MX367960B - Procedimiento para la preparacion de (4s)-4-(4-ciano-2-metoxifenil o)-5-etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridina-3-carboxamida y su purificacion para su uso como principio activo farmaceutico. - Google Patents

Procedimiento para la preparacion de (4s)-4-(4-ciano-2-metoxifenil o)-5-etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridina-3-carboxamida y su purificacion para su uso como principio activo farmaceutico.

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Publication number
MX367960B
MX367960B MX2018002027A MX2018002027A MX367960B MX 367960 B MX367960 B MX 367960B MX 2018002027 A MX2018002027 A MX 2018002027A MX 2018002027 A MX2018002027 A MX 2018002027A MX 367960 B MX367960 B MX 367960B
Authority
MX
Mexico
Prior art keywords
naphthyridine
carboxamide
methoxyphenyl
dihydro
ethoxy
Prior art date
Application number
MX2018002027A
Other languages
English (en)
Other versions
MX2018002027A (es
Inventor
Platzek Johannes
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53938271&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX367960(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of MX2018002027A publication Critical patent/MX2018002027A/es
Publication of MX367960B publication Critical patent/MX367960B/es

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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Abstract

La presente invención se refiere a un procedimiento nuevo y mejorado para la preparación de (4S)-4-(4-ciano-2-metoxifenilo)-5- etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridina-3-carboxamida de la fórmula (I). (ver Fórmula).
MX2018002027A 2015-08-21 2016-08-18 Procedimiento para la preparacion de (4s)-4-(4-ciano-2-metoxifenil o)-5-etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridina-3-carboxamida y su purificacion para su uso como principio activo farmaceutico. MX367960B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15182043 2015-08-21
PCT/EP2016/069558 WO2017032673A1 (de) 2015-08-21 2016-08-18 Verfahren zur herstellung von (4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carboxamid und dessen aufreinigung für die verwendung als pharmazeutischer wirkstoff

Publications (2)

Publication Number Publication Date
MX2018002027A MX2018002027A (es) 2018-06-15
MX367960B true MX367960B (es) 2019-09-12

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ID=53938271

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MX2018002027A MX367960B (es) 2015-08-21 2016-08-18 Procedimiento para la preparacion de (4s)-4-(4-ciano-2-metoxifenil o)-5-etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridina-3-carboxamida y su purificacion para su uso como principio activo farmaceutico.

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US (2) US10336749B2 (es)
EP (1) EP3337800B1 (es)
JP (1) JP6824247B2 (es)
KR (1) KR102669559B1 (es)
CN (1) CN107849043B (es)
AR (1) AR105774A1 (es)
AU (1) AU2016312904C1 (es)
CA (1) CA2995905A1 (es)
CL (1) CL2018000427A1 (es)
CO (1) CO2018001466A2 (es)
DK (1) DK3337800T3 (es)
ES (1) ES2739904T3 (es)
HR (1) HRP20191431T1 (es)
HU (1) HUE044574T2 (es)
IL (1) IL257371B (es)
JO (1) JOP20160186B1 (es)
LT (1) LT3337800T (es)
MX (1) MX367960B (es)
MY (1) MY195226A (es)
PE (1) PE20180554A1 (es)
PL (1) PL3337800T3 (es)
PT (1) PT3337800T (es)
RS (1) RS59055B1 (es)
RU (1) RU2743429C2 (es)
SG (1) SG11201801110TA (es)
SI (1) SI3337800T1 (es)
TW (1) TWI725045B (es)
UA (1) UA129174C2 (es)
UY (1) UY36864A (es)
WO (1) WO2017032673A1 (es)
ZA (1) ZA201801859B (es)

