NL8004877A - Farmaceutische preparaten met een anti-ulceractiviteit. - Google Patents

Farmaceutische preparaten met een anti-ulceractiviteit. Download PDF

Info

Publication number: NL8004877A
Authority: NL; Netherlands
Prior art keywords: oral; animals; formula; abc; gastritis
Prior art date: 1979-09-26

Application number

NL8004877A

Other languages

English (en)

Dutch (nl)

Original Assignee

Abc Ist Biolog Chem Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-09-26

Filing date

1980-08-28

Publication date

1981-03-30

1980-08-28 Application filed by Abc Ist Biolog Chem Spa filed Critical Abc Ist Biolog Chem Spa

1981-03-30 Publication of NL8004877A publication Critical patent/NL8004877A/nl

Links

230000000694 effects Effects 0.000 title claims description 14
230000000767 anti-ulcer Effects 0.000 title claims description 8
239000000825 pharmaceutical preparation Substances 0.000 title description 5
208000007107 Stomach Ulcer Diseases 0.000 claims description 11
238000000034 method Methods 0.000 claims description 10
239000000126 substance Substances 0.000 claims description 10
239000003814 drug Substances 0.000 claims description 7
AJRNYCDWNITGHF-UHFFFAOYSA-N oxametacin Chemical compound CC1=C(CC(=O)NO)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 AJRNYCDWNITGHF-UHFFFAOYSA-N 0.000 claims description 6
229960005205 prednisolone Drugs 0.000 claims description 5
OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims description 5
201000005917 gastric ulcer Diseases 0.000 claims description 4
239000000203 mixture Substances 0.000 claims description 4
238000002360 preparation method Methods 0.000 claims description 4
239000002775 capsule Substances 0.000 claims description 3
238000009472 formulation Methods 0.000 claims description 3
239000000546 pharmaceutical excipient Substances 0.000 claims description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
239000002253 acid Substances 0.000 claims description 2
VXMGLMHPFWGAJO-UHFFFAOYSA-N n-hydroxy-2-(5-methoxy-2-methyl-1h-indol-3-yl)acetamide Chemical compound COC1=CC=C2NC(C)=C(CC(=O)NO)C2=C1 VXMGLMHPFWGAJO-UHFFFAOYSA-N 0.000 claims description 2
229960002895 phenylbutazone Drugs 0.000 claims description 2
VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 claims description 2
150000003431 steroids Chemical class 0.000 claims description 2
208000007882 Gastritis Diseases 0.000 claims 4
239000002552 dosage form Substances 0.000 claims 2
239000004480 active ingredient Substances 0.000 claims 1
239000008194 pharmaceutical composition Substances 0.000 claims 1
241001465754 Metazoa Species 0.000 description 33
150000001875 compounds Chemical class 0.000 description 21
241000700159 Rattus Species 0.000 description 16
208000025865 Ulcer Diseases 0.000 description 15
238000011282 treatment Methods 0.000 description 14
229960004940 sulpiride Drugs 0.000 description 12
BGRJTUBHPOOWDU-NSHDSACASA-N (S)-(-)-sulpiride Chemical compound CCN1CCC[C@H]1CNC(=O)C1=CC(S(N)(=O)=O)=CC=C1OC BGRJTUBHPOOWDU-NSHDSACASA-N 0.000 description 10
229920002134 Carboxymethyl cellulose Polymers 0.000 description 10
235000010948 carboxy methyl cellulose Nutrition 0.000 description 10
238000007912 intraperitoneal administration Methods 0.000 description 10
230000001562 ulcerogenic effect Effects 0.000 description 10
230000037396 body weight Effects 0.000 description 9
231100000397 ulcer Toxicity 0.000 description 9
230000036269 ulceration Effects 0.000 description 7
CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 6
230000005764 inhibitory process Effects 0.000 description 5
239000001768 carboxy methyl cellulose Substances 0.000 description 4
239000008112 carboxymethyl-cellulose Substances 0.000 description 4
229940105329 carboxymethylcellulose Drugs 0.000 description 4
CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 description 4
229960001380 cimetidine Drugs 0.000 description 4
230000001186 cumulative effect Effects 0.000 description 4
231100000419 toxicity Toxicity 0.000 description 4
230000001988 toxicity Effects 0.000 description 4
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
231100000403 acute toxicity Toxicity 0.000 description 3
230000007059 acute toxicity Effects 0.000 description 3
230000007423 decrease Effects 0.000 description 3
235000021189 garnishes Nutrition 0.000 description 3
229960000905 indomethacin Drugs 0.000 description 3
235000012054 meals Nutrition 0.000 description 3
108090000623 proteins and genes Proteins 0.000 description 3
239000000725 suspension Substances 0.000 description 3
238000005303 weighing Methods 0.000 description 3
FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 2
-1 5-methyl-2-methyl-3-indolyl-acetohydroxamic acid Chemical compound 0.000 description 2
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 2
MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 2
MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 2
239000002260 anti-inflammatory agent Substances 0.000 description 2
230000003110 anti-inflammatory effect Effects 0.000 description 2
229960004544 cortisone Drugs 0.000 description 2
230000002349 favourable effect Effects 0.000 description 2
230000002008 hemorrhagic effect Effects 0.000 description 2
230000001681 protective effect Effects 0.000 description 2
238000013222 sprague-dawley male rat Methods 0.000 description 2
238000012453 sprague-dawley rat model Methods 0.000 description 2
208000018556 stomach disease Diseases 0.000 description 2
GKDLTXYXODKDEA-UHFFFAOYSA-N 1-phenylbutan-2-one Chemical compound CCC(=O)CC1=CC=CC=C1 GKDLTXYXODKDEA-UHFFFAOYSA-N 0.000 description 1
241000251468 Actinopterygii Species 0.000 description 1
240000006497 Dianthus caryophyllus Species 0.000 description 1
235000009355 Dianthus caryophyllus Nutrition 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
BKPRVQDIOGQWTG-ICOOEGOYSA-N [(1s,2r)-2-phenylcyclopropyl]azanium;[(1r,2s)-2-phenylcyclopropyl]azanium;sulfate Chemical compound [O-]S([O-])(=O)=O.[NH3+][C@H]1C[C@@H]1C1=CC=CC=C1.[NH3+][C@@H]1C[C@H]1C1=CC=CC=C1 BKPRVQDIOGQWTG-ICOOEGOYSA-N 0.000 description 1
RRUDCFGSUDOHDG-UHFFFAOYSA-N acetohydroxamic acid Chemical class CC(O)=NO RRUDCFGSUDOHDG-UHFFFAOYSA-N 0.000 description 1
229960001171 acetohydroxamic acid Drugs 0.000 description 1
239000013543 active substance Substances 0.000 description 1
231100000460 acute oral toxicity Toxicity 0.000 description 1
239000000654 additive Substances 0.000 description 1
230000000202 analgesic effect Effects 0.000 description 1
229940121363 anti-inflammatory agent Drugs 0.000 description 1
230000001754 anti-pyretic effect Effects 0.000 description 1
230000000026 anti-ulcerogenic effect Effects 0.000 description 1
239000011260 aqueous acid Substances 0.000 description 1
239000003637 basic solution Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
229940125904 compound 1 Drugs 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
231100000053 low toxicity Toxicity 0.000 description 1
239000000463 material Substances 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
HXVYXVZMLQQYSN-UHFFFAOYSA-N n-hydroxy-2-(1h-indol-3-yl)acetamide Chemical compound C1=CC=C2C(CC(=O)NO)=CNC2=C1 HXVYXVZMLQQYSN-UHFFFAOYSA-N 0.000 description 1
239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
230000009965 odorless effect Effects 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
KVNYFPKFSJIPBJ-UHFFFAOYSA-N ortho-diethylbenzene Natural products CCC1=CC=CC=C1CC KVNYFPKFSJIPBJ-UHFFFAOYSA-N 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
238000000746 purification Methods 0.000 description 1
210000001187 pylorus Anatomy 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
231100001274 therapeutic index Toxicity 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
230000002110 toxicologic effect Effects 0.000 description 1
231100000027 toxicology Toxicity 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NL8004877A 1979-09-26 1980-08-28 Farmaceutische preparaten met een anti-ulceractiviteit. NL8004877A (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2601679		1979-09-26
IT7926016A IT1212372B (it)	1979-09-26	1979-09-26	Composizioni farmaceutiche ad atti vita' antiulcera contenenti un derivato dell'acido acetoidrossamico

