NL2000397A1 - Bicyclische heteroarylverbindingen als PDE10 inhibitoren. - Google Patents
Bicyclische heteroarylverbindingen als PDE10 inhibitoren.Info
- Publication number
- NL2000397A1 NL2000397A1 NL2000397A NL2000397A NL2000397A1 NL 2000397 A1 NL2000397 A1 NL 2000397A1 NL 2000397 A NL2000397 A NL 2000397A NL 2000397 A NL2000397 A NL 2000397A NL 2000397 A1 NL2000397 A1 NL 2000397A1
- Authority
- NL
- Netherlands
- Prior art keywords
- bicyclic heteroaryl
- heteroaryl compounds
- pde10 inhibitors
- pde10
- inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75645006P | 2006-01-05 | 2006-01-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NL2000397A1 true NL2000397A1 (nl) | 2007-07-06 |
| NL2000397C2 NL2000397C2 (nl) | 2007-10-30 |
Family
ID=38131538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL2000397A NL2000397C2 (nl) | 2006-01-05 | 2006-12-21 | Bicyclische heteroarylverbindingen als PDE10 inhibitoren. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20070155779A1 (nl) |
| EP (1) | EP1979343A2 (nl) |
| JP (1) | JP2009522346A (nl) |
| AR (1) | AR058919A1 (nl) |
| CA (1) | CA2636264A1 (nl) |
| NL (1) | NL2000397C2 (nl) |
| PE (1) | PE20071116A1 (nl) |
| TW (1) | TW200736246A (nl) |
| UY (1) | UY30080A1 (nl) |
| WO (1) | WO2007077490A2 (nl) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009535394A (ja) * | 2006-05-02 | 2009-10-01 | ファイザー・プロダクツ・インク | Ｐｄｅ１０阻害剤としての二環式ヘテロアリール化合物 |
| PE20091953A1 (es) * | 2008-05-08 | 2010-01-09 | Du Pont | Azoles sustituidos como fungicidas |
| TWI501965B (zh) | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物 |
| US8133897B2 (en) | 2008-06-20 | 2012-03-13 | H. Lundbeck A/S | Phenylimidazole derivatives as PDE10A enzyme inhibitors |
| BRPI0914772A2 (pt) | 2008-06-25 | 2015-10-20 | Envivo Pharmaceuticals Inc | compostos heterocíclicos 1,2-dissubstituídos |
| RU2506260C2 (ru) * | 2008-06-25 | 2014-02-10 | Энвиво Фармасьютикалз, Инк. | 1,2-дизамещенные гетероциклические соединения |
| WO2010019861A1 (en) * | 2008-08-15 | 2010-02-18 | University Of Louisville Research Foundation, Inc. | Compounds, their syntheses, and their uses |
| TW201030001A (en) * | 2008-11-14 | 2010-08-16 | Amgen Inc | Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors |
| AU2009333214B2 (en) | 2008-12-17 | 2013-09-26 | Amgen Inc. | Aminopyridine and carboxypyridine compounds as phosphodiesterase 10 inhibitors |
| CA2761032A1 (en) * | 2009-05-07 | 2010-11-11 | Envivo Pharmaceuticals, Inc. | Phenoxymethyl heterocyclic compounds |
| NZ597140A (en) | 2009-06-05 | 2014-01-31 | Cephalon Inc | Preparation and uses of 1,2,4-triazolo [1,5a] pyridine derivatives |
| US8349830B2 (en) | 2009-10-30 | 2013-01-08 | Merck Sharp & Dohme | Aryl aminopyridine PDE10 inhibitors |
| WO2011051324A1 (en) * | 2009-10-30 | 2011-05-05 | Janssen Pharmaceutica Nv | Radiolabelled pde10 ligands |
| TWI487705B (zh) * | 2009-12-17 | 2015-06-11 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族芳基三唑衍生物 |
| TWI485151B (zh) | 2009-12-17 | 2015-05-21 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物 |
