MX380687B - Metodo para preparar células troncales con pluripotencia inducida a partir de células troncales mesenquimatosas utilizando una fracción de florotanino. - Google Patents

Metodo para preparar células troncales con pluripotencia inducida a partir de células troncales mesenquimatosas utilizando una fracción de florotanino.

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Publication number
MX380687B
MX380687B MX2016015357A MX2016015357A MX380687B MX 380687 B MX380687 B MX 380687B MX 2016015357 A MX2016015357 A MX 2016015357A MX 2016015357 A MX2016015357 A MX 2016015357A MX 380687 B MX380687 B MX 380687B
Authority
MX
Mexico
Prior art keywords
stem cells
induced
induced pluripotency
florotanin
pluripotence
Prior art date
Application number
MX2016015357A
Other languages
English (en)
Other versions
MX2016015357A (es
Inventor
Ho Bin Kim
Kye Ho Lee
Min Sun Oh
Sang Yeon Lee
Won Ju Jung
Original Assignee
Bbhc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bbhc filed Critical Bbhc
Priority claimed from PCT/KR2015/005183 external-priority patent/WO2015178728A1/ko
Publication of MX2016015357A publication Critical patent/MX2016015357A/es
Publication of MX380687B publication Critical patent/MX380687B/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/70—Undefined extracts
    • C12N2500/76—Undefined extracts from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C12N2506/025—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells from extra-embryonic cells, e.g. trophoblast, placenta
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1392—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from mesenchymal stem cells from other natural sources

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere al uso de una composición para medio que comprende de 20 a 150 ug/ml de una fracción de florotanino que es un compuesto de bieckol representado por la siguiente Fórmula Química 1 o sales del mismo para desdiferenciar células troncales mesenquimatosas en células troncales con pluripotencia inducida. [Fórmula Química 1].
MX2016015357A 2014-05-23 2015-05-22 Metodo para preparar células troncales con pluripotencia inducida a partir de células troncales mesenquimatosas utilizando una fracción de florotanino. MX380687B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20140062526 2014-05-23
KR1020150071240A KR101699761B1 (ko) 2014-05-23 2015-05-21 플로로탄닌 분획물을 이용한 중간엽 줄기세포로부터 유도만능 줄기세포를 제조하는 방법
PCT/KR2015/005183 WO2015178728A1 (ko) 2014-05-23 2015-05-22 플로로탄닌 분획물을 이용한 중간엽 줄기세포로부터 유도만능 줄기세포를 제조하는 방법

Publications (2)

Publication Number Publication Date
MX2016015357A MX2016015357A (es) 2017-06-20
MX380687B true MX380687B (es) 2025-03-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016015357A MX380687B (es) 2014-05-23 2015-05-22 Metodo para preparar células troncales con pluripotencia inducida a partir de células troncales mesenquimatosas utilizando una fracción de florotanino.

Country Status (24)

