MY117527A - Substituted heterocyclic compounds, method of preparing them and pharmaceutical compositions in which they are present - Google Patents
Substituted heterocyclic compounds, method of preparing them and pharmaceutical compositions in which they are presentInfo
- Publication number
- MY117527A MY117527A MYPI96000294A MYPI9600294A MY117527A MY 117527 A MY117527 A MY 117527A MY PI96000294 A MYPI96000294 A MY PI96000294A MY PI9600294 A MYPI9600294 A MY PI9600294A MY 117527 A MY117527 A MY 117527A
- Authority
- MY
- Malaysia
- Prior art keywords
- preparing
- present
- pharmaceutical compositions
- substituted heterocyclic
- heterocyclic compounds
- Prior art date
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
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- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
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- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
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- C07C219/22—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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- C—CHEMISTRY; METALLURGY
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- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
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- C07C255/36—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by hydroxy groups
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- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
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- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
- C07C255/43—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms the carbon skeleton being further substituted by singly-bound oxygen atoms
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- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/38—One oxygen atom attached in position 2
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- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
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- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
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Abstract
THE INVENTION RELATES TO COMPOUNDS OF THE FORMULA ( FORMULA 1 )IN WHICH:@A IS A DIVALENT RADICAL SELECTED FROM:@A1) -O-CO--@A2) -CH2-O-CO-@A3) -O-CH2-CO-@A4) -O-CH2-CH2-@A5) -N(R1)-CO-@A6) -N(R1)-CO-CO-@A7) -N(R1)-CH2-CH2-@A8) -O-CH2-IN WHICH:@- R1 IS A HYDROGEN OR A (C1-C4)-ALKYL; AND @- AM IS A NITROGEN-CONTAINING HETEROCYCLE.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9501016A FR2729952B1 (en) | 1995-01-30 | 1995-01-30 | SUBSTITUTED HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| FR9508046A FR2729953B1 (en) | 1995-01-30 | 1995-07-04 | SUBSTITUTED HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| FR9513005A FR2729954B1 (en) | 1995-01-30 | 1995-11-03 | SUBSTITUTED HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY117527A true MY117527A (en) | 2004-07-31 |
Family
ID=27253013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI96000294A MY117527A (en) | 1995-01-30 | 1996-01-26 | Substituted heterocyclic compounds, method of preparing them and pharmaceutical compositions in which they are present |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US5641777A (en) |
