NL1006532C2 - Werkwijze voor het bestrijden van parasieten en vooral van ectoparasieten van gewervelde dieren, vooral van zoogdieren en samenstellingen voor de toepassing van de werkwijze. - Google Patents

Werkwijze voor het bestrijden van parasieten en vooral van ectoparasieten van gewervelde dieren, vooral van zoogdieren en samenstellingen voor de toepassing van de werkwijze. Download PDF

Info

Publication number: NL1006532C2
Authority: NL; Netherlands
Prior art keywords: composition according; compound; formula; composition; alkyl
Prior art date: 1996-07-11

Application number

NL1006532A

Other languages

English (en)

Dutch (nl)

Other versions

NL1006532A1 (nl

Inventor

Philip Reid Timmons

Philippe Jeannin

Tai-Teh Wu

Bruno Julia

Jean-Yves Vienot

Marc Teichner

Kenneth Anthony Kukorowski

Original Assignee

Merial Sas

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-11

Filing date

1997-07-10

Publication date

1998-03-27

1996-07-11 Priority claimed from FR9608703A external-priority patent/FR2750860B1/fr

1997-07-10 Application filed by Merial Sas filed Critical Merial Sas

1998-01-15 Publication of NL1006532A1 publication Critical patent/NL1006532A1/xx

1998-03-27 Application granted granted Critical

1998-03-27 Publication of NL1006532C2 publication Critical patent/NL1006532C2/nl

Links

239000000203 mixture Substances 0.000 title claims description 69
244000078703 ectoparasite Species 0.000 title claims description 10
241000251539 Vertebrata <Metazoa> Species 0.000 title claims description 8
241000124008 Mammalia Species 0.000 title claims description 5
244000045947 parasite Species 0.000 title description 16
238000000034 method Methods 0.000 title description 14
150000001875 compounds Chemical class 0.000 claims description 37
125000000217 alkyl group Chemical group 0.000 claims description 23
241001465754 Metazoa Species 0.000 claims description 21
125000001188 haloalkyl group Chemical group 0.000 claims description 20
ZOCSXAVNDGMNBV-UHFFFAOYSA-N 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile Chemical compound NC1=C(S(=O)C(F)(F)F)C(C#N)=NN1C1=C(Cl)C=C(C(F)(F)F)C=C1Cl ZOCSXAVNDGMNBV-UHFFFAOYSA-N 0.000 claims description 17
241000238876 Acari Species 0.000 claims description 16
241000282472 Canis lupus familiaris Species 0.000 claims description 13
125000005843 halogen group Chemical group 0.000 claims description 13
239000003139 biocide Substances 0.000 claims description 12
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 11
AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 claims description 8
SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 claims description 8
229960002418 ivermectin Drugs 0.000 claims description 8
239000005660 Abamectin Substances 0.000 claims description 6
230000037396 body weight Effects 0.000 claims description 6
230000001793 endectocide Effects 0.000 claims description 6
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
238000002360 preparation method Methods 0.000 claims description 6
241000238421 Arthropoda Species 0.000 claims description 5
241000283690 Bos taurus Species 0.000 claims description 5
241001399426 Myas Species 0.000 claims description 5
241000282887 Suidae Species 0.000 claims description 5
238000013270 controlled release Methods 0.000 claims description 5
230000009885 systemic effect Effects 0.000 claims description 5
-1 -S-alkyl Chemical group 0.000 claims description 4
241000283707 Capra Species 0.000 claims description 4
241001494479 Pecora Species 0.000 claims description 4
125000002947 alkylene group Chemical group 0.000 claims description 4
239000002775 capsule Substances 0.000 claims description 4
238000007911 parenteral administration Methods 0.000 claims description 4
230000001717 pathogenic effect Effects 0.000 claims description 4
208000005687 scabies Diseases 0.000 claims description 4
210000002966 serum Anatomy 0.000 claims description 4
IBSREHMXUMOFBB-JFUDTMANSA-N 5u8924t11h Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 IBSREHMXUMOFBB-JFUDTMANSA-N 0.000 claims description 3
