MX9701465A - Formulacion de acetaminofeno, de liberacion sostenida. - Google Patents

Formulacion de acetaminofeno, de liberacion sostenida.

Info

Publication number
MX9701465A
MX9701465A MX9701465A MX9701465A MX9701465A MX 9701465 A MX9701465 A MX 9701465A MX 9701465 A MX9701465 A MX 9701465A MX 9701465 A MX9701465 A MX 9701465A MX 9701465 A MX9701465 A MX 9701465A
Authority
MX
Mexico
Prior art keywords
release
sustained
dosage form
particles
coated
Prior art date
Application number
MX9701465A
Other languages
English (en)
Other versions
MXPA97001465A (es
Inventor
Shirish A Shah
Chris Y Ho
Original Assignee
Perrigo L Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perrigo L Co filed Critical Perrigo L Co
Publication of MXPA97001465A publication Critical patent/MXPA97001465A/es
Publication of MX9701465A publication Critical patent/MX9701465A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

Se proporciona una forma de dosificacion de liberacion sostenida, administrable por vía oral, que incluye partículas de un ingrediente farmacéutico activo el está recubierto con un material polimérico que es insoluble en agua, pero permeable en agua e hinchable con agua, de manera que la forma de dosificacion de liberacion sostenida proporciona liberacion controlada la cual es independiente de ciertos factores fisiologicos variables tales como pH. De acuerdo con un aspecto de la invencion, el ingrediente activo es acetaminofeno y las partículas de acetaminofeno recubiertas se combinan con partículas de acetaminofeno no recubiertas para proporcionar una combinacion de forma de dosificacion de liberacion inmediata/liberacion sostenida. De acuerdo con otro aspecto de la invencion, el ingrediente farmacéutico activo está recubierto con copolímero de éster de metacrilato, y las partículas recubiertas se combinan con partículas no recubiertas de un ingrediente farmacéutico activo para proporcionar una combinacion de forma de dosificacion de liberacion inmediata/liberacion sostenida, en la que el componente de liberacion sostenida proporciona una velocidad de liberacion la cual es sustancialmente independiente de factores fisiologicos tales como el pH. La forma de dosificacion final, administrable por vía oral, puede presentarse como tabletas comprimidas, cápsulas o sacos.
MX9701465A 1996-02-27 1997-02-26 Formulacion de acetaminofeno, de liberacion sostenida. MX9701465A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08608839 1996-02-27
US08/608,839 US5773031A (en) 1996-02-27 1996-02-27 Acetaminophen sustained-release formulation

Publications (2)

Publication Number Publication Date
MXPA97001465A MXPA97001465A (es) 1998-04-01
MX9701465A true MX9701465A (es) 1998-04-30

Family

ID=24438247

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9701465A MX9701465A (es) 1996-02-27 1997-02-26 Formulacion de acetaminofeno, de liberacion sostenida.

Country Status (5)

Country Link
US (2) US5773031A (es)
JP (1) JPH1029936A (es)
CA (1) CA2198630C (es)
GB (1) GB2310601B (es)
MX (1) MX9701465A (es)

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US6126969A (en) 2000-10-03
CA2198630A1 (en) 1997-08-27
JPH1029936A (ja) 1998-02-03
US5773031A (en) 1998-06-30
GB9704069D0 (en) 1997-04-16
GB2310601A (en) 1997-09-03
GB2310601B (en) 1999-12-22

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