MY150711A - Il-12/p40 binding proteins - Google Patents
Il-12/p40 binding proteinsInfo
- Publication number
- MY150711A MY150711A MYPI20072353A MY150711A MY 150711 A MY150711 A MY 150711A MY PI20072353 A MYPI20072353 A MY PI20072353A MY 150711 A MY150711 A MY 150711A
- Authority
- MY
- Malaysia
- Prior art keywords
- hil
- antibodies
- activity
- antibody
- binding proteins
- Prior art date
Links
- 108091008324 binding proteins Proteins 0.000 title abstract 2
- 102000014914 Carrier Proteins Human genes 0.000 title 1
- 229940040731 human interleukin-12 Drugs 0.000 abstract 6
- 230000000694 effects Effects 0.000 abstract 3
- 102000013462 Interleukin-12 Human genes 0.000 abstract 1
- 108010065805 Interleukin-12 Proteins 0.000 abstract 1
- 102000023732 binding proteins Human genes 0.000 abstract 1
- 230000001627 detrimental effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
Abstract
THE PRESENT INVENTION ENCOMPASSES IL-12P4O BINDING PROTEINS, PARTICULARLY ANTIBODIES THAT BIND HUMAN INTERLEUKIN-12 (HIL-12) AND/OR HUMAN IL-23 (HIL-23). SPECIFICALLY, THE INVENTION RELATES TO ANTIBODIES THAT ARE CHIMERIC, CDR RAFTED AND HUMANIZED ANTIBODIES. PREFERRED ANTIBODIES HAVE HIGH AFFINITY FOR HIL-12 AND/OR HIL-23 AND NEUTRALIZE H IL-12 AND/OR HIL-23 ACTIVITY IN VITRO AND IN VIVO. AN ANTIBODY OF THE INVENTION CAN BE A FULL-LENGTH ANTIBODY OR AN ANTIGEN-BINDING PORTION THEREOF. METHOD OF MAKING AND METHOD OF USING THE ANTIBODIES OF THE INVENTION ARE ALSO PROVIDED. THE ANTIBODIES, OR ANTIBODY PORTIONS, OF THE INVENTION ARE USEFUL FOR DETECTING HIL-12 AND/OR HIL-23 AND FOR INHIBITING HIL-12 AND/OR HIL-23 ACTIVITY, E.G., IN A HUMAN SUBJECT SUFFERING FROM A DISORDER IN WHICH HIL-12 AND/OR HIL-23 ACTIVITY IS DETRIMENTAL.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MYPI20072353 MY150711A (en) | 2007-12-28 | 2007-12-28 | Il-12/p40 binding proteins |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MYPI20072353 MY150711A (en) | 2007-12-28 | 2007-12-28 | Il-12/p40 binding proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY150711A true MY150711A (en) | 2014-02-28 |
Family
ID=52595578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI20072353 MY150711A (en) | 2007-12-28 | 2007-12-28 | Il-12/p40 binding proteins |
Country Status (1)
| Country | Link |
|---|---|
| MY (1) | MY150711A (en) |
-
2007
- 2007-12-28 MY MYPI20072353 patent/MY150711A/en unknown
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