NL8302668A - Doxycyclinecapsules en werkwijze voor het vervaardigen daarvan. - Google Patents

Doxycyclinecapsules en werkwijze voor het vervaardigen daarvan. Download PDF

Info

Publication number: NL8302668A
Authority: NL; Netherlands
Prior art keywords: doxycycline; capsules; spheres; granules; excipients
Prior art date: 1982-12-10

Application number

NL8302668A

Other languages

English (en)

Dutch (nl)

Original Assignee

Distributa Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-12-10

Filing date

1983-07-27

Publication date

1984-07-02

1983-07-27 Application filed by Distributa Sa filed Critical Distributa Sa

1984-07-02 Publication of NL8302668A publication Critical patent/NL8302668A/nl

Links

229960003722 doxycycline Drugs 0.000 title claims abstract description 38
XQTWDDCIUJNLTR-CVHRZJFOSA-N doxycycline monohydrate Chemical compound O.O=C1C2=C(O)C=CC=C2[C@H](C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]1[C@H]2O XQTWDDCIUJNLTR-CVHRZJFOSA-N 0.000 title claims abstract description 38
239000002775 capsule Substances 0.000 title claims abstract description 24
239000008187 granular material Substances 0.000 title abstract 9
206010022653 Intestinal haemorrhages Diseases 0.000 title abstract 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 15
229930006000 Sucrose Natural products 0.000 claims abstract description 15
239000005720 sucrose Substances 0.000 claims abstract description 15
229920002261 Corn starch Polymers 0.000 claims abstract description 10
NEDGUIRITORSKL-UHFFFAOYSA-N butyl 2-methylprop-2-enoate;2-(dimethylamino)ethyl 2-methylprop-2-enoate;methyl 2-methylprop-2-enoate Chemical compound COC(=O)C(C)=C.CCCCOC(=O)C(C)=C.CN(C)CCOC(=O)C(C)=C NEDGUIRITORSKL-UHFFFAOYSA-N 0.000 claims abstract description 10
239000008120 corn starch Substances 0.000 claims abstract description 10
239000004922 lacquer Substances 0.000 claims abstract description 9
239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 9
229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 9
235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 9
239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 9
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims abstract description 8
229920003148 Eudragit® E polymer Polymers 0.000 claims abstract description 8
239000000969 carrier Substances 0.000 claims abstract description 8
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 5
239000013078 crystal Substances 0.000 claims abstract description 4
238000001035 drying Methods 0.000 claims abstract description 3
238000005507 spraying Methods 0.000 claims abstract 3
239000003814 drug Substances 0.000 claims description 10
238000000034 method Methods 0.000 claims description 10
229940079593 drug Drugs 0.000 claims description 9
PTNZGHXUZDHMIQ-UHFFFAOYSA-N 4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide;hydrochloride Chemical compound Cl.C1=CC=C2C(C)C(C(O)C3C(C(O)=C(C(N)=O)C(=O)C3N(C)C)(O)C3=O)C3=C(O)C2=C1O PTNZGHXUZDHMIQ-UHFFFAOYSA-N 0.000 claims description 5
229960004082 doxycycline hydrochloride Drugs 0.000 claims description 5
239000008240 homogeneous mixture Substances 0.000 claims description 5
239000011324 bead Substances 0.000 claims description 3
238000009835 boiling Methods 0.000 claims description 3
238000004519 manufacturing process Methods 0.000 claims description 3
238000010438 heat treatment Methods 0.000 claims 1
238000004090 dissolution Methods 0.000 abstract description 3
239000000203 mixture Substances 0.000 abstract description 3
239000011248 coating agent Substances 0.000 abstract description 2
238000000576 coating method Methods 0.000 abstract description 2
238000009472 formulation Methods 0.000 abstract 1
239000002245 particle Substances 0.000 abstract 1
230000002028 premature Effects 0.000 abstract 1
229920001328 Polyvinylidene chloride Polymers 0.000 description 3
210000003238 esophagus Anatomy 0.000 description 3
239000007903 gelatin capsule Substances 0.000 description 3
230000007935 neutral effect Effects 0.000 description 3
239000005033 polyvinylidene chloride Substances 0.000 description 3
239000012602 primary packaging material Substances 0.000 description 3
239000000454 talc Substances 0.000 description 3
229910052623 talc Inorganic materials 0.000 description 3
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
229920003149 Eudragit® E 100 Polymers 0.000 description 2
229910052802 copper Inorganic materials 0.000 description 2
239000010949 copper Substances 0.000 description 2
230000000694 effects Effects 0.000 description 2
239000011888 foil Substances 0.000 description 2
238000003908 quality control method Methods 0.000 description 2
229910001220 stainless steel Inorganic materials 0.000 description 2
239000010935 stainless steel Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
239000000725 suspension Substances 0.000 description 2
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
230000000740 bleeding effect Effects 0.000 description 1
230000008030 elimination Effects 0.000 description 1
238000003379 elimination reaction Methods 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
239000008188 pellet Substances 0.000 description 1
238000002360 preparation method Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NL8302668A 1982-12-10 1983-07-27 Doxycyclinecapsules en werkwijze voor het vervaardigen daarvan. NL8302668A (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
LU84526		1982-12-10
LU84526A LU84526A1 (de)	1982-12-10	1982-12-10	Doxycyclinkapseln und verfahren zu deren herstellung

Publications (1)

Publication Number	Publication Date
NL8302668A true NL8302668A (nl)	1984-07-02

Family

ID=19729998

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8302668A NL8302668A (nl)	1982-12-10	1983-07-27	Doxycyclinecapsules en werkwijze voor het vervaardigen daarvan.

Country Status (3)

Country	Link
BE (1)	BE897510A (de)
LU (1)	LU84526A1 (de)
NL (1)	NL8302668A (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2602423B1 (fr) *	1986-08-08	1989-05-05	Ethypharm Sa	Procede de preparation d'un medicament a base de fenofibrate, medicament obtenu par ce procede
EP0557670B1 (de) *	1992-02-25	1999-05-06	Spirig Ag Pharmazeutische Präparate	Minocyclin enthaltende Pellets

1982
- 1982-12-10 LU LU84526A patent/LU84526A1/de unknown
1983
- 1983-07-27 NL NL8302668A patent/NL8302668A/nl not_active Application Discontinuation
- 1983-08-10 BE BE0/211335A patent/BE897510A/nl not_active IP Right Cessation

Also Published As

Publication number	Publication date
BE897510A (nl)	1983-12-01
LU84526A1 (de)	1983-06-13

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Legal Events

Date	Code	Title	Description
1985-01-01	A85	Still pending on 85-01-01
1987-03-02	BV	The patent application has lapsed