| EP (5) | EP1688416A1 (en) |
| JP (4) | JP3234228B2 (en) |
| CN (6) | CN1295221C (en) |
| AR (2) | AR002955A1 (en) |
| AT (2) | ATE222251T1 (en) |
| AU (1) | AU707901B2 (en) |
| CA (1) | CA2211668C (en) |
| CY (2) | CY2369B1 (en) |
| CZ (2) | CZ293134B6 (en) |
| DE (2) | DE69634806T2 (en) |
| DK (2) | DK1156049T3 (en) |
| ES (2) | ES2181866T3 (en) |
| FI (1) | FI973148L (en) |
| FR (1) | FR2729954B1 (en) |
| HU (1) | HUP9800295A3 (en) |
| IL (3) | IL116957A (en) |
| MX (1) | MX9705590A (en) |
| MY (1) | MY117527A (en) |
| NO (1) | NO308795B1 (en) |
| NZ (1) | NZ301285A (en) |
| PL (1) | PL192164B1 (en) |
| PT (2) | PT807111E (en) |
| RU (1) | RU2157807C2 (en) |
| SI (2) | SI1156049T1 (en) |
| WO (1) | WO1996023787A1 (en) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2751654B1 (en) * | 1996-07-26 | 1998-10-23 | Sanofi Sa | SUBSTITUTED HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| GB9513972D0 (en) * | 1995-07-08 | 1995-09-06 | Merck Sharp & Dohme | Pharmaceutical compositions |
| HU224225B1 (en) | 1995-12-01 | 2005-06-28 | Sankyo Co. Ltd. | Heterocyclic compounds having tachykinin receptor antagonist activity, their preparation, and their use for the preparation of pharmaceutical compositions |
| GB9601680D0 (en) * | 1996-01-27 | 1996-03-27 | Pfizer Ltd | Therapeutic agents |
| FR2759584B1 (en) * | 1997-02-17 | 1999-06-11 | Sanofi Sa | PHARMACEUTICAL COMPOSITION FOR THE ORAL ADMINISTRATION OF HETEROCYCLIC COMPOUNDS IN QUATERNARY AMMONIUM FORM |
| FR2759585B1 (en) * | 1997-02-17 | 1999-06-11 | Sanofi Sa | PHARMACEUTICAL FORMULATIONS PRESENTED IN A DRY FORM FOR THE ORAL ADMINISTRATION OF A CYCLIC QUATERNARY AMMONIUM COMPOUND |
| JP3192631B2 (en) | 1997-05-28 | 2001-07-30 | äøå ±ę Ŗå¼ä¼ē¤¾ | Pharmaceuticals consisting of saturated heterocyclic compounds |
| BR9809713A (en) * | 1997-05-30 | 2000-07-11 | Sankyo Co | Compound, drug and composition comprising the same, use of the compound, and, processes for prophylaxis or treatment of diseases mediated with tachykinin, to inhibit an nk1 receptor and / or an nk2 receptor, and for prophylaxis or treatment of asthma and / or bronchitis, rhinitis, allergy, and urinary incontinence |
| DE69830615T2 (en) * | 1997-12-04 | 2006-03-16 | Sankyo Co., Ltd. | ALICTAL ACYLATED HETEROCYCLED DERIVATIVES |
| EP1112259A4 (en) * | 1998-09-11 | 2002-01-09 | Merck & Co Inc | PROCESS FOR PERFORMING SYNTHESIS OF N-BENZYL-3- (4-FLUOROPHENYL) -1,4-OXAZIN-2-ONE |
| WO2000034274A1 (en) * | 1998-12-10 | 2000-06-15 | Sankyo Company, Limited | Cyclohexylpiperidine derivatives |
| FR2787790A3 (en) * | 1998-12-23 | 2000-06-30 | Sanofi Sa | PROCESS FOR THE PREPARATION OF (R)-(+)-3-{1°2-(4-BENZOYL-2-(3,4-DIFLUOROPHENYL)MORPHOLIN-2-YL)ETHYL-4-PHENYLPIPERIDIN-4-YL} -1,1-DIMETHYLUREA, ITS SALTS, SOLVES AND/OR HYDRATES |
| FR2791346B3 (en) * | 1999-03-25 | 2001-04-27 | Sanofi Sa | NOVEL MORPHOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| FR2792199B3 (en) | 1999-04-13 | 2001-05-18 | Sanofi Sa | USE OF OSANETANT FOR THE PREPARATION OF MEDICINES USEFUL IN THE TREATMENT OF MOOD DISORDERS |
