NL1012191C2 - Gestabiliseerde antihistaminesiroop. - Google Patents

Gestabiliseerde antihistaminesiroop. Download PDF

Info

Publication number: NL1012191C2
Authority: NL; Netherlands
Prior art keywords: syrup; acid; antihistamine; loratadine; aminopolycarboxylic
Prior art date: 1998-06-01

Application number

NL1012191A

Other languages

English (en)

Dutch (nl)

Other versions

NL1012191A1 (nl

Inventor

Farah Joseph Munayyer

Frank Guazzo

Elliot Isaac Stupak

Imtiaz Ahmed Chaudry

Joel Agostinho Sequeira

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-01

Filing date

1999-05-31

Publication date

2000-01-04

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22209512&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL1012191(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-05-31 Application filed by Schering Corp filed Critical Schering Corp

1999-12-03 Publication of NL1012191A1 publication Critical patent/NL1012191A1/xx

2000-01-04 Application granted granted Critical

2000-01-04 Publication of NL1012191C2 publication Critical patent/NL1012191C2/nl

Links

239000006188 syrup Substances 0.000 title claims description 74
235000020357 syrup Nutrition 0.000 title claims description 74
239000000739 antihistaminic agent Substances 0.000 title claims description 19
GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 title claims description 16
230000001387 anti-histamine Effects 0.000 title claims description 16
JCCNYMKQOSZNPW-UHFFFAOYSA-N loratadine Chemical compound C1CN(C(=O)OCC)CCC1=C1C2=NC=CC=C2CCC2=CC(Cl)=CC=C21 JCCNYMKQOSZNPW-UHFFFAOYSA-N 0.000 claims description 25
229960003088 loratadine Drugs 0.000 claims description 25
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 22
239000000203 mixture Substances 0.000 claims description 20
239000004615 ingredient Substances 0.000 claims description 19
239000002253 acid Substances 0.000 claims description 18
238000009472 formulation Methods 0.000 claims description 17
150000003839 salts Chemical class 0.000 claims description 11
229960001271 desloratadine Drugs 0.000 claims description 8
JAUOIFJMECXRGI-UHFFFAOYSA-N Neoclaritin Chemical compound C=1C(Cl)=CC=C2C=1CCC1=CC=CN=C1C2=C1CCNCC1 JAUOIFJMECXRGI-UHFFFAOYSA-N 0.000 claims description 6
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SEBMTIQKRHYNIT-UHFFFAOYSA-N azatadine Chemical compound C1CN(C)CCC1=C1C2=NC=CC=C2CCC2=CC=CC=C21 SEBMTIQKRHYNIT-UHFFFAOYSA-N 0.000 claims description 5
KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 claims description 4
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XWSGEVNYFYKXCP-UHFFFAOYSA-N 2-[carboxymethyl(methyl)amino]acetic acid Chemical compound OC(=O)CN(C)CC(O)=O XWSGEVNYFYKXCP-UHFFFAOYSA-N 0.000 claims description 3
FCKYPQBAHLOOJQ-UHFFFAOYSA-N Cyclohexane-1,2-diaminetetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)C1CCCCC1N(CC(O)=O)CC(O)=O FCKYPQBAHLOOJQ-UHFFFAOYSA-N 0.000 claims description 3
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DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 claims description 3
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CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Oil, Petroleum & Natural Gas (AREA)
Immunology (AREA)
Pulmonology (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NL1012191A 1998-06-01 1999-05-31 Gestabiliseerde antihistaminesiroop. NL1012191C2 (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8812898		1998-06-01
US09/088,128 US6132758A (en)	1998-06-01	1998-06-01	Stabilized antihistamine syrup

Publications (2)

Publication Number	Publication Date
NL1012191A1 NL1012191A1 (nl)	1999-12-03
NL1012191C2 true NL1012191C2 (nl)	2000-01-04

Family

ID=22209512

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL1012191A NL1012191C2 (nl)	1998-06-01	1999-05-31	Gestabiliseerde antihistaminesiroop.