Publications (1)

Publication Number	Publication Date
NL8004877A true NL8004877A (nl)	1981-03-30

Family

ID=11218419

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8004877A NL8004877A (nl)	1979-09-26	1980-08-28	Farmaceutische preparaten met een anti-ulceractiviteit.

Country Status (9)

Country	Link
US (1)	US4285962A (fr)
JP (1)	JPS6019893B2 (fr)
BE (1)	BE884974A (fr)
CA (1)	CA1156556A (fr)
DE (1)	DE3032458C2 (fr)
FR (1)	FR2465481A1 (fr)
GB (1)	GB2058567A (fr)
IT (1)	IT1212372B (fr)
NL (1)	NL8004877A (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4428962A (en)	1981-10-30	1984-01-31	Schering Corporation	Indoles in treatment of peptic ulcers
JP4790594B2 (ja) *	2003-02-25	2011-10-12	トポターゲットユーケーリミテッド	Ｈｄａｃインヒビターとしての、二環式ヘテロアリール基を含むヒドロキサム酸化合物
CN102993153B (zh) *	2012-12-29	2015-05-13	吉首大学	异黄酮-n-甲基氧肟酸类尿素酶抑制剂及其合成和用途
CN102993152B (zh) *	2012-12-29	2015-04-01	吉首大学	尿素酶抑制剂异黄酮氧肟酸化合物及其合成和用途
JP7105708B2 (ja)	2019-02-18	2022-07-25	日本製鉄株式会社	還元ガスの吹込み量決定方法及び高炉の操業方法
AU2020393659B2 (en)	2019-11-29	2023-07-20	Jfe Steel Corporation	Blast furnace operation method