| FR2796069B3 (en) * | 1999-07-09 | 2001-08-24 | Sanofi Synthelabo | NOVEL SUBSTITUTED, ENANTIOMERICALLY PURE SUBSTITUTED 2- (2- ARYLMORPHOLIN-2-YL) ETHANOL DERIVATIVES AND INTERMEDIATE COMPOUNDS USEFUL IN SUCH PROCESSES |
| PE20021081A1 (en) * | 2001-04-12 | 2002-12-18 | Pharmacopeia Drug Discovery | ARIL AND BIARIL PIPERIDINES WITH MCH MODULATING ACTIVITY |
| FR2824828B1 (en) * | 2001-05-21 | 2005-05-20 | Sanofi Synthelabo | NOVEL DERIVATIVES OF PIPERIDINECARBOXAMIDE, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
| TW200403058A (en) * | 2002-04-19 | 2004-03-01 | Bristol Myers Squibb Co | Heterocyclo inhibitors of potassium channel function |
| AU2003300911A1 (en) | 2002-12-13 | 2004-07-09 | Smithkline Beecham Corporation | Heterocyclic compounds as ccr5 antagonists |
| TW200524868A (en) * | 2003-07-31 | 2005-08-01 | Zeria Pharm Co Ltd | Benzylamine derivatives |
| US7560549B2 (en) * | 2004-02-25 | 2009-07-14 | Sankyo Company, Limited | Sulfonyloxy derivatives |
| JP2007531743A (en) * | 2004-04-05 | 2007-11-08 | ć»ćć©ć³ć¢ ć¤ć³ć³ć¼ćć¬ć¼ććć | (R, R) -formoterol in combination with other drugs |
| US7955846B2 (en) * | 2004-05-17 | 2011-06-07 | The General Hospital Corporation | Compositions comprising female germline stem cells and methods of use thereof |
| GB0412865D0 (en) * | 2004-06-09 | 2004-07-14 | Glaxo Group Ltd | Chemical compounds |
| DOP2005000123A (en) * | 2004-07-02 | 2011-07-15 | Merck Sharp & Dohme | CETP INHIBITORS |
| FR2873373B1 (en) * | 2004-07-23 | 2006-09-08 | Sanofi Synthelabo | DERIVATIVES OF 4-ARYLMORPHOLIN-3-ONE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
| CA2678577A1 (en) | 2007-02-26 | 2008-09-04 | Vitae Pharmaceuticals, Inc. | Cyclic urea and carbamate inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| EP2183228B1 (en) * | 2007-07-26 | 2014-08-20 | Vitae Pharmaceuticals, Inc. | CYCLIC INHIBITORS OF 11Ć -HYDROXYSTERIOD DEHYDROGENASE 1 |
| AR069207A1 (en) * | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | CYCLIC UREAS AS INHIBITORS OF THE 11 BETA - HIDROXI-ESTEROIDE DESHIDROGENASA 1 |
| CA2708303A1 (en) | 2007-12-11 | 2009-06-18 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
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| JP5734666B2 (en) * | 2008-02-11 | 2015-06-17 | ć“ć”ć¤ćć£ć¼ ćć”ć¼ćć·ć„ć¼ćć£ć«ć«ćŗļ¼ć¤ć³ć³ć¼ćć¬ć¤ććć | 1,3-oxaazepan-2-one and 1,3-diazepan-2-one inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| US8598160B2 (en) * | 2008-02-15 | 2013-12-03 | Vitae Pharmaceuticals, Inc. | Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| JP5538356B2 (en) * | 2008-03-18 | 2014-07-02 | ć“ć”ć¤ćć£ć¼ ćć”ć¼ćć·ć„ć¼ćć£ć«ć«ćŗļ¼ć¤ć³ć³ć¼ćć¬ć¤ććć | Inhibitors of 11β-hydroxysteroid dehydrogenase type 1 |
| WO2009134387A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
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| CL2009001059A1 (en) * | 2008-05-01 | 2010-11-12 | Boehringer Ingelheim Int | Compounds derived from substituted 1,3-oxazin-2-one-3.6, inhibitors of the activity of 11-beta-hydroxysteroid dehydrogenase i; pharmaceutical composition that includes them; Useful in the treatment of diseases such as diabetes mellitus, among others. |