Country Status (29)

Country	Link
US (4)	US6132758A (sr)
EP (1)	EP1082117B1 (sr)
JP (2)	JP4166948B2 (sr)
AR (1)	AR019147A1 (sr)
AT (1)	ATE257705T1 (sr)
AU (1)	AU754469B2 (sr)
CA (1)	CA2333528C (sr)
CO (1)	CO5011119A1 (sr)
CR (1)	CR6035A (sr)
DE (1)	DE69914192T2 (sr)
DK (1)	DK1082117T3 (sr)
EG (1)	EG23908A (sr)
ES (1)	ES2211192T3 (sr)
GC (1)	GC0000330A (sr)
GT (2)	GT199900072A (sr)
HN (1)	HN1999000081A (sr)
JO (1)	JO2099B1 (sr)
ME (1)	ME01664B (sr)
MY (1)	MY123325A (sr)
NL (1)	NL1012191C2 (sr)
NO (1)	NO329124B1 (sr)
NZ (1)	NZ508037A (sr)
PA (1)	PA8474201A1 (sr)
PE (1)	PE20000565A1 (sr)
PT (1)	PT1082117E (sr)
RS (1)	RS49609B (sr)
SV (1)	SV1999000068A (sr)
TW (1)	TW589197B (sr)
WO (1)	WO1999062516A1 (sr)

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EP1568369A1 (en)	2004-02-23	2005-08-31	Boehringer Ingelheim Vetmedica Gmbh	Use of meloxicam for the treatment of respiratory diseases in pigs
GB0417909D0 (en) *	2004-08-11	2004-09-15	Novartis Consumer Health Sa	Drop preparations
US20060093631A1 (en) *	2004-10-29	2006-05-04	Buehler Gail K	Dye-free pharmaceutical suspensions and related methods
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US20070009558A1 (en) *	2004-12-22	2007-01-11	David Harris	Sugar-free storage-stable antihistaminic syrups
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ES2610603T3 (es) *	2007-06-08	2017-04-28	The Procter & Gamble Company	Composiciones que contienen miel natural y método de preparación
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1998
- 1998-06-01 US US09/088,128 patent/US6132758A/en not_active Expired - Lifetime
1999
- 1999-05-26 GT GT199900072A patent/GT199900072A/es unknown
- 1999-05-26 GT GT199900072AK patent/GT199900072AA/es unknown
- 1999-05-27 ME MEP-1999-235A patent/ME01664B/me unknown
- 1999-05-27 JP JP2000551772A patent/JP4166948B2/ja not_active Expired - Lifetime
- 1999-05-27 ES ES99955215T patent/ES2211192T3/es not_active Expired - Lifetime
- 1999-05-27 AR ARP990102500A patent/AR019147A1/es active IP Right Grant
- 1999-05-27 PT PT99955215T patent/PT1082117E/pt unknown
- 1999-05-27 RS YUP-235/99A patent/RS49609B/sr unknown
- 1999-05-27 DE DE69914192T patent/DE69914192T2/de not_active Expired - Lifetime
- 1999-05-27 EG EG60799A patent/EG23908A/xx active
- 1999-05-27 CO CO99033034A patent/CO5011119A1/es unknown
- 1999-05-27 WO PCT/US1999/010469 patent/WO1999062516A1/en not_active Ceased
- 1999-05-27 PA PA19998474201A patent/PA8474201A1/es unknown
- 1999-05-27 EP EP99955215A patent/EP1082117B1/en not_active Expired - Lifetime
- 1999-05-27 CA CA002333528A patent/CA2333528C/en not_active Expired - Fee Related
- 1999-05-27 AU AU43085/99A patent/AU754469B2/en not_active Expired
- 1999-05-27 TW TW088108750A patent/TW589197B/zh not_active IP Right Cessation
- 1999-05-27 PE PE1999000446A patent/PE20000565A1/es not_active IP Right Cessation
- 1999-05-27 DK DK99955215T patent/DK1082117T3/da active
- 1999-05-27 AT AT99955215T patent/ATE257705T1/de active
- 1999-05-27 MY MYPI99002108A patent/MY123325A/en unknown
- 1999-05-27 JO JO19992099A patent/JO2099B1/en active
- 1999-05-27 NZ NZ508037A patent/NZ508037A/xx not_active IP Right Cessation
- 1999-05-27 HN HN1999000081A patent/HN1999000081A/es unknown
- 1999-05-27 CR CR6035A patent/CR6035A/es unknown
- 1999-05-28 SV SV1999000068A patent/SV1999000068A/es not_active Application Discontinuation
- 1999-05-29 GC GCP1999161 patent/GC0000330A/en active
- 1999-05-31 NL NL1012191A patent/NL1012191C2/nl not_active IP Right Cessation
2000
- 2000-11-30 NO NO20006079A patent/NO329124B1/no not_active IP Right Cessation
2001
- 2001-07-05 US US09/899,764 patent/US6514520B2/en not_active Expired - Lifetime
2002
- 2002-11-15 US US10/298,175 patent/US6939550B2/en not_active Expired - Lifetime
2004
- 2004-06-29 JP JP2004192333A patent/JP2005015485A/ja not_active Withdrawn
2005
- 2005-08-01 US US11/194,318 patent/US20050261280A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE69914192T2 (de)	2004-10-21
US6939550B2 (en)	2005-09-06
YU23599A (sh)	2001-07-10
US6514520B2 (en)	2003-02-04
PA8474201A1 (es)	2001-07-31
ME01664B (me)	2007-06-04
GT199900072A (es)	2000-11-16
NZ508037A (en)	2002-11-26
US20020132805A1 (en)	2002-09-19
RS49609B (sr)	2007-06-04
CA2333528C (en)	2002-07-02
HN1999000081A (es)	1999-08-23
NO20006079D0 (no)	2000-11-30
JP2002516860A (ja)	2002-06-11
ATE257705T1 (de)	2004-01-15
JO2099B1 (en)	2000-05-21
MY123325A (en)	2006-05-31
GC0000330A (en)	2007-03-31
PT1082117E (pt)	2004-05-31
CO5011119A1 (es)	2001-02-28
CA2333528A1 (en)	1999-12-09
WO1999062516A1 (en)	1999-12-09
PE20000565A1 (es)	2000-07-05
DK1082117T3 (da)	2004-05-03
NL1012191A1 (nl)	1999-12-03
NO20006079L (no)	2000-11-30
EP1082117B1 (en)	2004-01-14
US20050261280A1 (en)	2005-11-24
DE69914192D1 (de)	2004-02-19
SV1999000068A (es)	2000-06-23
AU754469B2 (en)	2002-11-14
AU4308599A (en)	1999-12-20
EG23908A (en)	2007-12-30
US6132758A (en)	2000-10-17
JP4166948B2 (ja)	2008-10-15
NO329124B1 (no)	2010-08-30
US20030152595A1 (en)	2003-08-14
EP1082117A1 (en)	2001-03-14
AR019147A1 (es)	2001-12-26
GT199900072AA (es)	2000-11-16
TW589197B (en)	2004-06-01
JP2005015485A (ja)	2005-01-20
ES2211192T3 (es)	2004-07-01
CR6035A (es)	2008-11-26

