MX346362B - Composiciones y metodos para inhibir la adhesion celular o dirigir agentes de diagnostico o terapeuticos a sitios de enlace rgd. - Google Patents

Composiciones y metodos para inhibir la adhesion celular o dirigir agentes de diagnostico o terapeuticos a sitios de enlace rgd.

Info

Publication number
MX346362B
MX346362B MX2012005222A MX2012005222A MX346362B MX 346362 B MX346362 B MX 346362B MX 2012005222 A MX2012005222 A MX 2012005222A MX 2012005222 A MX2012005222 A MX 2012005222A MX 346362 B MX346362 B MX 346362B
Authority
MX
Mexico
Prior art keywords
binding sites
methods
therapeutic agents
rgd binding
cellular adhesion
Prior art date
Application number
MX2012005222A
Other languages
English (en)
Other versions
MX2012005222A (es
Inventor
Park John
John Mackel Michael
Original Assignee
Allegro Pharmaceuticals Inc *
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allegro Pharmaceuticals Inc * filed Critical Allegro Pharmaceuticals Inc *
Publication of MX2012005222A publication Critical patent/MX2012005222A/es
Publication of MX346362B publication Critical patent/MX346362B/es

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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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    • A61K51/04—Organic compounds
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    • A61K51/065—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P5/00—Drugs for disorders of the endocrine system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Surgery (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)

Abstract

La presente invención se refiere a compuestos que comprenden ácido R-G-cistéico (es decir, R-G-NH-CH (CH2-SO3H) COOH o Arg-GIy-NH-CH (CH2-SO3H) COOH) y sus derivados, incluyendo sus sales farmacéuticas aceptables, hidratos, estereoisómeros, multímeros, formas cíclicas, formas lineares, conjugados-fármaco, pro-fármacos y sus derivados. También se describen métodos para producir y usar tales compuestos incluyendo los métodos para inhibir la adhesión celular a los sitios de enlace RGD o suministrar otros agentes de diagnóstico o terapéuticos a los sitios de enlace RGD en sujetos humanos o animales.
MX2012005222A 2009-11-10 2010-11-10 Composiciones y metodos para inhibir la adhesion celular o dirigir agentes de diagnostico o terapeuticos a sitios de enlace rgd. MX346362B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25974809P 2009-11-10 2009-11-10
PCT/US2010/056277 WO2011060104A2 (en) 2009-11-10 2010-11-10 Compositions and methods for inhibiting cellular adhesion or directing diagnostic or therapeutic agents to rgd binding sites

Publications (2)

Publication Number Publication Date
MX2012005222A MX2012005222A (es) 2012-08-15
MX346362B true MX346362B (es) 2017-03-15

Family

ID=43992385

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012005222A MX346362B (es) 2009-11-10 2010-11-10 Composiciones y metodos para inhibir la adhesion celular o dirigir agentes de diagnostico o terapeuticos a sitios de enlace rgd.

Country Status (17)

Country Link
US (5) US9018352B2 (es)
EP (2) EP3586879A1 (es)
JP (3) JP5912082B2 (es)
KR (2) KR102237243B1 (es)
CN (3) CN105106934A (es)
AU (2) AU2010319559A1 (es)
BR (1) BR112012011731A2 (es)
CA (1) CA2780243C (es)
ES (1) ES2730927T3 (es)
HK (1) HK1218075A1 (es)
IL (2) IL219701A (es)
MX (1) MX346362B (es)
NZ (2) NZ700296A (es)
PL (1) PL2504035T3 (es)
RU (1) RU2642625C2 (es)
WO (1) WO2011060104A2 (es)
ZA (1) ZA201204209B (es)

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EP3570867A4 (en) * 2017-01-19 2020-12-23 Allegro Pharmaceuticals, LLC THERAPEUTIC PEPTIDES AND NEUROPROTECTORS
EP4389216A3 (en) 2017-06-19 2024-11-06 Allegro Pharmaceuticals, LLC Peptide compositions and therapeutic uses
US12454549B2 (en) 2017-06-19 2025-10-28 Jenius Pharma, Llc Treatments for diseases and disorders that involve oxidative stress
CN113825542A (zh) * 2019-03-21 2021-12-21 库特克希米公司 精氨酸牙龈蛋白酶抑制剂
EP3958915A4 (en) * 2019-04-22 2023-01-11 Allegro Ophthalmics, LLC COMPOSITIONS AND METHODS USABLE FOR THE TREATMENT OF DRY EYE
CN110669142B (zh) * 2019-09-30 2021-10-12 湖南农业大学 融合rgd的猪圆环病毒2型病毒样颗粒、突变型感染性克隆及其制备方法和应用
IL296239A (en) * 2020-03-06 2022-11-01 Allegro Pharmaceuticals Llc Treatments to improve or reduce damage to mitochondrial function
TWI776410B (zh) * 2021-03-02 2022-09-01 台灣基督長老教會馬偕醫療財團法人馬偕紀念醫院 短合成胜肽及其用於治療乾眼症之用途
WO2022234536A1 (en) * 2021-05-06 2022-11-10 Association For The Advancement Of Tissue Engineering And Cell Based Technologies & Therapies (A4Tec) - Associação Hydrogel based on hyaluronic acid polymer for use for treating solid tumours
CN113577246B (zh) * 2021-08-02 2023-11-03 赛克赛斯生物科技股份有限公司 一种预防瘢痕粘连的组合物、术后防粘连材料及应用
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