NL8220153A - 1,4-thiazancarbonzuurderivaten, de bereiding en toepassing ervan, alsmede de samenstellingen, die deze derivaten bevatten. - Google Patents

1,4-thiazancarbonzuurderivaten, de bereiding en toepassing ervan, alsmede de samenstellingen, die deze derivaten bevatten. Download PDF

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Publication number: NL8220153A
Authority: NL; Netherlands
Prior art keywords: group; derivative; formula; branched; straight
Prior art date: 1981-04-29

Application number

NL8220153A

Other languages

English (en)

Dutch (nl)

Original Assignee

Midit

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-04-29

Filing date

1982-04-21

Publication date

1983-03-01

1982-04-21 Application filed by Midit filed Critical Midit

1983-03-01 Publication of NL8220153A publication Critical patent/NL8220153A/nl

Links

239000000203 mixture Substances 0.000 title claims description 48
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238000002360 preparation method Methods 0.000 title claims description 12
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 75
239000000243 solution Substances 0.000 claims description 55
238000000034 method Methods 0.000 claims description 37
229910052739 hydrogen Inorganic materials 0.000 claims description 36
239000001257 hydrogen Substances 0.000 claims description 36
-1 3-phthalidyloxy group Chemical group 0.000 claims description 30
238000006243 chemical reaction Methods 0.000 claims description 27
150000001875 compounds Chemical class 0.000 claims description 19
230000008569 process Effects 0.000 claims description 19
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 18
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 18
150000002431 hydrogen Chemical class 0.000 claims description 17
150000003839 salts Chemical class 0.000 claims description 17
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 16
239000002609 medium Substances 0.000 claims description 14
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WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 12
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 12
229910052794 bromium Inorganic materials 0.000 claims description 12
239000000460 chlorine Substances 0.000 claims description 12
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125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 11
125000005843 halogen group Chemical group 0.000 claims description 11
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 10
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WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 2
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150000003457 sulfones Chemical class 0.000 claims description 2
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QEQYAQFYVFRGQD-YFKPBYRVSA-N (2s)-2-amino-5-[[methyl(nitroso)carbamoyl]amino]pentanoic acid Chemical compound O=NN(C)C(=O)NCCC[C@H](N)C(O)=O QEQYAQFYVFRGQD-YFKPBYRVSA-N 0.000 claims 1
MSTFRUQNYRRUKZ-UHFFFAOYSA-N 5,6-dihydro-2h-thiazine Chemical class C1CC=CNS1 MSTFRUQNYRRUKZ-UHFFFAOYSA-N 0.000 claims 1
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LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
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229960004889 salicylic acid Drugs 0.000 description 1
230000007017 scission Effects 0.000 description 1
JPJALAQPGMAKDF-UHFFFAOYSA-N selenium dioxide Chemical compound O=[Se]=O JPJALAQPGMAKDF-UHFFFAOYSA-N 0.000 description 1
238000000926 separation method Methods 0.000 description 1
RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
238000006884 silylation reaction Methods 0.000 description 1
URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
239000007858 starting material Substances 0.000 description 1
238000003860 storage Methods 0.000 description 1
229950000244 sulfanilic acid Drugs 0.000 description 1
150000003460 sulfonic acids Chemical class 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
239000000829 suppository Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
IXZDIALLLMRYOU-UHFFFAOYSA-N tert-butyl hypochlorite Chemical compound CC(C)(C)OCl IXZDIALLLMRYOU-UHFFFAOYSA-N 0.000 description 1
150000003573 thiols Chemical class 0.000 description 1
XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 1
229960000984 tocofersolan Drugs 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000041 toxicology testing Toxicity 0.000 description 1
229910052723 transition metal Inorganic materials 0.000 description 1
150000003624 transition metals Chemical class 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
239000004474 valine Substances 0.000 description 1
235000012141 vanillin Nutrition 0.000 description 1
MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
239000012808 vapor phase Substances 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
210000003462 vein Anatomy 0.000 description 1
UIYCHXAGWOYNNA-UHFFFAOYSA-N vinyl sulfide Chemical compound C=CSC=C UIYCHXAGWOYNNA-UHFFFAOYSA-N 0.000 description 1
239000008215 water for injection Substances 0.000 description 1
238000005303 weighing Methods 0.000 description 1
239000008096 xylene Substances 0.000 description 1
150000003754 zirconium Chemical class 0.000 description 1
239000002076 α-tocopherol Substances 0.000 description 1
235000004835 α-tocopherol Nutrition 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Facsimiles In General (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