| AR071236A1 (en) | 2008-05-01 | 2010-06-02 | Vitae Pharmaceuticals Inc | CYCLE INHIBITORS OF 11BETA-HYDROXIESTEROID DEHYDROGENASE 1 |
| CN102105454A (en) | 2008-07-25 | 2011-06-22 | č“ęę ¼å°.č±ę ¼ęµ·å§å½é ęéå ¬åø | Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
| WO2010011314A1 (en) | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1 |
| US8846668B2 (en) | 2008-07-25 | 2014-09-30 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| CA2744946A1 (en) | 2009-02-04 | 2010-08-12 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| TW201039034A (en) * | 2009-04-27 | 2010-11-01 | Chunghwa Picture Tubes Ltd | Pixel structure and the method of forming the same |
| UA109255C2 (en) | 2009-04-30 | 2015-08-10 | ŠŠµŃŃŠ½Š³ŠµŃ ŠŠ½Š³ŠµŠ»ŃŃ Š°Š¹Š¼ ŠŠ½ŃŠµŃŠ½ŠµŃнл ŠŠ¼Š±Ń | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| KR20120061771A (en) * | 2009-04-30 | 2012-06-13 | ė¹ķģ“ ķė§ģķ°ģ»¬ģ¦, ģøģ½ķ¬ė ģ“ķ°ė | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| EP2440537A1 (en) | 2009-06-11 | 2012-04-18 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure |
| WO2011002910A1 (en) | 2009-07-01 | 2011-01-06 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| JP5750449B2 (en) | 2009-11-05 | 2015-07-22 | ćć¼ćŖć³ć¬ć¼ ć¤ć³ć²ć«ćć¤ć ć¤ć³ćæć¼ćć·ć§ćć« ć²ć¼ć«ć·ć£ćć ććć ćć·ć„ć¬ć³ćÆćć« ćććć³ć° | New chiral phosphorus ligand |
| KR20120118008A (en) * | 2009-12-18 | 2012-10-25 | ģģ“ė°ėģ¤ ķė§ģķ°ģ¹¼ģ¤, ģøģ½ķ¬ė ģ“ķ°ė | 5,5-fused arylene or heteroarylene hepatitis c virus inhibitors |
| AU2011225095C1 (en) | 2010-03-11 | 2017-01-19 | Sumitomo Dainippon Pharma Co., Ltd. | N-Acyl cyclic amine derivative or pharmaceutically acceptable salt thereof |
| US8648192B2 (en) | 2010-05-26 | 2014-02-11 | Boehringer Ingelheim International Gmbh | 2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives |
| US8933072B2 (en) | 2010-06-16 | 2015-01-13 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| JP5813106B2 (en) | 2010-06-25 | 2015-11-17 | ćć¼ćŖć³ć¬ć¼ ć¤ć³ć²ć«ćć¤ć ć¤ć³ćæć¼ćć·ć§ćć« ć²ć¼ć«ć·ć£ćć ććć ćć·ć„ć¬ć³ćÆćć« ćććć³ć° | Azaspirohexanone as an inhibitor of 11-β-HSD1 for the treatment of metabolic disorders |
| PH12013500808A1 (en) | 2010-11-02 | 2015-10-07 | Boehringer Ingelheim Int | Pharmaceutical combinations for the treatment of metabolic disorders |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2398575A (en) * | 1946-04-16 | Theib manufacture | ||
| US2382285A (en) * | 1941-11-19 | 1945-08-14 | Roche Products Ltd | Manufacture of arylacetonitrile derivatives |
| US2513346A (en) * | 1948-12-21 | 1950-07-04 | Parke Davis & Co | Process for obtaining organic amino diols |
| US2689852A (en) * | 1951-11-03 | 1954-09-21 | Hoffmann La Roche | Pyridine derivatives |
| US3112311A (en) * | 1957-04-05 | 1963-11-26 | Geigy Chem Corp | 2-phenyl-5, 6-dimethyl-morpholines and 2-phenyl-5, 6-tetramethylene-morpholines |
| CH436295A (en) * | 1961-11-13 | 1967-05-31 | Mcneilab Inc | Process for the preparation of new 3-morpholinones |
| CA1199027A (en) * | 1981-11-12 | 1986-01-07 | Stuart D. Mills | Heterocyclic derivatives of pyridazinone, thiadiazinone, oxadiazinone and triazinone |
