MY102693A - Antiviral nucleosides - Google Patents

Antiviral nucleosides

Info

Publication number: MY102693A
Authority: MY; Malaysia
Prior art keywords: antiviral nucleosides; htlv; infections; deoxythymidine; azido
Prior art date: 1985-03-16

Application number

MYPI87001943A

Other languages

English (en)

Inventor

Nusinoff Lehrman Sandra

Walter Barry David

Allen Furman Phillip

Heider St Clair Martha

Lister Rideout Janet

Original Assignee

The Wellcome Foundation Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-03-16

Filing date

1987-09-25

Publication date

1992-09-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27516579&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MY102693(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1985-03-16 Priority claimed from GB858506869A external-priority patent/GB8506869D0/en

1985-05-09 Priority claimed from GB858511774A external-priority patent/GB8511774D0/en

1985-09-17 Priority claimed from US06/776,899 external-priority patent/US4724232A/en

1985-09-27 Priority claimed from GB858523881A external-priority patent/GB8523881D0/en

1986-02-12 Priority claimed from GB868603450A external-priority patent/GB8603450D0/en

1987-09-25 Application filed by The Wellcome Foundation Ltd filed Critical The Wellcome Foundation Ltd

1992-09-30 Publication of MY102693A publication Critical patent/MY102693A/en

Links

230000000840 anti-viral effect Effects 0.000 title 1
239000002777 nucleoside Substances 0.000 title 1
125000003835 nucleoside group Chemical group 0.000 title 1
208000031886 HIV Infections Diseases 0.000 abstract 1
208000005599 HTLV-I Infections Diseases 0.000 abstract 1
208000005074 Retroviridae Infections Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Virology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Biotechnology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

MYPI87001943A 1985-03-16 1987-09-25 Antiviral nucleosides MY102693A (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GB858506869A GB8506869D0 (en)	1985-03-16	1985-03-16	Antiviral compound
GB858511774A GB8511774D0 (en)	1985-05-09	1985-05-09	Antiviral compounds
US06/776,899 US4724232A (en)	1985-03-16	1985-09-17	Treatment of human viral infections
GB858523881A GB8523881D0 (en)	1985-09-27	1985-09-27	Antiviral compounds
GB868603450A GB8603450D0 (en)	1986-02-12	1986-02-12	Antiviral compounds

Publications (1)

Publication Number	Publication Date
MY102693A true MY102693A (en)	1992-09-30

Family

ID=27516579

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MYPI87001943A MY102693A (en)	1985-03-16	1987-09-25	Antiviral nucleosides

Country Status (21)