| AR081810A1 (es) | 2010-04-07 | 2012-10-24 | Bayer Cropscience Ag | Piridinilpirazoles biciclicos |
| CA2800618C (en) * | 2010-05-26 | 2018-08-28 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
| TW201215607A (en) | 2010-07-02 | 2012-04-16 | Lundbeck & Co As H | Aryl-and heteroarylamid derivatives as PDE10A enzyme inhibitor |
| WO2012124782A1 (ja) * | 2011-03-16 | 2012-09-20 | 武田薬品工業株式会社 | 縮合複素環化合物 |
| JP2014122161A (ja) * | 2011-03-31 | 2014-07-03 | Astellas Pharma Inc | ピラゾール化合物 |
| EP2714041B1 (en) | 2011-05-24 | 2016-10-19 | Merck Sharp & Dohme Corp. | Aryloxymethyl cyclopropane derivatives as pde10 inhibitors |
| US9938269B2 (en) | 2011-06-30 | 2018-04-10 | Abbvie Inc. | Inhibitor compounds of phosphodiesterase type 10A |
| WO2013028590A1 (en) * | 2011-08-25 | 2013-02-28 | Merck Sharp & Dohme Corp. | Pyrimidine pde10 inhibitors |
| CA2846758C (en) * | 2011-09-19 | 2017-09-12 | F. Hoffmann-La Roche Ag | Triazolopyridine compounds as pde10a inhibitors |
| BR112014011173A2 (pt) | 2011-11-09 | 2017-05-09 | Abbvie Deutschland | carboxamidas heterocíclicas úteis como inibidores de fosfodiesterase tipo 10a |
| US20130116241A1 (en) | 2011-11-09 | 2013-05-09 | Abbvie Inc. | Novel inhibitor compounds of phosphodiesterase type 10a |
| US9138494B2 (en) * | 2011-12-23 | 2015-09-22 | Abbvie Inc. | Radiolabeled PDE10A ligands |
| EP2841070B1 (en) * | 2012-04-24 | 2018-07-25 | Board Of Trustees Of Northern Illinois University | Design and synthesis of novel inhibitors of isoprenoid biosynthesis |
| EP2855489B1 (en) | 2012-04-26 | 2017-01-04 | Bristol-Myers Squibb Company | Imidazothiadiazole and imidazopyridazine derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation |
| EA201491967A1 (ru) | 2012-04-26 | 2015-03-31 | Бристол-Майерс Сквибб Компани | Производные имидазотиадиазола в качестве ингибиторов активируемых протеазой рецепторов 4 (par4) для лечения агрегации тромбоцитов |
| SMT201700457T1 (it) | 2012-04-26 | 2017-11-15 | Bristol Myers Squibb Co | DERlVATI IMIDAZOTIADIAZOLICI E IMIDAZOPIRAZINICI COME INIBITORI DEL RECETTORE ATTIVATO DA PROTEASI 4 (PAR4) PER IL TRATTAMENTO DELL'AGGREGAZIONE PIASTRINICA |
| US9464085B2 (en) | 2012-08-17 | 2016-10-11 | AbbVie Deutschland GmbH & Co. KG | Inhibitor compounds of phosphodiesterase type 10A |
| IN2015DN01900A (nl) | 2012-09-17 | 2015-08-07 | Abbvie Deutschland | |
| WO2014078568A1 (en) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| US9790203B2 (en) * | 2012-11-26 | 2017-10-17 | Abbvie Inc. | Inhibitor compounds of phosphodiesterase type 10A |
| US9200005B2 (en) | 2013-03-13 | 2015-12-01 | AbbVie Deutschland GmbH & Co. KG | Inhibitor compounds of phosphodiesterase type 10A |
| WO2014140184A1 (en) | 2013-03-14 | 2014-09-18 | AbbVie Deutschland GmbH & Co. KG | Novel inhibitor compounds of phosphodiesterase type 10a |
| US9464076B2 (en) | 2013-03-15 | 2016-10-11 | Daiichi Sankyo Company, Limited | Benzothiophene derivative |