| JPS6183170A (en) * | 1984-09-28 | 1986-04-26 | Nippon Chemiphar Co Ltd | Novel 1,3-oxazolidin-2-one derivative and its preparation |
| AU607735B2 (en) * | 1987-05-07 | 1991-03-14 | A.H. Robins Company, Incorporated | Novel cyclic carbamate derivatives |
| GB8807921D0 (en) | 1988-04-05 | 1988-05-05 | Fujisawa Pharmaceutical Co | Ws-9326 & its derivatives |
| JP2865756B2 (en) | 1988-08-12 | 1999-03-08 | ććŖć«ćÆć¹ć¦ć¢ć¼ć²ć³ć»ć¢ćÆćć§ć³ć²ć¼ć«ć·ć£ćć | Friction clutch |
| MX18467A (en) | 1988-11-23 | 1993-07-01 | Pfizer | THERAPEUTIC AGENTS OF QUINUCLIDINES |
| IE903957A1 (en) * | 1989-11-06 | 1991-05-08 | Sanofi Sa | Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present |
| FR2654726B1 (en) | 1989-11-23 | 1992-02-14 | Rhone Poulenc Sante | NEW ISOINDOLONE DERIVATIVES AND THEIR PREPARATION. |
| US5332817A (en) * | 1990-01-04 | 1994-07-26 | Pfizer Inc. | 3-aminopiperidine derivatives and related nitrogen containing heterocycles |
| UA41251C2 (en) | 1990-01-04 | 2001-09-17 | ŠŃайзеŃ, ŠŠ½Šŗ. | Hydrogenated nitrogen-containing heterocyclic substances, piperidine derivatives, pharmaceutical composition and method for inhibiting activity of p substance |
| DE69105131T2 (en) | 1990-06-01 | 1995-03-23 | Pfizer | 3-AMINO-2-ARYLCHINUCLIDINE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM. |
| IL99320A (en) * | 1990-09-05 | 1995-07-31 | Sanofi Sa | Arylalkylamines, their preparation and pharmaceutical compositions containing them |
| FR2676054B1 (en) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | NOVEL N-ALKYLENEPIPERIDINO COMPOUNDS AND THEIR ENANTIOMERS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| FR2676055B1 (en) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | AMINO POLYCYCLIC COMPOUNDS AND THEIR ENANTIOMERS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| FR2688219B1 (en) * | 1992-03-03 | 1994-07-08 | Sanofi Elf | AMATONIUM QUATERNARY SALTS OF AMINO AROMATIC COMPOUNDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| IL106142A (en) * | 1992-06-29 | 1997-03-18 | Merck & Co Inc | Morpholine and thiomorpholine tachykinin receptor antagonists, their preparation and pharmaceutical compositions containing them |
| FR2696178B1 (en) * | 1992-09-30 | 1994-12-30 | Sanofi Elf | Quaternary basic amides, process for their preparation and pharmaceutical compositions containing them. |
| ATE158580T1 (en) * | 1993-05-06 | 1997-10-15 | Merrell Pharma Inc | SUBSTITUTED PYRROLIDINE-3-ALKYL-PIPERIDINE USABLE AS TACHYKININ ANTAGONISTS |
-
1995
- 1995-11-03 FR FR9513005A patent/FR2729954B1/en not_active Expired - Fee Related
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1996
- 1996-01-26 MY MYPI96000294A patent/MY117527A/en unknown
- 1996-01-29 AR ARP960101182A patent/AR002955A1/en active IP Right Grant
- 1996-01-30 ES ES96902305T patent/ES2181866T3/en not_active Expired - Lifetime
- 1996-01-30 FI FI973148A patent/FI973148L/en not_active Application Discontinuation
- 1996-01-30 MX MX9705590A patent/MX9705590A/en not_active IP Right Cessation
- 1996-01-30 AT AT96902305T patent/ATE222251T1/en active
- 1996-01-30 IL IL11695796A patent/IL116957A/en not_active IP Right Cessation
