MY199045A - Poly-adp ribose polymerase (parp) inhibitors - Google Patents

Poly-adp ribose polymerase (parp) inhibitors

Info

Publication number
MY199045A
MY199045A MYPI2019003419A MYPI2019003419A MY199045A MY 199045 A MY199045 A MY 199045A MY PI2019003419 A MYPI2019003419 A MY PI2019003419A MY PI2019003419 A MYPI2019003419 A MY PI2019003419A MY 199045 A MY199045 A MY 199045A
Authority
MY
Malaysia
Prior art keywords
parp
poly
inhibitors
ribose polymerase
adp ribose
Prior art date
Application number
MYPI2019003419A
Other languages
English (en)
Inventor
Bharat Lagu
Taisuke Takahashi
Arthur Kluge
Nan Ji
Original Assignee
Mitobridge Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitobridge Inc filed Critical Mitobridge Inc
Publication of MY199045A publication Critical patent/MY199045A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MYPI2019003419A 2016-12-30 2017-12-28 Poly-adp ribose polymerase (parp) inhibitors MY199045A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662440581P 2016-12-30 2016-12-30
PCT/US2017/068636 WO2018125961A1 (fr) 2016-12-30 2017-12-28 Inhibiteurs de la poly-adp-ribose polymérase (parp)

Publications (1)

Publication Number Publication Date
MY199045A true MY199045A (en) 2023-10-11

Family

ID=61007849

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2019003419A MY199045A (en) 2016-12-30 2017-12-28 Poly-adp ribose polymerase (parp) inhibitors

Country Status (33)

Country Link
US (2) US11034670B2 (fr)
EP (1) EP3562822B1 (fr)
JP (1) JP7141399B2 (fr)
KR (1) KR102606799B1 (fr)
CN (1) CN110167926B (fr)
AR (1) AR110706A1 (fr)
AU (1) AU2017388376B2 (fr)
CA (1) CA3047137A1 (fr)
CO (1) CO2019007906A2 (fr)
CY (1) CY1124565T1 (fr)
DK (1) DK3562822T3 (fr)
EA (1) EA201991412A1 (fr)
ES (1) ES2875841T3 (fr)
HR (1) HRP20210887T1 (fr)
HU (1) HUE054382T2 (fr)
IL (1) IL267676B (fr)
JO (1) JOP20190115B1 (fr)
LT (1) LT3562822T (fr)
MA (1) MA47165B1 (fr)
MD (1) MD3562822T2 (fr)
MX (1) MX393606B (fr)
MY (1) MY199045A (fr)
PH (1) PH12019501529A1 (fr)
PL (1) PL3562822T3 (fr)
PT (1) PT3562822T (fr)
RS (1) RS61895B1 (fr)
SA (1) SA519401894B1 (fr)
SI (1) SI3562822T1 (fr)
SM (1) SMT202100321T1 (fr)
TW (1) TWI773718B (fr)
UA (1) UA124777C2 (fr)
WO (1) WO2018125961A1 (fr)
ZA (2) ZA201904004B (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA122237C2 (uk) * 2015-10-07 2020-10-12 Мітобрідж, Інк. Агоністи ppar, сполуки, фармацевтичні композиції та способи їх застосування
WO2018125961A1 (fr) * 2016-12-30 2018-07-05 Mitobridge, Inc. Inhibiteurs de la poly-adp-ribose polymérase (parp)
KR102293986B1 (ko) * 2019-10-30 2021-08-26 충남대학교산학협력단 이소퀴놀리논 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 폴리(adp-리보스)폴리머라제-1(parp-1) 관련 질환의 예방 또는 치료용 약학적 조성물
US20240336624A1 (en) * 2021-04-22 2024-10-10 Wigen Biomedicine Technology (shanghai) Co., Ltd. Parp inhibitor containing piperazine structure, preparation method therefor and pharmaceutical use thereof
CN118076585A (zh) * 2021-07-23 2024-05-24 国家医疗保健研究所 革兰氏阴性菌外排泵抑制剂
CN113603630B (zh) * 2021-08-10 2023-06-27 苏州小栗医药科技有限公司 一种4-苯基哌啶盐酸盐的合成方法
CN119894870A (zh) 2022-09-19 2025-04-25 巴斯夫欧洲公司 唑杀有害生物化合物
WO2024101336A1 (fr) 2022-11-07 2024-05-16 国立大学法人京都大学 Composé hétérocyclique contenant de l'azote
WO2024229406A1 (fr) 2023-05-04 2024-11-07 Revolution Medicines, Inc. Polythérapie pour une maladie ou un trouble lié à ras
CN120917007A (zh) * 2023-05-19 2025-11-07 上海海和药物研究开发股份有限公司 一种芳基脲类parp1抑制剂、其制备方法及用途
CN117024357B (zh) * 2023-07-03 2026-02-24 山东第二医科大学 一种针对brca突变的选择性抑制剂及其用途
US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
TW202530228A (zh) 2023-10-12 2025-08-01 美商銳新醫藥公司 Ｒａｓ抑制劑
CN117510404A (zh) * 2023-11-29 2024-02-06 山西永津集团有限公司 一种4-氨基烟酸的制备方法
WO2025111705A1 (fr) * 2023-11-30 2025-06-05 Waverley Pharma Inc. Dérivés de quinazolinone utilisés en tant qu'inhibiteurs de poly (adp ribose) polymérase 1 (parp-1)
WO2025171296A1 (fr) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Inhibiteurs de ras
CN118084678B (zh) * 2024-03-01 2024-09-06 长沙唯楚医药科技有限公司 一种2-溴-6-氟苯胺的制备方法
WO2025217307A1 (fr) 2024-04-09 2025-10-16 Revolution Medicines, Inc. Procédés de prédiction de la réponse à un inhibiteur de ras(on) et polythérapies
WO2025227032A1 (fr) * 2024-04-26 2025-10-30 Remix Therapeutics Inc. Procédés de dégradation de la cycline k et d'inhibition de kinases dépendantes de la cycline
TW202547461A (zh) 2024-05-17 2025-12-16 美商銳新醫藥公司 Ｒａｓ抑制劑
WO2025255438A1 (fr) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Procédés de traitement d'une maladie ou d'un trouble lié à la protéine ras
WO2025265060A1 (fr) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Compositions thérapeutiques et procédés de gestion d'effets liés au traitement
WO2026006747A1 (fr) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Inhibiteurs de ras
WO2026015801A1 (fr) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Méthodes de traitement d'une maladie ou d'un trouble liés à ras
WO2026015825A1 (fr) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Utilisation d'un inhibiteur de ras pour traiter le cancer du pancréas
WO2026015796A1 (fr) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Méthodes de traitement d'une maladie ou d'un trouble lié à ras
WO2026015790A1 (fr) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Méthodes de traitement d'une maladie ou d'un trouble lié à ras
WO2026050446A1 (fr) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Inhibiteurs de ras