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Date	Code	Title	Description
2000-02-01	AD1B	A search report has been drawn up
2000-03-01	PD2B	A search report has been drawn up
2012-10-03	TD	Modifications of names of proprietors of patents	Effective date: 20120924
2019-06-05	MK	Patent expired because of reaching the maximum lifetime of a patent	Effective date: 20190530

Publication	Publication Date	Title
JP4166948B2 (ja)	2008-10-15	安定化剤としてアミノポリカルボン酸を含有する安定化抗ヒスタミンシロップ
RU2468787C2 (ru)	2012-12-10	Жидкие композиции фенилэфрина с повышенной стабильностью
US9018193B2 (en)	2015-04-28	Aqueous drug delivery system
RS60267B1 (sr)	2020-06-30	Vodena farmaceutska formulacija tapentadola za oralnu primenu
KR20160048040A (ko)	2016-05-03	조합된 ａｐｉ를 위한 안정한 경구 용액
EP1372394A1 (en)	2004-01-02	Antifungal composition with enhanced bioavailability
JP4393192B2 (ja)	2010-01-06	リバビリンシロップ処方物
US20040101563A1 (en)	2004-05-27	Storage stable antihistaminic syrup formulations
CN117982446A (zh)	2024-05-07	双组分组合物
US8518439B2 (en)	2013-08-27	Liquid therapeutic composition
US20140275151A1 (en)	2014-09-18	Dye free liquid therapeutic solution
MXPA00011834A (en)	2001-09-07	A stabilized antihistamine syrup containing aminopolycarboxylic acid as stabilizer
JPS62270523A (ja)	1987-11-24	非刺激性のスプロフエン溶液
US20260130849A1 (en)	2026-05-14	Edaravone Oral Solution Compositions
Anderson et al.	2006	Excipients for oral liquid formulations
JP2003171311A (ja)	2003-06-20	内服液剤組成物、それを含む内服液剤品
WO2005034910A1 (en)	2005-04-21	Oral liquid pharmaceutical compositions of sertraline