Country	Link
EP (2)	EP0291633B1 (de)
JP (1)	JPH0780898B2 (de)
AP (1)	AP11A (de)
AT (4)	ATE81978T1 (de)
AU (1)	AU572019B2 (de)
CA (1)	CA1238277A (de)
CS (1)	CS385191A3 (de)
CY (2)	CY1508A (de)
DE (4)	DE3687069T2 (de)
DK (1)	DK164392C (de)
FI (1)	FI85978C (de)
GR (1)	GR860712B (de)
HK (2)	HK85789A (de)
IE (1)	IE56503B1 (de)
IL (1)	IL78158A (de)
MC (1)	MC1742A1 (de)
MY (1)	MY102693A (de)
NZ (1)	NZ215486A (de)
PH (1)	PH24388A (de)
PT (1)	PT82199B (de)
SG (1)	SG62889G (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2181128A (en) *	1985-09-17	1987-04-15	Wellcome Found	3'-azidonucleosides
US5077279A (en) *	1986-05-01	1991-12-31	University Of Georgia Research Foundation, Inc.	3'-azido-2',3'-dideoxy-5-methylcytidine anti-viral composition
US5084445A (en) *	1986-05-01	1992-01-28	University Of Georgia Research Foundation, Inc.	3'-azido-2',3'-dideoxy-5-methylcytidine
US4841039A (en) *	1986-05-01	1989-06-20	Emory University	2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents
US4916122A (en) *	1987-01-28	1990-04-10	University Of Georgia Research Foundation, Inc.	3'-Azido-2',3'-dideoxyuridine anti-retroviral composition
US4880782A (en) *	1986-11-21	1989-11-14	Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V.	Method of treating viral infections in humans and compositions therefor
FI892451L (fi) *	1986-11-21	1989-05-19	Max Planck Gesellschaft	Foerfarande med vilket virusinfektioner i maenniskor kan skoetas och kompositioner anvaenda daeri.
SE8605503D0 (sv) *	1986-12-19	1986-12-19	Astra Laekemedel Ab	Novel medicinal use
US5190926A (en) *	1987-01-28	1993-03-02	University Of Georgia Research Foundation, Inc.	3'-azido-2',3'-dideoxypyrimidines and related compounds as antiviral agents
EP0287215B1 (de) *	1987-03-16	1992-06-17	The Wellcome Foundation Limited	Therapeutische Nucleoside
EP0282618A1 (de) *	1987-03-18	1988-09-21	Vereniging Het Nederlands Kanker Instituut	1-Deoxynojirimycin als Anti-HIV-Therapeutikum
EP0286825A3 (de) *	1987-03-18	1989-04-12	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.	Verwendung von 3'-fluro-3'-deoxythymidine zur Herstellung von medicamenten zur Behandlung von Viruskrankheiten
US4950652A (en) *	1987-03-23	1990-08-21	Hem Research, Inc.	dsRNAs for combination therapy in the treatment of viral diseases
FI881413A7 (fi) *	1987-03-25	1988-09-26	The Wellcome Foundation Ltd	Menetelmä 3'-atsido-3'-deoksitymidiinin valmistamiseksi.
GB8707421D0 (en) *	1987-03-27	1987-04-29	Wellcome Found	Pharmaceutical formulations
IL86007A0 (en) *	1987-04-09	1988-09-30	Wellcome Found	6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them
US5185437A (en) *	1987-04-09	1993-02-09	Burroughs Wellcome Co.	Therapeutic nucleosides
IL86009A (en) *	1987-04-10	1991-09-16	Us Health	Liposome-encapsulated phosphorylated nucleosides for treatment of retroviral diseases
US5215970A (en) *	1987-04-16	1993-06-01	Medivir Ab	Nucleosides and nucleotide analogues, pharmaceutical composition and processes for the preparation of the compounds
SE8701605D0 (sv) *	1987-04-16	1987-04-16	Astra Ab	Novel medicinal compounds
DE3868125D1 (de) *	1987-04-24	1992-03-12	Wellcome Found	Antivirale mischungen.
US4863927A (en) *	1987-05-11	1989-09-05	Merck & Co., Inc.	1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils
YU110888A (en) *	1987-06-10	1989-08-31	Wellcome Found	Process for obtaining timine derivatives
USRE33887E (en) *	1987-06-22	1992-04-14	Hoffmann-La Roche Inc.	Anti-retroviral compounds
SU1548182A1 (ru) *	1987-12-29	1990-03-07	Институт молекулярной биологии АН СССР	5 @ -Фосфонаты 3 @ -азидо-2 @ ,3 @ -дидезоксинуклеозидов, вл ющиес специфическими ингибиторами вируса СПИД в культуре лимфоцитов человека Н9/ШВ
US5384396A (en) *	1988-02-23	1995-01-24	The University Of Georgia Research Foundation, Inc.	Process for the deoxygenation of nucleosides
DE3824669C2 (de) *	1988-07-20	1999-05-06	Wondrak Ewald M	Verwendung von Trinatrium-Phosphonoformat
US4987224A (en) *	1988-08-02	1991-01-22	University Of Georgia Research Foundation, Inc.	Method of preparation of 2',3'-dideoxynucleosides
EP0355245A1 (de) *	1988-08-26	1990-02-28	Michel Vandevelde	Anwendung von Inhibitoren der reversen Transcriptase von Retroviren
HU205089B (en) *	1989-05-31	1992-03-30	Biogal Gyogyszergyar	Process for producing new thymine derivatives and pharmaceutical compositions comprising same
DK173585B1 (da) *	1989-11-09	2001-04-02	Asta Medica Ag	Anvendelse af alfa-liponsyre til fremstilling af et lægemiddel til bekæmpelse af sygdomme fremkaldt af retrovirus
US5585367A (en) *	1990-04-19	1996-12-17	Previsan S.A.	Method of treating humans and animals infected with viruses of the retrovirus group
WO1991016054A1 (fr) *	1990-04-19	1991-10-31	Previsan S.A.	Derives azoiques, compositions pharmaceutiques et desinfectantes les contenant et leurs utilisations contre le sida
US6812233B1 (en)	1991-03-06	2004-11-02	Emory University	Therapeutic nucleosides
GB9104740D0 (en) *	1991-03-06	1991-04-17	Wellcome Found	Antiviral nucleoside combination
IL102548A (en) *	1991-08-02	1998-08-16	Medivir Ab	Thiourea derivatives for use in the preparation of medicaments for the inhibition of hiv and the treatment of aids and some such novel compounds
US5593993A (en) *	1991-08-02	1997-01-14	Medivir Ab	Method for inhibition of HIV related viruses
US6177435B1 (en)	1992-05-13	2001-01-23	Glaxo Wellcome Inc.	Therapeutic combinations
ATE184787T1 (de) *	1992-05-13	1999-10-15	Wellcome Found	Therapeutische kombinationen
GR920100326A (el) *	1992-07-21	1994-03-31	Medivir Ag	Ενώσεις και μέ?οδοι αναστολής του HIV και των σχετικών ιών.
DE4336640A1 (de) *	1993-10-22	1995-04-27	Deutsches Rheuma Forschungszen	Neue Metallchelate, Verfahren zu deren Herstellung sowie deren Verwendung als antivirale Arzneimittel
CA2270600A1 (en)	1999-05-03	2000-11-03	Infectio Recherche Inc.	Method and formulations for the treatment of diseases, particularly those caused by human immunodeficiency virus and leishmania
HU230248B1 (hu)	2001-10-26	2015-11-30	Msd Italia S.R.L.	N-szubsztituált hidroxipirimidinon-karboxamid HIV-integráz inhibitorok
IL163666A0 (en)	2002-02-22	2005-12-18	New River Pharmaceuticals Inc	Active agent delivery systems and methods for protecting and administering active agents
US8980894B2 (en)	2004-03-25	2015-03-17	Boehringer Ingelheim Vetmedica Gmbh	Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
EP1579862A1 (de)	2004-03-25	2005-09-28	Boehringer Ingelheim Vetmedica Gmbh	Verwendung von PDE III Ihibitoren zur Reduktion der Herzgrösse in an Herzversagen leidenden Säugern
PL3021832T3 (pl)	2013-07-19	2021-08-23	Boehringer Ingelheim Vetmedica Gmbh	Konserwowana ciekła wodna kompozycja farmaceutyczna zawierająca eteryfikowane pochodne cyklodekstryny
WO2022008025A1 (en) *	2020-07-05	2022-01-13	Since & Technology Development Fund Authority	2-hydroxyiminopyrimidine nucleosides and derivitives and antiviral uses thereto

