NL8201439A - Verbinding met periferale vasodilator activiteit, geschikt als huidprikkelend middel, werkwijze ter bereiding ervan en farmaceutische samenstellingen, die deze verbinding bevatten. - Google Patents

Verbinding met periferale vasodilator activiteit, geschikt als huidprikkelend middel, werkwijze ter bereiding ervan en farmaceutische samenstellingen, die deze verbinding bevatten. Download PDF

Info

Publication number: NL8201439A
Authority: NL; Netherlands
Prior art keywords: compound; preparing; skin; pharmaceutical compositions; tirifling
Prior art date: 1981-04-15

Application number

NL8201439A

Other languages

English (en)

Dutch (nl)

Original Assignee

Crosara Farma Bilog Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-04-15

Filing date

1982-04-05

Publication date

1982-11-01

1982-04-05 Application filed by Crosara Farma Bilog Lab filed Critical Crosara Farma Bilog Lab

1982-11-01 Publication of NL8201439A publication Critical patent/NL8201439A/nl

Links

150000001875 compounds Chemical class 0.000 title claims description 11
230000000694 effects Effects 0.000 title claims description 8
239000008194 pharmaceutical composition Substances 0.000 title claims description 5
239000003795 chemical substances by application Substances 0.000 title description 2
238000000034 method Methods 0.000 title description 2
229940124549 vasodilator Drugs 0.000 title 1
239000003071 vasodilator agent Substances 0.000 title 1
239000000203 mixture Substances 0.000 claims description 5
230000024883 vasodilation Effects 0.000 claims description 5
230000002093 peripheral effect Effects 0.000 claims description 4
230000004968 inflammatory condition Effects 0.000 claims description 3
239000002674 ointment Substances 0.000 claims description 3
230000000699 topical effect Effects 0.000 claims description 3
239000000969 carrier Substances 0.000 claims description 2
239000006071 cream Substances 0.000 claims description 2
239000003960 organic solvent Substances 0.000 claims description 2
238000002360 preparation method Methods 0.000 claims description 2
208000024891 symptom Diseases 0.000 claims description 2
UZGLOGCJCWBBIV-UHFFFAOYSA-N 3-(chloromethyl)pyridin-1-ium;chloride Chemical compound Cl.ClCC1=CC=CN=C1 UZGLOGCJCWBBIV-UHFFFAOYSA-N 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
231100000331 toxic Toxicity 0.000 claims 1
230000002588 toxic effect Effects 0.000 claims 1
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
PVNIIMVLHYAWGP-UHFFFAOYSA-N nicotinic acid Natural products OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 6
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 5
MXMLNPCLAHGEPV-UHFFFAOYSA-N cycloheptyl pyridine-3-carboxylate Chemical compound C(C1=CN=CC=C1)(=O)OC1CCCCCC1 MXMLNPCLAHGEPV-UHFFFAOYSA-N 0.000 description 4
235000001968 nicotinic acid Nutrition 0.000 description 4
239000011664 nicotinic acid Substances 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
238000006243 chemical reaction Methods 0.000 description 3
239000002085 irritant Substances 0.000 description 3
231100000021 irritant Toxicity 0.000 description 3
239000012071 phase Substances 0.000 description 3
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
QCRFMSUKWRQZEM-UHFFFAOYSA-N cycloheptanol Chemical compound OC1CCCCCC1 QCRFMSUKWRQZEM-UHFFFAOYSA-N 0.000 description 2
IXCSERBJSXMMFS-UHFFFAOYSA-N hcl hcl Chemical compound Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 2
229960003512 nicotinic acid Drugs 0.000 description 2
-1 nicotinic acid ester Chemical class 0.000 description 2
239000000810 peripheral vasodilating agent Substances 0.000 description 2
229960002116 peripheral vasodilator Drugs 0.000 description 2
229920001223 polyethylene glycol Polymers 0.000 description 2
238000003756 stirring Methods 0.000 description 2
239000000126 substance Substances 0.000 description 2
239000001993 wax Substances 0.000 description 2
XVMSFILGAMDHEY-UHFFFAOYSA-N 6-(4-aminophenyl)sulfonylpyridin-3-amine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=N1 XVMSFILGAMDHEY-UHFFFAOYSA-N 0.000 description 1
241000416162 Astragalus gummifer Species 0.000 description 1
208000008035 Back Pain Diseases 0.000 description 1
GSNUFIFRDBKVIE-UHFFFAOYSA-N DMF Natural products CC1=CC=C(C)O1 GSNUFIFRDBKVIE-UHFFFAOYSA-N 0.000 description 1
208000008930 Low Back Pain Diseases 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
208000002193 Pain Diseases 0.000 description 1
240000007711 Peperomia pellucida Species 0.000 description 1
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
229920001615 Tragacanth Polymers 0.000 description 1
239000013543 active substance Substances 0.000 description 1
230000007059 acute toxicity Effects 0.000 description 1
231100000403 acute toxicity Toxicity 0.000 description 1
239000008346 aqueous phase Substances 0.000 description 1
239000000440 bentonite Substances 0.000 description 1
229910000278 bentonite Inorganic materials 0.000 description 1
SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
DALDUXIBIKGWTK-UHFFFAOYSA-N benzene;toluene Chemical compound C1=CC=CC=C1.CC1=CC=CC=C1 DALDUXIBIKGWTK-UHFFFAOYSA-N 0.000 description 1
238000009835 boiling Methods 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
150000001805 chlorine compounds Chemical class 0.000 description 1
238000006482 condensation reaction Methods 0.000 description 1
239000012050 conventional carrier Substances 0.000 description 1
XCIXKGXIYUWCLL-UHFFFAOYSA-N cyclopentanol Chemical compound OC1CCCC1 XCIXKGXIYUWCLL-UHFFFAOYSA-N 0.000 description 1
238000000921 elemental analysis Methods 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
238000006386 neutralization reaction Methods 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
239000006072 paste Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
RGCLLPNLLBQHPF-HJWRWDBZSA-N phosphamidon Chemical compound CCN(CC)C(=O)C(\Cl)=C(/C)OP(=O)(OC)OC RGCLLPNLLBQHPF-HJWRWDBZSA-N 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000019871 vegetable fat Nutrition 0.000 description 1
238000005406 washing Methods 0.000 description 1
239000011787 zinc oxide Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)

