NL194960C - Werkwijze voor het bereiden van mutantstammen van Bordetella bronchiseptica en daarop gebaseerd levend verzwakt vaccin. - Google Patents
Werkwijze voor het bereiden van mutantstammen van Bordetella bronchiseptica en daarop gebaseerd levend verzwakt vaccin. Download PDFInfo
- Publication number
- NL194960C NL194960C NL8702728A NL8702728A NL194960C NL 194960 C NL194960 C NL 194960C NL 8702728 A NL8702728 A NL 8702728A NL 8702728 A NL8702728 A NL 8702728A NL 194960 C NL194960 C NL 194960C
- Authority
- NL
- Netherlands
- Prior art keywords
- strain
- organisms
- phase
- bronchiseptica
- vaccine
- Prior art date
Links
- 241000588779 Bordetella bronchiseptica Species 0.000 title claims description 27
- 238000000034 method Methods 0.000 title claims description 19
- 229940124590 live attenuated vaccine Drugs 0.000 title claims description 7
- 229940023012 live-attenuated vaccine Drugs 0.000 title claims description 7
- 238000002360 preparation method Methods 0.000 title description 7
- 229960005486 vaccine Drugs 0.000 claims description 31
- 238000012360 testing method Methods 0.000 claims description 27
- 241000282887 Suidae Species 0.000 claims description 22
- MHWLWQUZZRMNGJ-UHFFFAOYSA-N nalidixic acid Chemical compound C1=C(C)N=C2N(CC)C=C(C(O)=O)C(=O)C2=C1 MHWLWQUZZRMNGJ-UHFFFAOYSA-N 0.000 claims description 15
- 229960000210 nalidixic acid Drugs 0.000 claims description 14
- 230000002238 attenuated effect Effects 0.000 claims description 12
- 230000002068 genetic effect Effects 0.000 claims description 12
- 239000000427 antigen Substances 0.000 claims description 11
- 108091007433 antigens Proteins 0.000 claims description 11
- 102000036639 antigens Human genes 0.000 claims description 11
- 241000894006 Bacteria Species 0.000 claims description 10
- 230000035945 sensitivity Effects 0.000 claims description 9
- 239000002609 medium Substances 0.000 claims description 8
- 208000015181 infectious disease Diseases 0.000 claims description 7
- 239000001987 Bordet-Gengou agar Substances 0.000 claims description 6
- 101710110818 Dermonecrotic toxin Proteins 0.000 claims description 6
- 230000002159 abnormal effect Effects 0.000 claims description 5
- 238000011888 autopsy Methods 0.000 claims description 5
- 210000003928 nasal cavity Anatomy 0.000 claims description 5
- 238000011321 prophylaxis Methods 0.000 claims description 5
- 208000024891 symptom Diseases 0.000 claims description 5
- 238000012258 culturing Methods 0.000 claims description 4
- 231100000350 mutagenesis Toxicity 0.000 claims description 2
- 238000010187 selection method Methods 0.000 claims description 2
- 241000699670 Mus sp. Species 0.000 description 33
- 241001465754 Metazoa Species 0.000 description 20
- 229920001817 Agar Polymers 0.000 description 19
- 239000008272 agar Substances 0.000 description 19
- 210000004027 cell Anatomy 0.000 description 16
- 241000282898 Sus scrofa Species 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 9
- 241000699666 Mus <mouse, genus> Species 0.000 description 7
- 239000002253 acid Substances 0.000 description 6
- 230000004520 agglutination Effects 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000006285 cell suspension Substances 0.000 description 5
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 5
- 231100000518 lethal Toxicity 0.000 description 5
- 230000001665 lethal effect Effects 0.000 description 5
- 239000002953 phosphate buffered saline Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 231100000419 toxicity Toxicity 0.000 description 5
- 230000001988 toxicity Effects 0.000 description 5
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- 230000002733 dermonecrotic effect Effects 0.000 description 4
- 230000000521 hyperimmunizing effect Effects 0.000 description 4
- 230000003053 immunization Effects 0.000 description 4
- 238000002649 immunization Methods 0.000 description 4
- 230000005847 immunogenicity Effects 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 241000700199 Cavia porcellus Species 0.000 description 3
- 206010018910 Haemolysis Diseases 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000008588 hemolysis Effects 0.000 description 3
