers comprising polymers comprising multiple immunomodulatory agents
WO2013036296A1 (en) 2011-09-06 2013-03-14 Selecta Biosciences, Inc. Compositions and methods for producing antigen-specific induced tolerogenic dendritic cells with synthetic nanocarriers
KR102284689B1 (ko) 2011-10-21 2021-08-02 셀라토 파마슈티칼즈, 인코포레이티드 동결건조된 리포좀
WO2013113326A1 (en) * 2012-01-31 2013-08-08 Curevac Gmbh Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen
HK1204970A1 (en) * 2012-01-31 2015-12-11 Cerulean Pharma Inc. Polymer-agent conjugates, particles, compositions, and related methods of use
CA2876495C (en) * 2012-06-21 2023-10-17 Northwestern University Peptide conjugated particles
US9378793B2 (en) * 2012-12-20 2016-06-28 Qualcomm Incorporated Integrated MRAM module
HK1220368A1 (zh) 2013-03-13 2017-05-05 Cour Pharmaceuticals Development Company 用於治疗炎症的免疫修饰性颗粒
CN105555301B (zh) 2013-08-13 2021-04-16 西北大学 肽缀合颗粒
US20160243221A1 (en) * 2013-10-18 2016-08-25 Moderna Therapeutics, Inc. Compositions and methods for tolerizing cellular systems

Also Published As

Publication number Publication date
MX372849B (es) 2020-07-06
US20220008523A1 (en) 2022-01-13
ME03590B (me) 2020-07-20
PT3033102T (pt) 2019-12-19
BR112016003084A2 (pt) 2017-09-12
EP3033102A4 (en) 2017-03-22
US11389517B2 (en) 2022-07-19
KR20240015725A (ko) 2024-02-05
MX2023000194A (es) 2023-02-09
US11160851B2 (en) 2021-11-02
ES2762187T3 (es) 2020-05-22
AU2020203824B2 (en) 2023-06-22
US20150283218A1 (en) 2015-10-08
RU2016107998A (ru) 2017-09-18
SMT201900717T1 (it) 2020-03-13
US20170258880A1 (en) 2017-09-14
RU2685186C2 (ru) 2019-04-16
MX2023000192A (es) 2023-02-09
IL243632B (en) 2020-04-30
KR20250162913A (ko) 2025-11-19
US10617747B2 (en) 2020-04-14
PL3033102T5 (pl) 2024-04-08
HUE047329T2 (hu) 2020-04-28
US12533403B2 (en) 2026-01-27
RS59801B1 (sr) 2020-02-28
DK3033102T4 (da) 2024-02-26
WO2015023796A2 (en) 2015-02-19
KR20220084202A (ko) 2022-06-21
AU2023219813A1 (en) 2023-09-07
PL3033102T3 (pl) 2020-09-07
CY1122558T1 (el) 2021-01-27
KR20230008909A (ko) 2023-01-16
DK3033102T3 (da) 2019-12-16
ES2762187T5 (es) 2024-06-17
CN113332422B (zh) 2025-03-14
SI3033102T2 (sl) 2024-03-29
KR102485789B1 (ko) 2023-01-05
AU2020203822B2 (en) 2023-05-25
CN105555301A (zh) 2016-05-04
IL273615A (en) 2020-05-31
EP3033102B1 (en) 2019-10-23
JP7007335B2 (ja) 2022-02-10
EP3033102B2 (en) 2023-12-20
US9616113B2 (en) 2017-04-11
US20200316181A1 (en) 2020-10-08
EP3033102A2 (en) 2016-06-22
AU2020203824A1 (en) 2020-07-02
CA2918823A1 (en) 2015-02-19
JP2021193086A (ja) 2021-12-23
HRP20192270T4 (hr) 2024-03-01
US20250049901A1 (en) 2025-02-13
US20220000994A1 (en) 2022-01-06
EP3650047A1 (en) 2020-05-13
RU2019110510A (ru) 2019-10-21
KR20210099186A (ko) 2021-08-11
US20210000932A1 (en) 2021-01-07
US20180271962A1 (en) 2018-09-27
IL273615B (en) 2022-06-01
FI3033102T4 (fi) 2024-03-01
KR20250151570A (ko) 2025-10-21
KR20160042079A (ko) 2016-04-18
SI3033102T1 (sl) 2020-03-31
AU2014306603A1 (en) 2016-02-18
US20150190485A1 (en) 2015-07-09
JP2016528254A (ja) 2016-09-15
IL243632A0 (en) 2016-03-31
JP2024037982A (ja) 2024-03-19
CN113332422A (zh) 2021-09-03
CN105555301B (zh) 2021-04-16
IL292567A (en) 2022-06-01
MX2020004799A (es) 2020-10-19
IL292567B1 (en) 2025-02-01
LT3033102T (lt) 2020-03-10
JP7408604B2 (ja) 2024-01-05
JP6553033B2 (ja) 2019-07-31
US11129881B2 (en) 2021-09-28
RS59801B2 (sr) 2024-03-29
US10188711B2 (en) 2019-01-29
IL292567B2 (en) 2025-06-01
AU2020203822A1 (en) 2020-07-02
US9522180B2 (en) 2016-12-20
MX2016001931A (es) 2016-09-07
HRP20192270T1 (hr) 2020-06-12
IL318076A (en) 2025-02-01
AU2014306603B2 (en) 2020-03-12
JP2019196369A (ja) 2019-11-14
US20170312349A1 (en) 2017-11-02
WO2015023796A3 (en) 2015-06-18

Similar Documents

Publication Publication Date Title
MX2023000192A (es) Particulas conjugadas con peptidos.
MX363889B (es) Particulas conjugadas de peptidos.
MX393931B (es) Composiciones y usos de las mismas para inmunoterapia.
MX2019003214A (es) Formulaciones de proteina de inmunoglobulina del dominio variable dual estable.
CY1121560T1 (el) Ανοσογονικη συνθεση
EA201690314A1 (ru) Анти-garp-белок и его применения
EA201591137A1 (ru) Ингибиторы mk2 и их применения
MX2014012978A (es) Regiones de anticuerpo modificado y sus usos.
SG10201811017QA (en) Novel antibody frameworks
EA201690280A1 (ru) Композиции и способы, относящиеся к выделенным эндофитам
MX373334B (es) Composiciones y métodos.
ZA201600157B (en) Anti-complement factor c1q antibodies and uses thereof
CL2013000028S1 (es) Conector
MX391989B (es) Conjugados de amatoxina y anticuerpos.
MX371187B (es) Péptidos terapéuticos.
IN2014MN02276A (es)
IN2014MN02278A (es)
TR201905787T4 (tr) Liyofilize TAT-NR2B9C formülasyonu.
EA033491B1 (ru) Конъюгатные вакцины на основе сальмонеллы
EP3054010A4 (en) Tumor antigen peptide
EP3020806A4 (en) Tumor antigen peptide
TWD159828S (zh) 連接器
EP3008085A4 (en) Anti-factor viii antibodies or uses thereof
IN2014DN00168A (es)
IN2013CH02554A (es)