NL8220153A 1981-04-29 1982-04-21 1,4-thiazancarbonzuurderivaten, de bereiding en toepassing ervan, alsmede de samenstellingen, die deze derivaten bevatten. NL8220153A (nl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
LU83327		1981-04-29
LU83327A LU83327A1 (fr)	1981-04-29	1981-04-29	Procede de preparation de derives de 1,4-thiazine,leur utilisation ainsi que compositions contenant ces derives
BE8200009		1982-04-21
PCT/BE1982/000009 WO1982003860A1 (fr)	1981-04-29	1982-04-21	Derives de l'acide 1,4-thiazane-carboxylique, leurs preparation et utilisation ainsi que les compositions contenant ces derives

Publications (1)

Publication Number	Publication Date
NL8220153A true NL8220153A (nl)	1983-03-01

Family

ID=19729637

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8220153A NL8220153A (nl)	1981-04-29	1982-04-21	1,4-thiazancarbonzuurderivaten, de bereiding en toepassing ervan, alsmede de samenstellingen, die deze derivaten bevatten.

Country Status (16)

Country	Link
JP (1)	JPS58500713A (de)
KR (1)	KR830010089A (de)
BE (1)	BE893025A (de)
ES (1)	ES8307233A1 (de)
FI (1)	FI66366C (de)
FR (1)	FR2509303A1 (de)
GB (1)	GB2111056B (de)
GR (1)	GR75996B (de)
IT (1)	IT1190794B (de)
LU (1)	LU83327A1 (de)
NL (1)	NL8220153A (de)
NO (1)	NO824398L (de)
PT (1)	PT74813B (de)
SE (1)	SE8207294D0 (de)
WO (1)	WO1982003860A1 (de)
ZA (1)	ZA822926B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3436386A1 (de) *	1984-10-04	1986-04-10	Merck Patent Gmbh, 6100 Darmstadt	(thio)morpholine
FR2618434B1 (fr) *	1987-07-21	1991-02-08	Oreal	Esters d'acide thiamorpholinone carboxylique et de ses derives, leur procede de preparation et leur utilisation dans le domaine cosmetique et dermo-pharmaceutique
AU4750990A (en) *	1988-12-14	1990-07-10	Hicks, Richard	Method for predicting biological activity of antibiotics, and novel non beta-lactam antibacterial agents derived therefrom
UY34610A (es)	2012-02-03	2013-09-30	Sanofi Sa	Pirroldicarboxamidas condensadas y su uso como agentes farmacéuticos.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2187327B1 (de) *	1972-06-15	1975-06-20	Rech Pharm Scientifiques
US4179276A (en) *	1977-02-01	1979-12-18	E. I. Du Pont De Nemours And Company	Novel imidazothiazine-1,3 (2H)-diones
JPS5540658A (en) *	1978-09-19	1980-03-22	Tanabe Seiyaku Co Ltd	1,4-thiazan-3-carboxylic ester derivative and its preparation

1981
- 1981-04-29 LU LU83327A patent/LU83327A1/fr unknown
1982
- 1982-04-21 NL NL8220153A patent/NL8220153A/nl unknown
- 1982-04-21 JP JP57501451A patent/JPS58500713A/ja active Granted
- 1982-04-21 WO PCT/BE1982/000009 patent/WO1982003860A1/fr not_active Ceased
- 1982-04-21 GB GB08235353A patent/GB2111056B/en not_active Expired
- 1982-04-28 PT PT74813A patent/PT74813B/pt unknown
- 1982-04-28 ES ES82511759A patent/ES8307233A1/es not_active Expired
- 1982-04-29 GR GR68018A patent/GR75996B/el unknown
- 1982-04-29 FR FR8207461A patent/FR2509303A1/fr not_active Withdrawn
- 1982-04-29 ZA ZA822926A patent/ZA822926B/xx unknown
- 1982-04-29 KR KR1019820001874A patent/KR830010089A/ko not_active Ceased
- 1982-04-29 BE BE0/207967A patent/BE893025A/fr not_active IP Right Cessation
- 1982-04-29 IT IT20998/82A patent/IT1190794B/it active
- 1982-12-14 FI FI771226A patent/FI66366C/fi not_active IP Right Cessation
- 1982-12-21 SE SE8207294A patent/SE8207294D0/xx not_active Application Discontinuation
- 1982-12-28 NO NO824398A patent/NO824398L/no unknown