- 230000002949 hemolytic effect Effects 0.000 description 3
- 238000011081 inoculation Methods 0.000 description 3
- 238000010255 intramuscular injection Methods 0.000 description 3
- 239000007927 intramuscular injection Substances 0.000 description 3
- 239000003550 marker Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 230000001018 virulence Effects 0.000 description 3
- 201000008283 Atrophic Rhinitis Diseases 0.000 description 2
- 206010003694 Atrophy Diseases 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- 241000283073 Equus caballus Species 0.000 description 2
- 206010053759 Growth retardation Diseases 0.000 description 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
- 206010028735 Nasal congestion Diseases 0.000 description 2
- 239000001888 Peptone Substances 0.000 description 2
- 108010080698 Peptones Proteins 0.000 description 2
- 206010039088 Rhinitis atrophic Diseases 0.000 description 2
- 206010040047 Sepsis Diseases 0.000 description 2
- 230000037444 atrophy Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 230000002759 chromosomal effect Effects 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 210000004748 cultured cell Anatomy 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 238000000855 fermentation Methods 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- 231100000001 growth retardation Toxicity 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 235000019319 peptone Nutrition 0.000 description 2
- 230000001012 protector Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 235000020183 skimmed milk Nutrition 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- WTLKTXIHIHFSGU-UHFFFAOYSA-N 2-nitrosoguanidine Chemical compound NC(N)=NN=O WTLKTXIHIHFSGU-UHFFFAOYSA-N 0.000 description 1
- 241000588807 Bordetella Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 108010046334 Urease Proteins 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 208000029754 bordetellosis Diseases 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 230000005757 colony formation Effects 0.000 description 1
- 238000006114 decarboxylation reaction Methods 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000011597 hartley guinea pig Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- CEQFOVLGLXCDCX-WUKNDPDISA-N methyl red Chemical compound C1=CC(N(C)C)=CC=C1\N=N\C1=CC=CC=C1C(O)=O CEQFOVLGLXCDCX-WUKNDPDISA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000002850 nasal mucosa Anatomy 0.000 description 1
- 208000013435 necrotic lesion Diseases 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000011218 seed culture Methods 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 206010041232 sneezing Diseases 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 231100000747 viability assay Toxicity 0.000 description 1
- 238000003026 viability measurement method Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/099—Bordetella
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/825—Bacterial vaccine for porcine species, e.g. swine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/83—Drug, bio-affecting and body treating compositions involving temperature-sensitive mutant bacterium
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61280890A JP2537042B2 (ja) | 1986-11-27 | 1986-11-27 | ボルデテラ・ブロンキセプチカ感染症生菌ワクチン用原株の製造法および生菌ワクチン |
| JP28089086 | 1986-11-27 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NL8702728A NL8702728A (nl) | 1988-06-16 |
| NL194960B NL194960B (nl) | 2003-05-01 |
| NL194960C true NL194960C (nl) | 2003-09-02 |
Family
ID=17631367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8702728A NL194960C (nl) | 1986-11-27 | 1987-11-16 | Werkwijze voor het bereiden van mutantstammen van Bordetella bronchiseptica en daarop gebaseerd levend verzwakt vaccin. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4770875A (da) |
| JP (1) | JP2537042B2 (da) |
| BE (1) | BE1000255A4 (da) |
| BR (1) | BR8706053A (da) |
| CA (1) | CA1315226C (da) |
| DE (1) | DE3740182C2 (da) |
| DK (1) | DK620087A (da) |
| ES (1) | ES2005447A6 (da) |
| FR (1) | FR2607392B1 (da) |