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 3
229950008167 abamectin Drugs 0.000 claims description 3
238000010521 absorption reaction Methods 0.000 claims description 3
239000003096 antiparasitic agent Substances 0.000 claims description 3
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 3
RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical group C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 claims description 3
238000009826 distribution Methods 0.000 claims description 3
QLFZZSKTJWDQOS-YDBLARSUSA-N doramectin Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C3CCCCC3)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C QLFZZSKTJWDQOS-YDBLARSUSA-N 0.000 claims description 3
229960003997 doramectin Drugs 0.000 claims description 3
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
229910052736 halogen Inorganic materials 0.000 claims description 3
150000002367 halogens Chemical class 0.000 claims description 3
125000005842 heteroatom Chemical group 0.000 claims description 3
238000002347 injection Methods 0.000 claims description 3
239000007924 injection Substances 0.000 claims description 3
150000002596 lactones Chemical class 0.000 claims description 3
229910052757 nitrogen Inorganic materials 0.000 claims description 3
125000004433 nitrogen atom Chemical group N* 0.000 claims description 3
229910052760 oxygen Inorganic materials 0.000 claims description 3
239000001301 oxygen Substances 0.000 claims description 3
229910052717 sulfur Chemical group 0.000 claims description 3
239000011593 sulfur Chemical group 0.000 claims description 3
241000282326 Felis catus Species 0.000 claims description 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 2
125000004093 cyano group Chemical group *C#N 0.000 claims description 2
125000004438 haloalkoxy group Chemical group 0.000 claims description 2
125000001072 heteroaryl group Chemical group 0.000 claims description 2
229910052739 hydrogen Inorganic materials 0.000 claims description 2
239000001257 hydrogen Substances 0.000 claims description 2
239000000463 material Substances 0.000 claims description 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
230000000968 intestinal effect Effects 0.000 claims 2
229910004013 NO 2 Inorganic materials 0.000 claims 1
239000002671 adjuvant Substances 0.000 claims 1
239000002552 dosage form Substances 0.000 claims 1
210000000936 intestine Anatomy 0.000 claims 1
230000001681 protective effect Effects 0.000 claims 1
230000000699 topical effect Effects 0.000 claims 1
239000005899 Fipronil Substances 0.000 description 16
229940013764 fipronil Drugs 0.000 description 16
241000258242 Siphonaptera Species 0.000 description 11
238000009472 formulation Methods 0.000 description 9
239000004005 microsphere Substances 0.000 description 8
238000011282 treatment Methods 0.000 description 7
241000238631 Hexapoda Species 0.000 description 6
230000000694 effects Effects 0.000 description 6
239000000243 solution Substances 0.000 description 4
239000003405 delayed action preparation Substances 0.000 description 3
239000007943 implant Substances 0.000 description 3
229920000747 poly(lactic acid) Polymers 0.000 description 3
229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 3
239000004626 polylactic acid Substances 0.000 description 3
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 3
235000015112 vegetable and seed oil Nutrition 0.000 description 3
239000008158 vegetable oil Substances 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
241000239223 Arachnida Species 0.000 description 2
241000258922 Ctenocephalides Species 0.000 description 2
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 description 2
241001481703 Rhipicephalus <genus> Species 0.000 description 2
210000004369 blood Anatomy 0.000 description 2
239000008280 blood Substances 0.000 description 2
239000000839 emulsion Substances 0.000 description 2
230000002323 endectocidal effect Effects 0.000 description 2
239000000945 filler Substances 0.000 description 2
239000008187 granular material Substances 0.000 description 2
