MX366365B - Peptidos de kntc2 y vacunas que los contienen. - Google Patents

Peptidos de kntc2 y vacunas que los contienen.

Info

Publication number
MX366365B
MX366365B MX2015012012A MX2015012012A MX366365B MX 366365 B MX366365 B MX 366365B MX 2015012012 A MX2015012012 A MX 2015012012A MX 2015012012 A MX2015012012 A MX 2015012012A MX 366365 B MX366365 B MX 366365B
Authority
MX
Mexico
Prior art keywords
peptides
kntc2
ctl
methods
antigen
Prior art date
Application number
MX2015012012A
Other languages
English (en)
Other versions
MX2015012012A (es
Inventor
Tsunoda Takuya
Yoshimura Sachiko
Watanabe Tomohisa
Osawa Ryuji
Original Assignee
Oncotherapy Science Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncotherapy Science Inc filed Critical Oncotherapy Science Inc
Publication of MX2015012012A publication Critical patent/MX2015012012A/es
Publication of MX366365B publication Critical patent/MX366365B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/19—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a vacunas de péptidos contra el cáncer. En particular, se proporcionan péptidos epítopos aislados derivados del gen KNTC2 que provocan LTC y por lo tanto son convenientes para el uso en el contexto de la inmunoterapia del cáncer. Los péptidos de la invención abarcan tanto péptidos derivados de KNTC2 como versiones modificadas de los mismos, en las cuales uno, dos o varios aminoácidos son sustituidos, suprimidos, insertados o agregados, siempre que estas versiones modificadas retengan la inducibilidad de LTC necesaria de las secuencias originales. Además se proporcionan polinucleótidos que codifican estos péptidos, así como composiciones farmacéuticas que incluyen cualquiera de estos péptidos o polinucleótidos como agentes activos. También se proporcionan células presentadoras de antígeno y LTC aislados dirigidos a estos péptidos, así como métodos para inducir la célula presentadora de antígeno o el LTC. Además, la presente invención proporciona métodos para el tratamiento y/o la profilaxis (es decir, prevención) de cánceres (tumores) y/o la prevención de la recidiva metastásica o postoperatoria de los mismos, así como métodos para inducir LTC, métodos para inducir inmunidad antitumorosa, utilizando los péptidos derivados de KNTC2, polinucleótidos que codifican los péptidos o células presentadoras de antígeno que presentan los péptidos, o las composiciones farmacéuticas de la presente invención.
MX2015012012A 2013-03-12 2014-03-11 Peptidos de kntc2 y vacunas que los contienen. MX366365B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361777334P 2013-03-12 2013-03-12
PCT/JP2014/001350 WO2014141683A1 (en) 2013-03-12 2014-03-11 Kntc2 peptides and vaccines containing the same

Publications (2)

Publication Number Publication Date
MX2015012012A MX2015012012A (es) 2016-04-07
MX366365B true MX366365B (es) 2019-07-05

Family

ID=51536362

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015012012A MX366365B (es) 2013-03-12 2014-03-11 Peptidos de kntc2 y vacunas que los contienen.

Country Status (17)

Country Link
US (1) US9597382B2 (es)
EP (1) EP2970944B1 (es)
JP (1) JP6295491B2 (es)
KR (1) KR102213574B1 (es)
CN (1) CN105164256B (es)
AR (1) AR095386A1 (es)
AU (1) AU2014232630B2 (es)
BR (1) BR112015021828A2 (es)
CA (1) CA2903139C (es)
DK (1) DK2970944T3 (es)
ES (1) ES2739693T3 (es)
IL (1) IL240701B (es)
MX (1) MX366365B (es)
RU (1) RU2671395C2 (es)
SG (2) SG10201707316WA (es)
TW (1) TWI658049B (es)
WO (1) WO2014141683A1 (es)

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Also Published As

Publication number Publication date
RU2671395C2 (ru) 2018-10-30
SG10201707316WA (en) 2017-10-30
CN105164256A (zh) 2015-12-16
AU2014232630B2 (en) 2020-07-09
US20160008445A1 (en) 2016-01-14
HK1214838A1 (en) 2016-08-05
KR102213574B1 (ko) 2021-02-09
JP6295491B2 (ja) 2018-03-20
EP2970944A1 (en) 2016-01-20
KR20150126390A (ko) 2015-11-11
EP2970944B1 (en) 2019-05-08
RU2015143164A (ru) 2017-04-13
AR095386A1 (es) 2015-10-14
CA2903139A1 (en) 2014-09-18
SG11201507236XA (en) 2015-10-29
CA2903139C (en) 2022-07-26
JP2016511221A (ja) 2016-04-14
DK2970944T3 (da) 2019-07-22
CN105164256B (zh) 2018-10-19
WO2014141683A1 (en) 2014-09-18
IL240701B (en) 2022-02-01
ES2739693T3 (es) 2020-02-03
IL240701A0 (en) 2015-10-29
US9597382B2 (en) 2017-03-21
EP2970944A4 (en) 2017-04-19
MX2015012012A (es) 2016-04-07
AU2014232630A1 (en) 2015-09-17
TWI658049B (zh) 2019-05-01
BR112015021828A2 (pt) 2017-08-29
TW201443077A (zh) 2014-11-16

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