- 1996-01-30 WO PCT/FR1996/000152 patent/WO1996023787A1/en not_active Ceased
- 1996-01-30 ES ES01119949T patent/ES2243373T3/en not_active Expired - Lifetime
- 1996-01-30 CA CA002211668A patent/CA2211668C/en not_active Expired - Fee Related
- 1996-01-30 US US08/593,938 patent/US5641777A/en not_active Expired - Lifetime
- 1996-01-30 SI SI9630713T patent/SI1156049T1/en unknown
- 1996-01-30 HU HU9800295A patent/HUP9800295A3/en unknown
- 1996-01-30 CZ CZ19972436A patent/CZ293134B6/en not_active IP Right Cessation
- 1996-01-30 RU RU97114938/04A patent/RU2157807C2/en not_active IP Right Cessation
- 1996-01-30 AT AT01119949T patent/ATE296823T1/en active
- 1996-01-30 PL PL321640A patent/PL192164B1/en not_active IP Right Cessation
- 1996-01-30 EP EP06005775A patent/EP1688416A1/en not_active Withdrawn
- 1996-01-30 CN CNB2004100929315A patent/CN1295221C/en not_active Expired - Fee Related
- 1996-01-30 SI SI9630532T patent/SI0807111T1/en unknown
- 1996-01-30 PT PT96902305T patent/PT807111E/en unknown
- 1996-01-30 CN CN96191686A patent/CN1089764C/en not_active Expired - Fee Related
- 1996-01-30 IL IL12711496A patent/IL127114A/en not_active IP Right Cessation
- 1996-01-30 DK DK01119949T patent/DK1156049T3/en active
- 1996-01-30 DK DK96902305T patent/DK0807111T3/en active
- 1996-01-30 JP JP52330896A patent/JP3234228B2/en not_active Expired - Lifetime
- 1996-01-30 IL IL11605796A patent/IL116957A0/en unknown
- 1996-01-30 EP EP03012771A patent/EP1340754A1/en not_active Withdrawn
- 1996-01-30 NZ NZ301285A patent/NZ301285A/en not_active IP Right Cessation
- 1996-01-30 EP EP01119949A patent/EP1156049B1/en not_active Expired - Lifetime
- 1996-01-30 CN CNB200310119883XA patent/CN1293063C/en not_active Expired - Fee Related
- 1996-01-30 PT PT01119949T patent/PT1156049E/en unknown
- 1996-01-30 AU AU46669/96A patent/AU707901B2/en not_active Ceased
- 1996-01-30 DE DE69634806T patent/DE69634806T2/en not_active Expired - Lifetime
- 1996-01-30 EP EP96902305A patent/EP0807111B1/en not_active Expired - Lifetime
- 1996-01-30 CZ CZ20022243A patent/CZ294267B6/en not_active IP Right Cessation
- 1996-01-30 DE DE69622992T patent/DE69622992T2/en not_active Expired - Lifetime
- 1996-01-30 EP EP07150446A patent/EP1923391A1/en not_active Withdrawn
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1997
- 1997-03-18 US US08/820,716 patent/US5869663A/en not_active Expired - Lifetime
- 1997-07-29 NO NO973479A patent/NO308795B1/en not_active IP Right Cessation
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1998
- 1998-10-20 US US09/175,331 patent/US6242637B1/en not_active Expired - Fee Related
- 1998-10-20 US US09/175,332 patent/US5977359A/en not_active Expired - Lifetime
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2000
- 2000-11-09 JP JP2000342571A patent/JP3357660B2/en not_active Expired - Lifetime
- 2000-11-09 JP JP2000342606A patent/JP2001131171A/en active Pending
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2001
- 2001-04-11 CN CNB011163402A patent/CN1136189C/en not_active Expired - Fee Related
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2002
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2003
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