NL8100645A - Naftyridinederivaat, werkwijze voor het bereiden hiervan en geneesmiddelen tegen hersenaandoeningen op basis van dit derivaat. - Google Patents

Naftyridinederivaat, werkwijze voor het bereiden hiervan en geneesmiddelen tegen hersenaandoeningen op basis van dit derivaat. Download PDF

Info

Publication number: NL8100645A
Authority: NL; Netherlands
Prior art keywords: formula; derivative; compound; preparation; naphthyridine
Prior art date: 1980-02-12

Application number

NL8100645A

Other languages

English (en)

Dutch (nl)

Original Assignee

Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-02-12

Filing date

1981-02-11

Publication date

1981-09-01

1981-02-11 Application filed by Synthelabo filed Critical Synthelabo

1981-09-01 Publication of NL8100645A publication Critical patent/NL8100645A/nl

Links

238000002360 preparation method Methods 0.000 title claims description 8
239000003814 drug Substances 0.000 title claims description 6
150000005054 naphthyridines Chemical class 0.000 title claims description 6
238000000034 method Methods 0.000 title claims description 5
208000014644 Brain disease Diseases 0.000 title description 3
150000001875 compounds Chemical class 0.000 claims description 21
230000002490 cerebral effect Effects 0.000 claims description 3
230000000694 effects Effects 0.000 claims description 3
230000032683 aging Effects 0.000 claims description 2
210000004556 brain Anatomy 0.000 claims description 2
208000030159 metabolic disease Diseases 0.000 claims description 2
208000009999 tuberous sclerosis Diseases 0.000 claims description 2
229940126601 medicinal product Drugs 0.000 claims 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 7
241001465754 Metazoa Species 0.000 description 7
239000000126 substance Substances 0.000 description 6
APJYDQYYACXCRM-UHFFFAOYSA-N tryptamine Chemical compound C1=CC=C2C(CCN)=CNC2=C1 APJYDQYYACXCRM-UHFFFAOYSA-N 0.000 description 6
241000700159 Rattus Species 0.000 description 4
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
239000001301 oxygen Substances 0.000 description 4
229910052760 oxygen Inorganic materials 0.000 description 4
239000000243 solution Substances 0.000 description 4
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
241000699670 Mus sp. Species 0.000 description 3
229940079593 drug Drugs 0.000 description 3
150000003388 sodium compounds Chemical class 0.000 description 3
230000004083 survival effect Effects 0.000 description 3
GXFZCDMWGMFGFL-KKXMJGKMSA-N (+)-Tubocurarine chloride hydrochloride Chemical compound [Cl-].[Cl-].C([C@H]1[N+](C)(C)CCC=2C=C(C(=C(OC3=CC=C(C=C3)C[C@H]3C=4C=C(C(=CC=4CC[NH+]3C)OC)O3)C=21)O)OC)C1=CC=C(O)C3=C1 GXFZCDMWGMFGFL-KKXMJGKMSA-N 0.000 description 2
KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 description 2
SJZRECIVHVDYJC-UHFFFAOYSA-M 4-hydroxybutyrate Chemical compound OCCCC([O-])=O SJZRECIVHVDYJC-UHFFFAOYSA-M 0.000 description 2
SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 description 2
241001111317 Chondrodendron tomentosum Species 0.000 description 2
239000008709 Curare Substances 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
230000005587 bubbling Effects 0.000 description 2
239000002775 capsule Substances 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
230000008018 melting Effects 0.000 description 2
238000002844 melting Methods 0.000 description 2
239000000203 mixture Substances 0.000 description 2
238000007363 ring formation reaction Methods 0.000 description 2
230000004622 sleep time Effects 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
206010002091 Anaesthesia Diseases 0.000 description 1
244000025254 Cannabis sativa Species 0.000 description 1
208000020401 Depressive disease Diseases 0.000 description 1
208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
MUQUYTSLDVKIOF-CHJKCJHBSA-N alcuronium Chemical compound C/1([C@@H]23)=C\N([C@H]4\5)C6=CC=CC=C6[C@]4(CC[N@@+]4(CC=C)C\C6=C\CO)[C@@H]4C[C@@H]6C/5=C/N3C3=CC=CC=C3[C@@]22CC[N@@+]3(CC=C)C/C(=C/CO)[C@@H]\1C[C@H]32 MUQUYTSLDVKIOF-CHJKCJHBSA-N 0.000 description 1
230000037005 anaesthesia Effects 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
230000000496 anti-anoxic effect Effects 0.000 description 1
238000003556 assay Methods 0.000 description 1
230000006399 behavior Effects 0.000 description 1
238000009835 boiling Methods 0.000 description 1
239000000969 carrier Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
238000010586 diagram Methods 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
230000005059 dormancy Effects 0.000 description 1
239000008298 dragée Substances 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000007789 gas Substances 0.000 description 1
PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 1
RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
206010022437 insomnia Diseases 0.000 description 1
231100000636 lethal dose Toxicity 0.000 description 1
QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
229910052753 mercury Inorganic materials 0.000 description 1
230000021962 pH elevation Effects 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
238000010992 reflux Methods 0.000 description 1
230000000241 respiratory effect Effects 0.000 description 1
230000029058 respiratory gaseous exchange Effects 0.000 description 1
230000036387 respiratory rate Effects 0.000 description 1
230000004617 sleep duration Effects 0.000 description 1
239000002002 slurry Substances 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
238000007619 statistical method Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
230000006496 vascular abnormality Effects 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Hospice & Palliative Care (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Psychiatry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NL8100645A 1980-02-12 1981-02-11 Naftyridinederivaat, werkwijze voor het bereiden hiervan en geneesmiddelen tegen hersenaandoeningen op basis van dit derivaat. NL8100645A (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8003011A FR2475394A1 (fr)	1980-02-12	1980-02-12	Compositions pharmaceutiques contenant l'hexahydro-1, 2, 3, 3a, 4, 5, 6h indolo (3, 2, 1 - d. e) (1, 5) naphtyridinone - 6
FR8003011		1980-02-12