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001070737A2 (fr) 2000-03-20 2001-09-27 Sepracor, Inc. Composes therapeutiques permettant de traiter l'asthme et l'allergie et leurs methodes d'utilisation
EP1272187B1 (fr) 2000-03-27 2008-07-30 Abbott GmbH & Co. KG Ligands du recepteur d3 de la dopamine destines au traitement de la dependance
AUPR201600A0 (en) 2000-12-11 2001-01-11 Fujisawa Pharmaceutical Co., Ltd. Quinazolinone derivative
EP1217000A1 (fr) 2000-12-23 2002-06-26 Aventis Pharma Deutschland GmbH Inhibiteurs du factor Xa et factor VIIa
CN1922171B (zh) 2004-02-26 2012-10-17 Aska制药株式会社 嘧啶衍生物
EP1760071A4 (fr) 2004-06-23 2008-03-05 Ono Pharmaceutical Co Composé ayant une activité de liaison aux récepteurs s1p et utilisation de celui-ci
KR101286969B1 (ko) * 2004-06-30 2013-07-23 얀센 파마슈티카 엔.브이. Ｐａｒｐ 저해제로서의 퀴나졸리논 유도체
GB0419072D0 (en) 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
MX2008000745A (es) 2005-07-15 2008-03-14 Schering Corp Derivados de quinazolina utiles en el tratamiento del cancer.
EP2520567A3 (fr) 2006-02-23 2012-12-12 Shionogi & Co., Ltd. Dérivés d'hétérocycle contenant de l'azote substitués avec un groupe cyclique
EP2233472B1 (fr) 2006-03-28 2014-01-15 Atir Holding S.A. Composés hétérocycliques et leurs utilisations dans le traitement de troubles sexuels
US8901133B2 (en) 2010-11-10 2014-12-02 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2012140642A1 (fr) 2011-04-10 2012-10-18 Atir Holding S.A. Composés hétérocycliques et leurs utilisations dans le traitement de troubles sexuels
CN102838600A (zh) 2011-06-24 2012-12-26 山东亨利医药科技有限责任公司 苯基喹唑啉类PI3Kδ抑制剂
US9505749B2 (en) 2012-08-29 2016-11-29 Amgen Inc. Quinazolinone compounds and derivatives thereof
WO2015014442A1 (fr) 2013-07-31 2015-02-05 Merck Patent Gmbh Dérivés oxoquinazolinyl-butanamide
EP3140295B1 (fr) 2014-05-07 2018-09-12 Merck Patent GmbH Dérivés hétérocyclyl-butanamides
CN105924434A (zh) * 2015-02-28 2016-09-07 广东东阳光药业有限公司 取代的氨基嘧啶类化合物及其使用方法和用途
WO2018026371A1 (fr) 2016-08-04 2018-02-08 Sunovion Pharmaceuticals Inc. Inhibiteurs doubles de nav1.2/5ht2a pour traiter des troubles du snc
WO2018125961A1 (fr) * 2016-12-30 2018-07-05 Mitobridge, Inc. Inhibiteurs de la poly-adp-ribose polymérase (parp)