239000004530 micro-emulsion Substances 0.000 description 2
201000002266 mite infestation Diseases 0.000 description 2
230000003071 parasitic effect Effects 0.000 description 2
231100000255 pathogenic effect Toxicity 0.000 description 2
230000036470 plasma concentration Effects 0.000 description 2
239000000725 suspension Substances 0.000 description 2
230000002459 sustained effect Effects 0.000 description 2
239000003826 tablet Substances 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
238000002560 therapeutic procedure Methods 0.000 description 2
238000005303 weighing Methods 0.000 description 2
XKXLUPDANJWFIJ-UHFFFAOYSA-N 1-phenylpyrazole-3-carbonitrile Chemical class N1=C(C#N)C=CN1C1=CC=CC=C1 XKXLUPDANJWFIJ-UHFFFAOYSA-N 0.000 description 1
229940126062 Compound A Drugs 0.000 description 1
241000255925 Diptera Species 0.000 description 1
241000283086 Equidae Species 0.000 description 1
241000282324 Felis Species 0.000 description 1
NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 1
241000403354 Microplus Species 0.000 description 1
208000002193 Pain Diseases 0.000 description 1
206010033733 Papule Diseases 0.000 description 1
241001674048 Phthiraptera Species 0.000 description 1
208000003251 Pruritus Diseases 0.000 description 1
241001481696 Rhipicephalus sanguineus Species 0.000 description 1
241000509427 Sarcoptes scabiei Species 0.000 description 1
238000012338 Therapeutic targeting Methods 0.000 description 1
241000607479 Yersinia pestis Species 0.000 description 1
125000004429 atom Chemical group 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000004140 cleaning Methods 0.000 description 1
239000006071 cream Substances 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
239000003623 enhancer Substances 0.000 description 1
230000003628 erosive effect Effects 0.000 description 1
238000013265 extended release Methods 0.000 description 1
210000003608 fece Anatomy 0.000 description 1
235000013305 food Nutrition 0.000 description 1
244000144980 herd Species 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
239000002917 insecticide Substances 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
230000007803 itching Effects 0.000 description 1
239000002502 liposome Substances 0.000 description 1
239000007788 liquid Substances 0.000 description 1
238000011866 long-term treatment Methods 0.000 description 1
239000007937 lozenge Substances 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
239000003094 microcapsule Substances 0.000 description 1
239000011859 microparticle Substances 0.000 description 1
239000002088 nanocapsule Substances 0.000 description 1
239000002105 nanoparticle Substances 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
239000003921 oil Substances 0.000 description 1
235000019198 oils Nutrition 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
230000003108 parasitologic effect Effects 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
230000002085 persistent effect Effects 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
239000000843 powder Substances 0.000 description 1
230000033764 rhythmic process Effects 0.000 description 1
210000004767 rumen Anatomy 0.000 description 1
238000006748 scratching Methods 0.000 description 1
230000002393 scratching effect Effects 0.000 description 1
241000894007 species Species 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
238000007910 systemic administration Methods 0.000 description 1
239000012049 topical pharmaceutical composition Substances 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
210000003462 vein Anatomy 0.000 description 1
230000003442 weekly effect Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Agronomy & Crop Science (AREA)
Pest Control & Pesticides (AREA)
Plant Pathology (AREA)
Engineering & Computer Science (AREA)
Dentistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Environmental Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Tropical Medicine & Parasitology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

