MXPA04007775A - Derivados de sulfonilo como novedosos inhibidores de la histona desacetilasa. - Google Patents

Derivados de sulfonilo como novedosos inhibidores de la histona desacetilasa.

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Publication number
MXPA04007775A
MXPA04007775A MXPA04007775A MXPA04007775A MXPA04007775A MX PA04007775 A MXPA04007775 A MX PA04007775A MX PA04007775 A MXPA04007775 A MX PA04007775A MX PA04007775 A MXPA04007775 A MX PA04007775A MX PA04007775 A MXPA04007775 A MX PA04007775A
Authority
MX
Mexico
Prior art keywords
histone deacetylase
sulfonyl
derivatives
novel inhibitors
novel
Prior art date
Application number
MXPA04007775A
Other languages
English (en)
Inventor
Alexey Borisovich Dyatkin
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MXPA04007775A publication Critical patent/MXPA04007775A/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
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Abstract

Esta invencion comprende los novedosos compuestos de formula (I)(Ver formula I)en donde n, m, t, R1, R2, R3, R4, L, Q, X, Y, Z y (Ver formula) tienen significados definidos, teniendo actividad enzimatica inhibidora de la histona desacetilasa; su preparacion, composiciones que los contienen y su utilizacion como una medicina.
MXPA04007775A 2002-03-13 2003-03-11 Derivados de sulfonilo como novedosos inhibidores de la histona desacetilasa. MXPA04007775A (es)

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