MX378499B - Compuestos antifungicos. - Google Patents

Compuestos antifungicos.

Info

Publication number
MX378499B
MX378499B MX2017014848A MX2017014848A MX378499B MX 378499 B MX378499 B MX 378499B MX 2017014848 A MX2017014848 A MX 2017014848A MX 2017014848 A MX2017014848 A MX 2017014848A MX 378499 B MX378499 B MX 378499B
Authority
MX
Mexico
Prior art keywords
antifungal compounds
compounds
sub
formula
cyp51
Prior art date
Application number
MX2017014848A
Other languages
English (en)
Other versions
MX2017014848A (es
Inventor
Christopher M Yates
Gary D Gustafson
Javier Delgado
Kimberly Steward
Michael R Loso
Michael T Sullenberger
Robert J Schotzinger
William J Hoekstra
Xuelin Wang
Original Assignee
Mycovia Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mycovia Pharmaceuticals Inc filed Critical Mycovia Pharmaceuticals Inc
Publication of MX2017014848A publication Critical patent/MX2017014848A/es
Publication of MX378499B publication Critical patent/MX378499B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a compuestos de fórmula (I): en donde R1 es como se define en la presente o una sal, solvato, profármaco o hidrato aceptable del mismo. Los compuestos de fórmula I son inhibidores de metaloenzimas, tales como lanosterol desmetilasa (CYP51).
MX2017014848A 2015-05-18 2016-05-17 Compuestos antifungicos. MX378499B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562163106P 2015-05-18 2015-05-18
PCT/US2016/032877 WO2016187201A2 (en) 2015-05-18 2016-05-17 Antifungal compounds

Publications (2)

Publication Number Publication Date
MX2017014848A MX2017014848A (es) 2018-04-20
MX378499B true MX378499B (es) 2025-03-11

Family

ID=57320616

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017014848A MX378499B (es) 2015-05-18 2016-05-17 Compuestos antifungicos.

Country Status (25)

Country Link
US (2) US11051514B2 (es)
EP (2) EP3702353B1 (es)
JP (1) JP6908533B2 (es)
KR (1) KR20180000731A (es)
CN (1) CN107750248A (es)
AR (1) AR104695A1 (es)
AU (2) AU2016265932B2 (es)
BR (1) BR112017024463B1 (es)
CA (1) CA2986041C (es)
CL (1) CL2017002929A1 (es)
CO (1) CO2017012621A2 (es)
CR (1) CR20170574A (es)
DK (1) DK3297998T3 (es)
EA (1) EA034387B1 (es)
EC (1) ECSP17082683A (es)
ES (1) ES2776241T3 (es)
HK (2) HK1253073A1 (es)
IL (1) IL255605B (es)
LT (1) LT3297998T (es)
MX (1) MX378499B (es)
PH (1) PH12017502082B1 (es)
TW (1) TWI623527B (es)
UA (1) UA120784C2 (es)
WO (1) WO2016187201A2 (es)
ZA (1) ZA201707783B (es)

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Publication number Publication date
ZA201707783B (en) 2019-06-26
CL2017002929A1 (es) 2018-04-27
EP3297998A2 (en) 2018-03-28
BR112017024463B1 (pt) 2023-01-24
ES2776241T3 (es) 2020-07-29
JP6908533B2 (ja) 2021-07-28
CO2017012621A2 (es) 2018-04-30
HK1253073A1 (zh) 2019-06-06
EP3702353B1 (en) 2023-07-05
AU2020239669A1 (en) 2020-10-15
AR104695A1 (es) 2017-08-09
PH12017502082B1 (en) 2024-05-15
ECSP17082683A (es) 2018-02-28
EA201792519A1 (ru) 2018-04-30
UA120784C2 (uk) 2020-02-10
CR20170574A (es) 2018-07-19
US11051514B2 (en) 2021-07-06
TWI623527B (zh) 2018-05-11
JP2018522821A (ja) 2018-08-16
EP3297998A4 (en) 2018-11-14
TW201706260A (zh) 2017-02-16
DK3297998T3 (da) 2020-03-16
LT3297998T (lt) 2020-06-10
CA2986041C (en) 2021-06-29
IL255605B (en) 2021-03-25
CN107750248A (zh) 2018-03-02
IL255605A (en) 2018-01-31
AU2016265932B2 (en) 2020-10-08
CA2986041A1 (en) 2016-11-24
WO2016187201A2 (en) 2016-11-24
WO2016187201A3 (en) 2017-03-16
MX2017014848A (es) 2018-04-20
EP3702353A1 (en) 2020-09-02
EP3297998B1 (en) 2019-12-11
US20190216087A1 (en) 2019-07-18
US20210360921A1 (en) 2021-11-25
PH12017502082A1 (en) 2018-05-07
AU2016265932A1 (en) 2017-12-07
KR20180000731A (ko) 2018-01-03
HK1251569A1 (zh) 2019-02-01
BR112017024463A2 (pt) 2018-07-24
EA034387B1 (ru) 2020-02-03

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