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CN110317265B (zh) * 2018-03-28 2023-03-10 江苏豪森药业集团有限公司 比伐芦定晶型a及其制备方法
EP3560922A1 (de) 2018-04-24 2019-10-30 Bayer Aktiengesellschaft Verfahren zur herstellung von (4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbox-amid durch racemat-spaltung mittels diastereomerer weinsäureester
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JP7757278B2 (ja) * 2019-10-17 2025-10-21 バイエル アクチェンゲゼルシャフト （４ｓ）－（４－シアノ－２－メトキシフェニル）－５－エトキシ－２，８－ジメチル－１，４－ジヒドロ－１，６－ナフチリジン－３－カルボン酸のアシルオキシメチルエステルの製造方法
CN115340539B (zh) 2022-01-19 2024-02-27 奥锐特药业股份有限公司 制备非奈利酮及其中间体的方法
CN114524812A (zh) * 2022-03-18 2022-05-24 湖南凯铂生物药业有限公司 1,4-二氢-1,6-萘啶化合物的晶型制备以及合成方法
WO2023205164A1 (en) 2022-04-18 2023-10-26 Teva Pharmaceuticals International Gmbh Processes for the preparation of finerenone
WO2024075139A1 (en) * 2022-10-06 2024-04-11 Maithri Drugs Private Limited A process for preparation of finerenone and intermediates thereof
TW202438065A (zh) * 2023-03-17 2024-10-01 大陸商江蘇恒瑞醫藥股份有限公司 1,4-二氫-1,6-萘啶醯胺化合物的可藥用鹽、晶型及其製備方法
CN116715664B (zh) * 2023-06-12 2025-01-17 常州制药厂有限公司 一种非奈利酮关键中间体的制备方法
CN117924273A (zh) * 2024-01-05 2024-04-26 江苏德源药业股份有限公司 一种非奈利酮原料药的制备方法
CN119684288B (zh) * 2024-12-18 2026-04-17 中山百盛生物技术有限公司 非奈利酮的制备方法

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UY36864A (es) 2017-03-31
CA2995905A1 (en) 2017-03-02
KR102669559B1 (ko) 2024-05-28
SI3337800T1 (sl) 2019-08-30
ZA201801859B (en) 2019-11-27
CN107849043B (zh) 2020-10-16
MY195226A (en) 2023-01-11
AU2016312904C1 (en) 2021-05-27
US20180244670A1 (en) 2018-08-30
LT3337800T (lt) 2019-08-12
RU2743429C2 (ru) 2021-02-18
IL257371B (en) 2021-04-29
CO2018001466A2 (es) 2018-02-28
MX2018002027A (es) 2018-06-15
EP3337800B1 (de) 2019-06-12
NZ739774A (en) 2025-06-27
KR20180041138A (ko) 2018-04-23
JP2018523699A (ja) 2018-08-23
AU2016312904B9 (en) 2020-12-24
EP3337800A1 (de) 2018-06-27
AU2016312904A1 (en) 2018-03-08
RS59055B1 (sr) 2019-08-30
TWI725045B (zh) 2021-04-21
HRP20191431T1 (hr) 2019-11-01
AR105774A1 (es) 2017-11-08
ES2739904T3 (es) 2020-02-04
IL257371A (en) 2018-04-30
HUE044574T2 (hu) 2019-11-28
CN107849043A (zh) 2018-03-27
AU2016312904B2 (en) 2020-12-10
HK1251565A1 (zh) 2019-02-01
PL3337800T3 (pl) 2019-10-31
US10336749B2 (en) 2019-07-02
RU2018109761A (ru) 2019-09-23
PT3337800T (pt) 2019-08-05
JOP20160186B1 (ar) 2021-08-17
DK3337800T3 (da) 2019-08-19
WO2017032673A1 (de) 2017-03-02
USRE49826E1 (en) 2024-02-06
RU2018109761A3 (es) 2020-01-21
PE20180554A1 (es) 2018-04-02
SG11201801110TA (en) 2018-03-28
CL2018000427A1 (es) 2018-07-20
JP6824247B2 (ja) 2021-02-03
UA129174C2 (uk) 2025-02-05
TW201722944A (zh) 2017-07-01

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