MX394367B - Moléculas tipo esfingolípidos sintéticas, fármacos, métodos de su síntesis y usos de los mismos. - Google Patents

Moléculas tipo esfingolípidos sintéticas, fármacos, métodos de su síntesis y usos de los mismos.

Info

Publication number
MX394367B
MX394367B MX2018003685A MX2018003685A MX394367B MX 394367 B MX394367 B MX 394367B MX 2018003685 A MX2018003685 A MX 2018003685A MX 2018003685 A MX2018003685 A MX 2018003685A MX 394367 B MX394367 B MX 394367B
Authority
MX
Mexico
Prior art keywords
synthesis
methods
drugs
type molecules
formulations
Prior art date
Application number
MX2018003685A
Other languages
English (en)
Other versions
MX2018003685A (es
Inventor
Aimee Edinger
Stephen Hanessian
Original Assignee
Univ California
The Univ De Montreal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, The Univ De Montreal filed Critical Univ California
Publication of MX2018003685A publication Critical patent/MX2018003685A/es
Publication of MX394367B publication Critical patent/MX394367B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se proporcionan moléculas pequeñas de compuestos tipo esfingolípidos restringidas azacíclicas y métodos de su síntesis. También se proporcionan formulaciones y medicamentos que se dirigen al tratamiento de enfermedades, tales como, por ejemplo, neoplasmas, cánceres, y otras enfermedades. También se proporcionan terapéuticos que contienen una dosis terapéuticamente efectiva de uno o más compuestos de molécula pequeña, presentes ya sea como sal farmacéuticamente efectiva o en forma pura, incluyendo, pero no limitado a, formulaciones para administración oral, intravenosa, o intramuscular.
MX2018003685A 2015-09-24 2016-09-26 Moléculas tipo esfingolípidos sintéticas, fármacos, métodos de su síntesis y usos de los mismos. MX394367B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562232377P 2015-09-24 2015-09-24
PCT/US2016/053815 WO2017053990A1 (en) 2015-09-24 2016-09-26 Synthetic sphingolipid-like molecules, drugs, methods of their synthesis and methods of treatment

Publications (2)

Publication Number Publication Date
MX2018003685A MX2018003685A (es) 2018-08-15
MX394367B true MX394367B (es) 2025-03-24

Family

ID=58387539

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018003685A MX394367B (es) 2015-09-24 2016-09-26 Moléculas tipo esfingolípidos sintéticas, fármacos, métodos de su síntesis y usos de los mismos.

Country Status (7)

Country Link
US (3) US10995068B2 (es)
EP (1) EP3352753A4 (es)
JP (1) JP6853539B2 (es)
CN (1) CN108366990B (es)
CA (1) CA2999177A1 (es)
MX (1) MX394367B (es)
WO (1) WO2017053990A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3022176B8 (en) 2013-07-15 2019-12-25 The Regents of the University of California Azacyclic constrained analogs of fty720
CA2999177A1 (en) 2015-09-24 2017-03-30 The Regents Of The University Of California Synthetic sphingolipid-like molecules, drugs, methods of their synthesis and methods of treatment
MA50532A (fr) * 2017-11-03 2020-09-09 Univ Virginia Patent Foundation Compositions et méthodes pour le traitement de cancers
CA3103805A1 (en) * 2018-06-14 2019-12-19 The Regents Of The University Of California Synthetic cytotoxic molecules, drugs, methods of their synthesis and methods of treatment
WO2021062168A1 (en) * 2019-09-25 2021-04-01 The Regents Of The University Of California Synthetic sphingolipid inspired molecules with heteroaromatic appendages, methods of their synthesis and methods of treatment
US20220409617A1 (en) * 2019-11-13 2022-12-29 The Regents Of The University Of California Drug Formulations and Methods of Treatment for Metabolic Disorders
TWI885039B (zh) 2020-01-13 2025-06-01 美商邊際分析公司 經取代吡唑并嘧啶及其用途
CN116617221B (zh) * 2022-02-11 2025-06-17 复旦大学 Trpml1特异性小分子激动剂ml-sa1在制药中的用途

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Also Published As

Publication number Publication date
EP3352753A4 (en) 2019-03-13
EP3352753A1 (en) 2018-08-01
JP6853539B2 (ja) 2021-03-31
US10995068B2 (en) 2021-05-04
CN108366990B (zh) 2021-09-03
US20230122855A1 (en) 2023-04-20
US11999693B2 (en) 2024-06-04
MX2018003685A (es) 2018-08-15
JP2018534256A (ja) 2018-11-22
US11479530B2 (en) 2022-10-25
US20210261504A1 (en) 2021-08-26
CA2999177A1 (en) 2017-03-30
HK1259078A1 (zh) 2019-11-22
US20180265464A1 (en) 2018-09-20
CN108366990A (zh) 2018-08-03
WO2017053990A1 (en) 2017-03-30

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