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0199451B1 (de) *	1985-03-16	1996-03-06	The Wellcome Foundation Limited	Therapeutische Nukleoside

1986
- 1986-03-14 AP APAP/P/1986/000027A patent/AP11A/en active
- 1986-03-14 AT AT88101790T patent/ATE81978T1/de not_active IP Right Cessation
- 1986-03-14 EP EP88101790A patent/EP0291633B1/de not_active Expired - Lifetime
- 1986-03-14 DE DE8888101790T patent/DE3687069T2/de not_active Expired - Lifetime
- 1986-03-14 AT AT0068386A patent/AT390000B/de not_active IP Right Cessation
- 1986-03-14 CY CY1508A patent/CY1508A/xx unknown
- 1986-03-14 DE DE3650130T patent/DE3650130T3/de not_active Expired - Lifetime
- 1986-03-14 MC MC861828A patent/MC1742A1/fr unknown
- 1986-03-14 DK DK118086A patent/DK164392C/da not_active IP Right Cessation
- 1986-03-14 CA CA000504126A patent/CA1238277A/en not_active Expired
- 1986-03-14 IE IE677/86A patent/IE56503B1/en not_active IP Right Cessation
- 1986-03-14 EP EP86301897A patent/EP0196185B1/de not_active Expired
- 1986-03-14 DE DE198686301897T patent/DE196185T1/de active Pending
- 1986-03-14 FI FI861069A patent/FI85978C/fi not_active IP Right Cessation
- 1986-03-14 PH PH33532A patent/PH24388A/en unknown
- 1986-03-14 AU AU54758/86A patent/AU572019B2/en not_active Expired
- 1986-03-14 PT PT82199A patent/PT82199B/pt unknown
- 1986-03-14 NZ NZ215486A patent/NZ215486A/xx unknown
- 1986-03-14 GR GR860712A patent/GR860712B/el unknown
- 1986-03-14 AT AT88101795T patent/ATE113603T1/de not_active IP Right Cessation
- 1986-03-14 AT AT86301897T patent/ATE44464T1/de not_active IP Right Cessation
- 1986-03-14 IL IL78158A patent/IL78158A/xx unknown
- 1986-03-14 DE DE19863608606 patent/DE3608606A1/de not_active Withdrawn
1987
- 1987-09-25 MY MYPI87001943A patent/MY102693A/en unknown
1988
- 1988-03-29 JP JP63073488A patent/JPH0780898B2/ja not_active Expired - Lifetime
1989
- 1989-09-11 SG SG628/89A patent/SG62889G/en unknown
- 1989-10-26 HK HK857/89A patent/HK85789A/en not_active IP Right Cessation
1991
- 1991-12-17 CS CS913851A patent/CS385191A3/cs unknown
1995
- 1995-10-19 HK HK164395A patent/HK164395A/en not_active IP Right Cessation
1996
- 1996-11-22 CY CY188996A patent/CY1889A/xx unknown