NL8201439A 1981-04-15 1982-04-05 Verbinding met periferale vasodilator activiteit, geschikt als huidprikkelend middel, werkwijze ter bereiding ervan en farmaceutische samenstellingen, die deze verbinding bevatten. NL8201439A (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT21199/81A IT1137375B (it)	1981-04-15	1981-04-15	Composto ad attivita' vasodilatatrice periferica utile come rubefacente, procedimento per la sua preparazione e composizioni farmaceutiche a base di detto composto
IT2119981		1981-04-15

Publications (1)

Publication Number	Publication Date
NL8201439A true NL8201439A (nl)	1982-11-01

Family

ID=11178258

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8201439A NL8201439A (nl)	1981-04-15	1982-04-05	Verbinding met periferale vasodilator activiteit, geschikt als huidprikkelend middel, werkwijze ter bereiding ervan en farmaceutische samenstellingen, die deze verbinding bevatten.

Country Status (7)

Country	Link
KR (1)	KR830010075A (fr)
BE (1)	BE892870A (fr)
DE (1)	DE3213082A1 (fr)
FR (1)	FR2509301A1 (fr)
GB (1)	GB2096605A (fr)
IT (1)	IT1137375B (fr)
NL (1)	NL8201439A (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3570598D1 (en) *	1984-11-15	1989-07-06	Nitto Denko Corp	Composition for percutaneous administration
LU86574A1 (fr) *	1986-09-08	1988-04-05	Oreal	Composition pour induire et stimuler la croissance des cheveux et freiner leur chute,a base d'esters nicotiniques et de derives de pyrimidine
US5157036A (en) *	1986-09-08	1992-10-20	L'oreal	Composition for inducing and stimulating hair growth and retarding its loss, based on nicotinic esters and pyrimidine derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB620687A (en) *	1945-05-22	1949-03-29	Winthrop Chem Co Inc	Improvements in or relating to alkyl esters of nicotinic acid
NL6903138A (fr) *	1968-03-02	1969-09-04