NL1006532A 1996-07-11 1997-07-10 Werkwijze voor het bestrijden van parasieten en vooral van ectoparasieten van gewervelde dieren, vooral van zoogdieren en samenstellingen voor de toepassing van de werkwijze. NL1006532C2 (nl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
FR9608703		1996-07-11
FR9608703A FR2750860B1 (fr)	1996-07-11	1996-07-11	Procedes d'elimination des parasites, et notamment des ectoparasites de vertebres, notamment de mammiferes et compositions pour la mise en oeuvre de ce procede
FR9703025A FR2750861B1 (fr)	1996-07-11	1997-03-13	Procedes d'elimination des parasites, et notamment des ectoparasites de vertebres, notamment de mammiferes et compositions pour la mise en oeuvre de ce procede
FR9703025		1997-03-13

Publications (2)

Publication Number	Publication Date
NL1006532A1 NL1006532A1 (nl)	1998-01-15
NL1006532C2 true NL1006532C2 (nl)	1998-03-27

Family

ID=26232827

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL1006532A NL1006532C2 (nl)	1996-07-11	1997-07-10	Werkwijze voor het bestrijden van parasieten en vooral van ectoparasieten van gewervelde dieren, vooral van zoogdieren en samenstellingen voor de toepassing van de werkwijze.

Country Status (16)

Country	Link
US (1)	US6162820A (fr)
JP (1)	JP2000515509A (fr)
KR (1)	KR100484363B1 (fr)
AR (1)	AR008999A1 (fr)
AU (1)	AU736317B2 (fr)
BE (1)	BE1010974A3 (fr)
BR (1)	BR9710236A (fr)
CA (1)	CA2258926C (fr)
DE (1)	DE19781860T1 (fr)
ES (1)	ES2166299A1 (fr)
FR (1)	FR2750861B1 (fr)
GB (1)	GB2331242B (fr)
GR (1)	GR1003026B (fr)
IT (1)	IT1297555B1 (fr)
NL (1)	NL1006532C2 (fr)
WO (1)	WO1998002042A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0963695A1 (fr) *	1998-06-08	1999-12-15	Rhone Poulenc Agro	Méthode insecticide
EG22187A (en) *	1999-04-15	2002-10-31	Aventis Cropscience Sa	New composition
GB9916052D0 (en) *	1999-07-08	1999-09-08	Pfizer Ltd	Anthelmintic compositions
US20030056734A1 (en)	2000-06-16	2003-03-27	Centers For Disease Control And Prevention	Apparatus for applying chemicals to rodents
US6849266B2 (en) *	2000-06-16	2005-02-01	Centers For Disease Control & Prevention	Control of arthropod vectors of parasitic diseases
US7166294B2 (en)	2000-06-16	2007-01-23	Centers For Disease Control And Prevention	Control of arthropods in rodents
CA2311881C (fr) *	2000-06-16	2007-08-28	Gary O. Maupin	Lutte contre les arthropodes chez les rongeurs
US6663876B2 (en)	2002-04-29	2003-12-16	Piedmont Pharmaceuticals, Llc	Methods and compositions for treating ectoparasite infestation
CN1204123C (zh) *	2002-07-30	2005-06-01	王正权	N－苯基吡唑衍生物杀虫剂
NZ529177A (en) *	2003-10-24	2005-12-23	Agres Ltd	Administration process for a delivery device that releases the active agent over several days
GB2410436A (en) *	2004-01-30	2005-08-03	Reckitt Benckiser	Rodenticidal bait composition
BRPI0508140B1 (pt)	2004-03-05	2015-03-17	Nissan Chemical Ind Ltd	Composto benzamida substituída por isoxazolina da fórmula (1); da fórmula (2) substituído por 3,5-bis (aril substituído); da fórmula (4) substituída por alquinibenzeno ou um sal do mesmo; "pesticida, agroquímico, inseticida, parasiticida contendo como ingrediente ativo um ou mais composto benzamida substituída por isoxazolina e sal do mesmo"
BRPI0509673A (pt) *	2004-04-07	2007-10-09	Intervet Int Bv	composição para o tratamento de parasitas, forma de dosagem farmacêutica, método para tratar um organismo, e, processos para introduzir pelo menos um aditivo em um organismo, para fabricar uma composição, para liberar um aditivo em um organismo, e, para conformar um produto macio mastigável
DK2182945T3 (en) *	2007-06-27	2015-11-16	Du Pont	PROCEDURE TO COMBAT PESTS WITH ANIMALS
TWI556741B (zh)	2007-08-17	2016-11-11	英特威特國際股份有限公司	異唑啉組成物及其作為抗寄生蟲藥上的應用
WO2010106325A2 (fr)	2009-03-18	2010-09-23	Omnipharm Limited	Formulation parasiticide
MX379693B (es)	2011-12-02	2025-03-11	Merial Ltd	Formulaciones de moxidectina inyectables de larga acción y formas de cristal de moxidectina novedosas.