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1036004B (it) *	1968-05-21	1979-10-30	Abc Ist Biolog Chem Spa	Acidt 3 indolil adetoidrossamici

1979
- 1979-09-26 IT IT7926016A patent/IT1212372B/it active
1980
- 1980-08-25 US US06/180,920 patent/US4285962A/en not_active Expired - Lifetime
- 1980-08-28 NL NL8004877A patent/NL8004877A/nl not_active Application Discontinuation
- 1980-08-28 DE DE3032458A patent/DE3032458C2/de not_active Expired
- 1980-08-29 CA CA000359270A patent/CA1156556A/fr not_active Expired
- 1980-08-29 BE BE2/58719A patent/BE884974A/fr not_active IP Right Cessation
- 1980-09-12 JP JP55127844A patent/JPS6019893B2/ja not_active Expired
- 1980-09-24 FR FR8020510A patent/FR2465481A1/fr not_active Withdrawn
- 1980-09-26 GB GB8031170A patent/GB2058567A/en not_active Withdrawn

Also Published As

Publication number	Publication date
DE3032458A1 (de)	1981-04-09
DE3032458C2 (de)	1986-01-09
IT7926016A0 (it)	1979-09-26
BE884974A (fr)	1980-12-16
FR2465481A1 (fr)	1981-03-27
IT1212372B (it)	1989-11-22
CA1156556A (fr)	1983-11-08
JPS56123913A (en)	1981-09-29
JPS6019893B2 (ja)	1985-05-18
US4285962A (en)	1981-08-25
GB2058567A (en)	1981-04-15

Legal Events

Date	Code	Title
1981-11-02	BA	A request for search or an international-type search has been filed
1981-12-01	BB	A search report has been drawn up
1984-07-02	BC	A request for examination has been filed
1985-01-01	A85	Still pending on 85-01-01
1991-04-02	BV	The patent application has lapsed

Publication	Publication Date	Title
US4016268A (en)	1977-04-05	Method of combatting gastric ulceration
DE3204596A1 (de)	1982-09-09	Furo-(3,4-c)-pyridinderivate, verfahren zu deren herstellung und diese enthaltende therapeutische zusammensetzung
US4038416A (en)	1977-07-26	Pharmaceutical composition and method of the use thereof
NL8004877A (nl)	1981-03-30	Farmaceutische preparaten met een anti-ulceractiviteit.
DE2160148A1 (de)	1972-06-08	Arzneimittel
EP0761650A1 (fr)	1997-03-12	Modification cristalline thermostable et supportant le stockage du N-méthyle-N-((1S)-1-phényle-2-((3S)-3-hydroxypyrrolidin-1-yl)-éthyle)-2,2-diphényle-acétamide et procédé pour sa préparation
NL8000140A (nl)	1981-03-17	Glycerylfosforylderivaten en teepassing daarvan als geneesmiddel.
EP0059031B1 (fr)	1985-01-02	Composition analgésique et anti-inflammatoire
DE2462814C2 (fr)	1987-12-23
DE3046325C2 (de)	1983-01-05	Pharmazeutische Mittel mit antiphlogistischer, antipyretischer und analgetischer Wirkung
JPH02172920A (ja)	1990-07-04	抗潰瘍剤
WHEATLEY	1982	Analgesic properties of fluproquazone
US4447437A (en)	1984-05-08	Pharmaceutical composition and method for treatment of peptic ulcer
US3074848A (en)	1963-01-22	2-hydroxy-5,2'-dichloro-4'-nitrobenzanilide for combating tapeworms
JPS61134315A (ja)	1986-06-21	解熱鎮痛剤
DE3026053A1 (de)	1981-02-05	2-substituierte-4-thiazolidone
JPS58501911A (ja)	1983-11-10	類リュウマチ性関節炎治療薬
US4333938A (en)	1982-06-08	Imino derivatives of 5-aminobenzodioxole-1,3 which are useful as medicaments
DE2314387A1 (de)	1973-10-11	Arzneimittel zur behandlung boesartiger neubildungen, vorzugsweise von haemoblastosen und chorionepitheliom
JPS59128326A (ja)	1984-07-24	抗真菌剤
FR2566664A1 (fr)	1986-01-03	Composition utile au traitement de la diarrhee contenant du dextromethorphan
DE2450680B2 (de)	1980-10-09	Verwendung von acylierten Anilinobuttersäuren bei der Ulcusbekämpfung
CA1280372C (fr)	1991-02-19	Traitement des troubles gastro-intestinaux
DE3443858A1 (de)	1985-06-13	Pharmazeutische zusammensetzungen
KR840002071B1 (ko)	1984-11-09	2-치환-4-티아졸리돈의 제조방법