MXPA05007793A - Composiciones de nucleotidos enlazados con alquilo. - Google Patents

Composiciones de nucleotidos enlazados con alquilo.

Info

Publication number
MXPA05007793A
MXPA05007793A MXPA05007793A MXPA05007793A MXPA05007793A MX PA05007793 A MXPA05007793 A MX PA05007793A MX PA05007793 A MXPA05007793 A MX PA05007793A MX PA05007793 A MXPA05007793 A MX PA05007793A MX PA05007793 A MXPA05007793 A MX PA05007793A
Authority
MX
Mexico
Prior art keywords
alkyl
linked nucleotide
nucleotide
nucleotide compositions
methods
Prior art date
Application number
MXPA05007793A
Other languages
English (en)
Inventor
Klaas P Hardeman
Original Assignee
Serenex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serenex Inc filed Critical Serenex Inc
Publication of MXPA05007793A publication Critical patent/MXPA05007793A/es

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3819—Affinity chromatography of the nucleic acid-nucleic acid binding protein type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B01J20/289—Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

Se proporcionan composiciones de nucleotidos enlazados con alquilo y medios con afinidad a nucleotidos que comprenden un nucleotido enlazado con alquilo. El enlazador es generalmente un enlazador hidrofobico que puede ser una cadena de carbonos 3, 4, 5, 6, 7, 8, 9, 10 o mas larga. Tambien estan incluidos en la invencion metodos para la sintesis de un nucleotido enlazado con alquilo, medios con afinidad a nucleotidos y metodos para el uso de los mismos para cromatografia por afinidad y metodos de deteccion.
MXPA05007793A 2003-01-22 2004-01-22 Composiciones de nucleotidos enlazados con alquilo. MXPA05007793A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US45369703P 2003-01-22 2003-01-22
US53213403P 2003-12-23 2003-12-23
US10/762,078 US7371852B2 (en) 2003-01-22 2004-01-21 Alkyl-linked nucleotide compositions
PCT/US2004/001745 WO2004065566A2 (en) 2003-01-22 2004-01-22 Alkyl-linked nucleotide compositions

Publications (1)

Publication Number Publication Date
MXPA05007793A true MXPA05007793A (es) 2006-01-31

Family

ID=32777037

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05007793A MXPA05007793A (es) 2003-01-22 2004-01-22 Composiciones de nucleotidos enlazados con alquilo.

Country Status (7)

Country Link
US (1) US7371852B2 (es)
EP (1) EP1585754A2 (es)
JP (1) JP2007524804A (es)
AU (1) AU2004205922A1 (es)
CA (1) CA2513901A1 (es)
MX (1) MXPA05007793A (es)
WO (1) WO2004065566A2 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8802448B2 (en) * 2011-07-27 2014-08-12 Pall Corporation Mixed mode ligands
US9828599B2 (en) 2013-09-18 2017-11-28 General Electric Company Methods of selecting binding-elements and uses thereof
US10359419B2 (en) 2013-10-02 2019-07-23 General Electric Company Methods for detection of target using affinity binding
US20150093839A1 (en) 2013-10-02 2015-04-02 General Electric Company Methods and systems for detection of target and applications thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4529796A (en) * 1981-03-30 1985-07-16 Baker Instruments Corporation Method for making chromogenic and/or fluorogenic substrates for use in monitoring catalytic or enzymatic activity
US5650510A (en) * 1986-11-18 1997-07-22 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives
IL84477A (en) 1986-11-18 1995-12-08 Bristol Myers Squibb Co History of Phosphonomethoxyalkylene Purinopyrimidine and Pharmaceutical Preparations Containing Them
ATE98249T1 (de) 1988-04-19 1993-12-15 Merrell Dow Pharma Phosphonoalkylpurin-derivate.
EP0338168A1 (en) * 1988-04-19 1989-10-25 Merrell Dow Pharmaceuticals Inc. Phosphonoalkylpurine derivatives
JPH04503408A (ja) * 1989-02-21 1992-06-18 イーストマン コダック カンパニー 非多孔質単分散ポリマー充填物質を含む高速アフィニティクロマトグラフカラム
CA2083961A1 (en) * 1990-05-29 1991-11-30 Henk Van Den Bosch Synthesis of glycerol di- and triphosphate derivatives
JPH0490850A (ja) * 1990-08-02 1992-03-24 Toray Ind Inc 表面を化学的に活性化した微多孔性支持体
US5536822A (en) * 1994-03-09 1996-07-16 University Of Virginia Alumni Patents Foundation γ-phosphate linked adenosine 5' triphosphate sepharose
US5728369A (en) * 1994-10-05 1998-03-17 Immunomedics, Inc. Radioactive phosphorus labeling of proteins for targeted radiotherapy
WO1997021452A2 (en) * 1995-12-14 1997-06-19 Advanced Magnetics, Inc. Macromolecular prodrugs of nucleotide analogs
EP0917533A2 (en) * 1996-07-03 1999-05-26 President And Fellows Of Harvard College Oligonucleotide linker and techniques involving immobilized and linked oligonucleotides
AU774776B2 (en) * 1999-04-15 2004-07-08 University Of Virginia Patent Foundation Proteome mining
EP1208238B1 (en) * 1999-08-27 2008-11-12 Matrix Technologies Corporation Methods of immobilizing ligands on solid supports
DE10019136A1 (de) * 2000-04-18 2001-10-31 Aventis Pharma Gmbh Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung
US6623655B1 (en) * 2000-04-24 2003-09-23 Sigma-Aldrich Co. Metal chelating compositions
US20030027140A1 (en) * 2001-03-30 2003-02-06 Jingyue Ju High-fidelity DNA sequencing using solid phase capturable dideoxynucleotides and mass spectrometry
US7323319B2 (en) * 2003-05-29 2008-01-29 The University Of Southern Mississippi RNA containing coenzymes, biotin, or fluorophores, and methods for their preparation and use

Also Published As

Publication number Publication date
AU2004205922A1 (en) 2004-08-05
CA2513901A1 (en) 2004-08-05
WO2004065566A3 (en) 2004-11-18
JP2007524804A (ja) 2007-08-30
WO2004065566A2 (en) 2004-08-05
EP1585754A2 (en) 2005-10-19
US7371852B2 (en) 2008-05-13
US20040215009A1 (en) 2004-10-28

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