1981
- 1981-04-15 IT IT21199/81A patent/IT1137375B/it active
1982
- 1982-03-29 GB GB8209164A patent/GB2096605A/en not_active Withdrawn
- 1982-04-03 KR KR1019820001484A patent/KR830010075A/ko not_active Withdrawn
- 1982-04-05 NL NL8201439A patent/NL8201439A/nl not_active Application Discontinuation
- 1982-04-07 DE DE19823213082 patent/DE3213082A1/de not_active Withdrawn
- 1982-04-15 FR FR8206456A patent/FR2509301A1/fr active Pending
- 1982-04-15 BE BE0/207843A patent/BE892870A/fr unknown

Also Published As

Publication number	Publication date
KR830010075A (ko)	1983-12-26
FR2509301A1 (fr)	1983-01-14
DE3213082A1 (de)	1982-11-18
BE892870A (fr)	1982-08-02
IT8121199A0 (it)	1981-04-15
IT1137375B (it)	1986-09-10
GB2096605A (en)	1982-10-20

Legal Events

Date	Code	Title	Description
1984-12-03	BV	The patent application has lapsed

Publication	Publication Date	Title
EP0236628B1 (fr)	1992-12-02	Inhibition du sentier de 5-lipoxygénase
CN101337891B (zh)	2011-07-20	一氧化氮供体型丁基苯酞衍生物、其制备方法及医药用途
JP2655692B2 (ja)	1997-09-24	スルホンアミドチエニルカルボン酸化合物
EP0291159A2 (fr)	1988-11-17	Dérivés de l'acide aminosalicylique pour le traitement du psoriasis
JP2016034960A (ja)	2016-03-17	１，３−プロパンジスルホン酸を送達するための方法、化合物、および組成物
GB2025946A (en)	1980-01-30	Imidazole derivative
JPS61251642A (ja)	1986-11-08	リポキシゲナ−ゼ阻害化合物
CA1313372C (fr)	1993-02-02	Derives heterocycliques polycycliques, leur procede de preparation et leur utilisation en medecine humaine et veterinaire
EP0624575A1 (fr)	1994-11-17	Indoles substitués et les compositions pharmaceutiques qui les contiennent
US2659689A (en)	1953-11-17	Benzoic esters
EP3085690B1 (fr)	2019-09-11	Nouveau composé d'urée, son procédé de production et son application
NL8201439A (nl)	1982-11-01	Verbinding met periferale vasodilator activiteit, geschikt als huidprikkelend middel, werkwijze ter bereiding ervan en farmaceutische samenstellingen, die deze verbinding bevatten.
Zienty et al.	1947	N-Substituted 2-pyrrolidones
WO1992000967A1 (fr)	1992-01-23	Compose biheterocyclique
PL90769B1 (fr)	1977-01-31
JP5748670B2 (ja)	2015-07-15	組成物および使用の方法
LU81554A1 (de)	1980-02-14	Alkylthiophenoxyalkylamines
JPS5915886B2 (ja)	1984-04-12	ウイルス感染症の進展を阻止する獣医用薬剤
Duschinsky et al.	1948	Synthesis of Imidazolones Structurally Related to Biotin by Means of N-Bromosuccinimide1
EP3613735B1 (fr)	2023-04-12	Nouvel activateur de sirt1 et utilisation médicinale correspondante
US4011333A (en)	1977-03-08	Substituted thiophenecarboxylic acid and esters as hypolipidemic agents
US2614106A (en)	1952-10-14	alpha,alpha-n-trimethyl succinimide
AT387966B (de)	1989-04-10	Neue n-1h-tetrazol-5-yl-(5-ring)-carboxamidderivate sowie verwendung derartiger verbindungen
Ujan et al.	2019	Synthesis, crystal structure, Hirshfeld surface analysis and DNA binding studies of 1-((E)-3-(4-bromophenyl)-1-phenylallylidene)-2-(m-tolyl) hydrazine
Bergel et al.	1943	79. Cannabis indica. Part XII. Some analogues and a water-soluble derivative of tetrahydrocannabinol