Also Published As

Publication number Publication date
EP3562822A1 (fr) 2019-11-06
HUE054382T2 (hu) 2021-09-28
CY1124565T1 (el) 2022-07-22
RS61895B1 (sr) 2021-06-30
MX393606B (es) 2025-03-19
ES2875841T3 (es) 2021-11-11
TWI773718B (zh) 2022-08-11
JOP20190115A1 (ar) 2019-05-20
MD3562822T2 (ro) 2021-07-31
CA3047137A1 (fr) 2018-07-05
EP3562822B1 (fr) 2021-03-10
MA47165B1 (fr) 2021-06-30
DK3562822T3 (en) 2021-05-03
ZA202003310B (en) 2021-08-25
NZ754385A (en) 2024-07-05
MA47165A (fr) 2019-11-06
HRP20210887T1 (hr) 2021-07-23
TW201834657A (zh) 2018-10-01
BR112019011676A2 (pt) 2019-10-15
CO2019007906A2 (es) 2019-10-21
PL3562822T3 (pl) 2021-09-13
JOP20190115B1 (ar) 2023-09-17
PT3562822T (pt) 2021-06-02
CN110167926B (zh) 2022-09-13
US20200071299A1 (en) 2020-03-05
WO2018125961A8 (fr) 2019-05-23
KR102606799B1 (ko) 2023-11-28
AU2017388376A1 (en) 2019-07-04
IL267676B (en) 2021-09-30
AU2017388376B2 (en) 2022-01-06
EA201991412A1 (ru) 2019-11-29
US11034670B2 (en) 2021-06-15
JP7141399B2 (ja) 2022-09-22
SI3562822T1 (sl) 2021-08-31
US11993585B2 (en) 2024-05-28
PH12019501529A1 (en) 2020-09-14
CN110167926A (zh) 2019-08-23
MX2019007870A (es) 2019-08-16
WO2018125961A1 (fr) 2018-07-05
LT3562822T (lt) 2021-06-10
US20220033380A1 (en) 2022-02-03
IL267676A (en) 2019-08-29
UA124777C2 (uk) 2021-11-17
AR110706A1 (es) 2019-04-24
SMT202100321T1 (it) 2021-07-12
KR20190098760A (ko) 2019-08-22
ZA201904004B (en) 2022-12-21
JP2020512298A (ja) 2020-04-23
SA519401894B1 (ar) 2023-02-19

Similar Documents

Publication Publication Date Title
PH12019501529A1 (en) Poly-adp ribose polymerase (parp) inhibitors
PH12018500360A1 (en) Heteroaryl derivatives as parp inhibitors
SA518400547B1 (ar) مشتقات بيرازولو بيريميدين كمثبط كيناز
SA520412335B1 (ar) مشتقات أوكسي فلورو ببريدين كمثبط كيناز
PH12017501016A1 (en) Triazolopyrimidine compounds and uses thereof
PH12017501326A1 (en) Tgf-� inhibitors
PH12019501198A1 (en) Tetracyclic heterocycle compounds useful as hiv integrase inhibitors
GEP20207105B (en) 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2yl carbamate derivatives as magl inhibitors
TN2020000125A1 (en) Amino-fluoropiperidine derivative as kinase inhibitor
EA201490724A1 (ru) Замещенные соединения тетрагидроизохинолина в качестве ингибиторов фактора xia
MX2018008095A (es) Compuestos heterociclicos triciclicos condensados como inhibidores de integrasa del vih.
PH12018500061A1 (en) Oxysterols and methods of use thereof
WO2011123946A8 (fr) Inhibiteurs de kinases et procédé de traitement du cancer utilisant ceux-ci
MY196572A (en) Amino-Methyl Piperidine Derivative as Kinase Inhibitor
IN2015MN00002A (fr)
NZ746906A (en) Oxaborole esters and uses thereof
PH12017500007A1 (en) Quinolizinone derivatives as p13k inhibitors
MX364400B (es) Compuestos de tetraciclina.
MX357763B (es) Tratamiento para cancer pancreatico.
EA202191885A2 (ru) Бициклические гетероциклические производные в качестве ингибиторов irak4