| BR112016007563B1 (pt) * | 2013-10-11 | 2022-12-20 | F. Hoffmann-La Roche Ag | Tiazolopirimidinonas, seus usos, e composição farmacêutica |
| SG11201708294YA (en) | 2015-04-15 | 2017-11-29 | Hoffmann La Roche | Pyridopyrimidinones and their use as nmda receptor modulators |
| EP3856185A1 (en) | 2018-09-28 | 2021-08-04 | Takeda Pharmaceutical Company Limited | Balipodect for treating or preventing autism spectrum disorders |
| GB202002926D0 (en) | 2020-02-28 | 2020-04-15 | Benevolentai Tech Limited | Compositions and uses thereof |
| CN115335057A (zh) * | 2020-03-27 | 2022-11-11 | 北京原基华毅生物科技有限公司 | 抑制酪蛋白激酶的方法 |
| GB202110990D0 (en) * | 2021-07-30 | 2021-09-15 | Benevolentai Cambridge Ltd | Organic compound and their uses |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4876346A (en) * | 1985-05-02 | 1989-10-24 | American Home Products Corporation | Quinoline compounds |
| US4681940A (en) * | 1985-11-19 | 1987-07-21 | American Home Products Corporation | 5-[3-[[2-quinolyl]methoxy]phenyl]-1,3-oxazoles |
| US5843958A (en) * | 1996-11-27 | 1998-12-01 | Ortho Pharmaceutical Corporation | Arylpyrazoles as leukotriene inhibitors |
| EP1755611A1 (en) * | 2004-06-07 | 2007-02-28 | Pfizer Products Inc. | Phosphodiesterase 10 inhibition as treatment for obesity-related and metabolic syndrome-related conditions |
| EA012211B1 (ru) * | 2005-01-07 | 2009-08-28 | Пфайзер Продактс Инк. | Гетероароматические соединения хинолинов и их применение в качестве ингибиторов pde10 |
-
2006
- 2006-12-21 NL NL2000397A patent/NL2000397C2/nl not_active IP Right Cessation
- 2006-12-27 CA CA002636264A patent/CA2636264A1/en not_active Abandoned
- 2006-12-27 EP EP06831852A patent/EP1979343A2/en not_active Withdrawn
- 2006-12-27 JP JP2008549069A patent/JP2009522346A/ja not_active Withdrawn
- 2006-12-27 WO PCT/IB2006/003875 patent/WO2007077490A2/en not_active Ceased
-
2007
- 2007-01-03 US US11/619,218 patent/US20070155779A1/en not_active Abandoned
- 2007-01-03 PE PE2007000001A patent/PE20071116A1/es not_active Application Discontinuation
- 2007-01-03 UY UY30080A patent/UY30080A1/es not_active Application Discontinuation
- 2007-01-04 AR ARP070100041A patent/AR058919A1/es unknown
- 2007-01-04 TW TW096100305A patent/TW200736246A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007077490A2 (en) | 2007-07-12 |
| JP2009522346A (ja) | 2009-06-11 |
| WO2007077490A3 (en) | 2007-10-04 |
| AR058919A1 (es) | 2008-03-05 |
| TW200736246A (en) | 2007-10-01 |
| CA2636264A1 (en) | 2007-07-12 |
| EP1979343A2 (en) | 2008-10-15 |
| US20070155779A1 (en) | 2007-07-05 |
| PE20071116A1 (es) | 2007-11-17 |
| UY30080A1 (es) | 2007-08-31 |
| NL2000397C2 (nl) | 2007-10-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AD1A | A request for search or an international type search has been filed | ||
| RD2N | Patents in respect of which a decision has been taken or a report has been made (novelty report) |
Effective date: 20070827 |
|
| PD2B | A search report has been drawn up | ||
| V1 | Lapsed because of non-payment of the annual fee |
Effective date: 20100701 |