| GB (1) | GB2200844B (da) |
| IL (1) | IL84258A (da) |
| IT (1) | IT1223171B (da) |
| NL (1) | NL194960C (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1337859C (en) * | 1987-04-24 | 1996-01-02 | Masashi Chazono | Method for culturing bordetella pertussis, a pertussis toxoid and a pertussis vaccine |
| IT1236971B (it) * | 1989-11-03 | 1993-05-07 | Eniricerche Spa | Regione promotore dei geni codificanti le subunita' piliniche fim2, fm3 e fimx di bordetella pertussis e loro impiego per l'espressione di geni che codificano una proteina di interesse. |
| EP0680337A4 (en) * | 1993-01-12 | 1997-07-30 | Anthony George Gristina | METHODS AND COMPOSITIONS FOR DIRECT APPLICATION WITH HIGH CONCENTRATION OF ANTIBODIES, PRODUCING PASSIVE IMMUNITY. |
| US8337861B2 (en) * | 2003-01-09 | 2012-12-25 | The Trustees Of The University Of Pennsylvania | Compositions, methods and kits for enhancing the immunogenicity of a bacterial vaccine vector |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4016253A (en) * | 1975-04-02 | 1977-04-05 | Iowa State University Research Foundation, Inc. | Vaccine for immunization of swine against Bordetella bronchiseptica infection and method of use |
| US4530832A (en) * | 1978-12-07 | 1985-07-23 | Schering Corporation | Method of vaccination for prevention of Bordetella bronchiseptica infection |
| US4225583A (en) * | 1978-12-07 | 1980-09-30 | Iowa State University Research Foundation, Inc. | Intra-respiratory vaccine for prevention of Bordetella bronchiseptica infection and method of use |
| EP0012718B1 (en) * | 1978-12-07 | 1981-09-16 | Iowa State University Research Foundation, Inc. | Intra-respiratory vaccine, modified bacteria strain used in it, vaccine dose form and process for preparing it |
| JPS5953828B2 (ja) * | 1981-08-10 | 1984-12-27 | 健 清水 | ボルデテラ・プロンヒセブティカ感染症生菌ワクチン用改良原株の作出法および生菌ワクチン |
| FR2578424B1 (fr) * | 1985-03-08 | 1988-07-08 | Agronomique Inst Nat Rech | Souches mutantes, vaccinantes de bacteries, leur procede d'obtention, et preparations vaccinales les contenant |
-
1986
- 1986-11-27 JP JP61280890A patent/JP2537042B2/ja not_active Expired - Fee Related
-
1987
- 1987-10-23 IL IL84258A patent/IL84258A/xx not_active IP Right Cessation
- 1987-11-03 CA CA000550904A patent/CA1315226C/en not_active Expired - Fee Related
- 1987-11-10 BR BR8706053A patent/BR8706053A/pt not_active Application Discontinuation
- 1987-11-10 US US07/119,075 patent/US4770875A/en not_active Expired - Lifetime
- 1987-11-13 ES ES8703251A patent/ES2005447A6/es not_active Expired
- 1987-11-16 NL NL8702728A patent/NL194960C/nl not_active IP Right Cessation
- 1987-11-25 BE BE8701336A patent/BE1000255A4/fr not_active IP Right Cessation
- 1987-11-25 FR FR878716336A patent/FR2607392B1/fr not_active Expired - Lifetime
- 1987-11-26 DE DE3740182A patent/DE3740182C2/de not_active Expired - Fee Related
- 1987-11-26 DK DK620087A patent/DK620087A/da not_active Application Discontinuation
- 1987-11-27 IT IT22791/87A patent/IT1223171B/it active
- 1987-11-27 GB GB8727820A patent/GB2200844B/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CA1315226C (en) | 1993-03-30 |
| FR2607392A1 (fr) | 1988-06-03 |
| IT1223171B (it) | 1990-09-12 |
| DE3740182C2 (de) | 1995-03-16 |
| NL8702728A (nl) | 1988-06-16 |
| BE1000255A4 (fr) | 1988-09-27 |
| DK620087A (da) | 1988-05-28 |
| ES2005447A6 (es) | 1989-03-01 |
| IL84258A (en) | 1991-05-12 |
| IL84258A0 (en) | 1988-03-31 |
| BR8706053A (pt) | 1988-06-28 |
| FR2607392B1 (fr) | 1991-05-03 |
| GB8727820D0 (en) | 1987-12-31 |
| IT8722791A0 (it) | 1987-11-27 |
| US4770875A (en) | 1988-09-13 |
| GB2200844A (en) | 1988-08-17 |
| GB2200844B (en) | 1991-04-10 |
| JP2537042B2 (ja) | 1996-09-25 |
| DK620087D0 (da) | 1987-11-26 |
| DE3740182A1 (de) | 1988-08-18 |
| JPS63135335A (ja) | 1988-06-07 |
| NL194960B (nl) | 2003-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1A | A request for search or an international-type search has been filed | ||
| BB | A search report has been drawn up | ||
| BC | A request for examination has been filed | ||
| V1 | Lapsed because of non-payment of the annual fee |
Effective date: 20070601 |