Country Link
US (1) US10131881B2 (es)
EP (1) EP3147352B1 (es)
JP (1) JP6839982B2 (es)
KR (1) KR101699761B1 (es)
CN (1) CN105960452B (es)
AU (1) AU2015262123B2 (es)
CA (1) CA2949949C (es)
CY (1) CY1123348T1 (es)
DK (1) DK3147352T3 (es)
ES (1) ES2820577T3 (es)
HR (1) HRP20201525T1 (es)
HU (1) HUE050877T2 (es)
IL (1) IL249170A0 (es)
LT (1) LT3147352T (es)
MX (1) MX380687B (es)
MY (1) MY179152A (es)
PH (1) PH12016502330B1 (es)
PL (1) PL3147352T3 (es)
PT (1) PT3147352T (es)
RS (1) RS60817B1 (es)
RU (1) RU2668803C2 (es)
SG (1) SG11201609804RA (es)
SI (1) SI3147352T1 (es)
SM (1) SMT202000487T1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3064572B1 (en) 2013-11-01 2020-02-12 BBHC Co. Ltd. Method for producing induced pluripotent stem cell from mesenchymal stem cell and induced pluripotent stem cell produced by the method
KR101966315B1 (ko) * 2017-04-26 2019-04-08 제주대학교 산학협력단 감태 추출물과 괭생이모자반 추출물을 이용한 면역억제용 조성물
KR20200069238A (ko) * 2018-12-05 2020-06-16 주식회사 보타메디 플로로탄닌을 유효성분으로 포함하는 음식 향미 개선용 조성물
WO2021145742A1 (ko) * 2020-01-17 2021-07-22 주식회사 만나스 플로로탄닌을 유효성분으로 포함하는 운동 기능 개선용 조성물
CN111557869A (zh) * 2020-06-19 2020-08-21 湖北楚天香妆生物科技有限公司 昆布提取物的应用
CN114438037B (zh) * 2022-01-25 2024-06-04 深圳市乐土生物医药有限公司 一种制备诱导性间充质干细胞的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5818874A (ja) * 1981-07-28 1983-02-03 Shin Kobe Electric Mach Co Ltd 鉛蓄電池の製造法
JP2932660B2 (ja) 1990-10-09 1999-08-09 松下電器産業株式会社 スクリーン印刷用スキージ装置
JP4146146B2 (ja) 2002-03-25 2008-09-03 熊本県 フロロタンニン類を主成分とする抗菌剤
US7910755B2 (en) * 2004-09-29 2011-03-22 Harbor Biosciences, Inc. Stem cell expansion and uses
TWI456062B (zh) * 2006-09-13 2014-10-11 Abbvie Inc 細胞培養改良
WO2009157610A1 (en) * 2008-06-26 2009-12-30 Pusan National University Industry-University Cooperation Foundation Selenium dedifferentiated cell, preparation method and usage thereof
JP2010030917A (ja) * 2008-07-25 2010-02-12 Guraiko Materials:Kk 肝炎予防剤又は肝炎治療剤
CN101748096B (zh) * 2008-12-17 2013-03-13 北京汉氏联合生物技术有限公司 亚全能干细胞、其制备方法及其用途
KR101166257B1 (ko) * 2009-06-16 2012-07-19 한국생명공학연구원 미분화 다능성줄기세포의 제작, 유지 및 증식을 위한 뉴로펩타이드 ｙ를 포함하는 배지 조성물 및 이를 이용한 다능성줄기세포의 배양 방법
CN103210082A (zh) * 2010-09-15 2013-07-17 雷蒙特亚特特拉维夫大学有限公司 扩增胰岛β细胞和使其再分化的方法
KR101807704B1 (ko) * 2011-04-12 2017-12-13 차의과학대학교 산학협력단 역분화-증진제를 이용한 역분화 만능 줄기세포의 제조방법
US20150072416A1 (en) * 2012-05-29 2015-03-12 Korea Research Institute Of Bioscience And Biotech Metabolite for improving production, maintenance and proliferation of pluripotent stem cells, composition comprising the same, and method of culturing pluripotent stem cell using the same
KR101544195B1 (ko) * 2013-11-01 2015-08-12 주식회사 비비에이치씨 중간엽 줄기세포로부터 유도만능 줄기세포를 제조하는 방법 및 그 방법에 의해 제조된 유도만능 줄기세포
KR101542847B1 (ko) * 2013-11-01 2015-08-10 주식회사 비비에이치씨 중간엽 줄기세포로부터 유도된 만능 줄기세포를 이용하여 신경세포로 분화시키는 방법
KR101542849B1 (ko) * 2013-11-01 2015-08-10 주식회사 비비에이치씨 중간엽 줄기세포로부터 유도된 만능 줄기세포를 이용하여 간세포로 분화시키는 방법
KR101542846B1 (ko) * 2013-11-01 2015-08-10 주식회사 비비에이치씨 중간엽 줄기세포로부터 유도된 만능 줄기세포를 이용하여 연골세포로 분화시키는 방법
KR101542850B1 (ko) * 2013-11-01 2015-08-10 주식회사 비비에이치씨 중간엽 줄기세포로부터 유도된 만능 줄기세포를 이용하여 지방세포로 분화시키는 방법
KR101542848B1 (ko) * 2013-11-01 2015-08-10 주식회사 비비에이치씨 중간엽 줄기세포로부터 유도된 만능 줄기세포를 이용하여 골아세포로 분화시키는 방법

Also Published As

Publication number Publication date
SMT202000487T1 (it) 2020-11-10
EP3147352B1 (en) 2020-08-12
AU2015262123A1 (en) 2016-08-25
JP6839982B2 (ja) 2021-03-10
MY179152A (en) 2020-10-29
CN105960452A (zh) 2016-09-21
HRP20201525T1 (hr) 2021-02-19
ES2820577T3 (es) 2021-04-21
HUE050877T2 (hu) 2021-01-28
AU2015262123B2 (en) 2018-04-19
US10131881B2 (en) 2018-11-20
PL3147352T3 (pl) 2021-01-25
SI3147352T1 (sl) 2021-01-29
RU2016150687A (ru) 2018-06-25
CY1123348T1 (el) 2021-12-31
IL249170A0 (en) 2017-01-31
PH12016502330A1 (en) 2017-02-06
LT3147352T (lt) 2020-12-10
JP2017516455A (ja) 2017-06-22
EP3147352A4 (en) 2018-01-24
US20170107481A1 (en) 2017-04-20
KR20150135136A (ko) 2015-12-02
SG11201609804RA (en) 2016-12-29
KR101699761B1 (ko) 2017-01-25
DK3147352T3 (da) 2020-09-28
RU2668803C2 (ru) 2018-10-02
CA2949949A1 (en) 2015-11-26
MX2016015357A (es) 2017-06-20
RS60817B1 (sr) 2020-10-30
CA2949949C (en) 2023-03-28
RU2016150687A3 (es) 2018-06-25
PT3147352T (pt) 2020-09-29
PH12016502330B1 (en) 2017-02-06
EP3147352A1 (en) 2017-03-29
CN105960452B (zh) 2019-11-22

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