Citations (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0295117A1 (fr) *	1987-06-12	1988-12-14	Rhone-Poulenc Agriculture Limited	Dérivés de N-phénylpyrazoles
JPH04235104A (ja) *	1991-01-08	1992-08-24	Mitsubishi Kasei Corp	殺虫・殺ダニ剤組成物
EP0500209A1 (fr) *	1991-01-18	1992-08-26	Rhone-Poulenc Agrochimie	1-(2-Pyridyl)pyrazoles pesticides
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- 1997-07-08 ES ES009950001A patent/ES2166299A1/es active Pending
- 1997-07-08 KR KR10-1999-7000077A patent/KR100484363B1/ko not_active Expired - Lifetime
- 1997-07-08 BR BR9710236A patent/BR9710236A/pt not_active Application Discontinuation
- 1997-07-08 CA CA002258926A patent/CA2258926C/fr not_active Expired - Lifetime
- 1997-07-08 DE DE19781860T patent/DE19781860T1/de not_active Ceased
- 1997-07-08 AR ARP970103051A patent/AR008999A1/es not_active Application Discontinuation
- 1997-07-08 AU AU36247/97A patent/AU736317B2/en not_active Expired
- 1997-07-08 GB GB9900552A patent/GB2331242B/en not_active Expired - Lifetime
- 1997-07-08 JP JP10505659A patent/JP2000515509A/ja active Pending
- 1997-07-08 WO PCT/FR1997/001236 patent/WO1998002042A1/fr not_active Ceased
- 1997-07-09 IT IT97TO000607A patent/IT1297555B1/it active IP Right Grant
- 1997-07-10 BE BE9700598A patent/BE1010974A3/fr active
- 1997-07-10 US US08/891,047 patent/US6162820A/en not_active Expired - Lifetime
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Also Published As

Publication number	Publication date
BR9710236A (pt)	1999-08-10
GB2331242B (en)	2001-01-10
KR100484363B1 (ko)	2005-04-20
BE1010974A3 (fr)	1999-03-02
GB2331242A (en)	1999-05-19
US6162820A (en)	2000-12-19
ES2166299A1 (es)	2002-04-01
NL1006532A1 (nl)	1998-01-15
JP2000515509A (ja)	2000-11-21
AU736317B2 (en)	2001-07-26
ITTO970607A1 (it)	1999-01-09
FR2750861B1 (fr)	1998-12-24
DE19781860T1 (de)	1999-07-15
CA2258926A1 (fr)	1998-01-22
IT1297555B1 (it)	1999-12-17
WO1998002042A1 (fr)	1998-01-22
IE970489A1 (en)	2000-08-23
AU3624797A (en)	1998-02-09
FR2750861A1 (fr)	1998-01-16
GR1003026B (el)	1998-12-10
KR20000023628A (ko)	2000-04-25
AR008999A1 (es)	2000-03-08
CA2258926C (fr)	2008-09-23

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2017-07-12	MK	Patent expired because of reaching the maximum lifetime of a patent	Effective date: 20170709

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TW200924647A (en)	2009-06-16	Local topical administration formulations containing fipronil
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IE83881B1 (en)	2005-04-20	Methods for removing parasites and in particular ectoparasites of vertebrates, in particular of mammals, and compositions for the implementation of this method.
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KR20230161995A (ko)	2023-11-28	포유동물에서 진드기 감염을 제어하는 사료 및 방법
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