Also Published As

Publication number	Publication date
DE3650130T2 (de)	1995-03-16
DK118086A (da)	1986-09-17
ATE44464T1 (de)	1989-07-15
FI85978B (fi)	1992-03-13
HK164395A (en)	1995-10-27
CY1508A (en)	1990-08-03
DK164392C (da)	1992-11-09
ATE81978T1 (de)	1992-11-15
DE3608606A1 (de)	1986-09-18
AU572019B2 (en)	1988-04-28
ATE113603T1 (de)	1994-11-15
DE3650130T3 (de)	2003-07-24
EP0196185A3 (en)	1988-01-13
CS385191A3 (en)	1992-05-13
AT390000B (de)	1990-02-26
MC1742A1 (fr)	1987-02-26
EP0196185B1 (de)	1989-07-12
HK85789A (en)	1989-11-03
CA1238277A (en)	1988-06-21
FI85978C (fi)	1992-06-25
CY1889A (en)	1996-11-22
AU5475886A (en)	1986-09-18
AP8600027A0 (en)	1986-02-01
EP0291633A1 (de)	1988-11-23
JPS63290895A (ja)	1988-11-28
IL78158A (en)	1988-04-29
IE860677L (en)	1986-09-16
AP11A (en)	1987-12-22
DE3687069D1 (de)	1992-12-10
DK118086D0 (da)	1986-03-14
DE3650130D1 (de)	1994-12-08
SG62889G (en)	1990-01-26
FI861069L (fi)	1986-09-17
DE196185T1 (de)	1987-04-30
IE56503B1 (en)	1991-08-14
DK164392B (da)	1992-06-22
NZ215486A (en)	1988-09-29
FI861069A0 (fi)	1986-03-14
ATA68386A (de)	1989-08-15
PT82199A (en)	1986-04-01
DE3687069T2 (de)	1993-03-25
JPH0780898B2 (ja)	1995-08-30
IL78158A0 (en)	1986-07-31
EP0196185A2 (de)	1986-10-01
GR860712B (en)	1986-07-16
PT82199B (pt)	1990-11-07
PH24388A (en)	1990-06-13
EP0291633B1 (de)	1992-11-04

Publication	Publication Date	Title
MY102693A (en)	1992-09-30	Antiviral nucleosides
MY104069A (en)	1993-11-30	Therapeutic nucleosides
DK224286D0 (da)	1986-05-14	2',3'-dideoxy-nucleosider
ES8602840A1 (es)	1985-12-01	Un procedimiento para la preparacion de un nucleosido.
FI910031A7 (fi)	1991-01-03	Antiviraalisten nukleosidien lipidijohdannaiset, liposomaaliset assimi laatiot ja niiden käyttö
FI20001231L (fi)	2000-05-23	2-Deoksi-2,3-didehydro-N-asetyylineuramiinihapon johdannaisia ja niiden analogeja ja niiden käyttö antiviraalisina aineina
PT100199A (pt)	1993-07-30	Combinacao antiviral de nucleosidos e processo para a sua preparacao
MX9203217A (es)	1992-07-01	Nucleosidos terapeuticos.
NO932287D0 (no)	1993-06-21	2'-deoksy-2',2'-difluor(2,6,8-substituerte) purine nukleosider med antiviral- og anticanceraktivitet, og mellomprodukter
EP0306597A3 (de)	1992-08-19	Antivirale Nukleoside
ZA892284B (en)	1990-02-28	Novel fluorophosphonate nucleotide derivatives
EP0335770A3 (de)	1990-12-27	Derivate von Fluorphosphonat-Nukleotiden
GB2211185B (en)	1991-07-10	Uridine derivatives and antiviral agents containing them
GB9506644D0 (en)	1995-05-24	Preparation of nucleoside analogues
PT87462A (pt)	1989-05-31	Individual isomers of endo-bicyclo ]2.2.1" heptyl adenosine
ZA916542B (en)	1992-05-27	New phospholipid derivatives of nucleosides,processes for their preparation and antiviral use
LU88789I2 (fr)	1996-11-05	Mésylate de tirilazad et ses dérivés pharmaceutiquement acceptables (Freedox (R))
ZA907701B (en)	1991-07-31	6-substituted acyclopyrimidine nucleoside derivatives and antiviral agent containing the same as active ingredient thereof
AU654670C (en)	1995-08-31	New phospholipid derivatives of nucleosides, their preparation and their use as antiviral drugs
AU587739B2 (en)	1989-08-24	Derivatives of 3'-azido-3'-deoxythymidine
AU611284C (en)	1992-10-01	6-substituted acyclicpyrimidine nucleoside derivatives and antiviral agents containing same as active ingredients
AU642906C (en)	1998-06-18	6-substituted acyclopyrimidine nucleoside derivatives and antiviral agent containing the same as active ingredient thereof
FI940103L (fi)	1994-01-10	2',3'-deoksi-2',3'-didehydronukleosidien valmistus