Also Published As

Publication number	Publication date
FI824279L (fi)	1982-12-14
JPS58500713A (ja)	1983-05-06
BE893025A (fr)	1982-10-29
FI66366B (fi)	1984-06-29
SE8207294L (sv)	1982-12-21
LU83327A1 (fr)	1983-03-24
FI66366C (fi)	1984-10-10
JPH0330592B2 (de)	1991-04-30
ES511759A0 (es)	1983-07-01
PT74813B (fr)	1983-10-26
FI824279A0 (fi)	1982-12-14
GB2111056A (en)	1983-06-29
SE8207294D0 (sv)	1982-12-21
FR2509303A1 (fr)	1983-01-14
PT74813A (fr)	1982-05-01
WO1982003860A1 (fr)	1982-11-11
GB2111056B (en)	1985-03-06
GR75996B (de)	1984-08-03
IT1190794B (it)	1988-02-24
ES8307233A1 (es)	1983-07-01
IT8220998A0 (it)	1982-04-29
NO824398L (no)	1982-12-28
KR830010089A (ko)	1983-12-26
ZA822926B (en)	1983-03-30

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KR100339296B1 (ko)	2002-06-03	헤테로고리성 메탈로프로테아제 억제제
EP0243018B1 (de)	1990-10-24	Thiolactam-N-essigsäure-Derivate, ihre Herstellung und Verwendung
NO315373B1 (no)	2003-08-25	Spirosykliske metallprotease-inhibitorer
RO109645B1 (ro)	1995-04-28	Derivati de fenilacetamida si procedee pentru prepararea acestora
GB2196962A (en)	1988-05-11	Substituted 2-benzyl-mercapto-imidazoles and analogs useful as anti-inflammatory agents
EP1587516A1 (de)	2005-10-26	Amid- und ester-matrix-metalloproteinase-hemmer
RU2133745C1 (ru)	1999-07-27	Производные кумарина, их применение в качестве pla2-ингибиторов и лекарственное средство
EP0228959A2 (de)	1987-07-15	Aminostyryl-Verbindungen und diese als wirksame Bestandteile enthaltende leukotrienantagonistische Zusammensetzung und Verfahren um durch ihre Anwendung SRS entgegenzuwirken
WO1998025612A1 (fr)	1998-06-18	Nouvelle application therapeutique des derives du pyrrole
KR19990014049A (ko)	1999-02-25	헥사하이드로-1,4-디아제핀 유도체 또는 이의 염
KR20230129394A (ko)	2023-09-08	리아노딘 수용체를 수반하는 장애를 치료하기 위한 작용제
KR100431789B1 (ko)	2004-08-30	신규한벤조티아졸유도체
US5137904A (en)	1992-08-11	Thiohydantoin inhibitors of collagen-induced and ADP-induced platelet aggregation
RU2034834C1 (ru)	1995-05-10	(4-амино-2,6-диметилфенилсульфонил)нитрометан, (4-ацетамидо-2,6-диметилфенилсульфонил)нитрометан и фармацевтическая композиция, обладающая свойствами ингибитора фермента альдозоредуктазы
DK163924B (da)	1992-04-21	Spiro-oeimidazolidin-4,3'-azaindolinaa-2,2',5-trion-forbindelser og farmaceutisk praeparat indeholdende disse til behandling af med diabetes forbundne kroniske komplikationer
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JP7862858B2 (ja)	2026-05-20	Ｍｐｓ１を処置するための併用療法
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