Publications (1)

Publication Number	Publication Date
NL8100645A true NL8100645A (nl)	1981-09-01

Family

ID=9238471

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8100645A NL8100645A (nl)	1980-02-12	1981-02-11	Naftyridinederivaat, werkwijze voor het bereiden hiervan en geneesmiddelen tegen hersenaandoeningen op basis van dit derivaat.

Country Status (11)

Country	Link
JP (1)	JPS56127313A (fr)
AU (1)	AU6714581A (fr)
BE (1)	BE887468A (fr)
DE (1)	DE3104884A1 (fr)
FR (1)	FR2475394A1 (fr)
GB (1)	GB2068731A (fr)
IL (1)	IL62114A0 (fr)
IT (1)	IT1135422B (fr)
LU (1)	LU83128A1 (fr)
NL (1)	NL8100645A (fr)
ZA (1)	ZA81919B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LU84664A1 (fr) *	1983-02-25	1984-11-08	Onmichem S A	Alkyl-4-indolonaphtyridines et leur application therapeutique
CA1329597C (fr) *	1986-12-22	1994-05-17	Dagmar Hoeltje	Derives du tetrahydropyrido[1,2-a]indole
US5189041A (en) *	1990-11-16	1993-02-23	Syntex (U.S.A.) Inc.	Tricyclic 5-ht3 receptor antagonists

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2358146A1 (fr) *	1976-04-13	1978-02-10	Synthelabo	Derives de la tetrahydro-1,2,3,3a indolo(3,2,1-de) (1,5)naphtyridine

1980
- 1980-02-12 FR FR8003011A patent/FR2475394A1/fr active Granted
1981
- 1981-02-10 AU AU67145/81A patent/AU6714581A/en not_active Abandoned
- 1981-02-11 LU LU83128A patent/LU83128A1/fr unknown
- 1981-02-11 ZA ZA00810919A patent/ZA81919B/xx unknown
- 1981-02-11 DE DE19813104884 patent/DE3104884A1/de active Pending
- 1981-02-11 BE BE0/203762A patent/BE887468A/fr unknown
- 1981-02-11 IT IT19667/81A patent/IT1135422B/it active
- 1981-02-11 GB GB8104135A patent/GB2068731A/en not_active Withdrawn
- 1981-02-11 NL NL8100645A patent/NL8100645A/nl not_active Application Discontinuation
- 1981-02-11 IL IL62114A patent/IL62114A0/xx unknown
- 1981-02-12 JP JP2000581A patent/JPS56127313A/ja active Pending

Also Published As

Publication number	Publication date
GB2068731A (en)	1981-08-19
FR2475394B1 (fr)	1982-05-21
IL62114A0 (en)	1981-03-31
FR2475394A1 (fr)	1981-08-14
IT1135422B (it)	1986-08-20
DE3104884A1 (de)	1982-01-14
BE887468A (fr)	1981-08-11
LU83128A1 (fr)	1982-09-10
ZA81919B (en)	1982-03-31
JPS56127313A (en)	1981-10-06
IT8119667A0 (it)	1981-02-11
AU6714581A (en)	1981-08-20

Legal Events

Date	Code	Title
1983-10-03	BV	The patent application has lapsed
1985-01-01	A85	Still pending on 85-01-01
1987-07-01	BV	The patent application has lapsed

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GB2068731A (en)	1981-08-19	Naphthyridine derivative useful in therapy and pharmaceutical compositions containing the same
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